KEGG   ENZYME: 2.3.1.297
Entry
EC 2.3.1.297                Enzyme                                 
Name
very-long-chain ceramide synthase;
sphingoid base N-very-long-chain fatty acyl-CoA transferase;
mammalian ceramide synthase 2;
CERS3 (gene name);
LASS3 (gene name);
LAG1 (gene name);
LAC1 (gene name);
LOH1 (gene name);
LOH3 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
very-long-chain fatty acyl-CoA:sphingoid base N-acyltransferase
Reaction(IUBMB)
a very-long-chain fatty acyl-CoA + a sphingoid base = a very-long-chain ceramide + CoA
Reaction(KEGG)
(other) R01496 R06517 R06527
Substrate
very-long-chain fatty acyl-CoA;
sphingoid base
Product
very-long-chain ceramide;
CoA [CPD:C00010]
Comment
This entry describes ceramide synthase enzymes that are specific for very-long-chain fatty acyl-CoA substrates. The two isoforms from yeast and the plant LOH1 and LOH3 isoforms transfer 24:0 and 26:0 acyl chains preferentially and use phytosphingosine as the preferred sphingoid base. The mammalian CERS2 isoform is specific for acyl donors of 20-26 carbons, which can be saturated or unsaturated. The mammalian CERS3 isoform catalyses this activity, but has a broader substrate range and also catalyses the activity of EC 2.3.1.298, ultra-long-chain ceramide synthase. Both mammalian enzymes can use multiple sphingoid bases, including sphinganine, sphingosine, and phytosphingosine.
History
EC 2.3.1.297 created 2019
Pathway
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K04709  very-long-chain ceramide synthase
K24621  very-long-chain ceramide synthase
K24622  very-long-chain ceramide synthase / ultra-long-chain ceramide synthase
Genes
HSA204219(CERS3) 29956(CERS2) 79603(CERS4)
PTR453683(CERS3) 456435(CERS4) 469482(CERS2)
PPS100973710(CERS4) 100973768(CERS2) 100994802(CERS3)
GGO101128445(CERS3) 101148109(CERS2)
PON100174286(CERS2) 100437726(CERS4) 100451535(CERS3)
NLE100579482(CERS4) 100581669(CERS2) 100590821(CERS3)
MCC693696(CERS3) 706728(CERS4) 716180(CERS2)
MCF101926302(CERS4) 102116814(CERS2) 102143963(CERS3)
CSAB103231276(CERS3) 103247210(CERS2)
CATY105589123(CERS4) 105590207(CERS2) 105593986(CERS3)
PANU101007923(CERS3) 101008992(CERS4) 101026254(CERS2)
TGE112612466(CERS4) 112620332(CERS2) 112628897(CERS3)
RRO104676807(CERS3) 104681063(CERS2) 104682288(CERS4)
RBB108512618(CERS3) 108533256(CERS2) 108534518(CERS4)
TFN117070128(CERS3) 117074717(CERS4) 117075078(CERS2) 117080579 117080580
PTEH111527358(CERS3) 111535623 111543631(CERS2) 113224351 113224352 113224353
CJC100406591(CERS3) 100412093(CERS2) 100414013(CERS4)
SBQ101037762(CERS4) 101042956(CERS3) 101043514(CERS2)
CSYR103251381(CERS2) 103271525(CERS4) 103271544(CERS3)
MMUR105871278(CERS3) 105872998(CERS2) 105885662(CERS4)
LCAT123633946(CERS2) 123635544(CERS4) 123644504(CERS3)
OGA100941676(CERS4) 100941752(CERS3) 100949720(CERS2)
MMU545975(Cers3) 67260(Cers4) 76893(Cers2)
MCAL110291523(Cers2) 110299355(Cers3) 110299943(Cers4)
MPAH110320738(Cers2) 110333640(Cers3) 110336399(Cers4)
RNO304208(Cers4) 310667(Cers2) 499174(Cers3)
MCOC116068854(Cers4) 116093410(Cers2) 116102359(Cers3)
MUN110546438(Cers3) 110560786(Cers2)
CGE100758196(Cers4) 100765986(Cers2) 100770521(Cers3)
MAUA101827969(Cers2) 101839879(Cers4) 101843120(Cers3)
PLEU114682369(Cers2) 114686059(Cers4) 114695508(Cers3)
MORG121437841 121450503 121450848(Cers3) 121465122(Cers4)
AAMP119800752(Cers2) 119802861(Cers3) 119825101(Cers4)
NGI103726528(Cers4) 103730090(Cers2) 103747188(Cers3)
HGL101702770(Cers3) 101715336(Cers4) 101716285(Cers2)
CPOC100712857(Cers3) 100713142(Cers4) 100723224(Cers2)
CCAN109681206(Cers2) 109698441(Cers4) 109700448(Cers3)
DORD105982319(Cers3) 105984890(Cers2) 105998758(Cers4)
DSP122109124(Cers2) 122119701(Cers4) 122123985(Cers3)
NCAR124959721 124969450 124976987
OCU100337851(CERS3) 100352973(CERS4)
OPI101517601(CERS4) 101520281(CERS3) 101525914(CERS2)
TUP102475021(CERS3) 102495526(CERS4) 102502685(CERS2)
CFA483187(CERS2) 485008(CERS4) 607925(CERS3)
VVP112907770(CERS2) 112909651(CERS4) 112923446(CERS3)
VLG121489824(CERS3) 121490849(CERS2) 121495325(CERS4)
AML100466254(CERS3) 100475918(CERS4) 100481999(CERS2)
UMR103659988(CERS3) 103667533(CERS2) 103681884(CERS4)
UAH113242908(CERS4) 113246156(CERS2) 113263637(CERS3)
UAR123777564(CERS4) 123787734(CERS2) 123790831(CERS3)
ELK111152682 111161793 111162066
LLV125085893 125097120 125105651 125106359
MPUF101681709(CERS2) 101687825(CERS3) 101687877(CERS4)
ORO101372787(CERS2) 101379762(CERS4) 101381953(CERS3)
EJU114197338(CERS2) 114200818(CERS4) 114223819(CERS3)
ZCA113909841(CERS3) 113916940(CERS4) 113925261(CERS2)
MLX118000317(CERS2) 118004881(CERS4) 118022993(CERS3)
FCA101093918(CERS4) 101094362(CERS2) 101099301(CERS3)
PYU121013890(CERS4) 121021024(CERS2) 121042489(CERS3)
PBG122468302(CERS3) 122481138(CERS2) 122486821(CERS4)
PTG102968533(CERS3) 102970444(CERS2) 102972870(CERS4)
PPAD109254210(CERS4) 109257029(CERS2) 109273347(CERS3)
AJU106970780(CERS4) 106972088(CERS3) 106979828(CERS2)
HHV120233673(CERS3) 120241292(CERS2) 120244829(CERS4)
BTA505233(CERS4) 539223(CERS2) 614354(CERS3)
BOM102264858(CERS2) 102275684(CERS4) 102282323(CERS3)
BIU109555312(CERS2) 109561659(CERS4) 109575125(CERS3)
BBUB102400914(CERS4) 102405478(CERS3) 102409179(CERS2)
CHX102169911(CERS3) 102174737(CERS4) 102182556(CERS2)
OAS101102559(CERS4) 101109498(CERS2) 101110093(CERS3)
ODA120855907(CERS2) 120863889(CERS4) 120875266(CERS3)
CCAD122434380(CERS2) 122440335(CERS4) 122455117(CERS3)
SSC100127167(CERS4) 100152265(CERS3) 100156737(CERS2)
CFR102505196(CERS3) 102511821(CERS2) 102519510(CERS4)
CBAI105071736(CERS2) 105075152(CERS3) 105078294(CERS4)
CDK105087579(CERS4) 105093450(CERS3) 105103195(CERS2)
VPC102533284(CERS3) 102540969(CERS4) 102545684(CERS2)
BACU103009608(CERS2) 103009742(CERS4) 103016103(CERS3)
LVE103069846(CERS4) 103076923(CERS2) 103082414(CERS3)
OOR101271239(CERS2) 101287722(CERS3) 101289498(CERS4)
DLE111165990(CERS4) 111169745(CERS2) 111187344(CERS3)
PCAD102975484(CERS3) 102982142(CERS2) 102991761(CERS4)
PSIU116749338(CERS3) 116751347(CERS4) 116752069(CERS2)
ECB100050135(CERS3) 100055037(CERS2) 100066949(CERS4)
EPZ103543133(CERS4) 103547641(CERS2) 103561069(CERS3)
EAI106839474(CERS3) 106844495(CERS4) 106846528(CERS2)
MYB102242969(CERS3) 102250642(CERS4) 102256999(CERS2)
MYD102759130(CERS3) 102767770(CERS4) 102772826(CERS2)
MMYO118659187(CERS4) 118672751(CERS2) 118679202(CERS3)
MLF102428338(CERS3) 102430176(CERS4) 102441535(CERS2)
MNA107527642(CERS3) 107529900(CERS4) 107539131(CERS2)
PKL118704309(CERS3) 118725975(CERS4) 118727471(CERS2)
HAI109372275(CERS2) 109380354(CERS3) 109396095(CERS4)
DRO112305258(CERS4) 112306075(CERS3) 112313815(CERS2)
SHON118992022(CERS3) 118994065(CERS4)
AJM119034748(CERS2) 119049767(CERS3) 119059329(CERS4)
PDIC114488632(CERS3) 114488933 114504286(CERS4)
PHAS123804306(CERS2) 123809741(CERS3) 123826589(CERS4)
MMF118637045(CERS2) 118640928(CERS3) 118643610(CERS4)
RFQ117014541(CERS2) 117018868(CERS3) 117038183(CERS4)
PALE102885951(CERS2) 102889613(CERS3) 102890907(CERS4)
PGIG120585217(CERS2) 120587350(CERS3) 120598783(CERS4)
PVP105290275(CERS3) 105303823(CERS2) 105307708(CERS4)
RAY107499037(CERS2) 107515791(CERS3) 107519920(CERS4)
MJV108386501(CERS3) 108387090(CERS4) 108409468(CERS2)
TOD119237185(CERS2) 119240446(CERS4) 119245188(CERS3)
SARA101543849(CERS2) 101550104(CERS3) 101557274(CERS4)
LAV100671292(CERS3) 100673086(CERS2) 100674671(CERS4)
TMU101341813 101341917 101349081
DNM101414521(CERS3) 101429445(CERS4) 101440099(CERS2)
MDO100014952(CERS2) 100020588(CERS3) 100025505 100025643 100025667 100025736 100025782 100619489 103092904 103102488
GAS123232287 123232288 123234193(CERS3) 123244259 123244266 123244272 123244282(CERS2) 123256812 123256814
SHR100917962(CERS2) 100919047 100919316 100919629(CERS3) 100932082 100934161 116420809
PCW110192586(CERS3) 110202101 110202120 110202127 110202139 110202148 110202150 110220611(CERS2)
OAA100090289(CERS4) 100090484(CERS3) 100091312(CERS2)
GGA100859441(CERS2) 420050(CERS4) 426648(CERS3) 428318(CERS4L)
PCOC116238425(CERS2) 116240192(CERS4) 116240199 116240888
MGP100539644 100550977 104912889(CERS3) 104914444(CERS2)
CJO107318875(CERS3) 107324560(CERS2) 107325374 107325633(CERS4)
NMEL110388988 110389062 110403582(CERS3)
APLA101790332 101790516 101794409(CERS3) 101795233(CERS2)
ACYG106036468(CERS3) 106044958 106045005(CERS4) 106049279(CERS2)
AFUL116493542(CERS3) 116499024(CERS4) 116499256 116499766(CERS2)
TGU100217479(CERS4) 100223140(CERS3) 100228761(CERS2)
LSR110469450(CERS4) 110476809(CERS2) 110482993(CERS3)
SCAN103816094(CERS3) 103821875 103821972 103824026
PMOA120496355(CERS4) 120502596(CERS2) 120509089(CERS3)
OTC121335618(CERS2) 121343550(CERS3) 121345520 121345830
PRUF121352410(CERS4) 121353517(CERS2) 121354481(CERS3) 121354651
GFR102032032(CERS2) 102034358 102036650(CERS3) 102042316
FAB101812995(CERS4) 101818464(CERS3)
PHI102104999(CERS3) 102105767 102106078(CERS2) 102114515
PMAJ107209495(CERS3) 107214659(CERS2) 107215358 107215532
CCAE111934002(CERS3) 111939476(CERS2) 111940438(CERS4)
CCW104683905(CERS3) 104696921 104696922
ETL114065561 114068286(CERS3) 114071957(CERS2) 114072291
ZAB102062455 102070635(CERS3) 102071434(CERS4)
FPG101915529(CERS3) 101919852(CERS2) 101922241
FCH102047202 102049480(CERS2) 102054381(CERS3)
CLV102084875 102090020(CERS3)
EGZ104122870(CERS3) 104126317(CERS4) 104129703(CERS2)
NNI104014462(CERS2) 104017067(CERS3) 104022916(CERS4)
PLET104617867(CERS3) 104621078 104623334 104624507(CERS2)
PCRI104028856(CERS3) 104029310 104038972
ACUN113484146(CERS3) 113489464 113489465
TALA104355797 104367438 104368379(CERS3) 116959551 122152590 122152615
PADL103914771(CERS3) 103916058 103916087
ACHC115341326(CERS3) 115345550(CERS2) 115349332
CCRI104159440 104163289(CERS3)
AAM106495414(CERS2) 106495821(CERS3) 106497727(CERS4)
AROW112967620(CERS4) 112969803(CERS3) 112972525(CERS2)
NPD112943900(CERS4) 112948296(CERS3) 112952964(CERS2)
DNE112986258(CERS4) 112990033(CERS2) 112996295(CERS3)
ASN102368101 102383180(CERS2) 102388749(CERS3)
AMJ102575439(CERS3) 102575869(CERS2) 102576734(CERS4)
CPOO109309161(CERS3) 109324704(CERS2)
GGN109288466(CERS3) 109294738(CERS4)
PSS102445918(CERS2) 102447507(CERS4) 102452581(CERS3)
CMY102929497(CERS2) 102939917(CERS3)
CPIC101932603(CERS2) 101945509 101945790 101947682(CERS3)
TST117868902 117869001 117869707(CERS2) 117884533(CERS3)
CABI116816623(CERS3) 116817631(CERS2) 116822588 116825777
MRV120373108(CERS3) 120390027(CERS2) 120391689 120391774
ACS100554835(cers3) 100565999(cers2)
PVT110072464(CERS4) 110072978(CERS3) 110081442(CERS2)
SUND121916252(CERS2) 121934958(CERS3) 121936384(CERS4)
PBI103050368 103052910(CERS2) 103067220(CERS3)
PMUR107283879(CERS3) 107291598 107292912(CERS2)
TSR106544882
PGUT117656659 117669869(CERS3) 117670133(CERS2)
VKO123017614(CERS4) 123030808(CERS3) 123032930(CERS2)
PMUA114584561 114586234(CERS2) 114588341(CERS4)
ZVI118075632(CERS2) 118086384(CERS4) 118092579(CERS3)
GJA107106839 107107422 107111935 107121568(CERS2)
STOW125424565(CERS3) 125432719(CERS4) 125440970(CERS2)
XLA108699337(cers2.L) 108700334(cers2.S) 379135(cers3.L) 444162(cers3.S)
XTR100036728(cers2) 100379773(cers4) 448139(cers3)
NPR108789800(CERS2) 108790075(CERS3) 108792262
RTEM120915228 120920866(CERS2) 120931148(CERS3)
BBUF120982049(CERS2) 120985986(CERS3) 120989619
BGAR122923564 122927517(CERS3) 122946116
DRE100141367(cers3b) 100330155(cers4b) 100332380(cers3a) 259250(cers4a) 259251(cers2a) 565295(cers2b)
SRX107717160 107719675 107723220 107724109 107726244 107733272 107739494 107742325 107750802
SANH107660386 107662258 107662883 107678801 107686553 107688996 107689165 107692405 107693338 107696307 107702624
SGH107552707 107553816 107558627 107559674 107561597 107562918 107589411(cers2) 107596256 107599505
CCAR109047731 109050015 109052074 109057497 109069763 109087142 109090025 109109440 109111276 109112401
CAUA113039301 113045240 113051920 113052001 113059700 113060050 113062229 113074099 113099083 113100321 113105753 113112126 113116567 113118158 113119998
PPRM120464869(cers3b) 120480136(cers3a) 120483515(cers2a) 120485503(cers2b) 120486848(cers4a) 120491784(cers4b)
MAMB125243037(cers2b) 125251272(cers4b) 125254131(cers3b) 125263300(cers4a) 125264462(cers3a) 125275533(cers2a)
IPU100304753(cers2b) 108264168(cers3b) 108271085(cers3a) 108271250(cers4a) 108272661(cers2a) 108280569(cers4b)
PHYP113526340 113527612 113533498 113533812 113534993 113536588(cers3)
SMEO124381929(cers2a) 124384901 124391432(cers3a) 124391602(cers4a) 124395980(cers3b) 124402889(cers4b)
TFD113641288(cers2a) 113645133(cers4b) 113648509(cers2b) 113649636(cers3b) 113651092(cers4a) 113652894(cers3a)
AMEX103021336 103027866 103027875(cers3) 103029792 103032657 103047595
EEE113572621 113573098 113573945(cers3) 113577808 113580530 113585972
TRU101062351 101066117 101067286 101073186(cers2) 101079149
TNGGSTEN00015368G001 GSTEN00020926G001 GSTEN00028893G001 GSTEN00032562G001 GSTEN00035593G001
LCO104920255 104920545 104920977 104929077 104929719(cers3) 104935212
NCC104944843 104944903 104957244
CGOB115004452 115007077 115009955 115015523 115021359 115022640
ELY117254252 117255921(cers3a) 117261833(cers3b) 117263845(cers2a) 117266258 117271618
PLEP121940075 121944372(cers3a) 121945566(cers2b) 121950432(cers3b) 121952013 121957559(cers2a)
SLUC116037411 116045176(cers3a) 116045667(cers3b) 116047305 116049592 116055362
ECRA117946735(cers2b) 117947619(cers3a) 117948874(cers3b) 117950656 117953649 117957292(cers2a)
PFLV114554884 114556998 114560654 114561610 114565397 114568607
GAT120809008(cers3b) 120810545(cers2b) 120816498 120823625 120826405(cers2a)
PPUG119196632(cers3b) 119197844(cers2b) 119209113 119216838 119218788(cers2a)
MSAM119883380(cers3a) 119897551(cers2b) 119900685 119901488 119902224 119907045(cers2a) 119909769
CUD121510734(cers3a) 121512799 121514232(cers2b) 121515377(cers3b) 121519690 121523929(cers2a)
ALAT119006705(cers2b) 119011157 119017418(cers2a) 119018717(cers3a) 119025088 119029019(cers4a)
MZE101467232 101477435(cers3) 101480781 101487144 101487156 101487795
ONL100693121 100702158 100706045 100710068 100710960 100711452
OAU116313518(cers3b) 116314136 116319418(cers2a) 116320058(cers3a) 116321135(cers2b) 116324836
OLA101155637 101160439 101162853 101175635 111947541
OML112143751(cers2b) 112147188 112150084 112151761(cers3b) 112162387(cers2a)
XMA102223697 102231623(cers2) 102232695 102234103 102236156 102236647
XCO114141874(cers2) 114143780 114146085 114151528 114155557 114160349
XHE116708311 116717375(cers2) 116718874 116721356 116726320 116730843
PRET103462267 103464177 103466657 103472677 103478726(cers2) 103479311
PFOR103133806 103136618 103138524(cers4) 103140890 103144462 103146996 103149196(cers3)
PLAI106935855 106938370 106954363(cers4) 106955455 106956231 106959127(cers3) 106961134
PMEI106915516 106917884 106920192 106922001 106924919(cers4) 106924979 106925757(cers3)
GAF122830574 122835013(cers3b) 122838636 122841115 122843440(cers2a) 122846287(cers3a)
CVG107084032 107088596 107088791(cers2) 107096435 107101253 107102400
CTUL119773704(cers3a) 119774094 119779598(cers2a) 119783047(cers2b) 119798456
GMU124865383(cers2b) 124866838(cers3a) 124869452 124874365 124877958(cers3b) 124879413(cers2a)
NFU107379580(cers2) 107384166 107388829 107392650(cers4) 107394572
KMR108229836(cers3b) 108230657 108237998(cers2a) 108239552 108241136(cers2b) 108250391(cers3a)
ALIM106511829 106514312(cers3) 106515089 106520866 106524910
NWH119407809 119410008(cers2b) 119414647 119416282(cers3b) 119425225(cers2a) 119429828(cers3a)
AOCE111566866 111569286 111571929 111576810 111581063 111585929
MCEP125005721(cers3a) 125009687 125010781 125014337(cers3b) 125016682(cers2b) 125019418(cers2a)
CSEM103378927(cers3) 103388281 103393881 103394577
POV109623996 109624784(cers3) 109625338 109633297 109639172 109641126
SSEN122770564 122772881(cers3a) 122774731(cers2b) 122775403(cers3b) 122780927 122786643(cers2a)
HHIP117759513(cers3a) 117759753 117763801(cers3b) 117770185(cers2a) 117777186(cers2b) 117778396
HSP118109828(cers3b) 118112445(cers3a) 118113311 118117216 118121138 118124789(cers2a)
LCF108875121 108881327 108883654 108885907 108888842 108894327
SDU111217146 111220178(cers3) 111223154 111228613 111228973 111230173
SLAL111644372 111650211 111652195 111653318 111657618 111671075
XGL120784272(cers2b) 120786098(cers2a) 120790850 120793324(cers3b) 120796400(cers3a) 120799047
HCQ109513140 109522060 109522795 109527159 109528089
BPEC110160161 110162568 110163067(cers2) 110167260 110169205 110173536
MALB109951498 109951998 109967486 109967919 109969356 109970206
BSPL114843538(cers2b) 114844826 114853371 114857840(cers3b) 114866301(cers2a)
SASA100195452(lass2) 106562479 106562576 106568942 106570086 106588189 106613711
OTW112229979(cers2a) 112236968 112241699(cers3a) 112251793(cers4a) 112260321 112266648
OMY110496020 110500119 110506178 110513603(cers2a) 110517996 110524225(cers4a) 110530140 110536315
OGO123997797(cers4a) 123998192 124005905 124009956 124012557 124035401 124035507(cers3a) 124043671(cers2a)
ONE115107386 115114235 115125322 115128218 115131766
SALP111955207 111956364 111960660 111975423 112075352
SNH120027398(cers2a) 120039499 120041139 120055180(cers4a) 120056277 120057070(cers3a)
ELS105006811 105011493 105014426(cers3) 105018975 105024459
SFM108919843 108921609 108925207(cers2) 108931761 108941195(cers3)
PKI111841093 111845096(cers3) 111847592 111853313 111860425
AANG118215161 118225277 118227406(cers3a) 118229827 118231221 118233708
LOC102694534(cers3) 102698915(cers4) 102699256
PSPA121295084(cers3a) 121299274 121301462 121301626 121306918 121306924
ARUT117427980 117428846 117429295 117962556
LCM102356427(CERS2) 102362821(CERS4) 102365974(CERS3)
CMK103183569 103187682(cers3a)
RTP109928905 109932631
CIN100037724(lass6) 100101810(lag1-like3)
SCLV120332681 120336881 120345984 120347580
PCHN125041734
HAZT108664539 108664540 108679151 108679598 108680698
BGT106074897
GAE121382164
MMER123530680 123531216 123531585 123532589
QSU111999039 112018161 112021434 112026882
CMECYME_CMM258C
GSLGasu_14250
CCPCHC_T00009025001
SCEYHL003C(LAG1) YKL008C(LAC1)
SEUBDI49_3364 DI49_4845
SPAOSPAR_H00380 SPAR_K02010
AGOAGOS_ABR009W AGOS_ADL206W
ERCEcym_2439 Ecym_3334
KLAKLLA0_B13497g KLLA0_E08141g
KMXKLMA_30063(LAG1) KLMA_80123(lag1)
LTHKLTH0D06116g KLTH0G10582g
VPOKpol_1018p49 Kpol_1056p36
ZROZYRO0B01276g
CGRCAGL0K02739g CAGL0M10219g
NCSNCAS_0A05070(NCAS0A05070) NCAS_0F00970(NCAS0F00970)
NDINDAI_0H01460(NDAI0H01460) NDAI_0K02120(NDAI0K02120)
TPFTPHA_0C04030(TPHA0C04030) TPHA_0G03260(TPHA0G03260)
TBLTBLA_0B05480(TBLA0B05480) TBLA_0I00240(TBLA0I00240)
TDLTDEL_0A02770(TDEL0A02770)
TGBHG536_0A04320
KAFKAFR_0A01800(KAFR0A01800) KAFR_0D03370(KAFR0D03370)
KNGKNAG_0A06730(KNAG0A06730) KNAG_0B05390(KNAG0B05390)
ZMKHG535_0D03650
PPAPAS_chr1-1_0358 PAS_chr2-2_0193
DHADEHA2A09856g DEHA2E19954g
PICPICST_32904(LAG1.1) PICST_41505(LAG1.2) PICST_45900(LAG1.3)
PGUPGUG_02003 PGUG_05077
SPAASPAPADRAFT_59943 SPAPADRAFT_62293
LELLELG_00162 LELG_02788
CALCAALFM_C305730CA(LAC1) CAALFM_CR01060WA(LAG1)
CTPCTRG_00979 CTRG_02454
COTCORT_0A03240 CORT_0C02110
CDUCD36_26060 CD36_85670
CTENCANTEDRAFT_113057 CANTEDRAFT_114330
YLIYALI0D04026g YALI0F06424g
CLUCLUG_04758 CLUG_05416
CLUSA9F13_11g00363 A9F13_23g00583
CAURCJI97_002292 CJI97_004304
SLBAWJ20_1430(LAG1) AWJ20_4551(LAG1)
PKZC5L36_0C04220 C5L36_0C05500
BNNFOA43_001111 FOA43_003613
BBRXBRETT_003577 BRETT_004471
OPAHPODL_01318 HPODL_01926
SLUDSCDLUD_000004 SCDLUD_004105
NCRNCU00008 NCU02468
NTENEUTE1DRAFT150581(NEUTE1DRAFT_150581) NEUTE1DRAFT81502(NEUTE1DRAFT_81502)
SMPSMAC_00102 SMAC_05999
PANPODANSg3568 PODANSg4990
TTTTHITE_2111280 THITE_2111326 THITE_2119256
MTMMYCTH_2304458 MYCTH_2308111 MYCTH_2311044
CTHRCTHT_0011030 CTHT_0027250
MGRMGG_03090 MGG_05189
PPEIPpBr36_03566 PpBr36_09496
TMNUCRPA7_4812 UCRPA7_6736
SSCKSPSK_02395 SPSK_07420
FGRFGSG_03851 FGSG_05525 FGSG_09423
FPUFPSE_05190 FPSE_06629 FPSE_07958
FVRFVEG_00327 FVEG_00328 FVEG_06971 FVEG_12887 FVEG_15375
FOXFOXG_06109 FOXG_09367 FOXG_17179
NHENECHADRAFT_32956 NECHADRAFT_47179 NECHADRAFT_5078 NECHADRAFT_87190
TRETRIREDRAFT_109652 TRIREDRAFT_67010 TRIREDRAFT_67707 TRIREDRAFT_81097
TRRM419DRAFT_111102 M419DRAFT_142544 M419DRAFT_80278 M419DRAFT_83525
MAWMAC_02552 MAC_02873 MAC_02874 MAC_08483
MAJMAA_03478 MAA_08454
CMTCCM_00967 CCM_01351 CCM_05215
PLJVFPFJ_01268 VFPFJ_01643 VFPFJ_06030
VALVDBG_02291 VDBG_07031
VDAVDAG_02761 VDAG_06672
CFJCFIO01_01527 CFIO01_05315 CFIO01_05316 CFIO01_05618 CFIO01_09815
CHIGCH63R_02387 CH63R_07073 CH63R_12005 CH63R_13283
SAPOSAPIO_CDS10093 SAPIO_CDS7803
ELAUCREL1_4061 UCREL1_7409 UCREL1_8296
PFYPFICI_03833 PFICI_13788
SSLSS1G_01180 SS1G_03198 SS1G_03317
BFUBCIN_08g02750 BCIN_08g03630
MBEMBM_01143 MBM_09351
PSCOLY89DRAFT_681335 LY89DRAFT_711104
GLZGLAREA_02861 GLAREA_04750 GLAREA_04751 GLAREA_09105
ANIAN2464.2 AN4332.2
AFMAFUA_4G06290 AFUA_6G10460
ACTACLA_045600 ACLA_084070
NFINFIA_056240 NFIA_109860
AORAO090023000242 AO090023000962
ANGANI_1_1620094(An11g00990) ANI_1_194184(An04g00600) ANI_1_2320184(An04g10300)
AFVAFLA_006606 AFLA_007319
ALUCAKAW2_51100A(LAG1) AKAW2_80099S
ACHEACHE_20539A(LAG1) ACHE_60220A
APUUAPUU_20875A APUU_70504A(LAG1)
PCSPc21g19760 Pc22g16960 Pc22g17110
PDPPDIP_13990 PDIP_14140 PDIP_38430
TMFPMAA_027620 PMAA_034150 PMAA_062690
TRGTRUGW13939_03456 TRUGW13939_04554 TRUGW13939_05439 TRUGW13939_06725
CIMCIMG_04183 CIMG_09385
CPWCPC735_002410 CPC735_017620
UREUREG_04929 UREG_05623
PBLPAAG_04385 PAAG_05548
PBNPADG_04552 PADG_05702
ABEARB_00488 ARB_01673 ARB_03324
TVETRV_00035 TRV_01596 TRV_02738
AJEHCAG_02470 HCAG_08955
BGHBDBG_06202 BDBG_08336
PNOSNOG_02832 SNOG_10498
PTEPTT_14351 PTT_17003
BZECOCCADRAFT_26561 COCCADRAFT_42153 COCCADRAFT_9194
BSCCOCSADRAFT_184175 COCSADRAFT_41400
BORCOCMIDRAFT_38586 COCMIDRAFT_87628
AALTCC77DRAFT_1023491 CC77DRAFT_944241
ZTRMYCGRDRAFT_108882 MYCGRDRAFT_87833
PFJMYCFIDRAFT_163495 MYCFIDRAFT_30606
FFUCLAFUR5_03271 CLAFUR5_06404
BCOMBAUCODRAFT_121251 BAUCODRAFT_74877
NPAUCRNP2_3785 UCRNP2_912
TMLGSTUM_00004831001 GSTUM_00010169001
SPOSPAC1A6.09c(lag1) SPBC3E7.15c(lac1)
CNECNB00860 CNE04480 CNE04490
CNBCNBB4850 CNBE4480 CNBE4490
CNGCNAG_02086 CNAG_02087 CNAG_06717
CGICGB_B8100W CGB_E6060C CGB_E6070C
TMSTREMEDRAFT_30795 TREMEDRAFT_40462
TASAA1Q1_05040 A1Q1_07039
TVSTRAVEDRAFT_117731 TRAVEDRAFT_137730
DSQDICSQDRAFT_56433
PCOPHACADRAFT_120551 PHACADRAFT_249523 PHACADRAFT_250617
SHSSTEHIDRAFT_158245 STEHIDRAFT_167754 STEHIDRAFT_53905
HIRHETIRDRAFT_312589 HETIRDRAFT_313327
PSQPUNSTDRAFT_132551 PUNSTDRAFT_64598
ADLAURDEDRAFT_110422 AURDEDRAFT_110423 AURDEDRAFT_60887
FMEFOMMEDRAFT_125718 FOMMEDRAFT_21546 FOMMEDRAFT_90320
GTRGLOTRDRAFT_125743 GLOTRDRAFT_70062
LBCLACBIDRAFT_159106 LACBIDRAFT_246245 LACBIDRAFT_246558
MRRMoror_17483 Moror_7418
MOREE1B28_004263 E1B28_004265 E1B28_004408
CCICC1G_00262 CC1G_00386
SCMSCHCODRAFT_12822 SCHCODRAFT_41116 SCHCODRAFT_46389
ABPAGABI1DRAFT106395(AGABI1DRAFT_106395) AGABI1DRAFT113528(AGABI1DRAFT_113528)
ABVAGABI2DRAFT191824(AGABI2DRAFT_191824)
PCUBJR316_0004839
CPUTCONPUDRAFT_107673 CONPUDRAFT_122681 CONPUDRAFT_54054
SLASERLADRAFT_461036 SERLADRAFT_461309
WSEWALSEDRAFT_51066 WALSEDRAFT_60068
WICJ056_003238 J056_003251
UMAUMAG_02929 UMAG_03611
PFPPFL1_01326 PFL1_02536
MGLMGL_0158 MGL_3614
MRTMRET_0397 MRET_1159
MSYMMSY001_0538 MSY001_1371
PGRPGTG_08688 PGTG_08714
MLRMELLADRAFT_26073 MELLADRAFT_47359
 » show all
Reference
1  [PMID:11387200]
  Authors
Guillas I, Kirchman PA, Chuard R, Pfefferli M, Jiang JC, Jazwinski SM, Conzelmann A
  Title
C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p.
  Journal
EMBO J 20:2655-65 (2001)
DOI:10.1093/emboj/20.11.2655
  Sequence
Reference
2  [PMID:11543633]
  Authors
Pan H, Qin WX, Huo KK, Wan DF, Yu Y, Xu ZG, Hu QD, Gu KT, Zhou XM, Jiang HQ, Zhang PP, Huang Y, Li YY, Gu JR
  Title
Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1.
  Journal
Genomics 77:58-64 (2001)
DOI:10.1006/geno.2001.6614
  Sequence
[hsa:29956]
Reference
3  [PMID:11694577]
  Authors
Schorling S, Vallee B, Barz WP, Riezman H, Oesterhelt D
  Title
Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae.
  Journal
Mol Biol Cell 12:3417-27 (2001)
DOI:10.1091/mbc.12.11.3417
  Sequence
Reference
4  [PMID:15823095]
  Authors
Mizutani Y, Kihara A, Igarashi Y
  Title
Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.
  Journal
Biochem J 390:263-71 (2005)
DOI:10.1042/BJ20050291
  Sequence
[mmu:76893 67260]
Reference
5  [PMID:18165233]
  Authors
Laviad EL, Albee L, Pankova-Kholmyansky I, Epstein S, Park H, Merrill AH Jr, Futerman AH
  Title
Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate.
  Journal
J Biol Chem 283:5677-84 (2008)
DOI:10.1074/jbc.M707386200
  Sequence
[hsa:29956] [mmu:76893]
Reference
6  [PMID:19801672]
  Authors
Imgrund S, Hartmann D, Farwanah H, Eckhardt M, Sandhoff R, Degen J, Gieselmann V, Sandhoff K, Willecke K
  Title
Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas.
  Journal
J Biol Chem 284:33549-60 (2009)
DOI:10.1074/jbc.M109.031971
  Sequence
[mmu:76893]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.297
IUBMB Enzyme Nomenclature: 2.3.1.297
ExPASy - ENZYME nomenclature database: 2.3.1.297
BRENDA, the Enzyme Database: 2.3.1.297
LinkDB

DBGET integrated database retrieval system