KEGG ORTHOLOGY: K05614

ORTHOLOGY: K05614

Entry

K05614                      KO

Symbol

SLC1A3, EAAT1

Name

solute carrier family 1 (glial high affinity glutamate transporter), member 3

Pathway

map04082

Neuroactive ligand signaling

map04721

Synaptic vesicle cycle

map04724

Glutamatergic synapse

map05016

Huntington disease

Disease

H00749

Episodic ataxias

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    K05614  SLC1A3, EAAT1; solute carrier family 1 (glial high affinity glutamate transporter), member 3
09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    K05614  SLC1A3, EAAT1; solute carrier family 1 (glial high affinity glutamate transporter), member 3
   04721 Synaptic vesicle cycle
    K05614  SLC1A3, EAAT1; solute carrier family 1 (glial high affinity glutamate transporter), member 3
09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    K05614  SLC1A3, EAAT1; solute carrier family 1 (glial high affinity glutamate transporter), member 3
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K05614  SLC1A3, EAAT1; solute carrier family 1 (glial high affinity glutamate transporter), member 3
   04147 Exosome
    K05614  SLC1A3, EAAT1; solute carrier family 1 (glial high affinity glutamate transporter), member 3
Transporters [BR:ko02000]
Solute carrier family (SLC)
  SLC1: High-affinity glutamate and neutral amino acid transporter
   K05614  SLC1A3, EAAT1; solute carrier family 1 (glial high affinity glutamate transporter), member 3
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of cortical neuronal cells
   K05614  SLC1A3, EAAT1; solute carrier family 1 (glial high affinity glutamate transporter), member 3

Other DBs

GO:

0005314

TC:	2.A.23.2.1 2.A.23.2.6

Genes

HSA:	6507(SLC1A3)

PTR:	461918(SLC1A3)

PPS:	100977276(SLC1A3)

GGO:	101136491(SLC1A3)

PON:	100433620(SLC1A3)

PPYG:

129036109(SLC1A3)

NLE:	100587553(SLC1A3)

HMH:	116456906(SLC1A3)

SSYN:

129464403(SLC1A3)

MCC:	701109(SLC1A3)

MCF:	102117873(SLC1A3)

MTHB:

126957082

MNI:	105473081(SLC1A3)

CSAB:

103215141(SLC1A3)

CATY:

105583430(SLC1A3)

PANU:

101001168(SLC1A3)

TGE:	112626938(SLC1A3)

MLEU:

105555419(SLC1A3)

RRO:	104670191(SLC1A3)

RBB:	108527573(SLC1A3)

TFN:	117065029(SLC1A3)

PTEH:

111545516(SLC1A3)

CANG:

105513494(SLC1A3)

CJC:	100408230(SLC1A3)

SBQ:	101039681(SLC1A3)

CIMI:

108317625(SLC1A3)

ANAN:

105722489(SLC1A3)

CSYR:

103258142(SLC1A3)

MMUR:

105855461(SLC1A3)

LCAT:

123648438(SLC1A3)

PCOQ:

105814773(SLC1A3)

OGA:	100943024(SLC1A3)

MMU:	20512(Slc1a3)

MCAL:

110310236(Slc1a3)

MPAH:

110328755(Slc1a3)

RNO:	29483(Slc1a3)

MCOC:

116083755(Slc1a3)

ANU:	117723836(Slc1a3)

ASYL:

127666535(Slc1a3)

MUN:	110565630(Slc1a3)

CGE:	100689464(Slc1a3)

MAUA:

101836629(Slc1a3)

PROB:

127220630(Slc1a3)

PLEU:

114697357(Slc1a3)

MORG:

121432952(Slc1a3)

MFOT:

126499682

AAMP:

119809865(Slc1a3)

NGI:	103741320(Slc1a3)

HGL:	101703725(Slc1a3)

CPOC:

100713011(Slc1a3)

CCAN:

109702786(Slc1a3)

DORD:

105987400(Slc1a3)

DSP:	122117017(Slc1a3)

PLOP:

125367605(Slc1a3)

NCAR:

124986716

MMMA:

107151115(Slc1a3)

ITI:	101961435(Slc1a3)

OCU:

100345247

OPI:	101531728(SLC1A3)

TUP:	102495074(SLC1A3)

GVR:	103590780(SLC1A3)

CFA:	403748(SLC1A3)

CLUD:

112652633(SLC1A3)

VVP:	112933531(SLC1A3)

VLG:	121486764(SLC1A3)

NPO:	129509509(SLC1A3)

AML:	100479747(SLC1A3)

UMR:	103664705(SLC1A3)

UAH:	113260898(SLC1A3)

UAR:	123785487(SLC1A3)

ELK:

111140916

LLV:

125100513

MPUF:

101680500(SLC1A3)

MNP:	132028252(SLC1A3)

MLK:	131831664(SLC1A3)

NVS:	122895302(SLC1A3)

ORO:	101381668(SLC1A3)

EJU:	114204880(SLC1A3)

ZCA:	113929158(SLC1A3)

MLX:	118006424 118006558

NSU:	110586100(SLC1A3)

LWW:	102740052(SLC1A3)

FCA:	101098606(SLC1A3)

PYU:	121043568(SLC1A3)

PCOO:

112860223(SLC1A3)

PBG:	122494559(SLC1A3)

PVIV:

125166262(SLC1A3)

LRUF:

124522171

LGF:	123577792(SLC1A3)

AJU:

106980189

PTG:	102962493(SLC1A3)

PPAD:

109260097(SLC1A3)

PUC:

125934638

PLEZ:

122227425(SLC1A3)

HHV:	120244159(SLC1A3)

BTA:	282354(SLC1A3)

BOM:	102265758(SLC1A3)

BIU:	109574927(SLC1A3)

BBUB:

102416673(SLC1A3)

BBIS:

104998550(SLC1A3)

CHX:	102171550(SLC1A3)

OAS:	443246(SLC1A3)

BTAX:

128066056(SLC1A3)

CSUM:

138094410(SLC1A3)

ODA:	120879347(SLC1A3)

CCAD:

122454213(SLC1A3)

MREE:

136146571(SLC1A3)

OVR:	110141568(SLC1A3)

MBEZ:

129553315(SLC1A3)

SSC:	100516047(SLC1A3)

CFR:	102503505(SLC1A3)

CBAI:

105070555(SLC1A3)

CDK:	105086992(SLC1A3)

VPC:	102530896(SLC1A3)

BACU:

103006742(SLC1A3)

BMUS:

118893319(SLC1A3)

LVE:	103091502(SLC1A3)

OOR:	101272922(SLC1A3)

LALB:

132518012(SLC1A3)

DLE:	111187475(SLC1A3)

PCAD:

102975511(SLC1A3)

PSIU:

116752212(SLC1A3)

NASI:

112405986(SLC1A3)

ECB:	100053647(SLC1A3)

EPZ:	103557092(SLC1A3)

EAI:	106824759(SLC1A3)

MYB:	102260723(SLC1A3)

MYD:	102769790(SLC1A3)

MMYO:

118656628(SLC1A3)

MDT:	132233753(SLC1A3)

MYUM:

139008517(SLC1A3)

PKL:	118703502(SLC1A3)

EFUS:

103298087(SLC1A3)

MNA:	107545825(SLC1A3)

DRO:	112321023(SLC1A3)

SHON:

118998779(SLC1A3)

AJM:	119037017(SLC1A3)

PDIC:

114505445(SLC1A3)

PHAS:

123824798(SLC1A3)

MMF:	118642642(SLC1A3)

PPAM:

129078992(SLC1A3)

HAI:	109387071(SLC1A3)

RFQ:	117024827(SLC1A3)

PALE:

102881740(SLC1A3)

PGIG:

120586185(SLC1A3)

PVP:	105307450(SLC1A3)

RAY:	107509715(SLC1A3)

MJV:	108395992(SLC1A3)

TOD:	119260185(SLC1A3)

SARA:

101553671(SLC1A3)

SFUM:

130021324(SLC1A3)

SETR:

126001336(SLC1A3)

LAV:	100655719(SLC1A3)

TMU:

101348893

ETF:	101645577(SLC1A3)

DNM:	101422000(SLC1A3)

MDO:	100014533(SLC1A3)

GAS:	123231510(SLC1A3)

SHR:	100932840(SLC1A3)

AFZ:

127556672

PCW:	110214839(SLC1A3)

TVP:	118833512(SLC1A3)

PBRV:

138167377(SLC1A3)

OAA:	100086711(SLC1A3)

TACU:

119925562(SLC1A3)

GGA:	395443(SLC1A3)

PCOC:

116239113(SLC1A3)

MGP:	100543544(SLC1A3)

CJO:	107305870(SLC1A3)

TPAI:

128074555(SLC1A3)

LMUT:

125687014(SLC1A3)

NMEL:

110389953(SLC1A3)

APLA:

101801926(SLC1A3)

ACYG:

106036396(SLC1A3)

CATA:

118256629(SLC1A3)

AFUL:

116500585(SLC1A3)

TGU:	100229066(SLC1A3)

LSR:	110482478(SLC1A3)

SCAN:

103821011(SLC1A3)

PMOA:

120502483(SLC1A3)

OTC:	121331522(SLC1A3)

PRUF:

121352835(SLC1A3)

ATRC:

139589269(SLC1A3)

GFR:	102034585(SLC1A3)

FAB:	101815364(SLC1A3)

OMA:	130265296(SLC1A3)

PHI:	102113945(SLC1A3)

PMAJ:

107198292(SLC1A3)

CCAE:

111941160(SLC1A3)

CCW:	104686609(SLC1A3)

CBRC:

103612891(SLC1A3)

ACOE:

138103162(SLC1A3)

ETL:	114055028(SLC1A3)

ZAB:	102064530(SLC1A3)

ZLE:	135459346(SLC1A3)

ACHL:

103806975(SLC1A3)

SVG:	106852758(SLC1A3)

MMEA:

130572772(SLC1A3)

HRT:	120765746(SLC1A3)

SATI:

136374666(SLC1A3)

CCIC:

134056099(SLC1A3)

FPG:	101924026(SLC1A3)

FCH:	102048636(SLC1A3)

CCRI:

104159306

NNT:	104410203(SLC1A3)

SHAB:

115600595(SLC1A3)

ACUN:

113489645(SLC1A3)

TALA:

104361448(SLC1A3)

ACHC:

115336975(SLC1A3) 121233027

HALD:

104318357(SLC1A3)

HLE:	104830616(SLC1A3)

AGEN:

126035285 126036295

HHAR:

128136280 128137416(SLC1A3)

GCL:	127027272 127029278

CSTI:

104562543(SLC1A3)

LDI:	104345125(SLC1A3)

MNB:

103780068

DPUB:

104303132(SLC1A3)

PPUS:

135193017(SLC1A3)

AVIT:

104273513(SLC1A3)

BRHI:

104489348(SLC1A3)

EGZ:	104133853(SLC1A3)

NNI:	104014470 104020628

PCRI:

104027295(SLC1A3)

PCAO:

104043306(SLC1A3)

PADL:

103921468(SLC1A3)

AFOR:

103903873(SLC1A3)

FGA:

104084039

GSTE:

104259049(SLC1A3)

CLV:	102085400(SLC1A3)

MUI:

104546132

PGUU:

104468831(SLC1A3)

PLET:

104618504 104619441

EHS:	104508210(SLC1A3)

CMAC:

104481744

CUCA:

104060230(SLC1A3)

TEO:

104378193

BREG:

104639813

OHA:	104337676(SLC1A3)

ACAR:

104518958

CPEA:

104398597(SLC1A3)

CVF:	104290377 104294983(SLC1A3)

RTD:	128901978 128902518(SLC1A3)

CRID:

134508470(SLC1A3)

AAM:	106499526(SLC1A3)

AROW:

112976235(SLC1A3)

NPD:	112946192(SLC1A3)

TGT:	104567465 104576027

DNE:	112982177(SLC1A3)

SCAM:

104147789(SLC1A3)

ASN:	102388208(SLC1A3)

AMJ:	102560026(SLC1A3)

CPOO:

109307839(SLC1A3)

GGN:	109297891(SLC1A3)

PSS:

102457776

CMY:	102947915(SLC1A3)

CCAY:

125636613(SLC1A3)

DCC:	119855902(SLC1A3)

CPIC:

101933649(SLC1A3)

TST:	117878764(SLC1A3)

CABI:

116819929(SLC1A3)

MRV:	120408618(SLC1A3)

ACS:	100562038(slc1a3)

ASAO:

132766929(SLC1A3)

PVT:	110080072(SLC1A3)

SUND:

121923231(SLC1A3)

PBI:	103056318(SLC1A3)

PMUR:

107288339(SLC1A3)

CTIG:

120310023(SLC1A3)

TSR:	106540022(SLC1A3)

PGUT:

117679984(SLC1A3)

APRI:

131192300(SLC1A3)

PTEX:

113445166(SLC1A3)

NSS:	113411321(SLC1A3)

VKO:	123024025(SLC1A3)

PMUA:

114606264(SLC1A3)

PRAF:

128423349(SLC1A3)

ZVI:	118077231(SLC1A3)

HCG:	128346566(SLC1A3)

GJA:	107108083(SLC1A3)

STOW:

125436169(SLC1A3)

EMC:	129334490(SLC1A3)

XLA:	108707313(slc1a3.S) 398856(slc1a3.L)

XTR:	100127700(slc1a3)

NPR:	108796749(SLC1A3)

RTEM:

120927632(SLC1A3)

BBUF:

120992176(SLC1A3)

BGAR:

122938816(SLC1A3)

PWL:	138282979(SLC1A3)

MUO:	115462112(SLC1A3)

GSH:	117354801(SLC1A3)

DRE:	323439(slc1a3a) 556181(slc1a3b)

SRX:	107725163 107725178 107741153 107743401

SANH:

107653757 107667878 107680463 107697439 107704160

SGH:	107571034 107578186 107583342 107594554

CCAR:

109080183(slc1a3a) 109085655 109086857 109105812

CAUA:

113054369 113067987 113073039 113109976

CGIB:

127958128 127966517 128014835 128021003

PTET:

122331849(slc1a3b) 122344862(slc1a3a)

LROH:

127165026(slc1a3a) 127171747(slc1a3b)

OMC:	131540045(slc1a3a) 131548139(slc1a3b)

PPRM:

120482128(slc1a3b) 120488107(slc1a3a)

RKG:	130088179(slc1a3a) 130105288(slc1a3b)

MAMB:

125261347(slc1a3b) 125267246(slc1a3a)

CIDE:

127512890 127521560

CERY:

137029538(slc1a3b) 137034075(slc1a3a)

MASI:

127427651 127432956 127433947 127440023

TROS:

130546469(slc1a3b) 130566078(slc1a3a)

TDW:	130412153(slc1a3b) 130419833(slc1a3a)

MANU:

129439627(slc1a3a) 129446724(slc1a3b)

PDAB:

135732737(slc1a3a) 135742552(slc1a3b)

IPU:	108255653 108276844(slc1a3b)

IFU:	128619976(slc1a3b)

PHYP:

113525535 113544907(slc1a3)

SMEO:

124380867(slc1a3a) 124393601(slc1a3b)

TFD:	113637420(slc1a3a) 113638312(slc1a3b)

TVC:	132854874(slc1a3a) 132863604(slc1a3b)

CGAR:

128505488(slc1a3b) 128509286(slc1a3a)

NGRA:

132872675(slc1a3a) 132873493(slc1a3b)

TRN:	134332141(slc1a3b) 134335636(slc1a3a)

AMEX:

103023054(slc1a3b) 103038860(slc1a3a)

CMAO:

118824883(slc1a3b) 118827680(slc1a3a)

EEE:	113573322(slc1a3) 113591808

CHAR:

105893295 105901236(slc1a3a)

SPIL:

134071540(slc1a3b) 134088811(slc1a3a)

TRU:	101063470 101066193(slc1a3) 101066967 101067499

TFS:	130517531 130525392

TNG:	GSTEN00009151G001

LCO:	104920269 104931442 104938174

NCC:

104949677

TBEN:

117473249 117478896

CGOB:

115013669(slc1a3)

PGEO:

117443956 117452693

GACU:

117558230 117558611

EMAC:

134868351 134874118

ELY:	117252859(slc1a3a) 117269356

EFO:	125890183(slc1a3a) 125905819

PLEP:

121944324(slc1a3a) 121960205

SLUC:

116041393 116056768(slc1a3a)

ECRA:

117944375(slc1a3a) 117959229

ESP:	116688902 116704048(slc1a3)

PFLV:

114556141 114571047(slc1a3)

GAT:	120831052 120832344

PPUG:

119225217(slc1a3a) 119226589

AFB:	129101070(slc1a3a) 129102146

CLUM:

117736989(slc1a3a) 117740415

PSWI:

130197036 130205493

CANA:

137783501 137805363(slc1a3a)

CVE:	137866903 137868780

MSAM:

119891725(slc1a3a) 119901862 119914400

SCHU:

122865897 122875863(slc1a3a)

CUD:	121510017(slc1a3a) 121524959

SPUL:

138605077 138609743(slc1a3a)

LMIX:

132974659(slc1a3a) 132992421

ALAT:

119020215(slc1a3a) 119030060

ASTR:

137592208(slc1a3a) 137608358

MZE:	101470384 101471878

ONL:	100698754 100708927

OAU:	116321786 116336451(slc1a3a)

OLA:	101170347 101170607(slc1a3)

OML:	112140355 112148764(slc1a3a)

CSAI:

133450555 133454504

XMA:	102228594 102229300 102232419

XCO:	114150151(slc1a3) 114154745

XHE:	116723886 116729248

PRET:

103470222 103474103 103479781

PFOR:

103135379(slc1a3) 103146099 103153958

PLAI:

106942541 106953454

PMEI:

106922113 106927066(slc1a3)

GAF:	122819421 122828648

PPRL:

129355039 129372037(slc1a3a)

CVG:	107080668 107084457 107093930(slc1a3)

CTUL:

119780561 119797026

GMU:	124872124 124877525(slc1a3a)

NFU:	107375011(slc1a3) 107383594 107394027

KMR:	108232840 108232941 108232974 108234626(slc1a3a) 108250306

ALIM:

106516839 106516867 106526225 106531664(slc1a3)

NWH:	119413941(slc1a3a) 119424614

AOCE:

111576057 111576463(slc1a3a)

EJA:	138191723(slc1a3a) 138210010

BFRE:

138621408(slc1a3a) 138632028

MCEP:

124997140 125012396(slc1a3a)

CSEM:

103389190 103396479 103396488 103398163

POV:	109637191 109639800 109645960

SSEN:

122758566 122769767

SSOE:

131445935 131464415

HHIP:

117768177(slc1a3a) 117771421

HSP:	118098068 118115571(slc1a3a)

PPLT:

128424781 128438432(slc1a3a)

SMAU:

118284504 118314419(slc1a3a)

LCF:	108878290(slc1a3a) 108884176 108900751

SDU:	111221125(slc1a3) 111230923 111230991

SLAL:

111648071 111660966 111669157

XGL:	120805466(slc1a3a) 120806328

HCQ:	109514208 109529103

SSCV:

125979816 125994289

SBIA:

133490713 133499313

PEE:	133399865 133413963

PTAO:

133475306 133489973

BPEC:

110153484 110161922(slc1a3)

ENY:	140346936 140367570

MALB:

109961618 109970897

BSPL:

114861809(slc1a3a) 114866415

SJO:	128364198(slc1a3a) 128379788

SSCO:

133979032(slc1a3a) 133990058 133994902

GMH:	115542217 115545991

SASA:

106563909 106568174 106585918

STRU:

115149231 115159358 115165005

OTW:	112219853 112246686(slc1a3a) 112257533

OMY:	110523776 110525225(slc1a3a) 110537147

OGO:	124000860 124034667 124047836

ONE:	115105862 115111242 115128930

OKI:	109868501 109875062 109892064

OKE:	118387724 118391432 118392850

OMM:	135513811 135517791 135548301

OCLA:

139409997 139410597 139422863

SALP:

111961425 111974841 111980291

SNH:	120026164 120032547

CCLU:

121573855 121582181 121584369

ELS:

105014588

OEP:	134015431(slc1a3a) 134033513

SFM:	108932068(slc1a3) 108938088

PKI:	111842168(slc1a3) 111856635 111860159

AANG:

118206719(slc1a3a)

AROT:

135233606(slc1a3a)

CCOG:

133140309(slc1a3a)

LOC:	102695379(slc1a3)

PSPA:

121304830 121318343

ARUT:

117409075 117421060

PSEX:

120527293

LCM:	102353991(SLC1A3) 102358117

CMK:

CPLA:

HOC:

LERI:

BFO:

BBEL:

SPU:	576503 752140

APLC:

ARUN:

AAMU:

AFIL:

SKO:

PFLL:

DER:

DSI:	Dsimw501_GD23596(Dsim_GD23596)

DYA:	Dyak_GE18833

DSR:

DPO:

DPE:

DWI:

DMO:	Dmoj_GI12287

DAZ:

DNV:

DHE:

LCQ:

AAG:

ASUA:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

TLN:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

DPA:

DVV:

NVL:

API:

DNX:

AGS:

RMD:

PHU:	Phum_PHUM454560

BROR:

134537944

DPX:	DAPPUDRAFT_11662

AFRA:

136039604

MNZ:

135222731

MRJ:

136825784

PORN:

139762490(Eaat1)

DPTE:

113799286

DFR:

124491947

CSCU:

111627950 111634653

CVS:	136969012(Eaat1) 136977310

PTEP:

107447706

ABRU:

129976133

LPOL:

106478375

NAI:	NECAME_07090

TSP:

Tsp_02392

LGI:	LOTGIDRAFT_126471 LOTGIDRAFT_128333 LOTGIDRAFT_61417 LOTGIDRAFT_71933

PVUL:

126807953 126817288 126829356

PCAN:

112564851 112573178

LSAX:

138946378

GAE:	121375250 121375489 121381591

HRJ:

124261278

HASI:

137256323

HCRA:

139474292 139475682

MYI:	110457879 110457890 110457906 110465530

PMAX:

AIRR:

MMER:

DPOL:

OSN:

LJP:	135464488 135470618 135470619 135470620 135478293

LAK:	106175326 106177873 106177879 106177888

EPA:	110242862 110242873 110253206

ADF:	107340992 107354338 107354339 107354340 107354341 107354343

AMIL:

114948058 114969311 114969312 114969322 114969327

PDAM:

113675250 113675276 113675277

DGT:	114524737 114524936 114528748 114529334

XEN:

124437184

HMG:

100204398

TPV:

TP04_0725

PIF:	PITG_07994

PSOJ:

PHYSODRAFT_550321

SPAR:

SPRG_13285 SPRG_13286

NGR:	NAEGRDRAFT_77902

» show all

Reference

PMID:8218410

Authors

Shashidharan P, Plaitakis A

Title

Cloning and characterization of a glutamate transporter cDNA from human cerebellum.

Journal

Biochim Biophys Acta 1216:161-4 (1993)
DOI:10.1016/0167-4781(93)90057-k

Sequence

[hsa:6507]

Reference

PMID:12176072

Authors

Amara SG, Fontana AC

Title

Excitatory amino acid transporters: keeping up with glutamate.

Journal

Neurochem Int 41:313-8 (2002)
DOI:10.1016/S0197-0186(02)00018-9

LinkDB

DBGET integrated database retrieval system