KEGG T01001: 6789

Homo sapiens (human): 6789

Entry

6789              CDS       T01001

Symbol

STK4, KRS2, MST1, YSK3

Name

(RefSeq) serine/threonine kinase 4

K04411

serine/threonine kinase 4

Organism

hsa Homo sapiens (human)

Pathway

hsa04010

MAPK signaling pathway

hsa04014

Ras signaling pathway

hsa04068

FoxO signaling pathway

hsa05200

Pathways in cancer

hsa05223

Non-small cell lung cancer

Network

nt06213 Other RAS signaling (cancer)
nt06266 Non-small cell lung cancer

Element

N00096

EGF-EGFR-RAS-RASSF1 signaling pathway

N00097

Loss of RASSF1 to RAS-RASSF1 signaling pathway

Disease

H00093

Combined immunodeficiency

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    6789 (STK4)
   04014 Ras signaling pathway
    6789 (STK4)
   04068 FoxO signaling pathway
    6789 (STK4)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    6789 (STK4)
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    6789 (STK4)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    6789 (STK4)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: STE group
  STE20 family
   6789 (STK4)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr Mst1_SARAH ABC1 Pkinase_fungal Abi_2 Nore1-SARAH

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

20:44966512..45080021

AA seq 487 aa
METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ
VPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT
LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK
RNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNP
PPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDV
KLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDT
LPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLK
NSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAK
KRRQQNF

NT seq 1464 nt +upstreamnt +downstreamnt
atggagacggtacagctgaggaacccgccgcgccggcagctgaaaaagttggatgaagat
agtttaaccaaacaaccagaagaagtatttgatgtcttagagaaacttggagaagggtcc
tatggcagcgtatacaaagctattcataaagagaccggccagattgttgctattaagcaa
gttcctgtggaatcagacctccaggagataatcaaagaaatctctataatgcagcaatgt
gacagccctcatgtagtcaaatattatggcagttattttaagaacacagacttatggatc
gttatggagtactgtggggctggttctgtatctgatatcattcgattacgaaataaaacg
ttaacagaagatgaaatagctacaatattacaatcaactcttaagggacttgaatacctt
cattttatgagaaaaatacaccgagatatcaaggcaggaaatattttgctaaatacagaa
ggacatgcaaaacttgcagattttggggtagcaggtcaacttacagataccatggccaag
cggaatacagtgataggaacaccattttggatggctccagaagtgattcaggaaattgga
tacaactgtgtagcagacatctggtccctgggaataactgccatagaaatggctgaagga
aagcccccttatgctgatatccatccaatgagggcaatcttcatgattcctacaaatcct
cctcccacattccgaaaaccagagctatggtcagataactttacagattttgtgaaacag
tgtcttgtaaagagccctgagcagagggccacagccactcagctcctgcagcacccattt
gtcaggagtgccaaaggagtgtcaatactgcgagacttaattaatgaagccatggatgtg
aaactgaaacgccaggaatcccagcagcgggaagtggaccaggacgatgaagaaaactca
gaagaggatgaaatggattctggcacgatggttcgagcagtgggtgatgagatgggcact
gtccgagtagccagcaccatgactgatggagccaatactatgattgagcacgatgacacg
ttgccatcacaactgggcaccatggtgatcaatgcagaggatgaggaagaggaaggaact
atgaaaagaagggatgagaccatgcagcctgcgaaaccatcctttcttgaatattttgaa
caaaaagaaaaggaaaaccagatcaacagctttggcaagagtgtacctggtccactgaaa
aattcttcagattggaaaataccacaggatggagactacgagtttcttaagagttggaca
gtggaggaccttcagaagaggctcttggccctggaccccatgatggagcaggagattgaa
gagatccggcagaagtaccagtccaagcggcagcccatcctggatgccatagaggctaag
aagagacggcaacaaaacttctga

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