KEGG ORTHOLOGY: K04695

ORTHOLOGY: K04695

Entry

K04695                      KO

Symbol

SOCS2, CIS2

Name

suppressor of cytokine signaling 2

Pathway

map04630

JAK-STAT signaling pathway

map04910

Insulin signaling pathway

map04917

Prolactin signaling pathway

map04930

Type II diabetes mellitus

map04935

Growth hormone synthesis, secretion and action

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
   04917 Prolactin signaling pathway
    K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
   04935 Growth hormone synthesis, secretion and action
    K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K04695  SOCS2, CIS2; suppressor of cytokine signaling 2
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Multi subunit type E3
   Cul5 complex
    Target recognizing subunit
     K04695  SOCS2, CIS2; suppressor of cytokine signaling 2

Genes

HSA:	8835(SOCS2)

PTR:	452127(SOCS2)

PPS:	100989242(SOCS2)

GGO:	101141962(SOCS2)

PON:	100440378(SOCS2)

PPYG:

129010741(SOCS2)

HMH:	116479100(SOCS2)

SSYN:

129460043(SOCS2)

MCC:	715772(SOCS2)

MCF:	102125352(SOCS2)

MTHB:

126930306

MNI:	105483704(SOCS2)

CSAB:

103238870(SOCS2)

CATY:

105573385(SOCS2)

PANU:

100997018(SOCS2)

TGE:	112635152(SOCS2)

MLEU:

105548922(SOCS2)

RRO:	104678596(SOCS2)

RBB:	108527232(SOCS2)

TFN:	117089622(SOCS2)

PTEH:

111551025(SOCS2)

CANG:

105505887(SOCS2)

CJC:	100396208(SOCS2)

SBQ:	101040467(SOCS2)

CIMI:

108317927(SOCS2)

ANAN:

105728770(SOCS2)

CSYR:

103274028(SOCS2)

MMUR:

105867161 105868494 105868495 105877066(SOCS2) 109730136

LCAT:

123639443(SOCS2)

OGA:	100942876(SOCS2)

MMU:	216233(Socs2)

MCAL:

110303375(Socs2)

MPAH:

110326628(Socs2)

RNO:	84607(Socs2)

MCOC:

116075959(Socs2)

ANU:	117696875(Socs2)

ASYL:

127670841(Socs2)

MUN:	110562882(Socs2)

MAUA:

101834532(Socs2)

PROB:

127237871(Socs2)

PLEU:

114681943(Socs2)

MORG:

121460345(Socs2)

MFOT:

126503794

AAMP:

119803710(Socs2)

NGI:	103726290(Socs2)

HGL:	101716580(Socs2)

CCAN:

109688786(Socs2)

DORD:

105990479(Socs2)

DSP:	122119264(Socs2)

PLOP:

125360252(Socs2)

NCAR:

124983925

MMMA:

107140010(Socs2)

ITI:	101963516(Socs2) 101972189

OCU:

100354019

OPI:	101517558(SOCS2)

TUP:	102480737(SOCS2)

GVR:	103592159(SOCS2)

CFA:	100855737(SOCS2)

CLUD:

112654340(SOCS2) 125754135

VVP:	112914913(SOCS2)

VLG:	121481595(SOCS2)

NPO:	129516951(SOCS2)

AML:	100474808(SOCS2)

UMR:	103660099(SOCS2)

UAH:	113256161(SOCS2)

UAR:	123780802(SOCS2)

ELK:

111142151

LLV:	125106296 125107363

MPUF:

101680544(SOCS2)

MNP:	132019361(SOCS2)

MLK:	131839266(SOCS2)

NVS:	122891437(SOCS2)

ORO:	101373719(SOCS2)

EJU:	114211006(SOCS2)

ZCA:	113922515(SOCS2)

MLX:	117998887(SOCS2)

NSU:	110578011(SOCS2)

LWW:	102725696(SOCS2)

FCA:	101080980(SOCS2)

PYU:	121040616(SOCS2)

PCOO:

112863540(SOCS2)

PBG:	122472490(SOCS2)

PVIV:

125171150(SOCS2)

LRUF:

124502487

LGF:	123590507(SOCS2)

AJU:

106973415

PTG:	102953997(SOCS2)

PPAD:

109265338(SOCS2)

PUC:

125919424

PLEZ:

122224929(SOCS2)

HHV:	120234661(SOCS2)

BTA:	338437(SOCS2)

BOM:	102268022(SOCS2)

BIU:	109558981(SOCS2)

BBUB:

102405656(SOCS2)

BBIS:

104988407(SOCS2)

CHX:	102178979(SOCS2)

OAS:	101115017(SOCS2)

BTAX:

128047912(SOCS2)

CSUM:

138078263(SOCS2)

ODA:	120858377(SOCS2)

CCAD:

122427503(SOCS2) 122436448

OVR:	110129476 110139322(SOCS2)

MBEZ:

129536823(SOCS2) 129538306

SSC:	100037966(SOCS2)

CFR:	102505948(SOCS2)

CBAI:

105074996(SOCS2)

CDK:	105097413(SOCS2)

VPC:	102529072(SOCS2)

BACU:

103008379 103018227(SOCS2)

BMUS:

118902022(SOCS2)

LVE:	103070250(SOCS2)

OOR:	101289153(SOCS2)

LALB:

132529062(SOCS2)

DLE:	111163600(SOCS2)

PCAD:

102990576(SOCS2)

PSIU:

116761294(SOCS2)

NASI:

112405798(SOCS2)

ECB:	100051952(SOCS2)

EPZ:	103564583(SOCS2)

EAI:	106831177(SOCS2)

MYB:	102260836(SOCS2)

MYD:	102764738(SOCS2)

MMYO:

118651411(SOCS2)

MLF:	102426869(SOCS2)

MDT:	132214264 132228022(SOCS2)

MYUM:

139006844(SOCS2)

PKL:	118729108(SOCS2)

EFUS:

103288046(SOCS2)

MNA:	107538918(SOCS2)

SHON:

118997337 118999937(SOCS2)

AJM:	119055814 119064562(SOCS2)

PDIC:

114510311 114513532(SOCS2)

PHAS:

123805849 123813545(SOCS2)

MMF:	118616246 118624669(SOCS2)

PPAM:

129066770 129075951(SOCS2)

HAI:	109392673(SOCS2)

RFQ:	117029404(SOCS2)

PALE:

102889529(SOCS2)

PGIG:

120607291(SOCS2)

PVP:	105293246(SOCS2)

RAY:	107517179(SOCS2)

MJV:	108400461(SOCS2)

TOD:

119247431

SARA:

101545288(SOCS2)

SFUM:

130038301

SETR:

126021953(SOCS2)

LAV:	100660067(SOCS2)

TMU:

101349221

ETF:	101659183(SOCS2)

DNM:

101439874

MDO:	100011895(SOCS2)

GAS:	123255761(SOCS2)

SHR:	100925364(SOCS2)

AFZ:

127539448

PCW:	110221772(SOCS2)

TVP:	118852129(SOCS2)

PBRV:

138166686(SOCS2)

OAA:	100079417(SOCS2)

TACU:

119936601(SOCS2)

GGA:	395219(SOCS2)

PCOC:

116233499(SOCS2)

MGP:	100544272(SOCS2)

CJO:	107311591(SOCS2)

TPAI:

128073744(SOCS2)

LMUT:

125688019(SOCS2)

NMEL:

110393037(SOCS2)

CATA:

118250504(SOCS2)

AFUL:

116494822(SOCS2)

TGU:	115493536(SOCS2)

LSR:	110469353(SOCS2)

SCAN:

103813398(SOCS2)

PMOA:

120499800(SOCS2)

ATRC:

139588204(SOCS2)

GFR:	102031776(SOCS2)

FAB:	101816040(SOCS2)

OMA:	130248324(SOCS2)

PHI:	102114276(SOCS2)

PMAJ:

107204420(SOCS2)

CCAE:

111933710(SOCS2)

CCW:	104696565(SOCS2)

CBRC:

103618297(SOCS2)

ACOE:

138102384(SOCS2)

ETL:	114062240(SOCS2)

ZAB:	102067464(SOCS2)

ZLE:	135442348(SOCS2)

ACHL:

103799068(SOCS2)

SVG:	106861034(SOCS2)

MMEA:

130586036(SOCS2)

HRT:	120751877(SOCS2)

CCIC:

134043281(SOCS2)

FPG:	106112815(SOCS2)

FCH:	114017839(SOCS2)

CCRI:

104157168(SOCS2)

NNT:	104408124(SOCS2)

SHAB:

115605829(SOCS2)

ACUN:

113491108(SOCS2)

TALA:

104364524(SOCS2)

ACHC:

115336062(SOCS2)

HALD:

104312928(SOCS2)

HLE:	104828284(SOCS2)

AGEN:

126034436

HHAR:

128135555(SOCS2)

GCL:

127024030

CSTI:

104552538(SOCS2)

LDI:	104342200(SOCS2)

MNB:	103775809(SOCS2)

DPUB:

104305164(SOCS2)

PPUS:

135181650(SOCS2)

AVIT:

104277954(SOCS2)

BRHI:

104500592(SOCS2)

EGZ:	104132329(SOCS2)

NNI:	104011649(SOCS2)

PCRI:

104029960(SOCS2)

PCAO:

104044249(SOCS2)

PADL:

103914674(SOCS2)

AFOR:

103903313(SOCS2)

FGA:	104072271(SOCS2)

GSTE:

104253249(SOCS2)

CLV:	102097346(SOCS2)

MUI:	104535788(SOCS2)

PGUU:

104471707(SOCS2)

PLET:

104616054(SOCS2)

EHS:	104509984(SOCS2)

CMAC:

104483457(SOCS2)

CUCA:

104058417(SOCS2)

TEO:	104373215(SOCS2)

BREG:

104642891(SOCS2)

OHA:	104334509(SOCS2)

ACAR:

104520298(SOCS2)

CPEA:

104397984(SOCS2)

CVF:	104284327(SOCS2)

RTD:	128918406(SOCS2)

CRID:

134510028(SOCS2)

AAM:	106488466(SOCS2)

AROW:

112966192(SOCS2)

NPD:	112944155(SOCS2)

TGT:	104580881(SOCS2)

DNE:	112997268(SOCS2)

SCAM:

104143830(SOCS2)

ASN:	102388356(SOCS2)

AMJ:	102574136(SOCS2)

CPOO:

109316858(SOCS2)

GGN:	109295805(SOCS2)

PSS:	102447309 102453265(SOCS2)

CMY:	102945521(SOCS2) 102945560

CCAY:

125625042 125630100(SOCS2)

DCC:	119846203 119849830(SOCS2)

CPIC:

101933959 101943086(SOCS2)

TST:	117875873 117878502(SOCS2)

MRV:	120375665(SOCS2) 120404578

ACS:	100552196(socs2)

ASAO:

132776096(SOCS2)

PVT:	110091701(SOCS2)

SUND:

121932206(SOCS2)

PBI:	103051048(SOCS2)

PMUR:

107284805(SOCS2)

CTIG:

120314755(SOCS2)

TSR:	106541148(SOCS2)

PGUT:

117655392(SOCS2)

APRI:

131202456(SOCS2)

PTEX:

113435088(SOCS2)

NSS:	113431490(SOCS2)

VKO:	123036518(SOCS2)

PMUA:

114605160(SOCS2)

PRAF:

128422186(SOCS2)

ZVI:	118091491(SOCS2)

HCG:	128328374(SOCS2)

GJA:	107118612(SOCS2)

STOW:

125434765(SOCS2)

EMC:	129335717(SOCS2)

XLA:	108711062(socs2.L) 734276(socs2.S)

XTR:	100151723(socs2)

NPR:	108790061(SOCS2)

RTEM:

120932038(SOCS2)

BBUF:

120979931(SOCS2)

BGAR:

122925878(SOCS2)

PWL:	138287933(SOCS2)

MUO:	115478006(SOCS2)

GSH:	117364158(SOCS2)

DRE:	562062(socs2)

SRX:	107725676 107732999

SANH:

107664864 107695891

SGH:	107553891 107590271

CCAR:

109067656 109088139

CAUA:

113048140 113063119 113077875

CGIB:

127956671 127974586

PTET:

122343447(socs2)

LROH:

127163749(socs2)

OMC:	131539501(socs2)

PPRM:

120477003(socs2)

RKG:	130072294(socs2)

MAMB:

125245380(socs2)

CIDE:

127510451

CERY:

137024460(socs2)

MASI:

127435244 127436864

TROS:

130547760(socs2)

TDW:	130420665(socs2)

MANU:

129432557(socs2)

PDAB:

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

CGAR:

128510018(socs2)

TRN:	134322394(socs2) 134333337

AMEX:

103034993(socs2)

CMAO:

118812054(socs2) 118821967

EEE:

113585501

CHAR:

105894268 105909556(socs2)

SPIL:

134062290(socs2) 134087970

TRU:	100144308(socs2) 115246597

TFS:	130519268(socs2)

TNG:	GSTEN00011568G001

LCO:

104938686

NCC:	104961843(socs2)

TBEN:

117487658(socs2)

CGOB:

115004548

PGEO:

117441867(socs2)

EMAC:

134879034(socs2)

ELY:	117249520(socs2)

EFO:	125883111(socs2)

PLEP:

121966722(socs2)

SLUC:

116060793(socs2)

ECRA:

117939038(socs2)

PFLV:

114550326

GAT:	100190869(socs2)

PPUG:

119210316(socs2)

AFB:	129112712(socs2)

CLUM:

117726021(socs2)

PSWI:

130200323(socs2)

CVE:	137889923(socs2)

MSAM:

119895495 119895496

SCHU:

122871553(socs2)

CUD:	121505557(socs2)

SPUL:

138599520(socs2)

LMIX:

132956458(socs2)

ALAT:

119032536(socs2)

MZE:

101485857

ONL:	100708174(socs2)

OAU:	116313786(socs2)

OLA:

101164124

OML:	112154192(socs2)

CSAI:

133424100(socs2) 133424402

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122826468(socs2)

PPRL:

129351956(socs2)

CVG:	107100762(socs2)

CTUL:

119794134(socs2)

GMU:	124882834(socs2)

NFU:	107387837(socs2)

KMR:	108228578(socs2)

NWH:	119428421(socs2)

AOCE:

111581361(socs2)

EJA:	138198482(socs2)

BFRE:

138614384(socs2)

MCEP:

125000304(socs2)

CSEM:

103382466

POV:	109647841(socs2)

SSEN:

122765785(socs2)

SSOE:

131456260(socs2)

HHIP:

117757607(socs2)

HSP:	118101316(socs2)

PPLT:

128428526(socs2)

SMAU:

118290999(socs2)

LCF:	108890543(socs2)

SDU:

111229492

SLAL:

111669171

XGL:	120801334(socs2)

SBIA:

133493767(socs2)

PEE:	133397444(socs2)

PTAO:

133471804(socs2)

BPEC:

110161754

ENY:	140367477(socs2)

MALB:

109967714(socs2)

BSPL:

114861962(socs2)

SJO:	128385167(socs2)

SSCO:

134004274(socs2)

GMH:

115541471

SASA:

106567289 106576177(SOCS2a) 106609294(SOCS2b)

STRU:

115168132 115180264 115198823

OTW:	112214275(socs2) 112216920 112221959

OMY:	100272211 110492178 110500152(socs2) 110532426

OGO:	123994578 124014614 124045872

ONE:	115102313 115107007 115133110

OKI:	109869316 109879989 109907021 109910363

OKE:	118359838 118366271 118392388

OMM:	135514874 135515928 135528215

OCLA:

139367668 139378644 139393057

SALP:

111955951 111976262

SNH:	120032239 120050047 120060704

CCLU:

121543593 121559144

ELS:	105027835(socs2)

OEP:	134018946 134037786(socs2)

SFM:	108920753(socs2) 108939161

PKI:	111844330(socs2) 111855028

AANG:

118208662 118210940 118219183(socs2) 118231801

AROT:

135234354 135237335 135245917(socs2) 135258869

CCOG:

133110166 133119207(socs2) 133138765

LOC:	102692411(socs2) 102698069(cish)

PSPA:

121300287 121300299 121318297(socs2) 121319817

ARUT:

117395816 117415149 117419650 117964456

PSEX:

120525956 120534018(socs2)

LCM:	102356616(SOCS2) 102362993

CMK:

103179170

RTP:	109911338 109915652(socs2)

CPLA:

122561559(socs2) 122563219

HOC:	132826951(socs2) 132828196

LERI:

129707652(socs2) 129708669

PMRN:

116942431 116956730

LRJ:

133349402

BFO:	118422404 118422805

BBEL:

SPU:

LPIC:

AJJ:

ARUN:

AAMU:

PFLL:

AGRG:

BMOR:

100862764(SOCS2-12)

BMAN:

114253191

MSEX:

115443639

DPL:	KGM_200332

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

CSTB:

ACOO:

BTAB:

HHAL:

DPX:	DAPPUDRAFT_26988

AFRA:

136039399

PJA:	122248734 122265977

PCHN:

125043763

HAME:

121862756 121872930

PCLA:

123768213

CQD:	128700656 128700670

PTRU:

MNZ:

MRJ:

EAF:

RMP:

VDE:

VJA:

CSCU:

CVS:

PTEP:

ABRU:

SDM:	118185172 118200371

LPOL:

106463723 106473333 106476430

PVUL:

BGT:

CRG:

CANU:

CVN:

OED:	125658674 125670640 125670847 125671372 130054042

PMAX:

AIRR:

RPHI:

DPOL:

OBI:

OSN:

LJP:	135462078 135462081

LAK:

LLON:

NVE:

EPA:

ATEN:

AMIL:

MCAZ:

MFOO:

PDAM:

DGT:	114519344 114535975

XEN:

HSY:

RES:

AQU:

Reference

PMID:9266833

Authors

Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T

Title

Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.

Journal

Biochem Biophys Res Commun 237:79-83 (1997)
DOI:10.1006/bbrc.1997.7080

Sequence

[hsa:8835]

Reference

PMID:24031028

Authors

Iglesias-Gato D, Chuan YC, Wikstrom P, Augsten S, Jiang N, Niu Y, Seipel A, Danneman D, Vermeij M, Fernandez-Perez L, Jenster G, Egevad L, Norstedt G, Flores-Morales A

Title

SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer.

Journal

Carcinogenesis 35:24-33 (2014)
DOI:10.1093/carcin/bgt304

Sequence

[hsa:8835]

LinkDB

DBGET integrated database retrieval system