KEGG   ORTHOLOGY: K04466
Entry
K04466                      KO                                     
Symbol
MAP3K14, NIK
Name
mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
Pathway
map04010  MAPK signaling pathway
map04064  NF-kappa B signaling pathway
map04210  Apoptosis
map04380  Osteoclast differentiation
map04625  C-type lectin receptor signaling pathway
map04660  T cell receptor signaling pathway
map04668  TNF signaling pathway
map04672  Intestinal immune network for IgA production
map04936  Alcoholic liver disease
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05166  Human T-cell leukemia virus 1 infection
map05169  Epstein-Barr virus infection
map05208  Chemical carcinogenesis - reactive oxygen species
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
   04064 NF-kappa B signaling pathway
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
   04668 TNF signaling pathway
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
   04660 T cell receptor signaling pathway
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
   04672 Intestinal immune network for IgA production
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
   05169 Epstein-Barr virus infection
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  Other
   K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
Other DBs
GO: 0004709
Genes
HSA: 9020(MAP3K14)
PTR: 454750(MAP3K14)
PPS: 100984930(MAP3K14)
GGO: 101147819(MAP3K14)
PON: 100436201(MAP3K14)
NLE: 100600394(MAP3K14)
MCC: 716258(MAP3K14)
MCF: 102145584(MAP3K14)
CSAB: 103243289(MAP3K14)
CATY: 105585587(MAP3K14)
PANU: 101024657(MAP3K14)
TGE: 112609983(MAP3K14)
RRO: 104678377(MAP3K14)
RBB: 108532216(MAP3K14)
TFN: 117066854(MAP3K14)
PTEH: 111525786(MAP3K14)
CJC: 100401112(MAP3K14)
SBQ: 101044826(MAP3K14)
CSYR: 103262848(MAP3K14)
MMUR: 105883589(MAP3K14)
LCAT: 123621038(MAP3K14)
OGA: 100957606(MAP3K14)
MMU: 53859(Map3k14)
MCAL: 110304892(Map3k14)
MPAH: 110332218(Map3k14)
RNO: 360640(Map3k14)
MCOC: 116079161(Map3k14)
MUN: 110545661(Map3k14)
CGE: 100766459(Map3k14)
MAUA: 101825130(Map3k14)
PLEU: 114702264(Map3k14)
MORG: 121436161(Map3k14)
AAMP: 119813599(Map3k14)
NGI: 103738320(Map3k14)
HGL: 101703313(Map3k14)
CPOC: 100719582(Map3k14)
CCAN: 109691665(Map3k14)
DORD: 105997576(Map3k14)
DSP: 122103419(Map3k14)
NCAR: 124980247
OCU: 100351032(MAP3K14)
OPI: 101516061(MAP3K14)
TUP: 102500729(MAP3K14)
CFA: 490926(MAP3K14)
CLUD: 112655568(MAP3K14)
VVP: 112910639(MAP3K14)
VLG: 121473037(MAP3K14)
AML: 100472260(MAP3K14)
UMR: 103665883(MAP3K14)
UAH: 113265323(MAP3K14)
UAR: 123802960(MAP3K14)
ELK: 111158123
LLV: 125086838
MPUF: 101688261(MAP3K14)
ORO: 101363246(MAP3K14)
EJU: 114200618(MAP3K14)
ZCA: 113939264(MAP3K14)
MLX: 118024997(MAP3K14)
FCA: 101083468(MAP3K14)
PYU: 121045129(MAP3K14)
PBG: 122485712(MAP3K14)
PTG: 102964388(MAP3K14)
PPAD: 109258173(MAP3K14)
AJU: 106988147(MAP3K14)
HHV: 120222278(MAP3K14)
BTA: 508367(MAP3K14)
BOM: 102268339(MAP3K14)
BIU: 109574056(MAP3K14)
BBUB: 102397755(MAP3K14)
CHX: 102189617(MAP3K14)
OAS: 101118799(MAP3K14)
ODA: 120866995(MAP3K14)
CCAD: 122440265(MAP3K14)
SSC: 100520402(MAP3K14)
CFR: 102504523(MAP3K14)
CBAI: 105072525(MAP3K14)
CDK: 105094405(MAP3K14)
VPC: 102526769(MAP3K14)
BACU: 103015859(MAP3K14)
LVE: 103082490(MAP3K14)
OOR: 101270119(MAP3K14)
DLE: 111170190(MAP3K14)
PCAD: 102991269(MAP3K14)
PSIU: 116745052(MAP3K14)
ECB: 100050140(MAP3K14)
EPZ: 103554685(MAP3K14)
EAI: 106836478(MAP3K14)
MYB: 102262247(MAP3K14)
MYD: 102762988(MAP3K14)
MMYO: 118671685(MAP3K14)
MLF: 102432497(MAP3K14)
MNA: 107528876(MAP3K14)
PKL: 118726383(MAP3K14)
HAI: 109395015(MAP3K14)
DRO: 112298609(MAP3K14)
SHON: 119001650(MAP3K14)
AJM: 119061562(MAP3K14)
PDIC: 114502860(MAP3K14)
PHAS: 123817083(MAP3K14)
MMF: 118634183(MAP3K14)
RFQ: 117013869(MAP3K14)
PALE: 102897751(MAP3K14)
PGIG: 120589252(MAP3K14)
PVP: 105303461(MAP3K14)
RAY: 107508165(MAP3K14)
MJV: 108386996(MAP3K14)
TOD: 119230450(MAP3K14)
SARA: 101549152(MAP3K14)
LAV: 100661927(MAP3K14)
TMU: 101343418
DNM: 101428001(MAP3K14)
MDO: 100020668(MAP3K14)
GAS: 123243674(MAP3K14)
SHR: 100918124(MAP3K14)
PCW: 110215732(MAP3K14)
OAA: 100085554(MAP3K14)
GGA: 419964(MAP3K14)
PCOC: 116233854(MAP3K14)
MGP: 100538760(MAP3K14)
CJO: 107325016(MAP3K14)
NMEL: 110388448(MAP3K14)
APLA: 101791236(MAP3K14)
ACYG: 106046936(MAP3K14)
AFUL: 116498521(MAP3K14)
TGU: 100217837(MAP3K14)
LSR: 110475629(MAP3K14)
SCAN: 103821648(MAP3K14)
PMOA: 120498305(MAP3K14)
OTC: 121332978(MAP3K14)
PRUF: 121350568(MAP3K14)
GFR: 102038763(MAP3K14)
FAB: 101813386(MAP3K14)
PHI: 102113463(MAP3K14)
PMAJ: 107215307(MAP3K14)
CCAE: 111940095(MAP3K14)
CCW: 104698524(MAP3K14)
CBRC: 103622666(MAP3K14)
ETL: 114068663(MAP3K14)
ZAB: 102071857(MAP3K14)
FPG: 101919762(MAP3K14)
FCH: 102048630(MAP3K14)
CLV: 102088332(MAP3K14)
EGZ: 104132232(MAP3K14)
NNI: 104018900(MAP3K14)
PLET: 104623346(MAP3K14)
PCRI: 104028095(MAP3K14)
ACUN: 113489146(MAP3K14)
TALA: 104367810(MAP3K14)
PADL: 103921921(MAP3K14)
ACHC: 115344910(MAP3K14)
HALD: 104310773(MAP3K14)
CCRI: 104159125(MAP3K14)
CSTI: 104554972(MAP3K14)
EHS: 104513073(MAP3K14)
CMAC: 104478148(MAP3K14)
FGA: 104078879(MAP3K14)
GSTE: 104263875(MAP3K14)
LDI: 104349714(MAP3K14)
MNB: 103774719(MAP3K14)
OHA: 104333148(MAP3K14)
AAM: 106495649(MAP3K14)
AROW: 112971103(MAP3K14)
NPD: 112951091(MAP3K14)
DNE: 112987825(MAP3K14)
ASN: 102388858(MAP3K14)
AMJ: 102575720(MAP3K14)
CPOO: 109323075(MAP3K14)
GGN: 109302060(MAP3K14)
PSS: 102464024(MAP3K14)
CMY: 102939834(MAP3K14)
CPIC: 101932285(MAP3K14)
TST: 117869188(MAP3K14)
CABI: 116834675(MAP3K14)
MRV: 120385126(MAP3K14)
ACS: 100560190(map3k14)
PVT: 110081369(MAP3K14)
SUND: 121935260(MAP3K14)
PBI: 103066049(MAP3K14)
PMUR: 107303029(MAP3K14)
TSR: 106542520(MAP3K14)
PGUT: 117664727(MAP3K14)
VKO: 123031703(MAP3K14)
PMUA: 114581835(MAP3K14)
ZVI: 118094799(MAP3K14)
GJA: 107125527(MAP3K14)
STOW: 125444265
XLA: 108700848(map3k14.L) 108702551(map3k14.S)
XTR: 100489201(map3k14)
NPR: 108785983(MAP3K14)
RTEM: 120919584(MAP3K14)
BBUF: 121004595(MAP3K14)
BGAR: 122940347(MAP3K14)
DRE: 100004261(map3k14a) 795766
PPRM: 120488026 120489596(map3k14a)
MAMB: 125258494 125272060(map3k14a)
IPU: 108259239(map3k14a) 108263809
SMEO: 124384893 124397147(map3k14a)
TFD: 113648526 113652180(map3k14a)
ELY: 117246698 117268475(map3k14a)
EFO: 125879172(map3k14a) 125880629
PLEP: 121956795(map3k14a) 121959145
SLUC: 116059283(map3k14a) 116061531
ECRA: 117937009 117958471(map3k14a)
GAT: 120818953 120827961(map3k14a)
PPUG: 119212464 119220116(map3k14a)
MSAM: 119891999(map3k14a) 119916377
CUD: 121503832(map3k14a) 121528505
ALAT: 119009268 119014377(map3k14a)
OAU: 116312492(map3k14a) 120441419
OML: 112145949(map3k14a) 112154182
PLAI: 106938787(map3k14) 106953890
GAF: 122822000(map3k14a) 122822864
CTUL: 119776029 119778852(map3k14a)
KMR: 108246150(map3k14a)
ALIM: 106522002(map3k14) 106528348
NWH: 119421922(map3k14a) 119423565
MCEP: 124997473(map3k14a) 125021920
HHIP: 117752515 117766955(map3k14a)
HSP: 118100220 118123057(map3k14a)
XGL: 120788413(map3k14a) 120794657
BPEC: 110168889
BSPL: 114845633 114860603(map3k14a)
OTW: 112223536 112226021 112246048(map3k14a)
PSPA: 121301894(map3k14a)
ARUT: 117427187 117433487(map3k14a)
LCM: 102351315(MAP3K14)
CIN: 100177364
PCAN: 112563741
HRJ: 124270404
PMAX: 117343854
ATEN: 116298093
SPIS: 111344058
 » show all
Reference
PMID:9020361
  Authors
Malinin NL, Boldin MP, Kovalenko AV, Wallach D
  Title
MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.
  Journal
Nature 385:540-4 (1997)
DOI:10.1038/385540a0
  Sequence
[hsa:9020]
Reference
  Authors
Liao G, Zhang M, Harhaj EW, Sun SC
  Title
Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation.
  Journal
J Biol Chem 279:26243-50 (2004)
DOI:10.1074/jbc.M403286200
  Sequence
[hsa:9020]
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