KEGG ORTHOLOGY: K05741

ORTHOLOGY: K05741

Entry

K05741                      KO

Symbol

DIAPH2

Name

diaphanous 2

Pathway

map04810

Regulation of actin cytoskeleton

map04820

Cytoskeleton in muscle cells

Disease

H00627

Premature ovarian failure

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    K05741  DIAPH2; diaphanous 2
   04810 Regulation of actin cytoskeleton
    K05741  DIAPH2; diaphanous 2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K05741  DIAPH2; diaphanous 2
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Formins
     K05741  DIAPH2; diaphanous 2

Genes

HSA:	1730(DIAPH2)

PTR:	473694(DIAPH2)

PPS:	100981939(DIAPH2)

GGO:	101152796(DIAPH2)

PON:	100431376(DIAPH2)

PPYG:

129023934(DIAPH2)

NLE:	100579438(DIAPH2)

HMH:	116811128(DIAPH2)

SSYN:

129476469(DIAPH2)

MCC:	699140(DIAPH2)

MCF:	101925661(DIAPH2)

MTHB:

126945261

MNI:	105497495(DIAPH2)

CSAB:

103232331(DIAPH2)

CATY:

105592066(DIAPH2)

PANU:

101021756(DIAPH2)

TGE:	112615782(DIAPH2)

MLEU:

105544877(DIAPH2)

RRO:	104657151(DIAPH2)

TFN:	117078302(DIAPH2)

PTEH:

111536485(DIAPH2)

CANG:

105508403(DIAPH2)

CJC:	100395091(DIAPH2)

SBQ:	101035533(DIAPH2)

CIMI:

108317861(DIAPH2)

ANAN:

105725104(DIAPH2)

CSYR:

103276266(DIAPH2)

MMUR:

105856714(DIAPH2)

PCOQ:

105814908(DIAPH2)

OGA:	100942245(DIAPH2)

MMU:	54004(Diaph2)

MCAL:

110286471(Diaph2)

MPAH:

110314168(Diaph2)

RNO:	317189(Diaph2)

MCOC:

116093726(Diaph2)

ANU:	117694371(Diaph2)

ASYL:

127674882(Diaph2)

MUN:	110544494(Diaph2)

CGE:

100768845

MAUA:

101822750(Diaph2)

PROB:

127218127(Diaph2) 127218258

PLEU:

114696996

MORG:

121436627(Diaph2) 121437087

MFOT:

126491290

AAMP:

119805122(Diaph2)

NGI:	103746218(Diaph2)

HGL:	101713815(Diaph2)

CPOC:

100723370(Diaph2)

DORD:

105998959(Diaph2)

DSP:	122095527(Diaph2)

PLOP:

125344277(Diaph2)

NCAR:

124971809

MMMA:

107156234(Diaph2)

ITI:	101962413(Diaph2)

OCU:

100347936

OPI:	101534323(DIAPH2)

TUP:	106733711(DIAPH2)

GVR:	103594341(DIAPH2)

CFA:	480977(DIAPH2)

CLUD:

112649452(DIAPH2)

VVP:	112910223(DIAPH2)

VLG:	121483200(DIAPH2)

NPO:	129517681(DIAPH2)

AML:	100483532(DIAPH2)

UMR:	103673016(DIAPH2)

UAH:	113244284(DIAPH2)

UAR:

123787638

ELK:

111159173

MPUF:

101690551(DIAPH2)

MNP:	132007551(DIAPH2)

MLK:	131821123(DIAPH2)

NVS:	122897334(DIAPH2)

ORO:	101380635(DIAPH2)

EJU:	114207404(DIAPH2)

ZCA:	113930282(DIAPH2)

MLX:	118026091(DIAPH2)

NSU:	110575076(DIAPH2)

LWW:	102727555(DIAPH2)

FCA:	101081123(DIAPH2)

PYU:	121025225(DIAPH2)

PCOO:

112870724(DIAPH2)

PBG:	122477880(DIAPH2)

PVIV:

125157162(DIAPH2)

LRUF:

124509568

LGF:	123594080(DIAPH2)

AJU:

106971755

PTG:	102970758(DIAPH2)

PPAD:

109258453(DIAPH2)

PUC:

125932221

HHV:	120224971(DIAPH2)

BOM:	102287149(DIAPH2)

BIU:	109555160(DIAPH2)

BBUB:

102411583(DIAPH2)

CHX:	102191777(DIAPH2) 108635132

OAS:	101111608(DIAPH2)

BTAX:

128070104(DIAPH2)

CSUM:

138070720(DIAPH2)

ODA:	120882655(DIAPH2)

CCAD:

122434421(DIAPH2)

MREE:

136153216(DIAPH2)

OVR:	110122135(DIAPH2)

MBEZ:

129564350(DIAPH2)

SSC:	100155257(DIAPH2)

CFR:	106730767(DIAPH2)

CBAI:

105065937(DIAPH2)

CDK:	105085529(DIAPH2)

VPC:	102536750(DIAPH2)

BACU:

103018213(DIAPH2)

BMUS:

118888627(DIAPH2)

LVE:	103072122(DIAPH2)

OOR:	101276728(DIAPH2)

LALB:

132513576(DIAPH2)

DLE:	111178248(DIAPH2)

PCAD:

102996996(DIAPH2)

PSIU:

116747433(DIAPH2)

PPHC:

136142182(DIAPH2)

NASI:

112410522(DIAPH2)

ECB:	100057058(DIAPH2)

EPZ:	103560830(DIAPH2)

EAI:

106823074

MYB:	102249631(DIAPH2)

MYD:	102753630(DIAPH2)

MMYO:

118654105(DIAPH2)

MLF:	102430574(DIAPH2)

MDT:	132224276(DIAPH2)

PKL:	118720088(DIAPH2)

EFUS:

103296776(DIAPH2)

MNA:	107540140(DIAPH2)

DRO:	112321377(DIAPH2)

SHON:

118997207(DIAPH2)

AJM:	119064204(DIAPH2)

PDIC:

114504650(DIAPH2)

PHAS:

123805088(DIAPH2)

MMF:	118635684(DIAPH2)

PPAM:

129082219(DIAPH2)

HAI:	109381964(DIAPH2)

RFQ:	117023315(DIAPH2)

PALE:

102879994(DIAPH2)

PGIG:

120599947(DIAPH2)

PVP:	105299414(DIAPH2)

RAY:	107520504(DIAPH2)

TOD:

119245581

SARA:

101547425(DIAPH2)

SFUM:

130032558(DIAPH2)

SETR:

125998611(DIAPH2)

LAV:	100661482(DIAPH2)

TMU:

101361435

ETF:	101657440(DIAPH2)

DNM:	101417575(DIAPH2)

MDO:	100021927(DIAPH2)

GAS:	123253672(DIAPH2)

SHR:	100926343(DIAPH2)

AFZ:

127542304

PCW:	110192316(DIAPH2)

TVP:	118832934(DIAPH2)

PBRV:

138143966(DIAPH2)

OAA:	100081978(DIAPH2)

TACU:

119929639(DIAPH2)

GGA:	374040(DIAPH2)

PCOC:

116229664(DIAPH2)

MGP:	100539769(DIAPH2)

CJO:	107312709(DIAPH2)

TPAI:

128075769(DIAPH2)

LMUT:

125699917(DIAPH2)

NMEL:

110403000(DIAPH2)

APLA:

101790141(DIAPH2)

ACYG:

106037411(DIAPH2)

CATA:

118245605(DIAPH2)

AFUL:

116494241(DIAPH2)

TGU:	100222066(DIAPH2)

LSR:	110469593(DIAPH2)

SCAN:

103816452(DIAPH2)

PMOA:

120508687(DIAPH2)

OTC:	121331675(DIAPH2)

PRUF:

121363184(DIAPH2)

ATRC:

139597149(DIAPH2)

GFR:	102039602(DIAPH2)

FAB:	101811907(DIAPH2)

OMA:	130252928(DIAPH2)

PHI:	102099521(DIAPH2)

PMAJ:

107203813(DIAPH2)

CCAE:

111928722(DIAPH2)

CCW:	104691315(DIAPH2)

CBRC:

103623096(DIAPH2)

ACOE:

138110299(DIAPH2)

ETL:	114056039(DIAPH2)

ZAB:	102072907(DIAPH2)

ZLE:	135447664(DIAPH2)

ACHL:

103808717(DIAPH2)

SVG:	106858367(DIAPH2)

MMEA:

130583911

HRT:	120764822(DIAPH2)

SATI:

136373714(DIAPH2)

CCIC:

134050196(DIAPH2)

FPG:

101917857

FCH:	102053399(DIAPH2)

NNT:	104407769(DIAPH2)

SHAB:

115613132(DIAPH2)

ACUN:

113480195(DIAPH2)

TALA:

104369169(DIAPH2)

ACHC:

115333572(DIAPH2)

HALD:

104324506(DIAPH2)

HLE:	104834814(DIAPH2)

AGEN:

126050352

HHAR:

128153883(DIAPH2)

GCL:

127019785

CSTI:

104555605(DIAPH2)

DPUB:

104303653(DIAPH2)

PPUS:

135183891(DIAPH2)

AVIT:

104274307(DIAPH2)

BRHI:

104498125(DIAPH2)

EGZ:	104130015(DIAPH2)

NNI:	104012943(DIAPH2)

PCRI:

104031777

PADL:

103923959(DIAPH2)

AFOR:

103899478(DIAPH2)

FGA:

104079938

GSTE:

104264765

CBOY:

140658343(DIAPH2)

CLV:	102083532(DIAPH2)

CNIC:

135993312(DIAPH2)

PGUU:

104463290

PLET:

104628325(DIAPH2)

EHS:	104515286(DIAPH2)

CUCA:

104055084(DIAPH2)

TEO:

104376515

BREG:

104631160

OHA:	104331835(DIAPH2)

ACAR:

104526780(DIAPH2)

CPEA:

104388399(DIAPH2)

CVF:	104283579(DIAPH2)

RTD:	128914693(DIAPH2)

CRID:

134520407(DIAPH2)

AAM:	106496814(DIAPH2)

AROW:

112974080(DIAPH2)

NPD:	112944518(DIAPH2)

TGT:	104576450(DIAPH2)

DNE:	112991193(DIAPH2)

SCAM:

104150542(DIAPH2)

ASN:

102384216

AMJ:	102574037(DIAPH2)

CPOO:

109311034(DIAPH2)

GGN:	109300341(DIAPH2)

PSS:	102451814(DIAPH2)

CMY:	102935095(DIAPH2)

DCC:	119860939(DIAPH2)

CPIC:

101942340(DIAPH2)

TST:	117882639(DIAPH2)

CABI:

116816963(DIAPH2)

MRV:	120371717(DIAPH2)

ACS:	100563358(diaph2)

ASAO:

132763051(DIAPH2)

PVT:	110083895(DIAPH2)

SUND:

121936168(DIAPH2)

PBI:	103061750(DIAPH2)

PMUR:

107295434

CTIG:

120302141(DIAPH2)

TSR:

106545675

PGUT:

117665123(DIAPH2)

APRI:

131183843(DIAPH2)

PTEX:

113437787(DIAPH2)

NSS:	113416730(DIAPH2)

VKO:	123021955(DIAPH2)

PMUA:

114589056(DIAPH2)

PRAF:

128406799(DIAPH2)

ZVI:	118084125(DIAPH2)

HCG:	128335723(DIAPH2)

GJA:	107111172(DIAPH2)

STOW:

125442969(DIAPH2)

EMC:	129341046(DIAPH2)

XLA:	108698412(diaph2.L)

XTR:	100485481(diaph2)

NPR:	108804499(DIAPH2)

RTEM:

120914357(DIAPH2)

ACAT:

141107423(DIAPH2)

BBUF:

121009313(DIAPH2)

BGAR:

122919660(DIAPH2)

DTC:	141101046(DIAPH2)

PWL:	138265410(DIAPH2)

MUO:	115474951(DIAPH2)

GSH:	117360664(DIAPH2)

DRE:	556029(diaph2)

SRX:	107724831 107740173

SANH:

107680956 107690091

SGH:	107554827 107593228

CAUA:

113075386 113114122(diaph2)

CGIB:

127971609 128027467

PPRM:

120466018(diaph2)

RKG:	130103916(diaph2)

MAMB:

125259146(diaph2)

CIDE:

127494738

MASI:

127412971 127418368

MANU:

129422325(diaph2)

PDAB:

135758408(diaph2)

IPU:

108268820

PHYP:

113528845(diaph2)

SMEO:

124385805(diaph2)

TFD:	113635934(diaph2)

AMEX:

103033019(diaph2)

EEE:	113583144 113588371(diaph2)

CHAR:

105912581(diaph2)

SPIL:

134068513(diaph2)

TRU:	101072858(diaph2)

TFS:	130530795(diaph2)

TNG:	GSTEN00029289G001

LCO:	104919882(diaph2)

NCC:

104965380

CGOB:

115015013

EMAC:

134859617(diaph2)

ELY:	117261304(diaph2)

EFO:	125894001(diaph2)

PLEP:

121947914(diaph2)

SLUC:

116052278(diaph2)

ECRA:

117952144(diaph2)

ESP:	116696493(diaph1) 116696701(diaph2)

PFLV:

114562593(diaph2)

GAT:	120817217(diaph2)

PPUG:

119210650(diaph2)

AFB:	129089944(diaph2)

CLUM:

117737218(diaph2)

PSWI:

130210227(diaph2)

CANA:

137795008(diaph2)

CVE:	137875674(diaph2)

MSAM:

119888715(diaph2)

SCHU:

122880789(diaph2)

CUD:	121515995(diaph2)

SPUL:

138597910(diaph2)

LMIX:

132982170(diaph2)

ALAT:

119007021(diaph2)

ASTR:

137602470(diaph2)

MZE:	101472795(diaph2)

ONL:	100712010(diaph2)

OAU:	116317603(diaph2)

OLA:	101156584(diaph2)

OML:	112153214(diaph2)

CSAI:

133447183(diaph2)

XMA:	102221132(diaph2)

XCO:	114138829(diaph2)

XHE:	116714036(diaph2)

PRET:

103471532(diaph2)

PFOR:

103155363

PLAI:

106961172

PMEI:

106920028(diaph2)

GAF:	122837092(diaph2)

PPRL:

129360700 129360704

CVG:	107093667(diaph2)

CTUL:

119781017(diaph2)

GMU:	124860049(diaph2)

NFU:	107377717(diaph2)

KMR:	108231325(diaph2)

ALIM:

106514008(diaph2)

NWH:	119408396(diaph2)

AOCE:

111569106(diaph2)

EJA:	138211021(diaph2)

BFRE:

138618491(diaph2)

MCEP:

125007769(diaph2)

CSEM:

103390522(diaph2)

POV:	109626973(diaph2)

SSEN:

122778393(diaph2)

SSOE:

131472353(diaph2)

HHIP:

117768816(diaph2)

HSP:	118111926(diaph2)

PPLT:

128445447(diaph2)

SMAU:

118319008(diaph2)

LCF:

108895383

SDU:	111232382(diaph2)

SLAL:

111648187(diaph2)

XGL:	120785189(diaph2)

HCQ:

109515815

SSCV:

125984584(diaph2)

SBIA:

133508337(diaph2)

PEE:	133408169(diaph2)

PTAO:

133484794(diaph2)

BPEC:

110158866(diaph2)

ENY:	140350173(diaph2)

MALB:

109955274(diaph2)

BSPL:

114864153(diaph2)

SJO:	128363404(diaph2)

SSCO:

133985407(diaph2)

GMH:	115552397(diaph2)

SASA:

106591129 106604453 106611507 106611857

STRU:

115169876 115205051

OTW:	112221093(diaph2) 112256388

OMY:	110487748(diaph2) 110505192

OGO:	123993574(diaph2) 124011136

ONE:	115129597 115130864

OKI:	109904740 109910174

OKE:	118363647 118384044(diaph2)

OMM:	135526552 135545985

OCLA:

139366406 139391116

SALP:

111965882 111967632 112069830

SNH:	120047999(diaph2) 120061859

CCLU:

121535952 121540695

ELS:	105025903(diaph2)

OEP:	134032220(diaph2)

SFM:	108922942(diaph2)

PKI:	111835022(diaph2)

AANG:

118222415(diaph2)

AROT:

135251671(diaph2)

CCOG:

133123953(diaph2)

LOC:	102689729(diaph2)

PSPA:

121295178 121317874(diaph2)

ARUT:

117411924 117430578(diaph2)

PSEX:

120537229(diaph2)

LCM:	102357930(DIAPH2)

CMK:	103177616(diaph2) 103178647

CPLA:

122557143(diaph2)

HOC:	132820465(diaph2) 132823514

LERI:

129702237(diaph2)

HAKA:

140734453(diaph2)

PMRN:

LRJ:

BFO:

CIN:

SCLV:

SPU:

APLC:

AJC:

SKO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139105334(Dia)

TLN:	139825402(Dia)

HST:

DQU:

CFO:

FEX:

PMEC:

138940264(Dia)

LHU:	105673157(dia)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124217372(dia)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138128990(dia)

DPA:

109533699

ESIM:

136419552(dia)

EFOR:

136344810(dia)

ATD:

HAXR:

DVV:

NVL:

BMOR:

BMAN:

MSEX:

DPL:	KGM_203185 KGM_203186B

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137923106(dia)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

API:

DNX:

AGS:

RMD:

ACOO:

BTAB:

CLEC:

PHU:	Phum_PHUM368970

ZNE:

110831772

CSEC:

111868757

PAME:

138706267(dia)

BROR:

134529588

HAMR:

139687526(dia)

FCD:

110851323

DPX:	DAPPUDRAFT_220427

PVM:

PTRU:

ESN:

TUT:

DPTE:

PMEO:

CEL:	CELE_F11H8.4(cyk-1)

CBR:	CBG_16504(Cbr-cyk-1)

NAI:	NECAME_08887

LOA:	LOAG_16894

TSP:

Tsp_02047

HRO:	HELRODRAFT_192510

LGI:	LOTGIDRAFT_142208

PCAN:

LSAX:

HCRA:

DPOL:

MAEA:

OBI:

OSN:

LAK:	106150523 106165794

SMM:	Smp_068720

SHX:	MS3_00006343(DIAPH1)

EGL:

EGR_01611

LLON:

135493979

NVE:	5500494 5506749

MCAZ:

138015032

MFOO:

137999582

PDAM:

113671256

TAD:	TRIADDRAFT_60005

AQU:

100641591

SRE:	PTSG_06844

» show all

Reference

PMID:12577064

Authors

Gasman S, Kalaidzidis Y, Zerial M

Title

RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase.

Journal

Nat Cell Biol 5:195-204 (2003)
DOI:10.1038/ncb935

Sequence

[hsa:1730]

LinkDB

DBGET integrated database retrieval system