KEGG ORTHOLOGY: K04353

ORTHOLOGY: K04353

Entry

K04353                      KO

Symbol

RAP1A

Name

Ras-related protein Rap-1A

Pathway

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04024

cAMP signaling pathway

map04062

Chemokine signaling pathway

map04510

Focal adhesion

map04530

Tight junction

map04611

Platelet activation

map04670

Leukocyte transendothelial migration

map04720

Long-term potentiation

map04722

Neurotrophin signaling pathway

map04934

Cushing syndrome

map04972

Pancreatic secretion

map05211

Renal cell carcinoma

map05417

Lipid and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04353  RAP1A; Ras-related protein Rap-1A
   04014 Ras signaling pathway
    K04353  RAP1A; Ras-related protein Rap-1A
   04015 Rap1 signaling pathway
    K04353  RAP1A; Ras-related protein Rap-1A
   04024 cAMP signaling pathway
    K04353  RAP1A; Ras-related protein Rap-1A
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04353  RAP1A; Ras-related protein Rap-1A
   04530 Tight junction
    K04353  RAP1A; Ras-related protein Rap-1A
09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K04353  RAP1A; Ras-related protein Rap-1A
   04670 Leukocyte transendothelial migration
    K04353  RAP1A; Ras-related protein Rap-1A
   04062 Chemokine signaling pathway
    K04353  RAP1A; Ras-related protein Rap-1A
  09154 Digestive system
   04972 Pancreatic secretion
    K04353  RAP1A; Ras-related protein Rap-1A
  09156 Nervous system
   04720 Long-term potentiation
    K04353  RAP1A; Ras-related protein Rap-1A
   04722 Neurotrophin signaling pathway
    K04353  RAP1A; Ras-related protein Rap-1A
09160 Human Diseases
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    K04353  RAP1A; Ras-related protein Rap-1A
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04353  RAP1A; Ras-related protein Rap-1A
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04353  RAP1A; Ras-related protein Rap-1A
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins
    K04353  RAP1A; Ras-related protein Rap-1A
GTP-binding proteins [BR:ko04031]
Small (monomeric) G-proteins
  Ras Family
   Rap [OT]
    K04353  RAP1A; Ras-related protein Rap-1A

Genes

HSA:	5906(RAP1A)

PTR:	469408(RAP1A)

PPS:	100980934(RAP1A)

GGO:	101125618(RAP1A)

PON:	100433839(RAP1A)

NLE:	100603891(RAP1A)

MCC:	704404(RAP1A)

MCF:	102144586(RAP1A)

MTHB:

126930173

CSAB:

103224221(RAP1A)

CATY:

105594391(RAP1A)

PANU:

101002054(RAP1A)

TGE:	112626061(RAP1A)

RRO:	104658932(RAP1A)

RBB:	108525739 108528085(RAP1A)

TFN:	117076028(RAP1A)

PTEH:

111556041(RAP1A)

CJC:	100393183(RAP1A)

SBQ:	101048450(RAP1A)

CSYR:

103271454(RAP1A)

MMUR:

105878770(RAP1A)

LCAT:

123635037(RAP1A)

OGA:	100962069(RAP1A)

MMU:	109905(Rap1a)

MCAL:

110290796(Rap1a)

MPAH:

110319932(Rap1a)

RNO:	295347(Rap1a)

MCOC:

116092927 116093571(Rap1a)

MUN:	110549551(Rap1a)

CGE:	100751497(Rap1a)

MAUA:

101841364(Rap1a)

PLEU:

114707256(Rap1a)

MORG:

121437958 121449757

MFOT:

126495237

AAMP:

119800929(Rap1a)

NGI:	103734905(Rap1a)

HGL:	101698757(Rap1a)

CPOC:

100713608(Rap1a)

CCAN:

109695156(Rap1a)

DORD:

105991859(Rap1a)

DSP:	122104391(Rap1a)

NCAR:

124978224

OCU:	100351588(RAP1A)

OPI:	101516340(RAP1A)

TUP:	102475072(RAP1A)

CFA:	483225(RAP1A)

CLUD:

112663891(RAP1A)

VVP:	112907935(RAP1A)

VLG:	121490661(RAP1A)

AML:	100471801(RAP1A)

UMR:	103675043(RAP1A)

UAH:	113244427(RAP1A)

UAR:	123795072(RAP1A)

ELK:

111143648

LLV:

125096746

MPUF:

101684587(RAP1A)

ORO:	101375466(RAP1A)

EJU:	114207895(RAP1A)

ZCA:	113928623(RAP1A)

MLX:	118010439 118019003(RAP1A)

NSU:	110580572(RAP1A)

FCA:	101094942(RAP1A)

PYU:	121027680(RAP1A)

PBG:	122480933(RAP1A)

LRUF:

124516472

PTG:	102963243(RAP1A)

PPAD:

109272045(RAP1A)

AJU:	106969628(RAP1A)

HHV:	120247125(RAP1A)

BTA:	282031(RAP1A)

BOM:	102286224(RAP1A)

BIU:	109555931(RAP1A)

BBUB:

102394947(RAP1A)

CHX:	102176930(RAP1A)

OAS:	101115080(RAP1A)

ODA:	120856682(RAP1A)

CCAD:

122436539(RAP1A)

SSC:	100153199(RAP1A)

CFR:	102516450(RAP1A)

CBAI:

105063692(RAP1A)

CDK:	105102039(RAP1A)

VPC:	102544212(RAP1A)

BACU:

103017880(RAP1A)

LVE:	103069239(RAP1A)

OOR:	101287340(RAP1A)

DLE:	111180034(RAP1A)

PCAD:

102985661(RAP1A)

PSIU:

116755898(RAP1A)

ECB:	100049912 100058930(RAP1A)

EPZ:	103547802(RAP1A)

EAI:	106828599(RAP1A)

MYB:	102258771(RAP1A)

MYD:	102774675(RAP1A)

MMYO:

118672699(RAP1A)

MLF:	102418362(RAP1A)

MNA:	107545324(RAP1A)

PKL:	118727506(RAP1A) 118731567

HAI:	109373546(RAP1A)

DRO:	112313714(RAP1A)

SHON:

118982036(RAP1A)

AJM:	119054595(RAP1A)

PDIC:

114488957(RAP1A)

PHAS:

123804635(RAP1A)

MMF:	118637043(RAP1A)

RFQ:	117014781(RAP1A)

PALE:

102879271(RAP1A)

PGIG:

120585025(RAP1A)

PVP:	105296884(RAP1A)

RAY:	107499843(RAP1A)

MJV:	108395546(RAP1A)

TOD:	119235568(RAP1A)

SARA:

101543770(RAP1A)

LAV:	100676220(RAP1A)

TMU:

101352801

DNM:	101412472 101431654(RAP1A)

MDO:	100033128(RAP1A)

GAS:	123244057(RAP1A)

SHR:	100935403(RAP1A)

PCW:	110218764(RAP1A)

OAA:	100076731(RAP1A)

GGA:	419867(RAP1A)

PCOC:

116237094(RAP1A)

MGP:	100151696(RAP1A)

CJO:	107324916(RAP1A)

NMEL:

110388047(RAP1A)

APLA:

101800296(RAP1A)

ACYG:

106041314(RAP1A)

AFUL:

116498770(RAP1A)

TGU:	100151697(RAP1A)

LSR:	110475399(RAP1A)

SCAN:

103823268(RAP1A)

PMOA:

120495847(RAP1A)

OTC:	121348043(RAP1A)

PRUF:

121353155(RAP1A)

GFR:	102036447(RAP1A)

FAB:	101806584(RAP1A)

PHI:	102112636(RAP1A)

PMAJ:

107214847(RAP1A)

CCAE:

111939824(RAP1A)

CCW:	104692321(RAP1A)

CBRC:

103620353(RAP1A)

ETL:	114063112(RAP1A)

ZAB:	102070962(RAP1A)

ACHL:

103805174(RAP1A)

FPG:	101924077(RAP1A)

FCH:	102052801(RAP1A)

CLV:	102089030(RAP1A)

EGZ:	104126794(RAP1A)

NNI:	104010315(RAP1A)

PLET:

104618860(RAP1A)

PCRI:

104036618

ACUN:

113488776(RAP1A)

TALA:

104360909(RAP1A)

PADL:

103923560(RAP1A)

AFOR:

103893569(RAP1A)

ACHC:

115335056(RAP1A)

HALD:

104322485

CCRI:

104159090(RAP1A)

CSTI:

104553928

EHS:	104513138(RAP1A)

CMAC:

104485325

MUI:	104542974(RAP1A)

FGA:	104082410(RAP1A)

GSTE:

104264980

LDI:	104353529(RAP1A)

MNB:	103772591(RAP1A)

OHA:	104333159(RAP1A)

NNT:	104410007(RAP1A)

DPUB:

104296422(RAP1A)

PGUU:

104460010

ACAR:

104527015

AVIT:

104277180(RAP1A)

CVF:	104289481(RAP1A)

AAM:	106485263(RAP1A)

AROW:

112971578(RAP1A)

NPD:	112944571(RAP1A)

TGT:	104569825(RAP1A)

DNE:	112990243(RAP1A)

SCAM:

104142306(RAP1A)

ASN:	102385556(RAP1A)

AMJ:	102571106(RAP1A)

CPOO:

109317882(RAP1A)

GGN:	109295298(RAP1A)

PSS:	102461781(RAP1A)

CMY:	102948045(RAP1A)

CPIC:

101952443(RAP1A)

TST:	117877457(RAP1A)

MRV:	120404195(RAP1A)

ACS:	100556443(rap1a)

PVT:	110072354(RAP1A)

SUND:

121928393(RAP1A)

PBI:	103065471(RAP1A)

PMUR:

107292543(RAP1A)

CTIG:

120316127(RAP1A)

TSR:

106550518

PGUT:

117663826(RAP1A)

VKO:	123031805(RAP1A)

PMUA:

114599364(RAP1A)

ZVI:	118089490(RAP1A)

GJA:	107112269(RAP1A)

STOW:

125433058(RAP1A)

XLA:	414290(rap1a.S) 779127(rap1a.L)

XTR:	100124947(rap1a)

NPR:	108789680(RAP1A)

RTEM:

120927068(RAP1A)

BBUF:

120994960(RAP1A)

BGAR:

122930275 122930276

DRE:	406714(rap1ab) 415242(rap1aa)

SRX:	107711849 107742898 107745329 107751450

SANH:

107669014 107669591 107679791

SGH:	107556321 107557907 107560426 107591033 107594522

CCAR:

109078070 109103832

CAUA:

113054957 113069357 113072089 113107537 113107754

PPRM:

120484123(rap1aa)

MAMB:

125256596 125279745(rap1aa)

IPU:	108255244(rap1ab) 108265690(rap1aa)

PHYP:

113526347(rap1a) 113538035

SMEO:

124399916(rap1aa)

TFD:	113655771(rap1aa) 113656435(rap1ab)

AMEX:

103022868 103047011(rap1a)

EEE:	113572077(rap1a) 113586523

TRU:	101064935 101074250

TNG:	GSTEN00013536G001 GSTEN00023474G001

LCO:	104919934 104924467

NCC:

104961557

CGOB:

115004964 115006261 115007899

ELY:	117256736 117258625

EFO:	125891517 125896957

PLEP:

121946624 121957019

SLUC:

116043610(rap1aa) 116051393

ECRA:

117943332 117947038

ESP:	116688344 116692093

PFLV:

114553888 114558435

GAT:	120829663 120835153

PPUG:

119222818 119229933

MSAM:

119885910 119905851

CUD:	121517480 121528659

ALAT:

119021110 119022741

MZE:	101466020 101483640

ONL:	100690250 100692376

OAU:	116317168(rap1aa) 116320713

OLA:	101167529 101171247

OML:	112144686 112158849

XMA:	102226994 102235995

XCO:	114135748 114140864

XHE:	116710773(rap1a) 116712138

PRET:

103464617 103467749

PFOR:

103135492(rap1a) 103139095

PLAI:

106952760 106955536(rap1a)

PMEI:

106903419 106916736

GAF:	122833974 122838766(rap1aa)

CVG:	107090729 107103249

CTUL:

119794231 119799404(rap1aa)

GMU:	124856820 124875123

NFU:	107385357 107389464 107390354

KMR:	108231658 108232056

ALIM:

106515116(rap1a) 106527728 106531700

NWH:	119411850 119417490

AOCE:

111572080 111585086

MCEP:

125006269 125006718

CSEM:

103385603 103386699(rap1a)

POV:	109635540 109642729

SSEN:

122768573 122775382 122776902

HHIP:

117761319 117764251

HSP:	118104695 118111396

LCF:	108884107 108890490

SDU:	111224024 111234902

SLAL:

111650973 111661945

XGL:	120803735 120807409

HCQ:	109526885 109529211

BPEC:

110164509 110170275

MALB:

109954071 109959359 109970312

BSPL:

114855366 114858554(rap1aa)

SASA:

106566052(RAP1A) 106567206(RAP1B) 106572472(RAP1B) 106582744(RAP1B)

STRU:

115150983 115165695 115168039 115207441

OTW:	112216212 112221097 112221873 112254221

OMY:	100305315(rap1b) 110492737 110494688 110532523

OGO:	124003093 124031583 124032134 124045946

ONE:	115102395 115132366 115136059 115143474

SALP:

111966669 111969753 111976890

SNH:	120058606 120059240 120061134 120065036

CCLU:

121538058 121545693 121574894 121578376

ELS:	105022336(rap1b) 105023688(rap1a)

SFM:	108928254(rap1a) 108930477

PKI:	111839862 111851087(rap1a)

AANG:

118208143(rap1aa) 118211443

LOC:	102690385(rap1a)

PSPA:

121299977 121300003

ARUT:

117417594 117431526

LCM:	102354992(RAP1A)

CMK:	103182425(rap1a)

RTP:	109939006(rap1b)

BFO:	118409875 118415225 118415323

BBEL:

109487627 109487934

CIN:	445785(rap1b)

SPU:	115919354 580151

APLC:

110982135

DME:	Dmel_CG1956(Rap1)

DER:

6546030

DSE:

6610415

DSI:	Dsimw501_GD13432(Dsim_R)

DYA:	Dyak_GE20907

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI16691

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

RZE:	108360732 108369662

MDE:

101892158

SCAC:

106094360

LCQ:	111689646 111689784

LSQ:

119606771

HIS:

119661013

AGA:	AgaP_AGAP001874

ACOZ:

AARA:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ008396

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BPYO:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

LHT:

CCIN:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

692519(Ras3)

BMAN:

114253491

MSEX:

115440159 119192034 119193570

DPL:	KGM_210727

BANY:

NIQ:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:	119836534 119836566

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

CFEL:

API:

DNX:

AGS:

RMD:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

PHU:	Phum_PHUM226110

FOC:

TPAL:

ZNE:

CSEC:

FCD:	110845442 110851148

DPX:	DAPPUDRAFT_231811

DMK:

116925683

PVM:	113809417 113824747

PJA:

PCHN:

HAME:

PCLA:

PTRU:

HAZT:

EAF:	111704710 111714711

LSM:	121116213 121116596

PPOI:

119091908

ISC:	IscW_ISCW010282

DSV:	119446291 119466408

RSAN:

119407116

RMP:	119161650 119163534

VDE:	111245746 111255224

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

SDM:

CEL:	CELE_C27B7.8(rap-1)

CBR:	CBG_21720(Cbr-rap-1)

BMY:	BM_BM2428(Bma-rap-1)

LOA:	LOAG_05207

NAI:	NECAME_08250 NECAME_08256 NECAME_15432

TSP:

Tsp_02666

HRO:	HELRODRAFT_77994

LGI:	LOTGIDRAFT_226838

PCAN:

112572369

BGT:	106064066 106075417

GAE:	121367998 121381407

HRF:

124125080

HRJ:	124265142 124288595

MYI:

PMAX:

MMER:

OBI:

OSN:	115209907 115228804

LAK:	106163156 106163157

SMM:	Smp_142450

NVE:	5510684 5517110

EPA:	110236317 110236776

ATEN:

116291898 116295677

ADF:	107340152 107354004

AMIL:

114955013 114961376 114962244 114964104

PDAM:

SPIS:

DGT:

XEN:

TMS:	TREMEDRAFT_62789

TASA:

A1Q1_04105

SHS:	STEHIDRAFT_91025

FME:	FOMMEDRAFT_131416

LBC:	LACBIDRAFT_190473

CCI:	CC1G_14380

PCUB:

JR316_0006052

MRR:	Moror_1237

E1B28_011332

SCM:	SCHCO_02625881(SCHCODRAFT_02625881)

WSE:	WALSEDRAFT_41564

MBR:	MONBRDRAFT_37080

SRE:	PTSG_11774

DDI:	DDB_G0272857(rapB)

DPP:	DICPUDRAFT_26434(rapB)

DFA:

DFA_02753

EHI:	EHI_004860(203.t00010) EHI_049030 EHI_058090(179.t00009) EHI_101260(5.t00090)

EDI:	EDI_041020 EDI_090510 EDI_120240 EDI_216290 EDI_234890 EDI_244910 EDI_278170

EIV:	EIN_002150 EIN_051510 EIN_075710 EIN_082730 EIN_085550 EIN_114190 EIN_125800 EIN_181310 EIN_184940 EIN_249710 EIN_346100 EIN_362190 EIN_400010 EIN_408950

ACAN:

ACA1_095980 ACA1_384830 ACA1_396120

NGR:	NAEGRDRAFT_55569

TVA:	TVAG_2v0214390 TVAG_2v0750270 TVAG_2v0996810

» show all

Reference

PMID:2642744

Authors

Kitayama H, Sugimoto Y, Matsuzaki T, Ikawa Y, Noda M

Title

A ras-related gene with transformation suppressor activity.

Journal

Cell 56:77-84 (1989)
DOI:10.1016/0092-8674(89)90985-9

Sequence

[hsa:5906]

LinkDB

DBGET integrated database retrieval system