Homo sapiens (human): 2913
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Entry
2913 CDS
T01001
Symbol
GRM3, GLUR3, GPRC1C, MGLUR3, mGlu3
Name
(RefSeq) glutamate metabotropic receptor 3
KO
K04606
metabotropic glutamate receptor 3
Organism
hsa
Homo sapiens (human)
Pathway
hsa04072
Phospholipase D signaling pathway
hsa04080
Neuroactive ligand-receptor interaction
hsa04082
Neuroactive ligand signaling
hsa04724
Glutamatergic synapse
hsa05030
Cocaine addiction
Network
nt06544
Neuroactive ligand signaling
Element
N01879
Glutamate-GRM-GNAI/O signaling pathway
Drug target
Pomaglumetad methionil (
DG02201
):
D09949
D10896
Talaglumetad hydrochloride:
D09008
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04072 Phospholipase D signaling pathway
2913 (GRM3)
09133 Signaling molecules and interaction
04080 Neuroactive ligand-receptor interaction
2913 (GRM3)
04082 Neuroactive ligand signaling
2913 (GRM3)
09150 Organismal Systems
09156 Nervous system
04724 Glutamatergic synapse
2913 (GRM3)
09160 Human Diseases
09165 Substance dependence
05030 Cocaine addiction
2913 (GRM3)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04030 G protein-coupled receptors [BR:
hsa04030
]
2913 (GRM3)
G protein-coupled receptors [BR:
hsa04030
]
Metabotropic glutamate receptor family
Glutamate (metabotropic)
2913 (GRM3)
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Gene cluster
GFIT
Motif
Pfam:
ANF_receptor
7tm_3
NCD3G
Peripla_BP_6
Motif
Other DBs
NCBI-GeneID:
2913
NCBI-ProteinID:
NP_000831
OMIM:
601115
HGNC:
4595
Ensembl:
ENSG00000198822
UniProt:
Q14832
A4D1D0
Structure
PDB
PDBj
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Position
7:86643909..86864879
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AA seq
879 aa
AA seq
DB search
MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRI
NEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV
DEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSD
KSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNIC
IATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVAS
DGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQ
CSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD
AMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSY
LKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL
ADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIK
HNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALL
TKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLA
EKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCI
IWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLH
LNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
NT seq
2640 nt
NT seq
+upstream
nt +downstream
nt
atgaagatgttgacaagactgcaagttcttaccttagctttgttttcaaagggattttta
ctctctttaggggaccataactttctaaggagagagattaaaatagaaggtgaccttgtt
ttagggggcctgtttcctattaacgaaaaaggcactggaactgaagaatgtgggcgaatc
aatgaagaccgagggattcaacgcctggaagccatgttgtttgctattgatgaaatcaac
aaagatgattacttgctaccaggagtgaagttgggtgttcacattttggatacatgttca
agggatacctatgcattggagcaatcactggagtttgtcagggcatctttgacaaaagtg
gatgaagctgagtatatgtgtcctgatggatcctatgccattcaagaaaacatcccactt
ctcattgcaggggtcattggtggctcttatagcagtgtttccatacaggtggcaaacctg
ctgcggctcttccagatccctcagatcagctacgcatccaccagcgccaaactcagtgat
aagtcgcgctatgattactttgccaggaccgtgccccccgacttctaccaggccaaagcc
atggctgagatcttgcgcttcttcaactggacctacgtgtccacagtagcctccgagggt
gattacggggagacagggatcgaggccttcgagcaggaagcccgcctgcgcaacatctgc
atcgctacggcggagaaggtgggccgctccaacatccgcaagtcctacgacagcgtgatc
cgagaactgttgcagaagcccaacgcgcgcgtcgtggtcctcttcatgcgcagcgacgac
tcgcgggagctcattgcagccgccagccgcgccaatgcctccttcacctgggtggccagc
gacggctggggcgcgcaggagagcatcatcaagggcagcgagcatgtggcctacggcgcc
atcaccctggagctggcctcccagcctgtccgccagttcgaccgctacttccagagcctc
aacccctacaacaaccaccgcaacccctggttccgggacttctgggagcaaaagtttcag
tgcagcctccagaacaaacgcaaccacaggcgcgtctgcgacaagcacctggccatcgac
agcagcaactacgagcaagagtccaagatcatgtttgtggtgaacgcggtgtatgccatg
gcccacgctttgcacaaaatgcagcgcaccctctgtcccaacactaccaagctttgtgat
gctatgaagatcctggatgggaagaagttgtacaaggattacttgctgaaaatcaacttc
acggctccattcaacccaaataaagatgcagatagcatagtcaagtttgacacttttgga
gatggaatggggcgatacaacgtgttcaatttccaaaatgtaggtggaaagtattcctac
ttgaaagttggtcactgggcagaaaccttatcgctagatgtcaactctatccactggtcc
cggaactcagtccccacttcccagtgcagcgacccctgtgcccccaatgaaatgaagaat
atgcaaccaggggatgtctgctgctggatttgcatcccctgtgaaccctacgaatacctg
gctgatgagtttacctgtatggattgtgggtctggacagtggcccactgcagacctaact
ggatgctatgaccttcctgaggactacatcaggtgggaagacgcctgggccattggccca
gtcaccattgcctgtctgggttttatgtgtacatgcatggttgtaactgtttttatcaag
cacaacaacacacccttggtcaaagcatcgggccgagaactctgctacatcttattgttt
ggggttggcctgtcatactgcatgacattcttcttcattgccaagccatcaccagtcatc
tgtgcattgcgccgactcgggctggggagttccttcgctatctgttactcagccctgctg
accaagacaaactgcattgcccgcatcttcgatggggtcaagaatggcgctcagaggcca
aaattcatcagccccagttctcaggttttcatctgcctgggtctgatcctggtgcaaatt
gtgatggtgtctgtgtggctcatcctggaggccccaggcaccaggaggtatacccttgca
gagaagcgggaaacagtcatcctaaaatgcaatgtcaaagattccagcatgttgatctct
cttacctacgatgtgatcctggtgatcttatgcactgtgtacgccttcaaaacgcggaag
tgcccagaaaatttcaacgaagctaagttcataggttttaccatgtacaccacgtgcatc
atctggttggccttcctccctatattttatgtgacatcaagtgactacagagtgcagacg
acaaccatgtgcatctctgtcagcctgagtggctttgtggtcttgggctgtttgtttgca
cccaaggttcacatcatcctgtttcaaccccagaagaatgttgtcacacacagactgcac
ctcaacaggttcagtgtcagtggaactgggaccacatactctcagtcctctgcaagcacg
tatgtgccaacggtgtgcaatgggcgggaagtcctcgactccaccacctcatctctgtga
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