KEGG ORTHOLOGY: K05069

ORTHOLOGY: K05069

Entry

K05069                      KO

Symbol

IL2RB, CD122

Name

interleukin 2 receptor beta

Pathway

map04060

Cytokine-cytokine receptor interaction

map04061

Viral protein interaction with cytokine and cytokine receptor

map04144

Endocytosis

map04151

PI3K-Akt signaling pathway

map04630

JAK-STAT signaling pathway

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map05162

Measles

map05166

Human T-cell leukemia virus 1 infection

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

Disease

H02525

Disorders of innate immunity

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05069  IL2RB, CD122; interleukin 2 receptor beta
   04151 PI3K-Akt signaling pathway
    K05069  IL2RB, CD122; interleukin 2 receptor beta
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05069  IL2RB, CD122; interleukin 2 receptor beta
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05069  IL2RB, CD122; interleukin 2 receptor beta
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05069  IL2RB, CD122; interleukin 2 receptor beta
09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    K05069  IL2RB, CD122; interleukin 2 receptor beta
   04659 Th17 cell differentiation
    K05069  IL2RB, CD122; interleukin 2 receptor beta
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05069  IL2RB, CD122; interleukin 2 receptor beta
   05202 Transcriptional misregulation in cancer
    K05069  IL2RB, CD122; interleukin 2 receptor beta
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05069  IL2RB, CD122; interleukin 2 receptor beta
   05162 Measles
    K05069  IL2RB, CD122; interleukin 2 receptor beta
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K05069  IL2RB, CD122; interleukin 2 receptor beta
   04090 CD molecules
    K05069  IL2RB, CD122; interleukin 2 receptor beta
Cytokine receptors [BR:ko04050]
Interleukin receptor families
  IL2 receptor family
   K05069  IL2RB, CD122; interleukin 2 receptor beta
CD molecules [BR:ko04090]
Proteins
  K05069  CD122, IL2RB; interleukin 2 receptor, beta

Other DBs

GO:

0004911

Genes

HSA:	3560(IL2RB)

PTR:	470203(IL2RB)

PPS:	100992438(IL2RB)

GGO:	101139583(IL2RB)

PON:	100460977(IL2RB)

PPYG:

129023029(IL2RB)

NLE:	100581366(IL2RB)

HMH:	116458708(IL2RB)

SSYN:

129467875(IL2RB)

MCC:	696331(IL2RB)

MCF:	102138714(IL2RB)

MTHB:

126963717

MNI:	105464497(IL2RB)

CSAB:

103223268(IL2RB)

CATY:

105575817(IL2RB)

PANU:

101014683(IL2RB)

TGE:	112633515(IL2RB)

MLEU:

105538904(IL2RB)

RRO:	104682498(IL2RB)

RBB:	108512733(IL2RB)

TFN:	117070006(IL2RB)

PTEH:

111549045(IL2RB)

CANG:

105527810(IL2RB)

CJC:	100394910(IL2RB)

SBQ:	101030332(IL2RB)

CIMI:

108289466(IL2RB)

ANAN:

105733766(IL2RB)

CSYR:

103258838(IL2RB)

MMUR:

105883739(IL2RB)

LCAT:

123639296(IL2RB)

ERUF:

138396555(IL2RB)

PCOQ:

105805206(IL2RB)

OGA:	100957798(IL2RB)

MMU:	16185(Il2rb)

MCAL:

110310694(Il2rb)

MPAH:

110335025(Il2rb)

RNO:	25746(Il2rb)

MCOC:

116075473(Il2rb)

ANU:	117719030(Il2rb)

ASYL:

127667505(Il2rb)

MUN:	110548465(Il2rb)

CGE:

113832088

MAUA:

101831461(Il2rb)

PROB:

127225752(Il2rb)

PLEU:

114694353(Il2rb)

MORG:

121461444(Il2rb)

MFOT:

126515825

AAMP:

119823009(Il2rb)

NGI:	103748643(Il2rb)

HGL:	101726369(Il2rb)

CPOC:

100730639(Il2rb)

CCAN:

109698250(Il2rb)

DORD:

105992027(Il2rb)

DSP:	122119318(Il2rb)

DMER:

138811706(Il2rb) 138823827

PLOP:

125353753(Il2rb)

NCAR:

124981877

MMMA:

107139886(Il2rb)

ITI:	101974742(Il2rb)

OCU:

103346218

OPI:	101523537(IL2RB)

OCZ:	121160059(IL2RB)

TUP:	102467660(IL2RB)

GVR:	103606392(IL2RB)

CFA:	403439(IL2RB)

CLUD:

112668470(IL2RB)

VVP:	112929101(IL2RB)

VLG:	121490488(IL2RB)

NPO:	129511760(IL2RB)

AML:	100478292(IL2RB)

UMR:	103676409(IL2RB)

UAH:	113249383(IL2RB)

UAR:	123780861(IL2RB)

ELK:

111157559

LLV:

125107622

MPUF:

101674646(IL2RB)

MNP:	132019255(IL2RB)

MLK:	131839436(IL2RB)

NVS:	122891322(IL2RB)

ORO:	101366322(IL2RB)

EJU:	114218365(IL2RB)

ZCA:	113923121(IL2RB)

MLX:	117998718(IL2RB)

NSU:	110578110(IL2RB)

LWW:	102733398(IL2RB)

FCA:	101092622(IL2RB)

PYU:	121026678 121026680

PCOO:

112863752(IL2RB)

PBG:	122472705(IL2RB)

PVIV:

125170904(IL2RB)

LRUF:

124501540

LGF:	123590064(IL2RB)

AJU:

106981084

PTG:	102965369(IL2RB)

PPAD:

109265527(IL2RB)

PUC:

125919566

PLEZ:

122225091(IL2RB)

HHV:	120241202(IL2RB)

BTA:	104968644(IL2RB) 510185

BOM:	102284639(IL2RB)

BIU:	109559534(IL2RB)

BBUB:

102391873 102392192

BKE:	129641459(IL2RB)

BBIS:

105003412(IL2RB)

OAS:	101107088(IL2RB)

BTAX:

128048204(IL2RB)

CSUM:

138078489(IL2RB)

ODA:	120858560 120861184

CCAD:

122423665(IL2RB) 122423666

MREE:

136170774(IL2RB)

OVR:	110128764(IL2RB)

MBEZ:

129536097 129537055(IL2RB)

SSC:	100621776(IL2RB)

CFR:	102524470(IL2RB)

CBAI:

105073156(IL2RB)

CDK:	105101578(IL2RB)

VPC:	102526550(IL2RB)

BACU:

103006990(IL2RB)

BMUS:

118902256(IL2RB)

LVE:	103071005(IL2RB)

OOR:	101271954(IL2RB)

LALB:

132528832(IL2RB)

GMF:	115852841(IL2RB)

DDP:	132433326(IL2RB)

DLE:	111186349(IL2RB)

PCAD:

102995923(IL2RB)

PSIU:

116760998(IL2RB)

PPHC:

136131546(IL2RB)

NASI:

112410829(IL2RB)

ECB:	100069676(IL2RB)

EPZ:	103564462(IL2RB)

EAI:	106837581(IL2RB)

MYB:	102241115(IL2RB)

MYD:	102768408(IL2RB)

MMYO:

118651872(IL2RB)

MLF:	102420320(IL2RB)

MDT:	132227010(IL2RB)

MYUM:

139005772(IL2RB)

PKL:	118730561(IL2RB)

EFUS:

103288895(IL2RB)

MNA:	107545294(IL2RB)

DRO:	112321925(IL2RB)

SHON:

119002352(IL2RB)

AJM:	119060429(IL2RB)

PDIC:

114513750(IL2RB)

PHAS:

123816246(IL2RB)

MMF:	118624074(IL2RB)

PPAM:

129071253(IL2RB)

HAI:	109394467(IL2RB)

RFQ:	117029472(IL2RB)

PALE:

102883396(IL2RB)

PGIG:

120614851(IL2RB)

PVP:	105311493(IL2RB)

RAY:	107519288(IL2RB)

MJV:	108392662(IL2RB)

TOD:	119247294(IL2RB)

SARA:

101540128(IL2RB)

SFUM:

130044816(IL2RB)

SETR:

126006925(IL2RB)

LAV:	100669139(IL2RB)

TMU:

101344371

ETF:	101664105(IL2RB)

DNM:	101440447(IL2RB)

MDO:	100025393(IL2RB)

GAS:	123249336(IL2RB)

SHR:	100913275(IL2RB)

AFZ:

127538169

PCW:	110205742(IL2RB)

TVP:	118851466(IL2RB)

PBRV:

138156712(IL2RB)

MLAO:

141515363(IL2RB)

OAA:	100092851(IL2RB)

TACU:

119937077(IL2RB)

GGA:	100859707(IL2RB)

PCOC:

116233307(IL2RB)

MGP:	104911125(IL2RB)

CJO:	107313789(IL2RB)

TPAI:

128073638(IL2RB)

LMUT:

125687959(IL2RB)

NMEL:

110393218(IL2RB)

APLA:

101791719(IL2RB)

AACU:

137847278(IL2RB)

ACYG:

106035899(IL2RB)

CATA:

118250672(IL2RB)

AFUL:

116502307(IL2RB)

TGU:	101232975(IL2RB)

LSR:	110483875(IL2RB)

SCAN:

103813230(IL2RB)

PMOA:

120510114(IL2RB)

OTC:	121342420(IL2RB)

PRUF:

121361198(IL2RB)

ATRC:

139587984(IL2RB)

GFR:	102031500(IL2RB)

FAB:	101809303(IL2RB)

OMA:	130248433(IL2RB)

PHI:	102106386(IL2RB)

PMAJ:

107204849(IL2RB)

CCAE:

111935345(IL2RB)

CCW:	104696293(IL2RB)

CBRC:

103618066(IL2RB)

ACOE:

138104089(IL2RB)

ETL:	114055414(IL2RB)

ZAB:	102071658(IL2RB)

ZLE:	135457558(IL2RB)

ACHL:

103811052(IL2RB)

SVG:	106858521(IL2RB)

MMEA:

130586821(IL2RB)

HRT:	120752172(IL2RB)

SATI:

136361917(IL2RB)

CCIC:

134043185(IL2RB)

FPG:	101915263(IL2RB)

FCH:	102058748(IL2RB)

CCRI:

104169334(IL2RB)

NNT:	104409153(IL2RB)

SHAB:

115605378(IL2RB)

ACUN:

113475953(IL2RB)

TALA:

104369209(IL2RB)

ACHC:

115352724(IL2RB)

HALD:

104316499(IL2RB)

HLE:	104842809(IL2RB)

AGEN:

126047795

HHAR:

128143435(IL2RB)

BBUT:

142041723(IL2RB)

GCL:

127029358

CSTI:

104557104(IL2RB)

LDI:	104343967(IL2RB)

MNB:	103771298(IL2RB)

DPUB:

104302045(IL2RB)

PPUS:

135181555(IL2RB)

AVIT:

104273383

BRHI:

104494165(IL2RB)

EGZ:	104134213(IL2RB)

NNI:	104021675(IL2RB)

PCRI:

104037786

PCAO:

104047662(IL2RB)

PADL:

103924145(IL2RB)

AFOR:

103907726(IL2RB)

FGA:	104083494(IL2RB)

CBOR:

142084833(IL2RB)

GSTE:

104260064(IL2RB)

CBOY:

140655339(IL2RB)

MAME:

142409540(IL2RB)

CLV:	102091469(IL2RB)

CNIC:

136002751(IL2RB)

MUI:	104545018(IL2RB)

PGUU:

104465982(IL2RB)

PLET:

104623814(IL2RB)

EHS:	104515386(IL2RB)

CMAC:

104487050(IL2RB)

CUCA:

104065861(IL2RB)

TEO:	104376813(IL2RB)

BREG:

104633218 104636093(IL2RB)

OHA:	104332382(IL2RB)

ACAR:

104520854(IL2RB)

CPEA:

104396058(IL2RB)

CVF:	104283649(IL2RB)

RTD:	128912298(IL2RB)

CRID:

134510341(IL2RB)

LMIC:

141737761(IL2RB)

AAM:	106488409(IL2RB)

AROW:

112969360(IL2RB)

NPD:	112947763(IL2RB)

TGT:	104576752(IL2RB)

DNE:	112993906(IL2RB)

SCAM:

104150195(IL2RB)

ASN:	102376875(IL2RB)

AMJ:	102571730(IL2RB)

CPOO:

109316634(IL2RB)

GGN:	109296052(IL2RB)

PSS:	102449512(IL2RB)

CIZ:	142007273(IL2RB)

CMY:	102936500(IL2RB)

CCAY:

125628246(IL2RB)

LKP:	140906393(IL2RB)

NDS:	141985792(IL2RB)

DCC:	119861146(IL2RB)

CPIC:

101932173(IL2RB)

TST:	117880784(IL2RB)

CABI:

116824117(IL2RB)

MRV:	120396028(IL2RB)

ACS:	103278848(il2rb)

ASAO:

132777364(IL2RB)

PVT:	110075925(IL2RB)

SUND:

121930375(IL2RB)

PBI:	112541087(IL2RB)

PMUR:

107302587(IL2RB)

CTIG:

120312416(IL2RB)

TSR:	106555941(IL2RB)

PGUT:

117655570(IL2RB)

PCAE:

139319715(IL2RB)

APRI:

131201632(IL2RB)

PTEX:

113433313(IL2RB)

NSS:	113430419(IL2RB)

VKO:	123028920(IL2RB)

PMUA:

114605576(IL2RB)

PRAF:

128422417(IL2RB)

ZVI:	118090827(IL2RB)

HCG:	128327445(IL2RB)

GJA:	107120056(IL2RB)

STOW:

125435340(IL2RB)

EMC:	129335299(IL2RB)

XLA:	108713565 108715025

XTR:	101731938(il2rb)

RTEM:

120945328(IL2RB)

ACAT:

141103167(IL2RB)

PADS:

140337340(IL2RB)

BBUF:

120978814(IL2RB)

BGAR:

122943734(IL2RB)

DTC:	141088311(IL2RB)

PWL:	138292649(IL2RB)

MUO:	115460276(IL2RB)

GSH:	117353680(IL2RB)

DRE:	793920(il2rb)

SRX:	107705913 107723612 107738006 107748815(il2rb)

SANH:

107666717(il2rb) 107672152 107676730 107695139

SGH:	107572341 107583317 107602305(il2rb)

CCAR:

109057652 109073843

CAUA:

113046811 113047671 113089943 113095155

CGIB:

127945877 127953013

PTET:

122341846(il2rb)

LROH:

127163129(il2rb)

OMC:	131537510(il2rb)

PPRM:

120462286(il2rb)

RKG:	130075982(il2rb)

MAMB:

125273756(il2rb)

CIDE:

127508453

CERY:

137017366(il2rb)

MASI:

127450026 127452328

TROS:

130561495(il2rb)

TDW:	130426916(il2rb)

MANU:

129436470(il2rb)

PDAB:

135733996(il2rb)

IPU:	108272990(il2rb) 108273212

IFU:	128615568(il2rb)

PHYP:

113524023 113538295

SMEO:

124381757(il2rb)

TFD:	113650520(il2rb)

TVC:	132842569(il2rb)

CGAR:

128515966(il2rb)

NGRA:

132870589(il2rb)

TRN:	134301915(il2rb) 134317302

AMEX:

103036891 103042351 125797532

CMAO:

118805361(il2rb)

EEE:	113579429 113591411

CHAR:

105890682(il2rb)

SPIL:

134076499(il2rb)

TRU:

101076872

TFS:	130515471(il2rb) 130519694

LCO:	104936154(il2rb)

NCC:

104964346

TBEN:

117493527(il2rb) 117496524

CGOB:

115005484 115012725

PGEO:

117442898 117451130(il2rb)

GACU:

117535535(il2rb) 117536052

EMAC:

134862733 134877640(il2rb)

ELY:	117254604 117268216(il2rb)

EFO:	125879093(il2rb) 125885780

PLEP:

121941886 121957046(il2rb)

SLUC:

116042721 116065251(il2rb)

ECRA:

117952358 117957756(il2rb)

ESP:

116703789

PFLV:

114563754(csf2rb) 114563768 114570378(il2rb)

GAT:	120828204(il2rb)

PPUG:

119217935 119221110(il2rb)

AFB:	129095377 129098187(il2rb)

CLUM:

117730728 117735536(il2rb)

PSWI:

130189255(il2rb) 130190112

CANA:

137786839(il2rb) 137802000

CVE:	137877524 137878180(il2rb)

MSAM:

119885295(il2rb) 119898625

SCHU:

122871607

EARM:

139300587(il2rb)

CUD:	121503905(il2rb) 121508392 121508393

SPUL:

138594737 138604493(il2rb)

LMIX:

132954349 132995737(il2rb)

HTC:	141808297 141809646(il2rb)

ALAT:

119014395(il2rb) 119028782

ASTR:

137599890 137609205(il2rb)

PKLU:

139198783 139216619(il2rb)

MZE:	101486983 101487003 112435013

ONL:	102079296 102079789 106097203 112841661

OAU:	116312589 116312609 116327865(il2rb) 116329142 120440455 120440678

OLA:	101165891 105354598(csf2rb)

OML:	112137100 112146641(il2rb)

CSAI:

133422346(il2rb) 133461605

XMA:	102231600 111608559 111608671

XCO:	114143925 114144829 114160471

XHE:	116720625 116720768 116736262

PRET:

103468486 103478275

PFOR:

103147374 103156074 103156075

PLAI:

106936357 106936838 106936851

PMEI:

106906897 106919790 106919791

GAF:	122822224(il2rb) 122830320 122830324

PPRL:

129363916(il2rb) 129366816

CVG:	107084266 107087156

CTUL:

119771442 119798245 119798246 119798254

GMU:	124863197 124863926 124868875

NFU:	107375161 107375162 107376356

KMR:	108236105(il2rb) 108238836 108251503

ALIM:

106520638 106522494(csf2rb)

NWH:	119422104(il2rb)

AOCE:

111579444(il2rb) 111579883

EJA:	138198288(il2rb) 138209618 138209629

BFRE:

138615743 138622529(il2rb)

MCEP:

124997324(il2rb)

CSEM:

103393314 107989032

POV:	109639276 109641995

SSEN:

122771096 122785459(il2rb)

SSOE:

131466408 131474900(il2rb)

HHIP:

117759424 117765836(il2rb)

HSP:	118116518 118124013(il2rb)

PPLT:

128431601 128436870 128458928(il2rb)

SMAU:

118288772(il2rb) 118312014

LCF:

108877635

SDU:	111216643 111216653 111230365

SLAL:

111646317 111671820 111671822

XGL:	120785060(il2rb) 120800036

HCQ:

109520288

SBIA:

133506390 133515027(il2rb)

PEE:	133403744 133415463(il2rb)

PTAO:

133466366(il2rb) 133476680

BPEC:

110157753 110162360

ENY:	140357749(il2rb) 140377266

MALB:

109972408(il2rb)

BSPL:

114860176 114860207(il2rb) 114861501

SJO:	128378877(il2rb)

SSCO:

133995967 133999706(il2rb)

GMH:	115538017 115539714 115539715

SASA:

100195519(il2rb) 106564380 106564387 106564390 106591126 106607522

STRU:

115147448 115170931(il2rb) 115196369

OTW:	112222159 112225890 112258489(il2rb) 112263402

OMY:	101268906(il2rb2) 101268907(il2rb) 110495072 110495073 110513456

OGO:	124000842 124002720 124015733 124024591 124028110

ONE:	115104020 115110120

OKI:	109878997 109893203(il2rb) 109898289 116366488 116369121 116375811

OKE:	118365162 118374239 118384378(il2rb)

OMM:	135534313 135553935 135555853(il2rb)

OCLA:

139422141 139423889 139424239 139424240

SALP:

111980186 111980275

SNH:	120032458 120032460 120032928 120034127 120043966 120043967 120044467

SFON:

129822559 129832865 129839952

CCLU:

121551619 121570585

ELS:	105009012(il2rb) 105029657

OEP:	134023786 134039264(il2rb)

SFM:	108928832 108930689

PKI:	111835968 111845191

AANG:

118215957 118216815 118216867

AROT:

135243545 135244081 135248796

CCOG:

133114874

LOC:	102688112(il2rb)

PSPA:

121309365(il2rb)

ARUT:

LCM:

CMK:

CPUN:

SCAU:

119956506(il2rb)

LERI:

129713932

HAKA:

140718966

» show all

Reference

PMID:2785715

Authors

Hatakeyama M, Tsudo M, Minamoto S, Kono T, Doi T, Miyata T, Miyasaka M, Taniguchi T

Title

Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's.

Journal

Science 244:551-6 (1989)
DOI:10.1126/science.2785715

Sequence

[hsa:3560]

Reference

PMID:8476561

Authors

Minami Y, Kono T, Miyazaki T, Taniguchi T

Title

The IL-2 receptor complex: its structure, function, and target genes.

Journal

Annu Rev Immunol 11:245-68 (1993)
DOI:10.1146/annurev.iy.11.040193.001333

Reference

PMID:17108990

Authors

Bucheton B, Argiro L, Chevillard C, Marquet S, Kheir MM, Mergani A, El-Safi SH, Dessein AJ

Title

Identification of a novel G245R polymorphism in the IL-2 receptor beta membrane proximal domain associated with human visceral leishmaniasis.

Journal

Genes Immun 8:79-83 (2007)
DOI:10.1038/sj.gene.6364355

Sequence

[hsa:3560]

LinkDB

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