KEGG   ORTHOLOGY: K04709
Entry
K04709                      KO                                     
Symbol
LAG1, LAC1
Name
very-long-chain ceramide synthase [EC:2.3.1.297]
Pathway
map00600  Sphingolipid metabolism
map01100  Metabolic pathways
Module
M00094  Ceramide biosynthesis
M00099  Sphingosine biosynthesis
Reaction
R06517  acyl-CoA:sphingosine N-acyltransferase
R06527  acyl-CoA: phytosphingosine N-acyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00600 Sphingolipid metabolism
    K04709  LAG1, LAC1; very-long-chain ceramide synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.297  very-long-chain ceramide synthase
     K04709  LAG1, LAC1; very-long-chain ceramide synthase
Other DBs
COG: COG5058
GO: 0050291
Genes
SCE: YHL003C(LAG1) YKL008C(LAC1)
SEUB: DI49_3364 DI49_4845
SPAO: SPAR_H00380 SPAR_K02010
AGO: AGOS_ABR009W AGOS_ADL206W
ERC: Ecym_2439 Ecym_3334
KLA: KLLA0_B13497g KLLA0_E08141g
KMX: KLMA_30063(LAG1) KLMA_80123(lag1)
LTH: KLTH0D06116g KLTH0G10582g
VPO: Kpol_1018p49 Kpol_1056p36
ZRO: ZYRO0B01276g
CGR: 2890270(GVI51_K02585) 2891355(GVI51_M10197)
NCS: NCAS_0A05070(NCAS0A05070) NCAS_0F00970(NCAS0F00970)
NDI: NDAI_0H01460(NDAI0H01460) NDAI_0K02120(NDAI0K02120)
TPF: TPHA_0C04030(TPHA0C04030) TPHA_0G03260(TPHA0G03260)
TBL: TBLA_0B05480(TBLA0B05480) TBLA_0I00240(TBLA0I00240)
TGB: HG536_0A04320
TDL: TDEL_0A02770(TDEL0A02770)
KAF: KAFR_0A01800(KAFR0A01800) KAFR_0D03370(KAFR0D03370)
KNG: KNAG_0A06730(KNAG0A06730) KNAG_0B05390(KNAG0B05390)
ZMK: HG535_0D03650
SLUD: SCDLUD_000004 SCDLUD_004105
DHA: DEHA2A09856g DEHA2E19954g
PIC: PICST_32904(LAG1.1) PICST_41505(LAG1.2) PICST_45900(LAG1.3)
PGU: PGUG_02003 PGUG_05077
SPAA: SPAPADRAFT_59943 SPAPADRAFT_62293
LEL: PVL30_003632(lag1)
LBG: 92206129(LODBEIA_P09330) 92208589(LODBEIA_P33930)
CAL: CAALFM_C305730CA(LAC1) CAALFM_CR01060WA(LAG1)
CTP: CTRG_00979 CTRG_02454
COT: CORT_0A03240 CORT_0C02110
CDU: CD36_26060 CD36_85670
CTEN: 18246806(LAG1) 18247375(lag1)
CLU: CLUG_04758 CLUG_05416
CLUS: A9F13_11g00363 A9F13_23g00583
CAUR: CJI96_0002775
ASAU: 88174648(PUMCH_003585) 88175730(PUMCH_004670)
PPA: PAS_chr1-1_0358 PAS_chr2-2_0193
PKZ: C5L36_0C04220 C5L36_0C05500
BNN: FOA43_001111 FOA43_003613
BBRX: BRETT_003577 BRETT_004471
OPA: HPODL_01318 HPODL_01926
YLI: 2908386(YALI2_F00857g) 2911056(YALI2_D00079g)
SLB: AWJ20_1430(LAG1) AWJ20_4551(LAG1)
NCR: NCU00008 NCU02468
NTE: NEUTE1DRAFT150581(NEUTE1DRAFT_150581) NEUTE1DRAFT81502(NEUTE1DRAFT_81502)
SMP: 10808694(SMAC4_05999) 10809154(SMAC4_00102)
PAN: PODANSg3568 PODANSg4990
PBEL: QC761_0047320(LAG1_1) QC761_122190(lag1) QC761_705990(LAG1_2)
PPSD: QC762_122190(lag1) QC762_705990(LAG1_2)
PPSP: QC763_122190(lag1) QC763_705990(LAG1_2)
PPSA: QC764_122190(lag1) QC764_705990(LAG1_3)
TTT: THITE_2111280 THITE_2111326 THITE_2119256
MTM: MYCTH_2304458 MYCTH_2308111 MYCTH_2311044
CTHR: CTHT_0011030 CTHT_0027250
RTHE: 98122278(VTJ83DRAFT_1471) 98129263(VTJ83DRAFT_922)
MGR: MGG_03090 MGG_05189
PPEI: PpBr36_03566 PpBr36_09496
PGRI: PgNI_09564 PgNI_10253
TMN: UCRPA7_4812 UCRPA7_6736
SSCK: SPSK_02395 SPSK_07420
FGR: FGSG_03851 FGSG_05525 FGSG_09423
FPU: FPSE_05190 FPSE_06629 FPSE_07958
FPOA: FPOAC1_006288 FPOAC1_008138 FPOAC1_012245
FVN: FVRRES_06890 FVRRES_08691 FVRRES_13329
FVR: FVEG_00327 FVEG_00328 FVEG_06971 FVEG_12887 FVEG_15375
FOX: FOXG_06109 FOXG_09367 FOXG_17179
NHE: NECHADRAFT_32956 NECHADRAFT_47179 NECHADRAFT_5078 NECHADRAFT_87190
FFC: NCS54_00286500 NCS54_01038200 NCS54_01389900 NCS54_01390000
FKR: NCS57_00281800 NCS57_01031700 NCS57_01371600 NCS57_01371700
FMU: J7337_003978 J7337_009621 J7337_013651
TRE: TRIREDRAFT_109652 TRIREDRAFT_67010 TRIREDRAFT_67707 TRIREDRAFT_81097
TRR: M419DRAFT_111102 M419DRAFT_142544 M419DRAFT_80278 M419DRAFT_83525
TATV: 25777862(TrAtP1_012767) 25778484(TrAtP1_012923) 25782673(TrAtP1_005117) 25783643(TrAtP1_005118)
TASP: 36607129(TrAFT101_004506) 36607180(TrAFT101_004505) 36608325(TrAFT101_009825) 36614999(TrAFT101_009982)
MAW: 19246863(LAG1_1) 19247185(LAG1_2) 19252794(lag1_8)
MAJ: MAA_03478 MAA_08454
MBRN: 26244208(FUM18) 26244947(FUM17)
PCHM: VFPPC_04084 VFPPC_04358 VFPPC_10115
UVI: 66062669(UV8b_01891) 66067296(UV8b_06519)
CMT: CCM_00967 CCM_01351 CCM_05215
AMUS: LMH87_010887 LMH87_011235 LMH87_011691
PLJ: 28883402(PLICBS_000621) 28883776(PLICBS_000288) 28888154(PLICBS_003362)
PTKZ: JDV02_000480(lag1_1) JDV02_003042(lag1_2) JDV02_003322(lag1_3) JDV02_007406(LAG1)
DCON: 63712671(DCS_00028) 63715213(DCS_02570)
VAL: VDBG_02291 VDBG_07031
VDA: VDAG_02761 VDAG_06672
CFJ: CFIO01_01527 CFIO01_05315 CFIO01_05316 CFIO01_05618 CFIO01_09815
CLUP: CLUP02_03206 CLUP02_09254 CLUP02_12741
CHIG: CH63R_02387 CH63R_07073 CH63R_12005 CH63R_13283
CDET: 87937121(CDEST_00618) 87944250(CDEST_07747) 87946767(CDEST_10265) 87951518(CDEST_15018)
SAPO: SAPIO_CDS10093 SAPIO_CDS7803
ELA: UCREL1_4061 UCREL1_7409 UCREL1_8296
PFY: PFICI_03833 PFICI_13788
SSL: SS1G_01180 SS1G_03198 SS1G_03317
BFU: BCIN_08g02750 BCIN_08g03630
MBE: MBM_01143 MBM_09351
PSCO: LY89DRAFT_681335 LY89DRAFT_711104
GLZ: GLAREA_02861 GLAREA_04750 GLAREA_04751 GLAREA_09105
ANI: ANIA_02464 ANIA_04332
AFM: AFUA_4G06290 AFUA_6G10460
ACT: ACLA_045600 ACLA_084070
NFI: NFIA_056240 NFIA_109860
AOR: AO090023000242 AO090023000962
ANG: An04g00600 An04g10300 An11g00990
AFV: AFLA_006606 AFLA_007319
ALUC: AKAW2_51100A(LAG1) AKAW2_80099S
ACHE: ACHE_20539A(LAG1) ACHE_60220A
APUU: APUU_20875A APUU_70504A(LAG1)
PCS: N7525_004679 N7525_004696 N7525_006566
PDP: PDIP_13990 PDIP_14140 PDIP_38430
POU: POX_d04940 POX_f08002
TMF: EYB26_001220 EYB26_001894 EYB26_002436
TRG: TRUGW13939_03456 TRUGW13939_04554 TRUGW13939_05439 TRUGW13939_06725
CIM: CIMG_04183 CIMG_09385
CPW: 9692776(D8B26_007769) 9693702(LAG1)
URE: UREG_04929 UREG_05623
ABE: ARB_00488 ARB_01673 ARB_03324
TVE: TRV_00035 TRV_01596 TRV_02738
PBL: PAAG_04385 PAAG_05548
PBN: PADG_04552 PADG_05702
AJE: HCAG_02470 HCAG_08955
BGH: BDBG_06202 BDBG_08336
PNO: SNOG_02832 SNOG_10498
PTE: PTT_14351 PTT_17003
PTRR: 6339543(PtrM4_028110) 6348380(PtrM4_083020)
BZE: COCCADRAFT_26561 COCCADRAFT_42153 COCCADRAFT_9194
BSC: COCSADRAFT_184175 COCSADRAFT_41400
BOR: COCMIDRAFT_38586 COCMIDRAFT_87628
AALT: CC77DRAFT_1023491 CC77DRAFT_944241
ADAC: 96088180(ACET3X_007858)
ARAB: EKO05_0001245 EKO05_0007930
ZTR: MYCGRDRAFT_108882 MYCGRDRAFT_87833
PFJ: MYCFIDRAFT_163495 MYCFIDRAFT_30606
FFU: CLAFUR5_03271 CLAFUR5_06404
CBET: CB0940_02707 CB0940_08309
BCOM: BAUCODRAFT_121251 BAUCODRAFT_74877
NPA: UCRNP2_3785 UCRNP2_912
TML: GSTUM_00004831001 GSTUM_00010169001
SPO: 2540466(lac1) 2542464(lag1)
SOM: SOMG_01173(lac1) SOMG_01801(lag1)
CNE: CNB00860 CNE04480 CNE04490
CNB: CNBB4850 CNBE4480 CNBE4490
CNG: CNAG_02086 CNAG_02087 CNAG_06717
CGI: CGB_B8100W CGB_E6060C CGB_E6070C
CDEU: CNBG_5235 CNBG_5236 CNBG_6099
CDEC: 89989909(IAS62_003136) 89989911(IAS62_003138) 89991051(IAS62_004279) 89991052(IAS62_004280)
CTEG: 91989928(I308_103072) 91989929(I308_103073) 91993654(I308_106801)
CBAS: 91983026(I312_102980) 91984665(I312_104620) 91984666(I312_104621)
CDEP: 91088412(L203_104202) 91089625(L203_105416) 91089626(L203_105417)
KMG: 30160210(I203_104657) 30164710(I203_108003)
KNE: 92177792(IAR55_000532) 92180888(IAR55_003630)
KDJ: 28967606(I303_103888) 28969477(I303_105756)
KBI: 30210869(I302_107792) 30213017(I302_105332)
KPIN: 30169796(I206_103569) 30171814(I206_105653)
KSH: 87956051(IL334_003920) 87957378(IL334_005247)
KER: 91099275(V865_000471) 91107267(V865_008466)
KEP: 91090847(L201_000175) 91096449(L201_005779)
TMS: TREMEDRAFT_30795 TREMEDRAFT_40462
TASA: A1Q1_05040 A1Q1_07039
CCAC: CcaHIS019_0211210(LAG1) CcaHIS019_0501870(lag1)
TVS: TRAVEDRAFT_117731 TRAVEDRAFT_137730
DSQ: DICSQDRAFT_56433
PCO: PHACADRAFT_120551 PHACADRAFT_249523 PHACADRAFT_250617
SHS: STEHIDRAFT_158245 STEHIDRAFT_167754 STEHIDRAFT_53905
HIR: HETIRDRAFT_312589 HETIRDRAFT_313327
PSQ: PUNSTDRAFT_132551 PUNSTDRAFT_64598
ADL: AURDEDRAFT_110422 AURDEDRAFT_110423 AURDEDRAFT_60887
FME: FOMMEDRAFT_125718 FOMMEDRAFT_21546 FOMMEDRAFT_90320
GTR: GLOTRDRAFT_125743 GLOTRDRAFT_70062
RSX: RhiXN_00447 RhiXN_04515 RhiXN_06387
LBC: LACBIDRAFT_159106 LACBIDRAFT_246245 LACBIDRAFT_246558
CCI: CC1G_00262 CC1G_00386
ABP: AGABI1DRAFT106395(AGABI1DRAFT_106395) AGABI1DRAFT113528(AGABI1DRAFT_113528)
ABV: AGABI2DRAFT191824(AGABI2DRAFT_191824)
PCUB: JR316_0004839
MRR: Moror_17483 Moror_7418
MORE: E1B28_004263 E1B28_004265 E1B28_004408
SCM: SCHCO_02500392(SCHCODRAFT_02500392)
CPUT: CONPUDRAFT_107673 CONPUDRAFT_122681 CONPUDRAFT_54054
SLA: SERLADRAFT_461036 SERLADRAFT_461309
WSE: WALSEDRAFT_51066 WALSEDRAFT_60068
WIC: J056_003238 J056_003251
UMA: UMAG_02929 UMAG_03611
PFP: PFL1_01326 PFL1_02536
SGRA: EX895_005578 EX895_006549
MGL: MGL_0158 MGL_3614
MRT: MRET_0397 MRET_1159
MSYM: MSY001_0538 MSY001_1371
PGR: PGTG_08688 PGTG_08714
PTRC: PtA15_12A589 PtA15_17A380 PtA15_7A658 PtA15_7A687
PSTR: Pst134EA_013660 Pst134EA_013679 Pst134EA_013696 Pst134EA_022361 Pst134EA_032045
MLR: MELLADRAFT_26073 MELLADRAFT_47359
RIE: OCT59_003366 OCT59_021872
 » show all
Reference
PMID:11694577
  Authors
Schorling S, Vallee B, Barz WP, Riezman H, Oesterhelt D
  Title
Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae.
  Journal
Mol Biol Cell 12:3417-27 (2001)
DOI:10.1091/mbc.12.11.3417
  Sequence
[sce:YHL003C YKL008C]
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