KEGG ORTHOLOGY: K04411

ORTHOLOGY: K04411

Entry

K04411                      KO

Symbol

STK4, MST1

Name

serine/threonine kinase 4

Pathway

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04068

FoxO signaling pathway

map05200

Pathways in cancer

map05223

Non-small cell lung cancer

Disease

H00093

Combined immunodeficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04411  STK4, MST1; serine/threonine kinase 4
   04014 Ras signaling pathway
    K04411  STK4, MST1; serine/threonine kinase 4
   04068 FoxO signaling pathway
    K04411  STK4, MST1; serine/threonine kinase 4
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04411  STK4, MST1; serine/threonine kinase 4
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    K04411  STK4, MST1; serine/threonine kinase 4
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04411  STK4, MST1; serine/threonine kinase 4
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  STE20 family
   K04411  STK4, MST1; serine/threonine kinase 4

Genes

HSA:	6789(STK4)

PTR:	458275(STK4)

PPS:	100983482(STK4)

GGO:	101129803(STK4)

PON:	100438713(STK4)

PPYG:

129021430(STK4)

NLE:	100599164(STK4)

HMH:	116460867(STK4)

SSYN:

129474744(STK4)

MCC:	717730(STK4)

MCF:	102115733(STK4)

MTHB:

126963827

MNI:	105496420(STK4)

CSAB:

103245516(STK4)

CATY:

105588450(STK4)

PANU:

100137163(STK4)

TGE:	112633320(STK4)

MLEU:

105552097(STK4)

RRO:	104678859(STK4)

RBB:	108533369(STK4)

TFN:	117068819(STK4)

PTEH:

111553311(STK4)

CANG:

105502454(STK4)

CJC:	100407296(STK4)

SBQ:	101046861(STK4)

CIMI:

108313005(STK4)

ANAN:

105727442(STK4)

CSYR:

103269340(STK4)

MMUR:

105879873(STK4)

LCAT:

123622631(STK4)

PCOQ:

105821273(STK4)

OGA:	100959420(STK4)

MMU:	58231(Stk4)

MCAL:

110284093(Stk4)

MPAH:

110318679(Stk4)

RNO:	311622(Stk4)

MCOC:

116091355(Stk4)

ANU:	117704245(Stk4)

ASYL:

127686225(Stk4)

MUN:	110548224(Stk4)

CGE:	100757702(Stk4)

MAUA:

101837206(Stk4)

PROB:

127223930(Stk4)

PLEU:

114692609(Stk4)

MORG:

121460152(Stk4)

MFOT:

126506982

AAMP:

119815394(Stk4)

NGI:	103748401(Stk4)

HGL:	101704401(Stk4)

CPOC:

100715685(Stk4)

CCAN:

109681302(Stk4)

DORD:

105981524

DSP:	122120207(Stk4)

DMER:

138805201(Stk4)

PLOP:

125353820(Stk4)

NCAR:

124977469

MMMA:

107136512(Stk4)

ITI:	101955383(Stk4)

OCU:

100358822

OPI:	101526563(STK4)

TUP:	102481933(STK4)

GVR:	103604429(STK4)

CFA:	477240(STK4)

CLUD:

112674009(STK4)

VVP:	112920074(STK4)

VLG:	121478098(STK4)

NPO:	129495834(STK4)

AML:	100466725(STK4)

UMR:	103669878(STK4)

UAH:	113258646(STK4)

UAR:	123797028(STK4)

ELK:

111141470

LLV:

125108887

MPUF:

101694276(STK4)

MNP:	132021964(STK4)

MLK:	131807582(STK4)

NVS:	122916041(STK4)

ORO:	101382383(STK4)

EJU:	114223137(STK4)

ZCA:	113937320(STK4)

MLX:	118011523(STK4)

NSU:	110579448(STK4)

LWW:	102736975(STK4)

FCA:	101091185(STK4)

PYU:	121012141(STK4)

PCOO:

112868974(STK4)

PBG:	122496222(STK4)

PVIV:

125162691(STK4)

LRUF:

124503353

LGF:	123580145(STK4)

AJU:

106968996

PTG:	102954711(STK4)

PPAD:

109272385(STK4)

PUC:

125936555

PLEZ:

122215494(STK4)

HHV:	120242604(STK4)

BTA:	514886(STK4)

BOM:	102270413(STK4)

BIU:	109567475(STK4)

BBUB:

102395115(STK4)

BBIS:

104989357(STK4)

CHX:	102185193(STK4)

OAS:	101110437(STK4)

BTAX:

128058469(STK4)

CSUM:

138091350(STK4)

ODA:	120869551(STK4)

CCAD:

122448124(STK4)

MREE:

136159630(STK4)

OVR:	110149130(STK4) 139032643

MBEZ:

129564068(STK4)

SSC:	100517317(STK4)

CFR:	102514045(STK4)

CBAI:

105071910(STK4)

CDK:	105087816(STK4)

VPC:	102534580(STK4)

BACU:

103007242(STK4)

BMUS:

118881257(STK4)

LVE:	103079150(STK4)

OOR:	101269962(STK4)

LALB:

132505277(STK4)

GMF:	115845550(STK4)

DLE:	111184141(STK4)

PCAD:

102979937(STK4)

PSIU:

116740668(STK4)

PPHC:

136134353(STK4)

NASI:

112400908(STK4)

ECB:	100070861(STK4)

EPZ:	103557216(STK4)

EAI:	106843012(STK4)

MYB:	102249534(STK4)

MYD:	102769615(STK4)

MMYO:

118663625(STK4)

MLF:	102429707(STK4)

MDT:	132239912(STK4)

MYUM:

139014117(STK4)

PKL:	118708058(STK4)

EFUS:

103304083(STK4)

MNA:	107530916(STK4)

DRO:	112303982(STK4)

SHON:

118985521(STK4)

AJM:	119063192(STK4)

PDIC:

114506375(STK4)

PHAS:

123814838(STK4)

MMF:	118618755(STK4)

PPAM:

129070671(STK4)

HAI:	109379970(STK4)

RFQ:	117016094(STK4)

PALE:

102881410(STK4)

PGIG:

120603711(STK4)

PVP:	105298222(STK4)

RAY:	107514562(STK4)

MJV:	108398293(STK4)

TOD:	119235779(STK4)

SARA:

101540309(STK4)

SFUM:

130030380(STK4)

SETR:

126017350(STK4)

LAV:	100659146(STK4)

TMU:

101351731

ETF:	101651219(STK4)

DNM:	101416934(STK4)

MDO:	100024136(STK4)

GAS:	123237114(STK4)

SHR:	100929626(STK4)

AFZ:

127548851

PCW:	110206589(STK4)

TVP:	118844062(STK4)

PBRV:

138149024(STK4)

OAA:	100088971(STK4)

TACU:

119931503(STK4)

GGA:	419187(STK4)

PCOC:

116227589(STK4)

MGP:	100550208 104913988

CJO:	107322948(STK4)

TPAI:

128081147(STK4)

LMUT:

125701263(STK4)

NMEL:

110408095(STK4)

APLA:

101789768(STK4)

ACYG:

106041054(STK4)

CATA:

118248992(STK4)

AFUL:

116495676(STK4)

TGU:	100225740(STK4)

LSR:	110469282(STK4)

SCAN:

103818797(STK4)

PMOA:

120511281(STK4)

OTC:	121343789(STK4)

PRUF:

121359711(STK4)

ATRC:

139599331(STK4)

GFR:	102031383(STK4)

FAB:	101805689(STK4)

OMA:	130261302(STK4)

PHI:	102106810(STK4)

PMAJ:

107213380(STK4)

CCAE:

111938249(STK4)

CCW:	104687877(STK4)

CBRC:

103615664(STK4)

ACOE:

138120995(STK4)

ETL:	114064724(STK4)

ZAB:	102060816(STK4)

ZLE:	135456145(STK4)

ACHL:

103804870(STK4)

SVG:	106857750(STK4)

MMEA:

130573463(STK4)

HRT:	120760161(STK4)

SATI:

136368419(STK4)

CCIC:

134051256(STK4)

FPG:	101914167(STK4)

FCH:	102055434(STK4)

CCRI:

104155797

NNT:	104402051(STK4)

SHAB:

115615137(STK4)

ACUN:

113487649(STK4)

TALA:

104360658(STK4)

ACHC:

115339459(STK4)

HALD:

104314934(STK4)

HLE:	104833225(STK4)

AGEN:

126045821

HHAR:

128142730(STK4)

GCL:

127023236

CSTI:

104559322(STK4)

LDI:	104349003(STK4)

MNB:	103778880(STK4)

DPUB:

104308751(STK4)

PPUS:

135188110(STK4)

AVIT:

104269941(STK4)

BRHI:

104502329(STK4)

EGZ:	104124962(STK4)

NNI:	104019998(STK4)

PCRI:

104032748

PCAO:

104043684(STK4)

PADL:

103919331(STK4)

AFOR:

103901343(STK4)

FGA:	104079612(STK4)

GSTE:

104262285(STK4)

CBOY:

140659462(STK4)

CLV:	102097446(STK4)

CNIC:

135994647(STK4)

MUI:	104534374(STK4)

PGUU:

104468292(STK4)

PLET:

104614082(STK4)

EHS:	104508406(STK4)

CMAC:

104487282(STK4)

CUCA:

104065136(STK4)

TEO:	104381584(STK4)

BREG:

104633084(STK4)

OHA:	104328821(STK4)

ACAR:

104518649(STK4)

CPEA:

104389748(STK4)

CVF:	104291582(STK4)

RTD:	128916461(STK4)

CRID:

134522345(STK4)

AAM:	106500122(STK4)

AROW:

112971396(STK4)

NPD:	112949613(STK4)

TGT:	104575830(STK4)

DNE:	112979076(STK4)

SCAM:

104141696(STK4)

ASN:	102385000(STK4)

AMJ:	102569590(STK4)

CPOO:

109313170(STK4)

GGN:	109292417(STK4)

PSS:	102454656(STK4)

CMY:	102930227(STK4)

CCAY:

125622083(STK4)

DCC:	119841823(STK4)

CPIC:

101952056(STK4)

TST:	117885822(STK4)

CABI:

116817365(STK4)

MRV:	120380432(STK4)

ACS:	100555926(stk4)

ASAO:

132773187(STK4)

PVT:	110076762(STK4)

SUND:

121927860(STK4)

PBI:	103054805(STK4)

PMUR:

107287815(STK4)

CTIG:

120311618(STK4)

TSR:	106538332(STK4)

PGUT:

117663615(STK4)

PCAE:

139314387(STK4)

APRI:

131194850(STK4)

PTEX:

113434402(STK4)

NSS:	113410454(STK4)

VKO:	123028451(STK4)

PMUA:

114599575(STK4)

PRAF:

128416396(STK4)

ZVI:	118088497(STK4)

HCG:	128322332(STK4)

GJA:	107116155(STK4)

STOW:

125433175(STK4)

EMC:	129330851(STK4)

XLA:	398925(stk4.S) 779226(stk4.L)

XTR:	394860(stk4)

NPR:

108793685

RTEM:

120919202

ACAT:

141114391(STK4)

BBUF:

121004399

BGAR:

122940559

DTC:

141086399

PWL:	138303950(STK4)

MUO:	115476233(STK4)

GSH:	117369067(STK4)

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

SPIL:

TRU:

TFS:

TNG:	GSTEN00009280G001

LCO:

TBEN:

CGOB:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

CANA:

CVE:

MSAM:

SCHU:

CUD:

SPUL:

LMIX:

ALAT:

ASTR:

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:	116710623 116710769

PRET:

103464816

PFOR:

103150146

PLAI:

106937959(stk3) 106939673

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

EJA:

BFRE:

MCEP:

CSEM:

POV:	109635410(stk4) 109635565

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

ENY:

MALB:

BSPL:

SJO:

SSCO:

GMH:

SASA:

100380329(stk4)

STRU:

115151092(stk4)

OTW:

112254134

OMY:

110527676

OGO:

124007736

ONE:	115135215(stk4)

OKI:	109890783(stk4)

OKE:

118370032

OMM:

135542343

OCLA:

139413213

SALP:

111969651(stk4)

SNH:

CCLU:

ELS:

OEP:

SFM:

PKI:

AANG:

AROT:

CCOG:

LOC:	102697455(stk4)

PSPA:

121297674 121319472

ARUT:

117423476 117432045

PSEX:

120514749

LCM:	102354634(STK4)

CMK:

103190959

RTP:	109919516(stk3)

CPLA:

HOC:

LERI:

HAKA:

OTU:

MCAZ:

SRE:	PTSG_10780

DDI:	DDB_G0284181(krsA)

DPP:	DICPUDRAFT_93521

DFA:	DFA_04596(krsA)

EIV:	EIN_411260

ACAN:

ACA1_092980 ACA1_229520

PTM:	GSPATT00005557001 GSPATT00024234001 GSPATT00026130001 GSPATT00037330001

NGD:	NGA_0179701(STK3) NGA_0179702(STK3)

TVA:	4752888(TVAGG3_0473390)

GLA:	GL50803_0015514

GTT:	GUITHDRAFT_66089 GUITHDRAFT_88593

» show all

Reference

PMID:8816758

Authors

Taylor LK, Wang HC, Erikson RL

Title

Newly identified stress-responsive protein kinases, Krs-1 and Krs-2.

Journal

Proc Natl Acad Sci U S A 93:10099-104 (1996)
DOI:10.1073/pnas.93.19.10099

Sequence

[hsa:6789]

Reference

PMID:11937045

Authors

Feig LA, Buchsbaum RJ

Title

Cell signaling: life or death decisions of ras proteins.

Journal

Curr Biol 12:R259-61 (2002)
DOI:10.1016/S0960-9822(02)00787-X

LinkDB

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