KEGG ORTHOLOGY: K05498

ORTHOLOGY: K05498

Entry

K05498                      KO

Symbol

BMP15, GDF9B

Name

bone morphogenetic protein 15

Pathway

map04060

Cytokine-cytokine receptor interaction

map04913

Ovarian steroidogenesis

Disease

H00599

Ovarian dysgenesis

H00627

Premature ovarian failure

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05498  BMP15, GDF9B; bone morphogenetic protein 15
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K05498  BMP15, GDF9B; bone morphogenetic protein 15
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05498  BMP15, GDF9B; bone morphogenetic protein 15
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Transforming growth factors (RSTK binding)
   K05498  BMP15, GDF9B; bone morphogenetic protein 15

Genes

HSA:	9210(BMP15)

PTR:	473873(BMP15)

PPS:	100972521(BMP15)

GGO:	101138976(BMP15)

PON:	100441790(BMP15)

PPYG:

129025447(BMP15)

NLE:	100583339(BMP15)

HMH:	116811297(BMP15)

SSYN:

129475976(BMP15)

MCC:	695457(BMP15)

MCF:	102135938(BMP15)

MTHB:

126946600

MNI:	105493948(BMP15)

CSAB:

103231982(BMP15)

CATY:

105571912(BMP15)

PANU:

101025986(BMP15)

TGE:	112616541(BMP15)

MLEU:

105547680(BMP15)

RRO:	104678560(BMP15)

RBB:	108523836(BMP15)

TFN:	117078278(BMP15)

PTEH:

111531421(BMP15)

CANG:

105514973(BMP15)

CJC:	100392175(BMP15)

SBQ:	101039221(BMP15)

CIMI:

108293035(BMP15)

ANAN:

105730403(BMP15)

CSYR:

103258241(BMP15)

LCAT:

123628625 123628669

PCOQ:

105809055(BMP15)

OGA:	111722870(BMP15)

MMU:	12155(Bmp15)

MCAL:

110287502(Bmp15)

MPAH:

110314024(Bmp15)

RNO:	59302(Bmp15)

MCOC:

116091543(Bmp15)

ANU:	117694420(Bmp15)

ASYL:

127675696(Bmp15)

MUN:	110541772(Bmp15)

CGE:	100756159(Bmp15)

MAUA:

101822523(Bmp15)

PROB:

127217539(Bmp15)

PLEU:

114710001(Bmp15)

MORG:

121444361 121444380

MFOT:

126493702

AAMP:

119804142(Bmp15)

NGI:	103730280(Bmp15)

HGL:	101697994(Bmp15)

CPOC:

100732890(Bmp15)

CCAN:

109675709(Bmp15)

DORD:

105997861(Bmp15)

DSP:	122121049(Bmp15)

PLOP:

125344059(Bmp15)

NCAR:

124975310

MMMA:

107159275 107160936

ITI:	101960107 101967701 101968804(Bmp15)

OCU:	100355411(BMP15)

OPI:	101520198 101521969(BMP15)

TUP:	102501630(BMP15)

GVR:	103588619(BMP15)

CFA:	100856301(BMP15)

CLUD:

112673275(BMP15)

VVP:	112907210(BMP15)

VLG:	121482389(BMP15)

NPO:	129518768(BMP15)

AML:	100473231(BMP15)

UMR:

103661936

UAH:	113265827(BMP15)

UAR:	123796407(BMP15)

ELK:

111150546

LLV:

125092078

MPUF:

101673483(BMP15)

MNP:	132007472(BMP15)

MLK:	131822064(BMP15)

NVS:	122897106(BMP15)

ORO:	101383753(BMP15)

EJU:	114200701(BMP15)

ZCA:	113930980(BMP15)

MLX:	118009019(BMP15)

NSU:	110570659(BMP15)

LWW:	102731762(BMP15)

FCA:	100306941(BMP15)

PYU:	121025970(BMP15)

PCOO:

112871234(BMP15)

PBG:	122476878(BMP15)

PVIV:

125156871(BMP15)

LRUF:

124509199

LGF:	123594527(BMP15)

AJU:

106977270

PTG:	102970262(BMP15)

PPAD:

109248139(BMP15)

PUC:

125931696

PLEZ:

122229362(BMP15)

HHV:	120226833(BMP15)

BTA:	353351(BMP15)

BOM:	102279085(BMP15)

BBUB:

102393500(BMP15)

CHX:	100861233(BMP15)

OAS:	100141303(BMP15)

BTAX:

128070392(BMP15)

CSUM:

138071335(BMP15)

ODA:	120882145(BMP15)

CCAD:

122435399(BMP15)

MREE:

136154043(BMP15)

OVR:	110142060(BMP15)

MBEZ:

129535018(BMP15)

SSC:	448811(BMP15)

CFR:	102509470(BMP15)

CBAI:

105076107(BMP15)

CDK:	105104375(BMP15)

VPC:	102527371(BMP15)

BACU:

103010771

BMUS:

118888696(BMP15)

LVE:	103086608(BMP15)

OOR:	101278021(BMP15)

LALB:

132513608(BMP15)

DLE:	111169495(BMP15)

PCAD:

102996969(BMP15)

PSIU:

116747560(BMP15)

NASI:

112403252(BMP15)

ECB:	100052461(BMP15)

EPZ:	103566821(BMP15)

EAI:	106822123(BMP15)

MYB:	102264110(BMP15)

MYD:	102769649(BMP15)

MMYO:

118654567(BMP15) 118666816

MLF:	102423385 102438131(BMP15)

MDT:	132224206(BMP15)

PKL:	118731735(BMP15)

EFUS:

103301311(BMP15)

MNA:	107541458(BMP15)

DRO:	112322519(BMP15)

SHON:

118981034(BMP15)

AJM:	119059343(BMP15)

PDIC:

114505435(BMP15)

PHAS:

123832811(BMP15)

MMF:	118636516(BMP15)

PPAM:

129065109(BMP15)

RFQ:	117028655(BMP15)

PALE:

102890973(BMP15)

PGIG:

120612441(BMP15)

PVP:	105309035(BMP15)

RAY:	107515048(BMP15)

MJV:	108402815(BMP15)

TOD:	119246711(BMP15)

SARA:

101552175(BMP15)

SFUM:

130036712(BMP15)

SETR:

125999224(BMP15)

TMU:

101359282

ETF:	101657649(BMP15)

DNM:	101411422(BMP15)

MDO:	100020545(BMP15)

GAS:	123253333(BMP15)

SHR:	116420274(BMP15)

AFZ:

127542820

PCW:	110202675(BMP15)

TVP:	118832931(BMP15)

PBRV:

138177807(BMP15)

OAA:	100079709(BMP15)

TACU:

119930057(BMP15)

GGA:	428697(BMP15)

PCOC:

116229550(BMP15)

MGP:	100544957(BMP15)

CJO:	107312523(BMP15)

TPAI:

128076123(BMP15)

LMUT:

125699704(BMP15)

NMEL:

110403290(BMP15)

APLA:

101794104(BMP15)

ACYG:

106049531(BMP15)

CATA:

118245575(BMP15)

AFUL:

116494611(BMP15)

TGU:	100232314(BMP15)

LSR:	110480112(BMP15)

SCAN:

103816297(BMP15)

PMOA:

120512664(BMP15)

OTC:	121346415(BMP15)

PRUF:

121362868(BMP15)

ATRC:

139597116(BMP15)

GFR:	102034250(BMP15)

FAB:	101806676(BMP15)

OMA:	130252931(BMP15)

PHI:	102104227(BMP15)

PMAJ:

107203672(BMP15)

CCAE:

111929291

CCW:	104691578(BMP15)

CBRC:

103621924(BMP15)

ACOE:

138110656(BMP15)

ETL:	114068307(BMP15)

ZAB:	102071548(BMP15)

ZLE:	135447813(BMP15)

ACHL:

103806278(BMP15)

SVG:	106862168(BMP15)

MMEA:

130578703(BMP15)

HRT:	120762166(BMP15)

SATI:

136370380(BMP15)

CCIC:

134050247(BMP15)

FPG:	101910754(BMP15)

FCH:	102049975(BMP15)

CCRI:

104158183(BMP15)

NNT:	104399218(BMP15)

SHAB:

115613316(BMP15)

ACUN:

113480085(BMP15)

TALA:

104358752(BMP15)

ACHC:

115333705(BMP15)

HLE:	104831477(BMP15)

AGEN:

126050269

HHAR:

128153882(BMP15)

GCL:

127019703

LDI:	104353221(BMP15)

MNB:	103778178(BMP15)

DPUB:

104303656(BMP15)

PPUS:

135183898(BMP15)

AVIT:

104270061(BMP15)

BRHI:

104499877(BMP15)

EGZ:	104133012(BMP15)

NNI:	104012619(BMP15)

PCRI:

104038767

PADL:

103923623(BMP15)

AFOR:

103903410

FGA:

104074847

CLV:	102088708(BMP15)

MUI:	104541962(BMP15)

PLET:

104621011(BMP15)

CUCA:

104060523(BMP15)

TEO:	104384518(BMP15)

BREG:

104632285(BMP15)

OHA:	104327369(BMP15)

ACAR:

104523771

CPEA:

104393928(BMP15)

CVF:	104285044(BMP15)

RTD:	128915090(BMP15)

CRID:

134520738(BMP15)

AAM:	106497403(BMP15)

AROW:

112978182(BMP15)

NPD:	112947078(BMP15)

DNE:	112987751(BMP15)

ASN:	102373573(BMP15)

AMJ:	102570561(BMP15)

GGN:	109300515(BMP15)

CMY:	102930193(BMP15)

CCAY:

125643053(BMP15)

DCC:	119860931(BMP15)

CPIC:

101945310(BMP15)

TST:	117882949(BMP15)

CABI:

116831525(BMP15)

MRV:	120372152(BMP15)

ACS:	100566202(bmp15)

ASAO:

132763140(BMP15)

PVT:	110080136(BMP15)

SUND:

121937185(BMP15)

PBI:	103067097(BMP15)

PMUR:

114922192(BMP15)

CTIG:

120313234(BMP15)

TSR:	106551178(BMP15)

PGUT:

117679647(BMP15)

APRI:

131205007(BMP15)

PTEX:

113446857(BMP15)

NSS:	113423092(BMP15)

VKO:	123034926(BMP15)

HCG:	128335325(BMP15)

GJA:	107108499(BMP15)

STOW:

125442848(BMP15)

EMC:	129341042(BMP15)

XLA:	108698258(bmp15.L)

XTR:	100485893(bmp15)

NPR:	108793330(BMP15)

RTEM:

120913111(BMP15)

BBUF:

120977194(BMP15)

BGAR:

122919495(BMP15)

PWL:	138262108(BMP15)

MUO:	115474926(BMP15)

GSH:	117360518(BMP15)

DRE:	334183(bmp15)

SRX:	107707916 107711577

SANH:

107695335 107702216

SGH:	107557510 107596462

CCAR:

109073806 109094312

CAUA:

113051379 113106312

CGIB:

127962560 128017741

PTET:

122348177(bmp15)

LROH:

127168423(bmp15)

OMC:	131544358(bmp15)

PPRM:

120477268(bmp15)

RKG:	130091204(bmp15)

MAMB:

125265076(bmp15)

CIDE:

127515590

CERY:

137030378(bmp15)

MASI:

127444002 127449556

TROS:

130559139(bmp15)

TDW:	130423779(bmp15)

MANU:

129448383(bmp15)

PDAB:

135778918(bmp15)

IPU:	108267203(bmp15)

IFU:	128610082(bmp15)

PHYP:

113540502

SMEO:

124387502(bmp15)

TFD:	113635208(bmp15)

TVC:	132848649(bmp15)

CGAR:

128527837(bmp15)

NGRA:

132888227(bmp15)

TRN:	134311579(bmp15)

AMEX:

103023164(bmp15)

CMAO:

118825885(bmp15)

EEE:	113579830(bmp15)

CHAR:

105891153(bmp15)

SPIL:

134059750(bmp15)

TRU:	101070055(bmp15)

TFS:	130523109(bmp15)

LCO:	104935018(bmp15)

TBEN:

117494598(bmp15)

CGOB:

115023406(bmp15)

PGEO:

117444869(bmp15)

GACU:

117553374(bmp15)

EMAC:

134875729(bmp15)

ELY:	117245656(bmp15)

EFO:	125884392(bmp15)

PLEP:

121962201(bmp15)

SLUC:

116053279(bmp15)

ECRA:

117935045(bmp15)

ESP:	116669509(bmp15)

PFLV:

114545959(bmp15)

GAT:	120823151(bmp15)

PPUG:

119222951(bmp15)

AFB:	129093315(bmp15)

CLUM:

117748054(bmp15)

PSWI:

130211890(bmp15)

CANA:

137792132(bmp15)

MSAM:

119912587(bmp15) 119913317 119918936

SCHU:

122870602(bmp15)

CUD:	121504884(bmp15)

SPUL:

138601052(bmp15)

LMIX:

132958717(bmp15)

ALAT:

119027572(bmp15)

ASTR:

137590736(bmp15)

MZE:

101480089

ONL:

100708030

OAU:	116317262(bmp15)

OLA:	101159298(bmp15)

OML:	112156504(bmp15)

CSAI:

133420239(bmp15)

XMA:	102234708(bmp15)

XCO:	114156845(bmp15)

XHE:	116732237(bmp15)

PRET:

103480410(bmp15)

PFOR:

103144661(bmp15)

PLAI:

106950499(bmp15)

PMEI:

106914684(bmp15)

GAF:	122819942(bmp15)

PPRL:

129352360(bmp15)

CVG:

107091520

CTUL:

119788618(bmp15)

GMU:	124880720(bmp15)

NFU:	107377005(bmp15)

KMR:	108250950(bmp15)

ALIM:

106524445(bmp15)

NWH:	119415688(bmp15)

AOCE:

111562715(bmp15)

EJA:	138204149(bmp15)

BFRE:

138626344(bmp15)

MCEP:

125017931(bmp15)

CSEM:

103386318

POV:	109640809(bmp15)

SSEN:

122762788 122766972(bmp15)

SSOE:

131456876(bmp15)

HHIP:

117751951(bmp15)

HSP:	118102377(bmp15)

PPLT:

128430397(bmp15)

SMAU:

118284515(bmp15)

LCF:

108902074

SDU:	111233456(bmp15)

SLAL:

111667136(bmp15)

XGL:	120797158(bmp15)

HCQ:

109516498

SSCV:

125992561(bmp15)

SBIA:

133494582(bmp15)

PEE:	133397956(bmp15)

PTAO:

133472963(bmp15)

BPEC:

110153884

ENY:	140371755(bmp15)

MALB:

109971346(bmp15)

BSPL:

114847818(bmp15)

SJO:	128383717(bmp15)

SSCO:

134005970(bmp15)

GMH:

115529882

SASA:

106578107

STRU:

115194656

OTW:	112235094(bmp15)

OMY:	110531412(bmp15)

OGO:	124008584(bmp15)

ONE:

115123688

OKI:

109906817

OKE:	118378611(bmp15)

OMM:	135509910(bmp15)

OCLA:

139417083

SALP:

112074059

SNH:	120066537(bmp15)

CCLU:

121554613 121572451

ELS:	105007263(bmp15)

OEP:	134016292(bmp15)

SFM:	108934252(bmp15)

PKI:	111856894(bmp15)

AANG:

118222743(bmp15)

AROT:

135251208(bmp15)

CCOG:

133124550(bmp15)

LOC:	102692951(bmp15)

PSPA:

121295805 121317860

ARUT:

117411787 117430234(bmp15)

PSEX:

120537440(bmp15)

LCM:	102353361(BMP15)

CMK:	103191474(bmp15)

RTP:	109922328(bmp15)

CPLA:

122557235(bmp15)

HOC:	132820070(bmp15)

LERI:

LRJ:

TPAL:

VDE:

OSN:

Reference

PMID:16645022

Authors

Laissue P, Christin-Maitre S, Touraine P, Kuttenn F, Ritvos O, Aittomaki K, Bourcigaux N, Jacquesson L, Bouchard P, Frydman R, Dewailly D, Reyss AC, Jeffery L, Bachelot A, Massin N, Fellous M, Veitia RA

Title

Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure.

Journal

Eur J Endocrinol 154:739-44 (2006)
DOI:10.1530/eje.1.02135

Sequence

[hsa:9210]

Reference

PMID:10443672

Authors

Aaltonen J, Laitinen MP, Vuojolainen K, Jaatinen R, Horelli-Kuitunen N, Seppa L, Louhio H, Tuuri T, Sjoberg J, Butzow R, Hovata O, Dale L, Ritvos O

Title

Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis.

Journal

J Clin Endocrinol Metab 84:2744-50 (1999)
DOI:10.1210/jcem.84.8.5921

Sequence

[hsa:9210]

LinkDB

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