KEGG ORTHOLOGY: K04442

ORTHOLOGY: K04442

Entry

K04442                      KO

Symbol

MAPKAPK5, PRAK

Name

mitogen-activated protein kinase-activated protein kinase 5 [EC:2.7.11.1]

Pathway

map04010

MAPK signaling pathway

Disease

H02763

Neurocardiofaciodigital syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04442  MAPKAPK5, PRAK; mitogen-activated protein kinase-activated protein kinase 5
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04442  MAPKAPK5, PRAK; mitogen-activated protein kinase-activated protein kinase 5
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K04442  MAPKAPK5, PRAK; mitogen-activated protein kinase-activated protein kinase 5
Protein kinases [BR:ko01001]
Serine/threonine kinases: CAMK group
  MAPKAPK family [OT]
   K04442  MAPKAPK5, PRAK; mitogen-activated protein kinase-activated protein kinase 5

Genes

HSA:	8550(MAPKAPK5)

PTR:	738233(MAPKAPK5)

PPS:	100968937(MAPKAPK5)

GGO:	101152837(MAPKAPK5)

PON:	100434701(MAPKAPK5)

PPYG:

129009362(MAPKAPK5)

NLE:	100582875(MAPKAPK5)

HMH:	116477906(MAPKAPK5)

SSYN:

129460615(MAPKAPK5)

MCC:	713521(MAPKAPK5)

MCF:	102123012(MAPKAPK5)

MTHB:

126931474

MNI:	105493399(MAPKAPK5)

CSAB:

103239135(MAPKAPK5)

CATY:

105573171(MAPKAPK5)

PANU:

101002049(MAPKAPK5)

TGE:	112635040(MAPKAPK5)

MLEU:

105552272(MAPKAPK5)

RRO:	104674546(MAPKAPK5)

RBB:	108512159(MAPKAPK5)

TFN:	117089388(MAPKAPK5)

PTEH:

111537063(MAPKAPK5)

CANG:

105507937(MAPKAPK5)

CJC:	100412389(MAPKAPK5)

SBQ:	101046534(MAPKAPK5)

CIMI:

108313981(MAPKAPK5)

ANAN:

105728602(MAPKAPK5)

CSYR:

103261955(MAPKAPK5)

MMUR:

105878702(MAPKAPK5)

LCAT:

123626042(MAPKAPK5)

PCOQ:

105825633(MAPKAPK5)

OGA:	100948121(MAPKAPK5)

MMU:	17165(Mapkapk5)

MCAL:

110294137(Mapkapk5)

MPAH:

110339137(Mapkapk5)

RNO:	498183(Mapkapk5)

MCOC:

116068345(Mapkapk5)

ANU:	117698177(Mapkapk5)

ASYL:

127672779(Mapkapk5)

MUN:	110546396(Mapkapk5)

CGE:	100763285(Mapkapk5)

MAUA:

101844688(Mapkapk5)

PROB:

127216054(Mapkapk5)

PLEU:

114681888(Mapkapk5)

MORG:

121446378(Mapkapk5)

MFOT:

126511672

AAMP:

119824856(Mapkapk5)

NGI:	103745570(Mapkapk5)

HGL:	101703557(Mapkapk5)

CPOC:

100730794(Mapkapk5)

CCAN:

109695391(Mapkapk5)

DORD:

105990698(Mapkapk5)

DSP:	122098539(Mapkapk5)

PLOP:

125349115(Mapkapk5)

NCAR:

124990359

MMMA:

107156444(Mapkapk5)

ITI:	101968547(Mapkapk5)

OCU:

100338774

OPI:	101530885(MAPKAPK5)

TUP:	102488226(MAPKAPK5)

GVR:	103590468(MAPKAPK5)

CFA:	477480(MAPKAPK5)

CLUD:

112676559(MAPKAPK5)

VVP:	112935248(MAPKAPK5)

VLG:	121475349(MAPKAPK5)

NPO:	129507709(MAPKAPK5)

AML:	100482977(MAPKAPK5)

UMR:	103661188(MAPKAPK5)

UAH:	113266972(MAPKAPK5)

UAR:	123778968(MAPKAPK5)

ELK:

111156360

LLV:

125082576

MPUF:

101676293(MAPKAPK5)

MNP:	132023166(MAPKAPK5)

MLK:	131811582(MAPKAPK5)

NVS:	122903424(MAPKAPK5)

ORO:	101362132 101383640(MAPKAPK5)

EJU:	114219142(MAPKAPK5)

ZCA:	113912477(MAPKAPK5)

MLX:	118018479(MAPKAPK5) 118025959

NSU:	110573846 110588213(MAPKAPK5)

LWW:	102732408 102748255(MAPKAPK5)

FCA:	101082699(MAPKAPK5)

PYU:	121010328(MAPKAPK5)

PCOO:

112870502(MAPKAPK5)

PBG:	122470229(MAPKAPK5)

PVIV:

125148911(MAPKAPK5)

LRUF:

124518233

LGF:	123587326(MAPKAPK5)

AJU:

106982092

PTG:	102957096(MAPKAPK5)

PPAD:

109277637(MAPKAPK5)

PUC:

125914561

PLEZ:

122204268(MAPKAPK5)

HHV:	120232724(MAPKAPK5)

BTA:	535625(MAPKAPK5)

BOM:	102273447(MAPKAPK5)

BIU:	109571249(MAPKAPK5)

BBUB:

102402243(MAPKAPK5)

BBIS:

104980045(MAPKAPK5)

CHX:	102169693(MAPKAPK5)

OAS:	101116258(MAPKAPK5)

BTAX:

128062190(MAPKAPK5)

CSUM:

138094101(MAPKAPK5)

ODA:	120871394(MAPKAPK5)

MREE:

136145665(MAPKAPK5)

OVR:	110144293(MAPKAPK5)

MBEZ:

129542764(MAPKAPK5)

SSC:	100153404(MAPKAPK5)

CFR:	102511529(MAPKAPK5)

CBAI:

105080598(MAPKAPK5)

CDK:	105102475(MAPKAPK5)

VPC:	102531617(MAPKAPK5)

BACU:

103007521(MAPKAPK5)

BMUS:

118880259(MAPKAPK5)

LVE:	103075402(MAPKAPK5)

OOR:	101285223(MAPKAPK5)

LALB:

132503844(MAPKAPK5)

DLE:	111162753(MAPKAPK5)

PCAD:

102977266(MAPKAPK5)

PSIU:

116739067(MAPKAPK5)

NASI:

112397317(MAPKAPK5)

ECB:	100057579(MAPKAPK5)

EPZ:	103554564(MAPKAPK5)

EAI:	106842262(MAPKAPK5)

MYB:	102254612(MAPKAPK5)

MYD:	102757546(MAPKAPK5)

MLF:	102440217(MAPKAPK5)

MDT:	132221856(MAPKAPK5)

MYUM:

138997737(MAPKAPK5)

PKL:	118725369(MAPKAPK5)

EFUS:

103287061(MAPKAPK5)

MNA:	107529569(MAPKAPK5)

DRO:	112310875(MAPKAPK5)

SHON:

118991104(MAPKAPK5)

AJM:	119040477(MAPKAPK5)

PDIC:

114509429(MAPKAPK5)

PHAS:

123821864(MAPKAPK5)

MMF:	118640017(MAPKAPK5)

PPAM:

129087383(MAPKAPK5)

HAI:	109382258(MAPKAPK5)

RFQ:	117017705(MAPKAPK5)

PALE:

102888973(MAPKAPK5)

PGIG:

120616106(MAPKAPK5)

PVP:	105289230(MAPKAPK5)

RAY:	107513262(MAPKAPK5)

MJV:	108406797(MAPKAPK5)

TOD:	119244974(MAPKAPK5)

SARA:

101550429(MAPKAPK5)

SFUM:

130016434(MAPKAPK5)

SETR:

126029498(MAPKAPK5)

LAV:	100673038(MAPKAPK5)

TMU:

101349635

ETF:	101651379(MAPKAPK5)

DNM:	101445091(MAPKAPK5)

MDO:	100017664(MAPKAPK5)

GAS:	123256866(MAPKAPK5)

SHR:	100918701(MAPKAPK5)

AFZ:

127545480

PCW:	110196808(MAPKAPK5)

TVP:	118851110(MAPKAPK5)

PBRV:

138156222(MAPKAPK5)

OAA:	100092465(MAPKAPK5)

TACU:

119942113(MAPKAPK5)

GGA:	373929(MAPKAPK5)

PCOC:

116228574(MAPKAPK5)

MGP:	100548508(MAPKAPK5)

CJO:	107321159(MAPKAPK5)

TPAI:

128084724(MAPKAPK5)

LMUT:

125701613(MAPKAPK5)

NMEL:

110406631(MAPKAPK5)

APLA:

119718502(MAPKAPK5)

ACYG:

106031108(MAPKAPK5)

CATA:

118257588(MAPKAPK5)

AFUL:

116496123(MAPKAPK5)

TGU:	100230432(MAPKAPK5)

LSR:	110478172(MAPKAPK5)

SCAN:

103818142(MAPKAPK5)

PMOA:

120509796(MAPKAPK5)

OTC:	121338963(MAPKAPK5)

PRUF:

121364813(MAPKAPK5)

ATRC:

139598590(MAPKAPK5)

GFR:	102033005(MAPKAPK5)

FAB:	101806570(MAPKAPK5)

OMA:	130259907(MAPKAPK5)

PHI:	102102877(MAPKAPK5)

PMAJ:

107211692(MAPKAPK5)

CCAE:

111936426(MAPKAPK5)

CCW:	104688673(MAPKAPK5)

CBRC:

103615938(MAPKAPK5)

ACOE:

138119251(MAPKAPK5)

ETL:	114062666(MAPKAPK5)

ZAB:	102073596(MAPKAPK5)

ZLE:	135454480(MAPKAPK5)

ACHL:

103801196(MAPKAPK5)

SVG:	106852356(MAPKAPK5)

MMEA:

130580499(MAPKAPK5)

HRT:	120760350(MAPKAPK5)

SATI:

136369020(MAPKAPK5)

CCIC:

134051107(MAPKAPK5)

FPG:	101923584(MAPKAPK5)

FCH:	102047513(MAPKAPK5)

CCRI:

104163580(MAPKAPK5)

NNT:	104411282(MAPKAPK5)

SHAB:

115614762(MAPKAPK5)

ACUN:

113486113(MAPKAPK5)

TALA:

104367420(MAPKAPK5)

ACHC:

115345772(MAPKAPK5)

HALD:

104310650(MAPKAPK5)

AGEN:

126041119

HHAR:

128145615(MAPKAPK5)

GCL:

127022746

CSTI:

104561434(MAPKAPK5)

LDI:	104340806(MAPKAPK5)

MNB:	103778425(MAPKAPK5)

DPUB:

104308421(MAPKAPK5)

PPUS:

135188718(MAPKAPK5)

AVIT:

104280146(MAPKAPK5)

BRHI:

104501723(MAPKAPK5)

EGZ:	104123764(MAPKAPK5)

NNI:	104019336(MAPKAPK5)

PCRI:

104038839(MAPKAPK5)

PCAO:

104046419(MAPKAPK5)

PADL:

103925668(MAPKAPK5)

AFOR:

103902771(MAPKAPK5)

FGA:	104080996(MAPKAPK5)

GSTE:

104258801(MAPKAPK5)

CLV:	102097070(MAPKAPK5)

MUI:	104545032(MAPKAPK5)

PGUU:

104468818(MAPKAPK5)

PLET:

104622437(MAPKAPK5)

EHS:	104513144(MAPKAPK5)

CMAC:

104477257(MAPKAPK5)

CUCA:

104058807(MAPKAPK5)

TEO:	104376007(MAPKAPK5)

BREG:

104633003(MAPKAPK5)

OHA:	104335306(MAPKAPK5)

ACAR:

104528288(MAPKAPK5)

CPEA:

104389436(MAPKAPK5)

CVF:	104282224(MAPKAPK5)

RTD:	128916949(MAPKAPK5)

CRID:

134523061(MAPKAPK5)

AAM:	106492977(MAPKAPK5)

AROW:

112963326(MAPKAPK5)

NPD:	112949385(MAPKAPK5)

TGT:	104565909(MAPKAPK5)

DNE:	112991834(MAPKAPK5)

SCAM:

104145644(MAPKAPK5)

ASN:	102373021(MAPKAPK5)

AMJ:	102573148(MAPKAPK5)

CPOO:

109312665(MAPKAPK5)

GGN:	109290560(MAPKAPK5)

PSS:	102464040(MAPKAPK5)

CMY:	102939720(MAPKAPK5)

CCAY:

125622869(MAPKAPK5)

DCC:	119843710(MAPKAPK5)

CPIC:

101951610(MAPKAPK5)

TST:	117888017(MAPKAPK5)

CABI:

116836710(MAPKAPK5)

MRV:	120385892(MAPKAPK5)

ACS:	100553264(mapkapk5)

ASAO:

132781682(MAPKAPK5)

PVT:	110083852(MAPKAPK5)

SUND:

121916524(MAPKAPK5)

PBI:	103051505(MAPKAPK5)

PMUR:

107286958(MAPKAPK5)

CTIG:

120316670(MAPKAPK5)

TSR:	106553611(MAPKAPK5)

PGUT:

117672252(MAPKAPK5) 132709057

APRI:

131185484(MAPKAPK5)

PTEX:

113448708(MAPKAPK5)

NSS:	113426801(MAPKAPK5)

VKO:	123028758(MAPKAPK5)

PMUA:

114602744(MAPKAPK5)

PRAF:

128419927(MAPKAPK5)

ZVI:	118085986(MAPKAPK5)

HCG:	128337837(MAPKAPK5)

GJA:	107112158(MAPKAPK5)

STOW:

125442348(MAPKAPK5)

EMC:	129341485(MAPKAPK5)

XLA:	108707170(mapkapk5.S) 108716917(mapkapk5.L)

XTR:	448643(mapkapk5)

NPR:	108788534(MAPKAPK5)

RTEM:

120933213(MAPKAPK5)

BBUF:

120988544(MAPKAPK5)

BGAR:

122924564(MAPKAPK5)

PWL:	138266252(MAPKAPK5)

MUO:	115479855(MAPKAPK5)

GSH:	117364831(MAPKAPK5)

DRE:	436608(mapkapk5)

SRX:	107728268 107739990(mapkapk5)

SANH:

107662046 107702970

SGH:	107548527 107556043

CCAR:

109074165(mapkapk5)

CAUA:

113085231 113094267

CGIB:

127957403 127990153

PTET:

122345188(mapkapk5)

LROH:

127165094(mapkapk5)

OMC:	131541618(mapkapk5)

PPRM:

120472097(mapkapk5) 120472103

RKG:	130069091(mapkapk5)

MAMB:

125267626(mapkapk5)

CIDE:

127513244

CERY:

137034721(mapkapk5)

MASI:

127426178 127435834

TROS:

130568811(mapkapk5)

TDW:	130419953(mapkapk5)

MANU:

129440834(mapkapk5)

PDAB:

135774164(mapkapk5)

IPU:

108255819

IFU:	128599004(mapkapk5)

PHYP:

113542460(mapkapk5)

SMEO:

124380862(mapkapk5)

TFD:	113642334(mapkapk5)

TVC:	132854577(mapkapk5)

CGAR:

128509665(mapkapk5)

NGRA:

132872220(mapkapk5)

TRN:	134335378(mapkapk5)

AMEX:

103036713(mapkapk5)

CMAO:

118826855(mapkapk5)

EEE:	113589460(mapkapk5)

CHAR:

105895558(mapkapk5)

SPIL:

134059819(mapkapk5)

TRU:	101063016(mapkapk5)

TFS:	130525552(mapkapk5)

TNG:	GSTEN00030940G001

LCO:	104920823(mapkapk5)

NCC:	104950288(mapkapk5)

TBEN:

117472775(mapkapk5)

CGOB:

115013356(mapkapk5)

PGEO:

117451844(mapkapk5)

GACU:

117558629(mapkapk5)

EMAC:

134873602(mapkapk5)

ELY:	117252021(mapkapk5)

EFO:	125889945(mapkapk5)

PLEP:

121944044(mapkapk5)

SLUC:

116054358(mapkapk5)

ECRA:

117944296(mapkapk5)

ESP:	116689221(mapkapk5)

PFLV:

114555651(mapkapk5)

GAT:	120830571(mapkapk5)

PPUG:

119224714(mapkapk5)

AFB:	129101136(mapkapk5)

CLUM:

117736333(mapkapk5)

PSWI:

130196271(mapkapk5)

CANA:

137805348(mapkapk5)

CVE:	137867615(mapkapk5)

MSAM:

119891311(mapkapk5)

SCHU:

122876921(mapkapk5)

CUD:	121510194(mapkapk5)

SPUL:

138610695(mapkapk5)

LMIX:

132974559(mapkapk5)

ALAT:

119019043(mapkapk5)

ASTR:

137592995(mapkapk5)

MZE:	101472028(mapkapk5)

ONL:	100707298(mapkapk5)

OAU:	116310505(mapkapk5)

OLA:	101160912(mapkapk5)

OML:	112148658(mapkapk5)

CSAI:

133450631(mapkapk5)

XMA:	102222319(mapkapk5)

XCO:	114155243(mapkapk5)

XHE:	116730453(mapkapk5)

PRET:

103470107(mapkapk5)

PFOR:

103141769(mapkapk5)

PLAI:

106944949(mapkapk5)

PMEI:

106924714(mapkapk5)

GAF:	122827905(mapkapk5)

PPRL:

129365685(mapkapk5)

CVG:	107086298(mapkapk5)

CTUL:

119798558(mapkapk5)

GMU:	124878519(mapkapk5)

NFU:	107394143(mapkapk5)

KMR:	108233538(mapkapk5)

ALIM:

106533634(mapkapk5)

NWH:	119413275(mapkapk5)

AOCE:

111564689(mapkapk5)

EJA:	138191573(mapkapk5)

BFRE:

138621502(mapkapk5)

MCEP:

125012605

CSEM:

103396963 103397646

POV:	109636971(mapkapk5)

SSEN:

122769484(mapkapk5)

SSOE:

131464673(mapkapk5)

HHIP:

117768544(mapkapk5)

HSP:	118115562(mapkapk5)

PPLT:

128437675(mapkapk5)

SMAU:

118313793(mapkapk5)

LCF:

108882218

SDU:	111230770(mapkapk5)

SLAL:

111645145(mapkapk5)

XGL:	120805611(mapkapk5)

HCQ:	109526234(mapkapk5)

SSCV:

125993730(mapkapk5)

SBIA:

133499215(mapkapk5)

PEE:	133399930(mapkapk5)

PTAO:

133475202(mapkapk5)

BPEC:

110167047(mapkapk5)

ENY:	140346899(mapkapk5)

MALB:

109956634(mapkapk5)

BSPL:

114862018(mapkapk5)

SJO:	128365422(mapkapk5)

SSCO:

133978776(mapkapk5)

GMH:	115545364(mapkapk5)

SASA:

106580195(mapkapk5) 106585864

STRU:

115164960 115199712

OTW:	112247401 112263426

OMY:	110525268 110535681

OGO:	124034628 124035967

ONE:	115111280 115139689

OKI:	109875420 109895592

OKE:	118357987 118370857

OMM:	135514431 135517885

OCLA:

139389269 139410627

SALP:

111957833 111974227

SNH:	120046043 120063026

CCLU:

121584416 121587494

ELS:	105014602(mapkapk5)

OEP:	134015097(mapkapk5)

SFM:	108934823(mapkapk5)

PKI:	111850582(mapkapk5)

AANG:

118206360(mapkapk5)

AROT:

135264634(mapkapk5)

CCOG:

133140294(mapkapk5)

LOC:	102683684(mapkapk5)

PSPA:

121297226 121300052

ARUT:

117427196 117428474

PSEX:

120540984(mapkapk5)

LCM:	102358958(MAPKAPK5)

CMK:	103184054(mapkapk5)

CPLA:

122562588(mapkapk5)

HOC:	132827075(mapkapk5)

LERI:

129709153(mapkapk5)

PMRN:

116939243(MAPKAPK5)

LRJ:	133348252(MAPKAPK5)

BFO:

118406060

BBEL:

109471942

CIN:	100177625 113473991

SCLV:

120326030

SPU:	576140 585654

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

HRO:	HELRODRAFT_75608

LGI:	LOTGIDRAFT_168501

PVUL:

PCAN:

LSAX:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:	111099062 111132035

OED:

MYI:

PMAX:

AIRR:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:	135683296 135683297

AQU:

100637494

MBR:	MONBRDRAFT_28343

SRE:	PTSG_03766 PTSG_07730

» show all

Reference

PMID:9480836

Authors

Ni H, Wang XS, Diener K, Yao Z

Title

MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase.

Journal

Biochem Biophys Res Commun 243:492-6 (1998)
DOI:10.1006/bbrc.1998.8135

Sequence

[mmu:17165]

LinkDB

DBGET integrated database retrieval system