KEGG ORTHOLOGY: K05438

ORTHOLOGY: K05438

Entry

K05438                      KO

Symbol

Name

growth hormone

Pathway

map04060

Cytokine-cytokine receptor interaction

map04080

Neuroactive ligand-receptor interaction

map04081

Hormone signaling

map04151

PI3K-Akt signaling pathway

map04630

JAK-STAT signaling pathway

map04935

Growth hormone synthesis, secretion and action

Disease

H00254

Growth hormone deficiency

H02035

Isolated growth hormone deficiency

H02039

Kowarski syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05438  GH; growth hormone
   04151 PI3K-Akt signaling pathway
    K05438  GH; growth hormone
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K05438  GH; growth hormone
   04081 Hormone signaling
    K05438  GH; growth hormone
   04060 Cytokine-cytokine receptor interaction
    K05438  GH; growth hormone
09150 Organismal Systems
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    K05438  GH; growth hormone
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05438  GH; growth hormone
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  CSF and other factors
   K05438  GH; growth hormone

Genes

HSA:	1442(CSH1) 1443(CSH2) 1444(CSHL1) 2688(GH1) 2689(GH2)

PTR:	100505396(GH2) 449574(PL-D) 449575(PL-B) 454774(GH1) 739315(CSH1)

PPS:	100971425 100972442 100973020 100983900 117976712 129392943

GGO:	101124194(GH1) 101125803 101126399 101126984 115934631 115934632 134756429

PON:	100446663(CSH2) 100447767(GH2) 100448861 103892869

PPYG:

129017951(CSH2) 129017952(GH2) 129017953 129017954 129017955

NLE:	100579700 100580921 100582356 100585742 115830369 115830462

HMH:

116458733

SSYN:

129469529 129469551 129469667 129469929 129469930 129469931 129469932

MCC:	114669732 114669819 114673168 114673169 700885(GHV) 717562(CSH2) 718116(CSH4) 718135(CSH3) 718156(GH1) 718474 735307

MCF:	102139443(CSH2) 102141100(CSH4) 102143728(GH1) 102973054(CSH3) 102973055(GHV) 123571569 135967741 135967742 135967819 135967886

MTHB:

126939474 126939475 126939476 126939559 126939561 126939562 126939566

MNI:	105468986 105468988(GH1) 105469367 105483028 105483030

CSAB:

103243211 103243213 103243214 103243843 108449889

CATY:

105590745 105590746 105590765

PANU:

100126758(GH1) 100379157(GHV) 100381193(CSH1) 100999056 110741552

TGE:	112617465 112617528 112617625 112617626 112617660 112617661 112617667

MLEU:

105551725 105551727 105551728 105551730 105551752

RRO:	104675453 104675456 104675458 104675500 104675501 104675502

RBB:	108511984 108536240 108536264 108536266 108536269

TFN:

117067429

PTEH:

111532246 111532415 111532431 111533513 113224568 113224570 113224571 113224572

CANG:

105515980 105515982 105515983 105515984 105515997 105519388

CJC:	100392546(GH1) 100412128(GH1P5) 100412471(GH1P6)

SBQ:	101039453 101041089 101053083 101053411 101053718 104649998 104649999

CIMI:

108295581(GH1) 108298936 108298937 108318254 108318256 108318314 119474203

CSYR:

103250786(GH1)

MMUR:

LCAT:

ERUF:

PCOQ:

OGA:

MMU:

14599(Gh)

MCAL:

110305672(Gh1)

MPAH:

110332223

RNO:	24391(Gh1)

MCOC:

116077584

ANU:	117711092(Gh1)

ASYL:

127693578(Gh1)

MUN:

110547057

CGE:	100770534(Gh1)

MAUA:

101843583(Gh1)

PROB:

127218378(Gh1)

PLEU:

PMAV:

MORG:

MFOT:

AAMP:

CNL:	130878088(Gh1)

NGI:

103744748

HGL:	101712254(Gh1)

CPOC:

100379559(Gh1)

CCAN:

109700526(Gh1)

DORD:

105998539

DSP:

122103287

DMER:

138830419

PLOP:

125366293(Gh1)

NCAR:

MMMA:

ITI:

OCU:

OPI:	101530491(GH1)

OCZ:

121162406

TUP:	102493219 102493625

GVR:	103595645(GH1)

CFA:	403795(GH1)

CLUD:

VVP:

VLG:

NPO:

AML:	100471532(GH1)

UMR:

103665901

UAH:	113265156(GH1)

UAR:	123803168(GH1)

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

MANO:

NSU:

LWW:

FCA:	493931(GH1)

PYU:

121015217

PCOO:

112864677

PBG:

122484753

PVIV:

125151566(GH1)

LRUF:

124512899

LGF:

123604686

AJU:

106978672

PTG:	102954011(GH1)

PPAD:

PUC:

PLEZ:

HHV:

CCRU:

BTA:	280804(GH1)

BOM:

102271788

BIU:

109574543

BJV:

133232639

BBUB:

102406287(GH)

BKE:

129651162

BBIS:

105000612

CHX:	100861230(GH1) 108638229

OAS:	114116958 443329(GH)

OCAN:

138414758 138415294

BTAX:

128065055(GH1)

CSUM:

138082805(GH1)

ODA:

120866938

CCAD:

122439621

MREE:

136149199

OVR:	110125915(GH1)

MBEZ:

129537887(GH1)

SSC:	396884(GH1)

CFR:

102518081

CBAI:

105069779

CDK:

105090400

VPC:	102537102(GH1)

BACU:

103018096(GH1)

BMUS:

118886641

LVE:	103077460(GH1)

OOR:

LALB:

GMF:

DDP:

DLE:

PCAD:

PSIU:

PPHC:

NASI:

ECB:	100034180(GH1)

EPZ:

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:	132219307(GH1)

MYUM:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:	119036309(GH1)

PDIC:

114502866

PHAS:

123816860

MMF:

118634340

PPAM:

129070175(GH1)

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SFUM:

130035640(GH1)

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:	554243(GH1)

GAS:

SHR:

AFZ:

PCW:

TVP:

PBRV:

MLAO:

OAA:	114815005(GH1)

TACU:

119934712(GH1) 119949096 119949681

GGA:	378781(GH)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

101790997(GH1)

OJA:

118178727

ACYG:

125180016(GH1)

CATA:

118258263

AFUL:

116498334

TGU:	100218808 100232594

LSR:	110471658 110479562

VMC:

128819893

VCHA:

128800222

AIB:	137468733 137486674

SCAN:

103821672 103823758

PMOA:

120498393 120500563

OTC:	121333015(GH1)

PRUF:

121350506 121353429

ATRC:

139593239 139601642

MATE:

118696598(GH1)

MAEN:

136567405 136567913

GFR:	102035525 102045001

FAB:	101810386(GH1) 101816810

OMA:	130254138 130263879

PHI:	102100455 102108332

PMAJ:

107199940 107215237(GH1)

CCAE:

111940061 111944001

CCW:	104686959 104698501

CBRC:

103613826 103616989

ACOE:

138099327 138100558

ETL:	114069211 114070629(GH1)

ZAB:	102068325 102073216

ZLE:	135442240 135458492

ACHL:

103803169 103807929

SVG:	106856603 106858240

MMEA:

130578084 130586144

HRT:	120748920 120766129(GH1)

SATI:

136372063 136373643

CFAI:

136301860 136305486

CCIC:

134053197 134054815

FPG:	101911583(GH1)

FCH:	102050341(GH1)

FRS:	119158776(GH1)

CCRI:

104163159

NNT:

104410485

SHAB:

115617777(GH1)

ACUN:

113489170

ANOC:

141970201(GH1)

TALA:

ACHC:

HALD:

HLE:

AGEN:

HHAR:

BBUT:

GCL:

CSTI:

LDI:

MNB:

PPUS:

135191782(GH1)

AVIT:

BRHI:

EGZ:

NNI:

PCRI:

PCAO:

PARX:

142068114(GH1)

PADL:

AFOR:

FGA:

CBOR:

GSTE:

CBOY:

MAME:

CNIC:

135998112(GH1)

MUI:

PGUU:

PLET:

CMAC:

CUCA:

PCUR:

138731058(GH1)

TEO:

BREG:

GAME:

OHA:

ACAR:

CPEA:

CVF:

RTD:

CRID:

134524391(GH1)

LMIC:

141732690(GH1)

NARQ:

141474684(GH1)

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:	102387497(GH1)

AMJ:

102576793

CPOO:

109322439

GGN:

109301680

PSS:	102460820(GH1)

CIZ:	142002678(GH1)

CMY:

CCAY:

LKP:

NDS:

DCC:

CPIC:

101940316(GH1)

TST:	117869418(GH1)

EOB:	135894504(GH1)

CABI:

116817881

MRV:	120384947(GH1)

EMQ:	137158504(GH1)

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

131198195 131198196 131198209

PTEX:

113453619

NSS:	113429490 113429491 113429494 113429495

VKO:

123017384

PMUA:

114582042(GH1)

PRAF:

128400600

ZVI:	118094575(GH1)

HCG:	128331321 128332037

GJA:	107114953(GH1)

STOW:

125444957

EMC:

129339089

XLA:	373617(gh2.S) 378580(gh1.L) 399154(gh1.S)

XTR:	100490878(gh2) 100492540(gh1)

NPR:

RTEM:

ACAT:

PADS:

BBUF:

BGAR:

PWL:	138283339 138301525

MUO:

115481408

GSH:	117347125(GH1)

DRE:	407639(gh1) 572522(smtla)

DAES:

130245772(smtla)

SRX:	107709547 107739156 107740644 107754309

SANH:

107656966 107662423 107683683 107692520

SGH:	107582917 107585059 107590731

CCAR:

109052277 109070509 109104194 109110701

CAUA:

113046794 113048197 113061304 113110476 113114411 113118697

CGIB:

127934600 127946808 127952303 127977105

PTET:

122322898(smtla) 122341353(gh1)

LROH:

127163047(gh1) 127181149(smtla)

OMC:

131524509

PPRM:

120460015(smtla) 120489451(gh1)

RKG:	130070010(smtla) 130070317(gh1)

MAMB:

125254224(smtla) 125272631(gh1)

CIDE:

127499705 127509069

CERY:

137010691(gh1) 137022539(smtla)

MASI:

127417448 127450982 127451599

TROS:

130561333(gh1) 130562621(smtla)

TDW:	130426859(gh1) 130435547(smtla)

MANU:

129419308(smtla) 129436389(gh1)

PDAB:

135768310(gh1) 135773119(smtla)

IPU:	100305005(gh1) 108276625(smtlb)

IFU:	128616278(gh1) 128620178(smtlb)

PHYP:

113543885 113544880

SMEO:

124381993(gh1) 124393665(smtlb)

TFD:	113650380(smtlb) 113662765(gh1)

TVC:	132842137(gh1) 132863259(smtlb)

CGAR:

128505419(smtlb) 128515817(gh1)

NGRA:

132870294(gh1) 132873559(smtlb) 132888336(smtla)

TRN:	134323380(smtla) 134333901(gh1)

AMEX:

103022738(gh1) 103037048(smtlb)

CMAO:

118803676(gh1) 118818426(smtla) 118824661(smtlb)

EEE:

113587837

CHAR:

105890783(gh1) 122133141(smtla)

SPIL:

134075821(gh1) 134100103(smtla)

ASAD:

121684502(smtla)

TRU:	101061166 101070289

TFS:	130520103(gh1) 130535338(smtla)

TNG:	GSTEN00019559G001

LCO:	104931893 104940493

NCC:

104960967

TBEN:

117469146(gh1) 117470206(smtla)

CGOB:

115017825

PGEO:

117443967(gh1) 117457052(smtla)

GACU:

117551745(smtla) 117559415(gh1)

EMAC:

134878569(gh1) 134880391(smtla)

ELY:	117259303(smtla) 117269070(gh1)

EFO:	125879224(gh1) 125888767(smtla)

PLEP:

121943686(smtla) 121965607(gh1)

SLUC:

116043900(smtla) 116063544(gh1)

SVIT:

144513142(smtla)

ECRA:

117941304(gh1) 117941781(smtla)

ESP:

116685715

PFLV:

114552555 114568956

PFLT:

120572420(smtla)

GAT:	120827717(smtla) 120828067(gh1)

PPUG:

119220374(gh1) 119222108(smtla)

AFB:	129091691(smtla) 129098133(gh1)

CLUM:

117734622(gh1) 117741421(smtla)

PSWI:

130210864(smtla)

CANA:

137790606(smtla) 137803445(gh1)

CVE:	137874759(smtla) 137884027(gh1)

AMIR:

142959202(smtla)

MSAM:

119882337(smtla) 119896148(gh1) 119911183

SCHU:

122869373(gh1) 122879413(smtla)

EARM:

139285069(smtla) 139299876(gh1)

CUD:	121503512(gh1) 121522467(smtla)

SPUL:

138596989(smtla) 138604000(gh1)

LMIX:

132980039(smtla) 132995755(gh1)

HTC:	141798000(smtla) 141809274(gh1)

ALAT:

119006997(smtla) 119013881(gh1)

ASTR:

137596796(smtla) 137609789(gh1)

PKLU:

139199955(smtla) 139217361(gh1)

MZE:	101468270(smtla) 101482244(gh1)

ONL:	100534452 100711096

OAU:	116319389(gh1) 116323295(smtla)

OLA:	100049402 101171460

OML:	112139712(gh1) 112149555(smtla)

CSAI:

133442278 133442289(smtla) 133457966(gh1)

XMA:	102222100 102233429

XCO:	114159494 114161391

XHE:	116736294 116737242

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122821807(gh1) 122832389(smtla)

PPRL:

129359144(smtla) 129373713(gh1)

CVG:	107083471 107089309

CTUL:

119781667(gh1) 119791036(smtla)

GMU:	124862327 124863788 124884283(smtla)

NFU:	107390293 107396211

KMR:	108238150(smtla) 108243233(gh1)

ALIM:

106526269 106528097

NWH:	119411187(smtla) 119421286(gh1)

LTU:	140273624(gh1) 140314553(smtla)

AOCE:

111568175(gh1) 111569181(smtla)

EJA:	138196900(smtla) 138207908(gh1)

BFRE:

138616699(smtla) 138631359(gh1)

MCEP:

124997264(gh1) 125013566(smtla)

CSEM:

103377636 103387754

POV:	109634465 109643344

SSEN:

122773694(smtla) 122781992(gh1)

SSOE:

131462754(smtla) 131474051(gh1)

HHIP:

117766138(gh1) 117773484(smtla)

HSP:	118105694(smtla) 118124061(gh1)

PPLT:

128440254(smtla) 128458091(gh1)

SMAU:

118289219(gh1) 118299890(smtla)

LCF:	108873234(gh1) 108898852(smtla)

SDU:	111222547 111239800

SLAL:

111657519 111657876

XGL:	120783339(gh1) 120792076(smtla)

HCQ:	109512828 109513754

SSCV:

125972679(smtla) 125983358(gh1)

SBIA:

133504661(smtla) 133514222(gh1)

PEE:	133405015(smtla) 133414361(gh1)

PTAO:

133466395(gh1) 133482715(smtla)

BPEC:

110161975 110164350

ENY:	140358184(gh1) 140367215(smtla)

MALB:

109960341 109972673

BSPL:

114861059(gh1) 114868472(smtla)

SJO:	128360650(smtla) 128378555(gh1)

SSCO:

133980376(smtla) 133999164(gh1)

TTY:	137168130(gh1) 137185844(smtla)

GMH:	115528931 115532095

SASA:

100136491 100136588(gh) 100196589 106607462

STRU:

115154053 115163535 115170947 115196507

OTW:	112225899 112228339(smtlb) 112258502(gh1) 112265609

OMY:	100136733(gh1) 100136734(gh2) 110507854 110534909(smtlb)

OGO:	123992659(smtla) 123994908(smtlb) 123999031(gh1) 124016361

ONE:	115104032 115110133 115136498 115137594

OKI:	109872980 109893213 109898300 109904868

OKE:	118365171 118384394 118389856(smtlb) 118397521(smtla)

OMM:	135550922(smtlb) 135553021 135553945 135555840

OCLA:

139385905 139419449 139422144 139423895

SALP:

111950789 111980263 112070195

SNH:	120018744 120034139 120044469 120056470

SFON:

129822116 129822748 129832875 129868158(smtlb)

CCLU:

121551272 121567031 121568185 121569713 121580136

ELS:	105023357 105028755

OEP:	134040793(gh1) 134040821

SFM:	108921486 108932297 108941578

PKI:	111849226 111850622 111856077

AANG:

118217101(gh1) 118236329(smtlb)

AROT:

135243543(gh1)

CCOG:

133114904(gh1) 133133183(smtlb)

LOC:	102687524 102694171

PSPA:

121304062(smtla) 121323985(gh1)

ARUT:

117397256 117433528 117435114(gh1) 117966556

PSEX:

120518007 120534924

LCM:	102349296 102356179

CMK:	103187720(gh1)

RTP:	109910501(gh1)

CPLA:

122539993

CPUN:

140465890

HOC:	132830750(gh1)

SCAU:

LERI:

HAKA:

Reference

PMID:20956999

Authors

Clayton PE, Banerjee I, Murray PG, Renehan AG

Title

Growth hormone, the insulin-like growth factor axis, insulin and cancer risk.

Journal

Nat Rev Endocrinol 7:11-24 (2011)
DOI:10.1038/nrendo.2010.171

Reference

PMID:3379057

Authors

Cooke NE, Ray J, Emery JG, Liebhaber SA

Title

Two distinct species of human growth hormone-variant mRNA in the human placenta predict the expression of novel growth hormone proteins.

Journal

J Biol Chem 263:9001-6 (1988)

Sequence

[hsa:2688 2689]

LinkDB

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