KEGG ORTHOLOGY: K04537

ORTHOLOGY: K04537

Entry

K04537                      KO

Symbol

GNB2

Name

guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

Pathway

map04014

Ras signaling pathway

map04062

Chemokine signaling pathway

map04081

Hormone signaling

map04082

Neuroactive ligand signaling

map04151

PI3K-Akt signaling pathway

map04371

Apelin signaling pathway

map04713

Circadian entrainment

map04723

Retrograde endocannabinoid signaling

map04724

Glutamatergic synapse

map04725

Cholinergic synapse

map04726

Serotonergic synapse

map04727

GABAergic synapse

map04728

Dopaminergic synapse

map04926

Relaxin signaling pathway

map05032

Morphine addiction

map05034

Alcoholism

map05163

Human cytomegalovirus infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05170

Human immunodeficiency virus 1 infection

map05200

Pathways in cancer

Disease

H00729

Sick sinus syndrome

H02705

Neurodevelopmental disorder with glutamatergic synapse dysfunction

H02885

Neurodevelopmental disorder with hypotonia and dysmorphic facies

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
   04371 Apelin signaling pathway
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
   04151 PI3K-Akt signaling pathway
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
   04081 Hormone signaling
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
  09156 Nervous system
   04724 Glutamatergic synapse
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
   04727 GABAergic synapse
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
   04725 Cholinergic synapse
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
   04728 Dopaminergic synapse
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
   04726 Serotonergic synapse
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
   04723 Retrograde endocannabinoid signaling
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
   05163 Human cytomegalovirus infection
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
  09165 Substance dependence
   05032 Morphine addiction
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
   05034 Alcoholism
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
   04031 GTP-binding proteins
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Exosome [BR:ko04147]
Exosomal proteins
  Proteins found in most exosomes
   K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
GTP-binding proteins [BR:ko04031]
Heterotrimeric G-proteins
  Beta Subunits
   Beta [OT]
    K04537  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

Genes

HSA:	2783(GNB2)

PTR:	739897(GNB2)

PPS:	100982509(GNB2)

GGO:	101139939(GNB2)

PON:	100458183(GNB2)

PPYG:

129041120(GNB2)

NLE:	100590367(GNB2)

HMH:	116463853 116463857

SSYN:

129489668(GNB2)

MCC:	719248(GNB2)

MCF:	101867297(GNB2)

MTHB:

126950415

MNI:	105497010(GNB2)

CSAB:

103246723(GNB2)

CATY:

105584442(GNB2)

PANU:

101017982(GNB2)

TGE:	112620636(GNB2)

MLEU:

105543670(GNB2)

RRO:	104673624(GNB2)

RBB:	108538195(GNB2)

TFN:	117072288(GNB2)

PTEH:

111530203(GNB2)

CANG:

105513099(GNB2)

CJC:	100395033(GNB2)

SBQ:	101050677(GNB2)

CIMI:

108307981(GNB2)

ANAN:

105732582(GNB2)

CSYR:

103255674

MMUR:

105868427(GNB2)

LCAT:

123631640(GNB2)

PCOQ:

105806018(GNB2)

OGA:	100940763(GNB2)

MMU:	14693(Gnb2)

MCAL:

110294718(Gnb2)

MPAH:

110339066(Gnb2)

RNO:	81667(Gnb2)

MCOC:

116068597(Gnb2)

ANU:	117698102(Gnb2)

ASYL:

127673391(Gnb2)

MUN:	110556769(Gnb2)

CGE:	100756281(Gnb2)

MAUA:

101832216(Gnb2)

PROB:

127237177(Gnb2)

PLEU:

114686769(Gnb2)

MORG:

121445292(Gnb2)

MFOT:

126493984

AAMP:

119824505(Gnb2)

NGI:	103733509(Gnb2)

HGL:	101711479(Gnb2)

CPOC:

100718398(Gnb2)

CCAN:

109685390

DORD:

105997382(Gnb2)

DSP:	122113749(Gnb2)

PLOP:

125367713(Gnb2)

NCAR:

124969987

MMMA:

107147087(Gnb2)

ITI:	101978298(Gnb2)

OCU:

100356799

OPI:	101529615(GNB2)

TUP:	102484212(GNB2)

GVR:	103596930(GNB2)

CFA:	479733(GNB2)

CLUD:

112646227(GNB2)

VVP:	112935784(GNB2)

VLG:	121486810(GNB2)

NPO:	129520313(GNB2)

AML:	100484553(GNB2)

UMR:	103670041(GNB2)

UAH:	113267850(GNB2)

UAR:	123777259(GNB2)

ELK:

111145586

LLV:

125090700

MPUF:

101678181(GNB2)

MNP:	132026562(GNB2)

MLK:	131819170(GNB2)

NVS:	122896086(GNB2)

ORO:	101378633(GNB2)

EJU:	114214309(GNB2)

ZCA:	113910568 113930871 113933707(GNB2)

MLX:	117999428(GNB2)

NSU:	110571879(GNB2)

LWW:	102740677(GNB2)

FCA:	101093317(GNB2)

PYU:	121017640(GNB2)

PCOO:

112859921(GNB2)

PBG:	122471298(GNB2)

PVIV:

125153968(GNB2)

LRUF:

124519383

LGF:	123589736(GNB2)

AJU:

106987417

PTG:	102955271(GNB2)

PPAD:

109251301(GNB2)

PUC:

125928229

PLEZ:

122209485(GNB2)

HHV:	120223690(GNB2)

BTA:	281202(GNB2)

BOM:	102272842(GNB2)

BIU:	109578415(GNB2)

BBUB:

102399170(GNB2)

BBIS:

104987131(GNB2)

OAS:	101102864(GNB2)

BTAX:

128068195(GNB2)

CSUM:

138075633(GNB2)

ODA:	120879254(GNB2)

CCAD:

122432849(GNB2)

MREE:

136160803(GNB2)

OVR:	110126307(GNB2)

MBEZ:

129545675(GNB2)

SSC:	100516546(GNB2)

CFR:	102508739(GNB2)

CBAI:

105067755(GNB2)

CDK:	105088562(GNB2)

VPC:	102534586(GNB2)

BACU:

103000308(GNB2)

BMUS:

118880696(GNB2)

LVE:	103072092(GNB2)

OOR:	101277504(GNB2)

LALB:

132505531(GNB2)

DLE:	111181977(GNB2)

PCAD:

102975750(GNB2)

PSIU:

116739605(GNB2)

NASI:

112399926(GNB2)

ECB:	100067486(GNB2)

EPZ:	103555641(GNB2)

EAI:	106839312(GNB2)

MYB:	102257762(GNB2)

MYD:	102762354(GNB2)

MMYO:

118655733(GNB2)

MLF:	102420482(GNB2)

MDT:	132233258(GNB2)

MYUM:

139008914(GNB2)

PKL:	118703924(GNB2)

EFUS:

103285992(GNB2)

MNA:	107540939(GNB2)

DRO:	112314848(GNB2)

SHON:

118992860(GNB2)

AJM:	119041561(GNB2)

PDIC:

114496264(GNB2)

PHAS:

123806391(GNB2)

MMF:	118641555(GNB2)

PPAM:

129083812(GNB2)

HAI:	109374903(GNB2)

RFQ:	117025270(GNB2)

PALE:

102882744(GNB2)

PGIG:

120591822(GNB2)

PVP:	105299738(GNB2)

RAY:	107500009(GNB2)

MJV:	108409379(GNB2)

TOD:	119241578(GNB2)

SARA:

101556740(GNB2)

SFUM:

130036507(GNB2)

SETR:

126031035(GNB2)

LAV:	100677127(GNB2)

TMU:

101345319

ETF:	101648866(GNB2)

DNM:	101426538(GNB2)

MDO:	100017392(GNB2)

GAS:	123244840(GNB2)

SHR:	100917513(GNB2)

AFZ:

127560972

PCW:	110202795(GNB2)

TVP:	118856302(GNB2)

OAA:	114807890(GNB2)

TACU:

119946854(GNB2)

AROW:

112965814

PSS:	102445015(GNB2)

CMY:	119565004(GNB2)

CCAY:

125628566(GNB2)

DCC:	119849306(GNB2)

CABI:

116814969(GNB2)

MRV:	120381775(GNB2)

ACS:

100562262

ASAO:

132779162(GNB2) 132779163

SUND:

121934918(GNB2)

PBI:	103059456(GNB2)

PMUR:

107285051(GNB2)

CTIG:

120299730(GNB2)

TSR:

106553141

PGUT:

117676813(GNB2)

APRI:

131197811(GNB2)

VKO:	123016698(GNB2)

PMUA:

114581940(GNB2)

PRAF:

128399585(GNB2)

ZVI:	118094223(GNB2)

HCG:	128329851(GNB2)

GJA:	107124437(GNB2)

EMC:	129340401(GNB2)

PWL:	138266893(GNB2)

MUO:

115459126

GSH:	117349969(GNB2)

DRE:	541370(gnb2)

SRX:

107746402

SANH:

107661206 107663406

SGH:	107580506 107596185 107599221

CCAR:

109090755(gnb2) 109105200

CAUA:

113049102 113077403

CGIB:

127958801 128003781

PTET:

122345887(gnb2)

LROH:

127166050(gnb2)

OMC:	131540261(gnb2)

PPRM:

120469986(gnb2)

RKG:	130072044(gnb2)

MAMB:

125266956(gnb2)

CIDE:

127512360

CERY:

137033749(gnb2)

MASI:

127429714 127435263

TROS:

130569675(gnb2)

TDW:	130419387(gnb2)

MANU:

129440443(gnb2)

PDAB:

135748586(gnb2)

IPU:	108260230(gnb2)

IFU:	128603438(gnb2)

PHYP:

113531205

SMEO:

124379091(gnb2)

TFD:	113641501(gnb2)

TVC:	132841199(gnb2)

CGAR:

128512317(gnb2)

NGRA:

132875833(gnb2)

TRN:	134303026(gnb2)

AMEX:

103031762(gnb2)

CMAO:

118803872(gnb2)

EEE:

113586818

CHAR:

105906614(gnb2)

SPIL:

134080117(gnb2)

TRU:	101066891(gnb2)

TFS:	130537895(gnb2)

TNG:	GSTEN00022138G001

LCO:

104939000

NCC:

104962945

TBEN:

117490421(gnb2)

CGOB:

115019168(gnb2)

PGEO:

117458440(gnb2)

GACU:

117534094(gnb2)

EMAC:

134872539(gnb2)

ELY:	117247128(gnb2)

EFO:	125898944(gnb2)

PLEP:

121952450(gnb2)

SLUC:

116064964(gnb2)

ECRA:

117956124(gnb2)

ESP:	116700628(gnb2)

PFLV:

114566754

GAT:	120821947(gnb2)

PPUG:

119215153(gnb2)

AFB:	129113080(gnb2)

CLUM:

117742687(gnb2)

PSWI:

130191649(gnb2)

CANA:

137802431(gnb2)

CVE:	137876570(gnb2)

MSAM:

119884595

SCHU:

122888838(gnb2)

CUD:	121519126(gnb2)

SPUL:

138595601(gnb2)

LMIX:

132988875(gnb2)

ALAT:

119031850(gnb2)

ASTR:

137605883(gnb2)

MZE:

101463772

ONL:

100692028

OAU:	116330253(gnb2)

OLA:

101175500

OML:	112142408(gnb2)

CSAI:

133459680(gnb2)

XMA:

XCO:

XHE:

PFOR:

PLAI:

106953376(gnb2)

PMEI:

106904740

GAF:	122845188(gnb2)

PPRL:

129368665(gnb2)

CVG:	107099790(gnb2)

CTUL:

119779187(gnb2)

GMU:	124876885(gnb2)

NFU:	107386500(gnb2)

KMR:	108248275(gnb2)

ALIM:

106516374

NWH:	119420678(gnb2)

AOCE:

111583347(gnb2)

EJA:	138196524(gnb2)

BFRE:

138631449(gnb2)

MCEP:

125021209(gnb2)

CSEM:

103395411(gnb2)

POV:

109628666

SSEN:

122779463(gnb2)

SSOE:

131458572(gnb2)

HHIP:

117774156(gnb2)

HSP:	118121929(gnb2)

PPLT:

128456853(gnb2)

SMAU:

118300467(gnb2)

LCF:	108893375(gnb2)

SDU:

111234326

SLAL:

111653996

XGL:	120802869(gnb2)

HCQ:	109512444(gnb2)

SSCV:

125982598(gnb2)

SBIA:

133491588(gnb2)

PEE:	133415898(gnb2)

PTAO:

133467294(gnb2)

BPEC:

110158650

ENY:	140360886(gnb2)

MALB:

109959438

BSPL:

114868973(gnb2)

SJO:	128371352(gnb2)

SSCO:

133993978(gnb2)

GMH:	115547296(gnb2)

SASA:

100380691(gbb2) 106567879

STRU:

115148966 115154423

OTW:	112228631 112257774

OMY:	110533726 110537401

OGO:	123999609 124009834

ONE:	115105621 115135836

OKI:	109875665 109892679

OKE:	118390163 118391231

OMM:	135548514 135550621

OCLA:

139418321 139423041

SALP:

111950399 111980922

SNH:	120045148 120057114(gnb2)

CCLU:

121573631 121579830

ELS:	105023919(gnb2)

OEP:	134039449(gnb2)

SFM:	108920340 108922889

PKI:	111835042 111860894

AANG:

118223438 118235979(gnb2)

AROT:

135251472 135263361(gnb2)

CCOG:

133123385 133132787(gnb2)

PSPA:

ARUT:

PSEX:

RTP:

CPLA:

HOC:

PMRN:

LRJ:

SLB:	AWJ20_498(STE4)

» show all

Reference

PMID:3108879

Authors

Fong HK, Amatruda TT 3rd, Birren BW, Simon MI

Title

Distinct forms of the beta subunit of GTP-binding regulatory proteins identified by molecular cloning.

Journal

Proc Natl Acad Sci U S A 84:3792-6 (1987)
DOI:10.1073/pnas.84.11.3792

Sequence

[hsa:2783]

LinkDB

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