KEGG ORTHOLOGY: K04606

ORTHOLOGY: K04606

Entry

K04606                      KO

Symbol

GRM3

Name

metabotropic glutamate receptor 3

Pathway

map04072

Phospholipase D signaling pathway

map04080

Neuroactive ligand-receptor interaction

map04082

Neuroactive ligand signaling

map04724

Glutamatergic synapse

map05030

Cocaine addiction

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    K04606  GRM3; metabotropic glutamate receptor 3
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04606  GRM3; metabotropic glutamate receptor 3
   04082 Neuroactive ligand signaling
    K04606  GRM3; metabotropic glutamate receptor 3
09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    K04606  GRM3; metabotropic glutamate receptor 3
09160 Human Diseases
  09165 Substance dependence
   05030 Cocaine addiction
    K04606  GRM3; metabotropic glutamate receptor 3
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04606  GRM3; metabotropic glutamate receptor 3
G protein-coupled receptors [BR:ko04030]
Metabotropic glutamate receptor family
  Glutamate (metabotropic)
   K04606  GRM3; metabotropic glutamate receptor 3

Other DBs

GO:

0001641

Genes

HSA:	2913(GRM3)

PTR:	746019(GRM3)

PPS:	100979630(GRM3)

GGO:	101136022(GRM3)

PON:	100172627(GRM3)

PPYG:

129041257(GRM3)

NLE:	100594386(GRM3)

HMH:	116814151(GRM3)

SSYN:

129479540(GRM3)

MCC:	706645(GRM3)

MCF:	101925540(GRM3)

MTHB:

126951263

MNI:	105475430(GRM3)

CSAB:

103226618(GRM3)

CATY:

105595512(GRM3)

PANU:

101009386(GRM3)

TGE:	112620555(GRM3)

MLEU:

105550958(GRM3)

RRO:	104668024(GRM3)

RBB:	108515138(GRM3)

TFN:	117072577(GRM3)

PTEH:

111552435(GRM3)

CANG:

105501666(GRM3)

CJC:	100408550(GRM3)

SBQ:	101049103(GRM3)

CIMI:

108300320(GRM3)

ANAN:

105723316 105723321

CSYR:

103272377

MMUR:

105879357(GRM3)

LCAT:

123647779(GRM3)

PCOQ:

105809663(GRM3)

OGA:	100966520(GRM3)

MMU:	108069(Grm3)

MCAL:

110294639(Grm3)

MPAH:

110316261(Grm3)

RNO:	24416(Grm3)

MCOC:

116097480(Grm3)

ANU:	117720316(Grm3)

ASYL:

127677302(Grm3)

MUN:	110555235(Grm3)

CGE:	100760036(Grm3)

MAUA:

101842648(Grm3)

PROB:

127214176(Grm3)

PLEU:

114687478(Grm3)

MORG:

121434795 121458618

MFOT:

126500177

AAMP:

119804007(Grm3)

NGI:	103725169(Grm3)

HGL:	101713039(Grm3)

CPOC:

100731837(Grm3)

CCAN:

109702358(Grm3)

DORD:

105992929(Grm3)

DSP:	122111913(Grm3)

PLOP:

125345825(Grm3)

NCAR:

124991869

MMMA:

107152647(Grm3)

ITI:	101977678(Grm3)

OCU:

100356452

OPI:	101524230(GRM3)

TUP:	102483840(GRM3)

GVR:	103604717(GRM3)

CFA:	100683236(GRM3)

CLUD:

112675004(GRM3)

VVP:	112935086(GRM3)

VLG:	121474465(GRM3)

NPO:	129498083(GRM3)

AML:	100474356(GRM3)

UMR:	103658785(GRM3)

UAH:	113259411(GRM3)

UAR:	123789339(GRM3)

ELK:

111155316

LLV:

125081223

MPUF:

101683300(GRM3)

MNP:	132015982(GRM3)

MLK:	131829322(GRM3)

NVS:	122904770(GRM3)

ORO:	101366239(GRM3)

EJU:	114221727(GRM3)

ZCA:	113911531(GRM3)

MLX:	118021321(GRM3)

NSU:	110580075(GRM3)

LWW:	102747417(GRM3)

FCA:	101095810(GRM3)

PYU:	121028783(GRM3)

PCOO:

112866774(GRM3)

PBG:	122487832(GRM3)

PVIV:

125160427(GRM3)

LRUF:

124525120

LGF:	123606395(GRM3)

AJU:

106971747

PTG:	102956816(GRM3)

PPAD:

109263637(GRM3)

PUC:

125929862

PLEZ:

122213163(GRM3)

HHV:	120222233(GRM3) 120225119

BTA:	541056(GRM3)

BOM:	102280421(GRM3)

BIU:	109557324(GRM3)

BBUB:

102411939(GRM3)

BBIS:

105002490(GRM3)

CHX:	102181359(GRM3)

OAS:	101113057(GRM3)

BTAX:

128046798(GRM3)

CSUM:

138080141(GRM3)

ODA:	120878107(GRM3)

CCAD:

122438237(GRM3)

MREE:

136170965(GRM3)

OVR:	110143455(GRM3)

MBEZ:

129552329(GRM3)

SSC:	100521916(GRM3)

CFR:	102513392(GRM3)

CBAI:

105062370(GRM3)

CDK:	105087351(GRM3)

VPC:	102534192(GRM3)

BACU:

102999582(GRM3)

BMUS:

118900420(GRM3)

LVE:	103089829(GRM3)

OOR:	101275396(GRM3)

LALB:

132524299(GRM3)

DLE:	111182327(GRM3)

PCAD:

102982821(GRM3)

PSIU:

116759432(GRM3)

NASI:

112395334(GRM3)

ECB:	100049918(GRM3)

EPZ:	103562299(GRM3)

EAI:	106838945(GRM3)

MYB:	102262324(GRM3)

MYD:	102764328(GRM3)

MMYO:

118666267(GRM3)

MLF:	102422463(GRM3)

MDT:	132242896(GRM3)

MYUM:

139016312(GRM3)

PKL:	118714343(GRM3)

EFUS:

103293194(GRM3)

MNA:	107541756(GRM3)

DRO:	112302050(GRM3)

SHON:

119000981(GRM3)

AJM:	119036999(GRM3)

PDIC:

114508224(GRM3)

PHAS:

123811031(GRM3)

MMF:	118620000(GRM3)

PPAM:

129062974(GRM3)

HAI:	109371302(GRM3)

RFQ:	117012514(GRM3)

PALE:

102881876(GRM3)

PGIG:

120615080(GRM3)

PVP:	105294889(GRM3)

RAY:	107512461(GRM3)

MJV:	108402826(GRM3)

TOD:	119244771(GRM3)

SARA:

101548725(GRM3)

SFUM:

130027383(GRM3)

SETR:

126005201(GRM3)

LAV:	100663502(GRM3)

TMU:

101347015

ETF:	101662549(GRM3)

DNM:	101430245(GRM3)

MDO:	100012410(GRM3)

GAS:	123249546(GRM3)

SHR:	100929851(GRM3)

AFZ:

127564071

PCW:	110217391(GRM3)

TVP:	118852423(GRM3)

PBRV:

138175865 138176014

OAA:	100085098(GRM3)

TACU:

119921064(GRM3)

GGA:	418644(GRM3)

PCOC:

116235727(GRM3)

MGP:	100549860(GRM3)

CJO:	107320082(GRM3)

TPAI:

128079639(GRM3)

LMUT:

125701924(GRM3)

NMEL:

110392508(GRM3)

APLA:

101803353(GRM3)

ACYG:

106035553(GRM3)

CATA:

118249436(GRM3)

AFUL:

116488984(GRM3)

TGU:	751962(GRM3)

LSR:	110470945(GRM3)

SCAN:

103813550(GRM3)

PMOA:

120509299(GRM3)

OTC:	121340561(GRM3)

PRUF:

121362327(GRM3)

ATRC:

139588535(GRM3)

GFR:	102044527(GRM3)

FAB:	101817776(GRM3)

OMA:	130248374(GRM3)

PHI:	102113129(GRM3)

PMAJ:

107205045(GRM3)

CCAE:

111923094(GRM3)

CCW:	104694485(GRM3)

CBRC:

103619794(GRM3)

ACOE:

138104541(GRM3)

ETL:

114066867

ZAB:	102074056(GRM3)

ZLE:	135442776(GRM3)

ACHL:

103810328

SVG:	106857196(GRM3)

MMEA:

130573749(GRM3)

HRT:	120752116(GRM3)

SATI:

136361090(GRM3)

CCIC:

134042911(GRM3)

FPG:	101913502(GRM3)

FCH:	102057003(GRM3)

CCRI:

104161815(GRM3)

NNT:	104408566(GRM3)

SHAB:

115605470(GRM3)

ACUN:

113487703(GRM3)

TALA:

104363967(GRM3)

ACHC:

115341930(GRM3)

HALD:

104318800(GRM3)

HLE:	104840183(GRM3)

AGEN:

126044428

HHAR:

128143361(GRM3)

GCL:

127019240

CSTI:

104555915

LDI:

104343719

MNB:	103776751 103779987

DPUB:

104300043(GRM3)

PPUS:

135174919(GRM3)

AVIT:

104268594

BRHI:

104489657(GRM3)

EGZ:	104132384(GRM3)

NNI:	104014607(GRM3)

PCRI:

104037325

PCAO:

104043969(GRM3)

PADL:

103915020(GRM3)

AFOR:

103904140(GRM3)

FGA:

104076391

GSTE:

104259638

CLV:	102084053(GRM3)

MUI:	104540273(GRM3)

PGUU:

104469892(GRM3)

PLET:

104617722(GRM3)

EHS:	104510061(GRM3)

CMAC:

104482693

CUCA:

104066136(GRM3)

TEO:	104375219(GRM3)

BREG:

104634785

OHA:	104337615(GRM3)

ACAR:

104530579

CPEA:

104391907(GRM3)

CVF:	104284583(GRM3)

RTD:	128914389(GRM3)

CRID:

134510356(GRM3)

AAM:	106485312(GRM3)

AROW:

112978088(GRM3)

NPD:	112942364(GRM3)

TGT:	104569911(GRM3)

DNE:	112994806(GRM3)

SCAM:

104147708(GRM3)

ASN:	102387340(GRM3)

AMJ:	102562670(GRM3)

CPOO:

109315778(GRM3)

GGN:	109292190(GRM3)

PSS:	102447321(GRM3)

CMY:	102935313(GRM3)

CCAY:

125630490(GRM3)

DCC:	119849799(GRM3)

CPIC:

101948606(GRM3)

TST:	117874851(GRM3)

CABI:

116816515(GRM3)

MRV:	120395740(GRM3)

ACS:	100554492(grm3)

ASAO:

132776491(GRM3)

PVT:	110082715(GRM3)

SUND:

121932192(GRM3)

PBI:

103057760

PMUR:

107298327

CTIG:

120314455(GRM3)

TSR:

106549450

PGUT:

117669988(GRM3)

APRI:

131201973(GRM3)

PTEX:

113444411(GRM3)

NSS:	113421957(GRM3)

VKO:	123020046(GRM3)

PMUA:

114606034(GRM3)

PRAF:

128422835(GRM3)

ZVI:	118091029(GRM3)

HCG:	128327906(GRM3)

GJA:	107125951(GRM3)

STOW:

125434960(GRM3)

EMC:	129335810(GRM3)

XLA:	108711210(grm3.L) 108713057(grm3.S)

XTR:	100492610(grm3)

NPR:	108794073(GRM3)

RTEM:

120931725(GRM3)

BBUF:

120987120(GRM3)

BGAR:

122925401(GRM3)

PWL:	138287828(GRM3)

MUO:	115478805(GRM3)

GSH:	117366925(GRM3)

DRE:	565256(grm3)

SRX:	107710363 107729995(grm3)

SANH:

107665551 107671160

SGH:	107559415 107563413

CCAR:

109083813 109108952(grm3)

CAUA:

113073058 113118191

CGIB:

127934237 127977304

PTET:

122363135(grm3)

LROH:

127181110(grm3)

OMC:	131523987(grm3)

PPRM:

120462077(grm3)

RKG:	130085414(grm3)

MAMB:

125254036(grm3)

CIDE:

127500063

CERY:

137023243(grm3)

MASI:

127417063 127456204

TROS:

130562468(grm3)

TDW:	130435681(grm3)

MANU:

129419100(grm3)

PDAB:

135773767(grm3)

IPU:	108263977(grm3)

IFU:	128606927(grm3)

PHYP:

113534598(grm3)

SMEO:

124396113(grm3)

TFD:	113652627(grm3)

TVC:	132851370(grm3)

CGAR:

128528278(grm3)

NGRA:

132887882(grm3)

TRN:	134323332(grm3)

AMEX:

103035018(grm3)

CMAO:

118818286(grm3)

EEE:

113577199

CHAR:

105910335(grm3)

SPIL:

134094464(grm3)

TRU:

101065663

TFS:	130536135(grm3)

TNG:	GSTEN00035548G001

LCO:

104918117

NCC:

104944051

TBEN:

117491671(grm3)

CGOB:

115009528

PGEO:

117448222(grm3)

GACU:

117557668(grm3)

EMAC:

134858591(grm3)

ELY:	117262721(grm3)

EFO:	125887212(grm3)

PLEP:

121950341(grm3)

SLUC:

116045708(grm3)

ECRA:

117949111(grm3)

ESP:

116694681

PFLV:

114560001

GAT:	120808768 120812435

PPUG:

119195777(grm3)

AFB:	129108084(grm3)

CLUM:

117732769(grm3)

PSWI:

130195209(grm3)

CANA:

137803582(grm3)

CVE:	137881106(grm3)

MSAM:

119894311(grm3)

SCHU:

122875516(grm3)

CUD:	121515794(grm3)

SPUL:

138612439(grm3)

LMIX:

132972403(grm3)

ALAT:

119025028(grm3)

ASTR:

137593632(grm3)

MZE:

101468980

ONL:

100706095

OAU:	116318312(grm3)

OLA:

101166047

OML:	112151932(grm3)

CSAI:

133444299(grm3)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

106954904(grm3)

PMEI:

106924857

GAF:	122835497(grm3)

PPRL:

129360901(grm3)

CVG:

107090533

CTUL:

119772469(grm3)

GMU:	124860116(grm3)

NFU:

107388863

KMR:	108230065(grm3)

ALIM:

106514278

NWH:	119416274(grm3)

AOCE:

111582531(grm3)

EJA:	138206650(grm3)

BFRE:

138628262(grm3)

MCEP:

125014955(grm3)

CSEM:

103380084

POV:

109624632

SSEN:

122775736(grm3)

SSOE:

131469938(grm3)

HHIP:

117762665(grm3)

HSP:	118110173(grm3)

PPLT:

128444508(grm3)

SMAU:

118315139(grm3)

LCF:	108875143(grm3)

SDU:

111228466

SLAL:

111653321

XGL:	120793230(grm3)

HCQ:

109526847

SSCV:

125970059(grm3)

SBIA:

133502390(grm3)

PEE:	133403152(grm3)

PTAO:

133478130(grm3)

BPEC:

110169199

ENY:	140349543(grm3)

MALB:

109967210

BSPL:

114857731(grm3)

SJO:	128358310(grm3)

SSCO:

133982550(grm3)

GMH:

115550568

SASA:

106561201 106573453

STRU:

115152037 115196713

OTW:	112245324 112253833

OMY:	110496093 110532210(grm3)

OGO:	123992608 124036234

ONE:	115109458 115134210

OKI:	109866954 109888853

OKE:

118400844

OMM:	135509309 135524348

OCLA:

139382192 139405858

SALP:

111952759 112071787

SNH:	120053245 120066692

CCLU:

121531947(grm3) 121576583 121576584

ELS:	105018424 109616650

SFM:	108921125(grm3) 108936375

PKI:	111842401 111846174(grm3)

AANG:

118219054 118232260

AROT:

135246117 135259140(grm3)

CCOG:

133118965 133134835

LOC:	102688659(grm3)

PSPA:

121313900 121318197 121319913

ARUT:

117414463 117419755

PSEX:

120534147(grm3)

LCM:	102363231(GRM3)

CMK:

103172906

CPLA:

122561484

HOC:	132826829(grm3)

LERI:

129707980(grm3)

PMRN:

116942374 116949365 116951105

LRJ:	133339212 133342626 133349464 133356455

BFO:	118416473 118422149 118422613

BBEL:

109464570 109476804 109487375 109487458

SPU:	115918908 115928606 576160 579746

LPIC:

129257305

AJJ:	139962445 139962502 139962935

APLC:

110974631 110976785 110977076 110979837 110979954 110983086 110983088 110983629 110983692 110984651 110987904 110987905

ARUN:

117290376 117294327 117294687 117294695 117296753

AAMU:

139936645 139939564 139940587 139940652 139940803 139940825 139940913 139945190 139947593 139951021

AJC:	117115077 117117839 117117841

SKO:	100370120 100373691 100378908 102806886 102810127

PFLL:

139119933 139119980 139122745 139134608 139135254 139138048 139141605 139142413 139144862 139149053

DME:	Dmel_CG11144(mGluR)

DER:

6555835

DSE:

6620124

DSI:	Dsimw501_GD28322(Dsim_GD28322)

DYA:	Dyak_GE14562

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI14041

DAZ:

108617842

DNV:

108655496

DHE:

111597961

DVI:	6636272(mGluR)

CCAT:

101455575

RZE:	108361385 108375333

AOQ:	129250356 129250821

ALUD:

TDA:

GFS:

ECOE:

HIS:

AME:	406151(mGlutR1)

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139109881(Mglur)

TLN:	139821722(Mglur)

HST:

105183564

DQU:

106742892

CFO:

105254229

FEX:	115242086 115242118

PMEC:

138931723(Mglur)

LHU:	105676744(mGluR)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124220682(mGluR)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138139735(mGluR)

DPA:

109533892

ESIM:

136409581(mGluR)

EFOR:

136348490(mGluR)

SOY:

AGRG:

ATD:

AGB:

APLN:

CCRN:

FOC:

TPAL:

CSEC:

IEL:

DPX:	DAPPUDRAFT_44069(Grm1)

DMK:	116916942 116917767 116920205

DPZ:

124336883

AFRA:

136026542

PJA:	122249166 122252142

PCHN:

125029876 125041148

PMOO:

119580654

HAME:

121859314 121867817

PCLA:

123745931 123750728 123772135

CQD:	128688348 128694933(mGluR)

PTRU:

123498824 123502668

ESN:	127001044 127005352

MNZ:

135215364

MRJ:	136843072(mGluR)

PORN:

139765923(mGluR) 139766936

HAZT:

108670555 108682560

EAF:

111708836

LSM:	121128203 121130171

PPOI:

119096592 119108354 119108356 119108357

ISC:

8034476

DSV:	119436009 119461995

RSAN:

119389538 119396747

RMP:	119173973 119176880 119181489

VDE:	111243762 111245193

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136975507 136977915(mGluR)

PTEP:

107455042

ABRU:

129963673

UDV:	129216578 129220528 129225934 129228365 129231008

SDM:	118183080 118183082

LPOL:

106457167 106460753 106460966 106462694

PMEO:

129599197 129601761

LGI:	LOTGIDRAFT_108603 LOTGIDRAFT_130830

PVUL:

PCAN:

LSAX:

BGT:

GAE:	121368533 121369091 121379654

HRF:

124134084

HRJ:

124258627

HASI:

137296098 137296706

HCRA:

139445567 139448018 139456437

CRG:

105324931

CANU:

128158900 128189217

CVN:	111110409 111132378

OED:	125654484 125664027

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

128215834 128223213 128223217

OBI:	106867234 106869985

OSN:

115217464

LJP:	135471652 135479690

LAK:	106160125 106160965

SMM:	Smp_150370

OVI:	T265_13658

EGL:

EGR_05288

LLON:

135483290 135487465 135487773 135488370 135490663 135491255 135501559 135502748

NVE:	5506645 5510322 5513085 5518217 5518769 5519820

EPA:	110245252 110245306 110248423

ATEN:

116294316 116305632

ADF:

107353563

AMIL:

114955935 114958024 114959292 114967496 114970184 114977547 114977548 122965136

MCAZ:

138013446 138027431 138028338 138028526 138045484 138054464

MFOO:

137970883 137974670 137980109 137983882 137983902 137994521 137995363 137996516

PDAM:

113669276 113683240 113685008

SPIS:

111325905 111329867 111329901 111339108 111340388

DGT:	114515731 114515732 114515733 114515845 114522869 114523407 114525345 114529382

XEN:	124447093 124451351

HMG:	100200306 100200660 100200924 100203972 100206413 100209446 100211274 105843299 105847599

HSY:	130612104 130612847 130614362 130631049 130636897 130642118 130645179 130646920 130647430 130648584 130648802 130649052 130649226 130654919

RES:	135685483 135689465 135689466 135690101

TAD:	TRIADDRAFT_15193 TRIADDRAFT_19351 TRIADDRAFT_59554

AQU:	100631483 100631612 100641630

MBR:	MONBRDRAFT_24906

» show all

Reference

PMID:8840013

Authors

Makoff A, Volpe F, Lelchuk R, Harrington K, Emson P

Title

Molecular characterization and localization of human metabotropic glutamate receptor type 3.

Journal

Brain Res Mol Brain Res 40:55-63 (1996)
DOI:10.1016/0169-328x(96)00037-x

Sequence

[hsa:2913]

Reference

PMID:12782243

Authors

Pin JP, Galvez T, Prezeau L

Title

Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.

Journal

Pharmacol Ther 98:325-54 (2003)
DOI:10.1016/S0163-7258(03)00038-X

LinkDB

DBGET integrated database retrieval system