KEGG ORTHOLOGY: K05687

ORTHOLOGY: K05687

Entry

K05687                      KO

Symbol

PARK7

Name

protein DJ-1 [EC:3.5.1.124]

Pathway

map05012

Parkinson disease

map05022

Pathways of neurodegeneration - multiple diseases

Disease

H00057

Parkinson disease

H01600

Parkinsonian syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K05687  PARK7; protein DJ-1
   05022 Pathways of neurodegeneration - multiple diseases
    K05687  PARK7; protein DJ-1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K05687  PARK7; protein DJ-1
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K05687  PARK7; protein DJ-1
Enzymes [BR:ko01000]
3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.124  protein deglycase
     K05687  PARK7; protein DJ-1
Peptidases and inhibitors [BR:ko01002]
Cysteine peptidases
  Family C56: PfpI endopeptidase family
   K05687  PARK7; protein DJ-1
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K05687  PARK7; protein DJ-1

Other DBs

GO:

0036524

Genes

HSA:	11315(PARK7)

PTR:	465864 746063(PARK7)

PPS:	100969783(PARK7)

GGO:	101135675(PARK7)

PON:	100447504(PARK7)

PPYG:

129008641(PARK7)

NLE:	100590226(PARK7)

HMH:	116812867(PARK7)

SSYN:

129472222(PARK7)

MCC:	708377(PARK7)

MCF:	101865893(PARK7) 102128495

MTHB:

126930527 126953579 126961482

MNI:	105479272(PARK7) 105492808

CSAB:

103225666(PARK7)

CATY:

105580915(PARK7)

PANU:

101019084(PARK7)

TGE:	112610948(PARK7)

MLEU:

105540728(PARK7)

RRO:	104657558(PARK7) 115895970 115895993 115896206

RBB:	108517940(PARK7)

TFN:	117062340 117093379(PARK7)

PTEH:

111544628(PARK7)

CANG:

105509145(PARK7) 105517597

CJC:	100410814 100413204(PARK7) 108588492

SBQ:	101052951(PARK7)

CIMI:

108282393(PARK7)

ANAN:

105715048 105731776(PARK7)

CSYR:

103260864(PARK7)

MMUR:

105886089(PARK7)

LCAT:

123634530(PARK7) 123640722

PCOQ:

105824910(PARK7) 105825287

OGA:	100949675(PARK7)

MMU:	57320(Park7)

MCAL:

110293202(Park7)

MPAH:

110323526(Park7)

RNO:	117287(Park7)

MCOC:

116097068(Park7)

ANU:	117709213(Park7)

MUN:	110560422(Park7)

CGE:	100759195(Park7)

MAUA:

101826467(Park7)

PROB:

127213413(Park7)

PLEU:

114702637(Park7)

MORG:

121441802 121448444

MFOT:

126505830 126508225 126515430

AAMP:

119817006(Park7)

NGI:	103725143(Park7)

HGL:	101723322(Park7)

CPOC:

100723185(Park7)

CCAN:

109697924(Park7)

DORD:

105999800(Park7)

DSP:	122121478(Park7)

PLOP:

125354529(Park7)

NCAR:

124983002

MMMA:

107155537(Park7)

OCU:

100352938

OPI:	101536129(PARK7)

TUP:	102470939(PARK7) 102474007

GVR:	103609572(PARK7)

CLUD:

112646897(PARK7)

VVP:	112924680(PARK7)

VLG:	121500473(PARK7)

NPO:	129497193(PARK7)

AML:	100475637(PARK7)

UMR:	103666687(PARK7)

UAH:	113270555(PARK7)

UAR:	123796171(PARK7)

ELK:

111154652

LLV:

125097941

MPUF:

101683731(PARK7)

MNP:	132000881(PARK7)

MLK:	131809708(PARK7)

NVS:	122899412(PARK7)

ORO:	101380867(PARK7)

EJU:	114213290(PARK7) 114217636

ZCA:	113909781(PARK7) 113919238 113922510 113928786

MLX:	118020045(PARK7)

NSU:	110573970 110574645(PARK7)

LWW:	102746230(PARK7)

FCA:	101092868(PARK7)

PYU:	121020241(PARK7)

PCOO:

112869372(PARK7)

PBG:	122479891(PARK7)

PVIV:

125172871(PARK7)

LRUF:

124515077

PTG:	102959550(PARK7)

PPAD:

109274044(PARK7)

PUC:

125913152

AJU:

106982200

HHV:	120233637(PARK7)

BTA:	511268(PARK7)

BOM:	102288078(PARK7)

BIU:	109570573(PARK7)

BBUB:

102397062(PARK7)

BBIS:

104995881(PARK7)

CHX:	102177646(PARK7)

OAS:	101119489(PARK7)

BTAX:

128061497(PARK7)

ODA:	120880166(PARK7)

CCAD:

122452007(PARK7)

MBEZ:

129551486(PARK7)

SSC:	780404(PARK7)

CFR:	102503983(PARK7)

CBAI:

105071005(PARK7)

CDK:	105106986(PARK7)

VPC:	102543412(PARK7)

BACU:

103019344(PARK7)

BMUS:

118904946(PARK7)

LVE:	103082032(PARK7)

OOR:	101275264(PARK7)

DLE:	111187180(PARK7)

PCAD:

102986390(PARK7) 102991297

PSIU:

116739967(PARK7)

NASI:

112402776(PARK7)

ECB:	100052123(PARK7)

EPZ:	103561708(PARK7)

EAI:	106844319(PARK7)

MYB:	102263235(PARK7)

MYD:	102774693(PARK7)

MMYO:

118676714(PARK7)

MLF:	102441466(PARK7)

MDT:	132231727(PARK7)

PKL:	118731999(PARK7)

EFUS:

103295298(PARK7)

MNA:	107538443(PARK7)

DRO:	112299067(PARK7)

SHON:

118998125(PARK7)

AJM:	119055942(PARK7)

PDIC:

114497495(PARK7)

PHAS:

123832179(PARK7)

MMF:	118626382(PARK7)

PPAM:

129075687(PARK7)

HAI:	109381309(PARK7)

RFQ:	117021448 117027458(PARK7) 117033454

PALE:

102884675(PARK7)

PGIG:

120585857(PARK7)

PVP:	105297663(PARK7)

RAY:	107517703(PARK7)

MJV:	108391155(PARK7)

TOD:	119235764(PARK7)

SARA:

101546456(PARK7)

SETR:

126011597(PARK7)

LAV:	100664838(PARK7)

TMU:

101357070

ETF:	101643079(PARK7)

DNM:	101411568 101445205

MDO:	100010357(PARK7)

GAS:	123240248(PARK7)

SHR:	100923337(PARK7)

AFZ:

127555917

PCW:	110199783(PARK7)

TVP:	118837624(PARK7)

OAA:	100073498(PARK7)

GGA:	395277(PARK7)

PCOC:

116242666(PARK7)

MGP:	100544576(PARK7)

CJO:	107323475(PARK7)

TPAI:

128084944(PARK7)

LMUT:

125703366(PARK7)

NMEL:

110408733(PARK7)

APLA:

101794503(PARK7)

ACYG:

106047231(PARK7)

CATA:

118253430(PARK7)

AFUL:

116497685(PARK7)

TGU:	100190506(PARK7)

LSR:	110472504(PARK7)

SCAN:

103820830(PARK7)

PMOA:

120511071(PARK7)

OTC:	121344053(PARK7)

PRUF:

121358462(PARK7)

GFR:	102045424(PARK7)

FAB:	101810201(PARK7)

OMA:	130261619(PARK7)

PHI:	102112820(PARK7)

PMAJ:

107213629(PARK7)

CCAE:

111938587(PARK7) 111945711

CCW:	104693267(PARK7)

CBRC:

103616139(PARK7)

ETL:	114060124(PARK7)

ZAB:	102075254(PARK7)

ZLE:	135456617(PARK7)

ACHL:

103800910(PARK7)

SVG:	106857711(PARK7)

MMEA:

130579086(PARK7)

HRT:	120762232(PARK7)

SATI:

136370735(PARK7)

FPG:	101920065(PARK7)

FCH:	102046650(PARK7)

CCRI:

104163258(PARK7)

NNT:	104401750(PARK7)

SHAB:

115617500(PARK7)

ACUN:

113487774(PARK7)

TALA:

104360590(PARK7)

ACHC:

115342668(PARK7)

HALD:

104316236(PARK7)

HLE:	104830445(PARK7)

AGEN:

126042260

GCL:

127024848

CSTI:

104551510(PARK7)

LDI:	104341334(PARK7)

MNB:	103773190(PARK7)

DPUB:

104309898(PARK7)

AVIT:

104277482(PARK7)

BRHI:

104493065(PARK7)

EGZ:	104132789(PARK7)

NNI:	104008922(PARK7)

PCRI:

104030308(PARK7)

PCAO:

104046088(PARK7)

PADL:

103924749(PARK7)

AFOR:

103894680(PARK7)

FGA:	104071164(PARK7)

GSTE:

104252198(PARK7)

CLV:	102092024(PARK7)

MUI:	104534949(PARK7)

PGUU:

104458823(PARK7) 104460488

PLET:

104627143(PARK7)

EHS:	104504573(PARK7)

CMAC:

104486959(PARK7)

CUCA:

104060532(PARK7)

TEO:	104375821(PARK7)

BREG:

104639874(PARK7)

OHA:	104330203(PARK7)

ACAR:

104528005(PARK7)

CPEA:

104395505(PARK7)

CVF:	104285607(PARK7)

RTD:	128918411(PARK7)

AAM:	106496706(PARK7)

AROW:

112975454(PARK7)

NPD:	112957409(PARK7)

TGT:	104568192(PARK7)

DNE:	112989049(PARK7)

SCAM:

104139061(PARK7)

ASN:	102383069(PARK7)

AMJ:	102576304(PARK7)

CPOO:

109314170(PARK7)

GGN:	109293579(PARK7)

PSS:	102460414(PARK7)

CMY:	102930935(PARK7)

CCAY:

125624229(PARK7)

DCC:	119844927(PARK7)

CPIC:

101952912(PARK7)

TST:	117868008(PARK7)

CABI:

116815437(PARK7)

MRV:	120387718(PARK7)

ACS:	100551640(park7)

ASAO:

132764687(PARK7)

PVT:	110082464(PARK7)

SUND:

121936362(PARK7)

PBI:	103055741(PARK7)

PMUR:

107284672(PARK7)

CTIG:

120319077(PARK7)

PGUT:

117656617(PARK7)

APRI:

131187180(PARK7)

PTEX:

113450775(PARK7)

NSS:	113430871(PARK7)

VKO:	123018610(PARK7)

PMUA:

114602370(PARK7)

PRAF:

128419596(PARK7)

ZVI:	118087684(PARK7)

HCG:	128338709(PARK7)

GJA:	107108653(PARK7)

STOW:

125446048(PARK7)

EMC:	129345035(PARK7)

XLA:	399179(park7.L) 444724(park7.S)

XTR:	548568(park7)

NPR:	108783953(PARK7) 108796089

RTEM:

120915783(PARK7)

BBUF:

120998520(PARK7)

BGAR:

122926893(PARK7) 122928893

MUO:	115456787(PARK7)

GSH:	117349464(PARK7)

DRE:	449674(park7)

SRX:

107708261

SANH:

107657982 107701995

SGH:	107580665 107592885(park7)

CCAR:

CAUA:

CGIB:

PTET:

LROH:

127173349(park7)

OMC:	131549432(park7)

PPRM:

120480242(park7)

RKG:	130088496(park7)

MAMB:

125256998(park7)

CIDE:

127522658

CERY:

137020953(park7)

MASI:

127427920

TROS:

130571286(park7)

TDW:	130409945(park7)

MANU:

129428022(park7)

IPU:

108255284

IFU:	128625057(park7)

PHYP:

113537791(park7)

SMEO:

124402480(park7)

TFD:	113657203(park7)

TVC:	132838312(park7)

TRN:	134301693(park7)

AMEX:

103030353(park7)

CMAO:

118799822(park7)

EEE:	113572456(park7)

CHAR:

105908352(park7)

TRU:	101065925(park7)

TFS:	130524996(park7)

TNG:	GSTEN00027576G001

LCO:	104919346(park7)

NCC:	104963216(park7)

TBEN:

117489965(park7)

CGOB:

115008311(park7)

PGEO:

117446740(park7)

GACU:

117548172(park7)

EMAC:

134882189(park7)

ELY:	117256569(park7)

EFO:	125895387(park7)

PLEP:

121950937(park7)

SLUC:

116051561(park7)

ECRA:

117943160(park7)

ESP:	116687266(park7)

PFLV:

114554073(park7)

GAT:	120835396(park7)

PPUG:

119194156(park7)

AFB:	129106044(park7)

CLUM:

117730834(park7)

PSWI:

130208890(park7)

MSAM:

119886674(park7)

SCHU:

122865047(park7)

CUD:	121503666(park7)

ALAT:

119021146(park7)

MZE:	101464488(park7)

ONL:	100709464(park7)

OAU:	116314622(park7)

OLA:	100049299(park7)

OML:	112145430(park7)

CSAI:

133449413(park7)

XMA:	102227669(park7)

XCO:	114134940(park7)

XHE:	116709724(park7)

PRET:

103464454(park7)

PFOR:

103136395 103136417

PLAI:

106941571 106941633

PMEI:

106909251 106909295

GAF:	122834754(park7)

PPRL:

129352382(park7)

CVG:	107087537(park7)

CTUL:

119774784(park7)

GMU:	124856680(park7)

NFU:	107385278(park7)

KMR:	108231526(park7)

ALIM:

106513834(park7)

NWH:	119412400(park7) 119412773

AOCE:

111580698(park7)

MCEP:

125007311(park7)

CSEM:

103385637(park7)

POV:	109635367(park7)

SSEN:

122768835(park7)

HHIP:

117762035(park7)

HSP:	118105179(park7)

PPLT:

128459729(park7)

SMAU:

118309798(park7)

LCF:

108899924

SDU:	111223981(park7)

SLAL:

111657909(park7)

XGL:	120783507(park7)

HCQ:	109529237(park7)

SSCV:

125977483

SBIA:

133507990(park7)

PEE:	133408656(park7)

PTAO:

133483862(park7)

BPEC:

110168456(park7)

MALB:

109961751(park7)

BSPL:

114856302(park7)

SJO:	128356021(park7)

SASA:

100136349(dj-1) 100286560(park7)

STRU:

115150690 115207740

OTW:	112215669(park7) 112254495

OMY:	110494422(park7) 110528021

OGO:	124003720 124031371

ONE:	115139117(park7) 115143249

OKI:	109891059 109896428

OKE:	118388496(park7) 118400225

SALP:

111967599 112068743

SNH:	120059358 120065137

CCLU:

121575954(park7) 121578550

ELS:	105017254(park7)

SFM:	108918226(park7)

PKI:	111856937(park7)

AANG:

118211524

LOC:	102699182(park7)

PSPA:

121329173 121329174

ARUT:

117425447 117963610

PSEX:

120531101(park7)

LCM:	102361342(PARK7)

CMK:	103181420(park7)

RTP:	109913779(park7)

CPLA:

122540359(park7)

HOC:	132833700(park7)

LERI:

129711588(park7)

PMRN:

116950498(PARK7)

LRJ:	133352329(PARK7)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:

DME:	Dmel_CG1349 Dmel_CG6646

DER:	6549427 6555140

DSE:	6609068 6612914

DSI:	Dsimw501_GD21547(Dsim_GD21547) Dsimw501_GD25730(Dsim_GD25730)

DYA:	Dyak_GE10903 Dyak_GE13330

DAN:	6494018 6505573

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI18446

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108365327 108370989 108378592

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:	119641500 119641507

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ003149

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:	103579978 106693191

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:	107219199 124293979

NVG:	124301953 124304494

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:	111517882 111517890

DVV:

114348331

NVL:	108558080 108558082

APLN:

108739397 108740246

PPYR:

116160928

OTU:	111414099 111428323

BMOR:

100422789(BmDJ-1beta)

BMAN:

114246571

MSEX:

115446397

DPL:	KGM_214399

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:	111052955 120349758

HVI:	124361958 124361959

MQU:	128990132 128990594 128990978 128991181

PHU:	Phum_PHUM336660

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_201296

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:	119446546 119446548

RSAN:

RMP:

VDE:

VJA:

TUT:

DFR:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_B0432.2(djr-1.1) CELE_C49G7.11(djr-1.2)

CBR:	CBG_07015(Cbr-djr-1.2) CBG_07016(Cbr-djr-1.1)

CRQ:	GCK72_002612 GCK72_008143

BMY:	BM_BM1804(Bm1804)

LOA:	LOAG_06487

TSP:

Tsp_11803

HRO:	HELRODRAFT_156251

LGI:	LOTGIDRAFT_223821

PVUL:

126827585

PCAN:

112557206

BGT:

106054229

GAE:	121390033 121391611

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:	115224773 115228735

LJP:

135475293

LAK:

106174742

SMM:	Smp_082030

SHX:	MS3_00007117(PARK7)

OVI:	T265_15401

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

AQU:

PNO:	SNOG_07399(SNOG_07398)

PTE:

PTT_13806

PTRR:

6344420(PtrM4_101080)

BZE:	COCCADRAFT_27608

BSC:	COCSADRAFT_181323

BOR:	COCMIDRAFT_87889

TML:	GSTUM_00004685001

TVS:	TRAVEDRAFT_171260

PCO:	PHACADRAFT_160579

SHS:	STEHIDRAFT_124932

HIR:	HETIRDRAFT_436865

PSQ:	PUNSTDRAFT_52328

ADL:	AURDEDRAFT_110250

FME:	FOMMEDRAFT_103672

RSX:	RhiXN_06079

CCI:	CC1G_10336

ABP:	AGABI1DRAFT121441(AGABI1DRAFT_121441)

ABV:	AGABI2DRAFT187606(AGABI2DRAFT_187606)

PCUB:

JR316_0012908

MRR:	Moror_7710

E1B28_005711

CPUT:

CONPUDRAFT_76002

SLA:	SERLADRAFT_457197

WSE:	WALSEDRAFT_59511

WIC:	J056_002205

UMA:	UMAG_10481

PFP:	PFL1_01187

SGRA:

MGL:

MRT:

MSYM:

RIE:	OCT59_013790

MBR:	MONBRDRAFT_8547

GTT:	GUITHDRAFT_77239

AFI:	Acife_0961

SCL:

sce6209

SCU:	SCE1572_37395

» show all

Reference

PMID:15502874

Authors

Shendelman S, Jonason A, Martinat C, Leete T, Abeliovich A

Title

DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation.

Journal

PLoS Biol 2:e362 (2004)
DOI:10.1371/journal.pbio.0020362

Sequence

[hsa:11315]

Reference

PMID:17015834

Authors

Clements CM, McNally RS, Conti BJ, Mak TW, Ting JP

Title

DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2.

Journal

Proc Natl Acad Sci U S A 103:15091-6 (2006)
DOI:10.1073/pnas.0607260103

Sequence

[hsa:11315] [mmu:57320]

Reference

PMID:25416785

Authors

Richarme G, Mihoub M, Dairou J, Bui LC, Leger T, Lamouri A

Title

Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues.

Journal

J Biol Chem 290:1885-97 (2015)
DOI:10.1074/jbc.M114.597815

Sequence

[hsa:11315]

Reference

PMID:9070310

Authors

Nagakubo D, Taira T, Kitaura H, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H

Title

DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras.

Journal

Biochem Biophys Res Commun 231:509-13 (1997)
DOI:10.1006/bbrc.1997.6132

Sequence

[hsa:11315]

LinkDB

DBGET integrated database retrieval system