KEGG ORTHOLOGY: K05871

ORTHOLOGY: K05871

Entry

K05871                      KO

Symbol

PTK2B, FAK2

Name

focal adhesion kinase 2 [EC:2.7.10.2]

Pathway

map04020

Calcium signaling pathway

map04062

Chemokine signaling pathway

map04072

Phospholipase D signaling pathway

map04650

Natural killer cell mediated cytotoxicity

map04670

Leukocyte transendothelial migration

map04912

GnRH signaling pathway

map05135

Yersinia infection

map05161

Hepatitis B

map05163

Human cytomegalovirus infection

map05170

Human immunodeficiency virus 1 infection

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K05871  PTK2B, FAK2; focal adhesion kinase 2
   04072 Phospholipase D signaling pathway
    K05871  PTK2B, FAK2; focal adhesion kinase 2
09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K05871  PTK2B, FAK2; focal adhesion kinase 2
   04670 Leukocyte transendothelial migration
    K05871  PTK2B, FAK2; focal adhesion kinase 2
   04062 Chemokine signaling pathway
    K05871  PTK2B, FAK2; focal adhesion kinase 2
  09152 Endocrine system
   04912 GnRH signaling pathway
    K05871  PTK2B, FAK2; focal adhesion kinase 2
09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K05871  PTK2B, FAK2; focal adhesion kinase 2
   05161 Hepatitis B
    K05871  PTK2B, FAK2; focal adhesion kinase 2
   05163 Human cytomegalovirus infection
    K05871  PTK2B, FAK2; focal adhesion kinase 2
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K05871  PTK2B, FAK2; focal adhesion kinase 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05871  PTK2B, FAK2; focal adhesion kinase 2
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K05871  PTK2B, FAK2; focal adhesion kinase 2
Protein kinases [BR:ko01001]
Non-receptor tyrosine kinases
  FAK family
   K05871  PTK2B, FAK2; focal adhesion kinase 2

Other DBs

GO:

0004715

Genes

HSA:	2185(PTK2B)

PTR:	464073(PTK2B)

PPS:	100991936(PTK2B)

GGO:	101135800(PTK2B)

PON:	100174613(PTK2B)

PPYG:

129043148(PTK2B)

NLE:	100599503(PTK2B)

HMH:	116461989(PTK2B)

SSYN:

129491434(PTK2B)

MCC:	712787(PTK2B)

MCF:	102130539(PTK2B)

MTHB:

126961760

MNI:	105482017(PTK2B)

CSAB:

103215524(PTK2B)

CATY:

105579176(PTK2B)

PANU:

101023887(PTK2B)

TGE:	112630290(PTK2B)

MLEU:

105542344(PTK2B)

RRO:	104673947(PTK2B)

RBB:	108537591(PTK2B)

TFN:	117093809(PTK2B)

PTEH:

111545732(PTK2B)

CANG:

105513663(PTK2B)

CJC:	100404210(PTK2B)

SBQ:	101032561(PTK2B)

CIMI:

108312440(PTK2B)

ANAN:

105705327(PTK2B)

CSYR:

103251411(PTK2B)

MMUR:

105877126(PTK2B)

LCAT:

123626648(PTK2B)

PCOQ:

105825274(PTK2B)

OGA:	100959766(PTK2B)

MMU:	19229(Ptk2b)

MCAL:

110308944(Ptk2b)

MPAH:

110325924(Ptk2b)

RNO:	50646(Ptk2b)

MCOC:

116085323(Ptk2b)

ANU:	117705222(Ptk2b)

MUN:	110559230(Ptk2b)

CGE:	100758086(Ptk2b)

MAUA:

101835508(Ptk2b)

PROB:

127230243(Ptk2b)

PLEU:

114707316(Ptk2b)

MORG:

121455807(Ptk2b)

MFOT:

126507587

AAMP:

119799720(Ptk2b)

NGI:	103730003(Ptk2b)

HGL:	101714384(Ptk2b)

CPOC:

100734027(Ptk2b)

CCAN:

109698054(Ptk2b)

DORD:

105991587(Ptk2b)

DSP:	122123482(Ptk2b)

PLOP:

125339296(Ptk2b)

NCAR:

124982353

MMMA:

107153900(Ptk2b)

OCU:

100342358

OPI:	101526211(PTK2B)

TUP:	102481841(PTK2B)

GVR:	103595200(PTK2B)

CFA:	486102(PTK2B)

CLUD:

112669698(PTK2B)

VVP:	112926788(PTK2B)

VLG:	121497328(PTK2B)

NPO:	129523357(PTK2B)

AML:	100478801(PTK2B)

UMR:	103675966(PTK2B)

UAH:	113269957(PTK2B)

UAR:	123777394(PTK2B)

ELK:

111153692

LLV:

125092973

MPUF:

101688546(PTK2B)

MNP:	131999727(PTK2B)

MLK:	131833269(PTK2B)

NVS:	122889648(PTK2B)

ORO:	101373391(PTK2B)

EJU:	114217420(PTK2B)

ZCA:	113924963(PTK2B)

MLX:	118022110(PTK2B)

NSU:	110588553(PTK2B)

LWW:

102736119

FCA:	101091691(PTK2B)

PYU:	121022204(PTK2B)

PCOO:

112858915(PTK2B)

PBG:	122473846(PTK2B)

PVIV:

125163560(PTK2B)

LRUF:

124520193

PTG:	102955963(PTK2B)

PPAD:

109262338(PTK2B)

PUC:

125923801

AJU:

106973108

HHV:	120220289(PTK2B)

BTA:	541008(PTK2B)

BOM:	102266592(PTK2B)

BIU:	109563157(PTK2B)

BBUB:

102411722(PTK2B)

BBIS:

104988719(PTK2B)

CHX:	102184810(PTK2B)

OAS:	101106906(PTK2B)

BTAX:

128052409(PTK2B)

ODA:	120860357 120866066

CCAD:

122431820(PTK2B)

MBEZ:

129556920(PTK2B)

SSC:	100157507(PTK2B)

CFR:	102520664(PTK2B)

CBAI:

105063850(PTK2B)

CDK:	105102240(PTK2B)

VPC:	102535738(PTK2B)

BACU:

103016023(PTK2B)

BMUS:

118896881(PTK2B)

LVE:	103083166(PTK2B)

OOR:	101281402(PTK2B)

DLE:	111185408(PTK2B)

PCAD:

102995810(PTK2B)

PSIU:

116755418(PTK2B)

NASI:

112414976(PTK2B)

ECB:	100054547(PTK2B)

EPZ:	103550428(PTK2B)

EAI:	106832511(PTK2B)

MYB:	102256791(PTK2B)

MYD:	102756394(PTK2B)

MMYO:

118659060(PTK2B)

MLF:	102442091(PTK2B)

MDT:	132235324(PTK2B)

PKL:	118710950(PTK2B)

EFUS:

103294332(PTK2B)

MNA:	107538557(PTK2B)

DRO:	112312413(PTK2B)

SHON:

118984359(PTK2B)

AJM:	119044625(PTK2B)

PDIC:

114502461(PTK2B)

PHAS:

123814030(PTK2B)

MMF:	118615360(PTK2B)

PPAM:

129072531(PTK2B)

HAI:	109379535(PTK2B)

RFQ:	117037602(PTK2B)

PALE:

102886432(PTK2B)

PGIG:

120613198(PTK2B)

PVP:	105292221(PTK2B)

RAY:	107515459(PTK2B)

MJV:	108394326(PTK2B)

TOD:	119258011(PTK2B)

SARA:

101544808(PTK2B)

SETR:

126006104(PTK2B)

LAV:	100667505(PTK2B)

TMU:

101354947

ETF:	101661831(PTK2B)

DNM:	101440141(PTK2B)

MDO:	100025175(PTK2B)

GAS:	123237099(PTK2B)

SHR:	100923387(PTK2B)

AFZ:

127548792

PCW:	110206529(PTK2B)

TVP:	118843207(PTK2B)

OAA:	100085161(PTK2B)

GGA:	421998(PTK2B)

PCOC:

116235641(PTK2B)

MGP:	100549921(PTK2B)

CJO:	107312386(PTK2B)

TPAI:

128084692(PTK2B)

LMUT:

125689756(PTK2B)

NMEL:

110395785(PTK2B)

ACYG:

106049520(PTK2B)

CATA:

118259056(PTK2B)

AFUL:

116487529(PTK2B)

LSR:	110477410(PTK2B)

PMOA:

120503435(PTK2B)

OTC:

121341216

FAB:	101806020(PTK2B)

PHI:	102099730(PTK2B)

PMAJ:

107199198

CCAE:

111927477(PTK2B)

CBRC:

103611216(PTK2B)

ZLE:	135446305(PTK2B)

ACHL:

103812159(PTK2B)

SVG:	106860376(PTK2B)

FPG:	101919541(PTK2B)

FCH:	102058792(PTK2B)

CCRI:

104164311(PTK2B)

NNT:	104407198(PTK2B)

SHAB:

115609824(PTK2B)

ACUN:

113478314(PTK2B)

TALA:

116959317(PTK2B)

ACHC:

115351243(PTK2B)

HLE:	104841481(PTK2B)

AGEN:

126046526

GCL:

127015229

CSTI:

104555780(PTK2B)

DPUB:

104306721(PTK2B)

AVIT:

104281029(PTK2B)

BRHI:

104500477(PTK2B)

EGZ:	104132028(PTK2B)

NNI:	104014715(PTK2B)

PCRI:

104027161(PTK2B)

AFOR:

103895523(PTK2B)

CLV:	102085172(PTK2B)

MUI:	104541088(PTK2B)

PGUU:

104462502(PTK2B)

EHS:	104508908(PTK2B)

CUCA:

104061781(PTK2B)

TEO:	104376880(PTK2B)

OHA:	104329906(PTK2B)

ACAR:

104518097(PTK2B)

CPEA:

104392787(PTK2B)

CVF:	104295692(PTK2B)

RTD:	128907579(PTK2B)

AAM:	106486362(PTK2B)

AROW:

112966660(PTK2B)

NPD:	112948924(PTK2B)

TGT:	104578163(PTK2B)

DNE:	112993186(PTK2B)

SCAM:

104154089(PTK2B)

ASN:	102383255(PTK2B)

AMJ:	102569140(PTK2B)

CPOO:

109311565(PTK2B)

PSS:	102461932(PTK2B)

CMY:	102944545(PTK2B)

CCAY:

125634745(PTK2B)

DCC:	119852626(PTK2B)

CPIC:

101946809(PTK2B)

TST:	117875441(PTK2B)

CABI:

116830885(PTK2B)

MRV:	120400397(PTK2B)

ACS:	100563957(ptk2b)

ASAO:

132761642(PTK2B)

PVT:	110089495(PTK2B)

SUND:

121921082(PTK2B)

PBI:	103053129(PTK2B)

PMUR:

107293495(PTK2B)

CTIG:

120309118(PTK2B)

TSR:

106543337

PGUT:

117667683(PTK2B)

APRI:

131189001(PTK2B)

PTEX:

113446316(PTK2B)

NSS:	113414579(PTK2B)

VKO:	123033644(PTK2B)

PMUA:

114594952(PTK2B)

PRAF:

128411461(PTK2B)

ZVI:	118082945(PTK2B)

HCG:	128324699(PTK2B)

GJA:	107111937(PTK2B)

STOW:

125444273(PTK2B)

EMC:	129335860(PTK2B)

XLA:	108717254(ptk2b.L) 108718305(ptk2b.S)

XTR:	496459(ptk2b)

NPR:

108801309

RTEM:

120936042(PTK2B)

BBUF:

120997154(PTK2B)

BGAR:

122936340(PTK2B)

MUO:	115467030(PTK2B)

GSH:	117357009(PTK2B)

DRE:	245950(ptk2bb) 557258(ptk2ba)

SRX:	107707077 107733482(ptk2b)

SANH:

107653750 107692419 107697310 107701495

SGH:	107552084(ptk2b) 107563684 107589060 107594075

CCAR:

109103027 109106793(ptk2b) 109113399

CAUA:

113060836 113091776 113097198 113117730 113121041 113121042

CGIB:

127938895 127976309 127983888 128031808

PTET:

122343211 122362180(ptk2ba)

LROH:

127179473(ptk2ba) 127183199(ptk2bb)

OMC:	131522807(ptk2ba) 131526926(ptk2bb)

PPRM:

120470523(ptk2bb) 120480831(ptk2ba)

RKG:	130088952(ptk2ba) 130097563(ptk2bb)

MAMB:

125268325(ptk2ba) 125277755(ptk2bb)

CIDE:

127499105 127502502

CERY:

137006698(ptk2ba) 137018848(ptk2bb)

MASI:

127409784 127411419 127455323

TROS:

130560132(ptk2ba) 130565649(ptk2bb)

TDW:	130434320(ptk2bb) 130436856(ptk2ba)

MANU:

129417672(ptk2ba) 129429005(ptk2bb)

IPU:	108258133(ptk2bb) 108270138(ptk2ba)

IFU:	128601246(ptk2bb) 128612220(ptk2ba)

PHYP:

113538681(ptk2b) 113545212

SMEO:

124376976(ptk2bb) 124389721(ptk2ba)

TFD:	113644777(ptk2bb) 113659549(ptk2ba)

TVC:	132843328(ptk2bb) 132852357(ptk2ba)

TRN:	134320875(ptk2bb) 134325823(ptk2ba)

AMEX:

103031863(ptk2bb) 103036889(ptk2ba)

CMAO:

118815521(ptk2bb) 118823514(ptk2ba)

EEE:	113572664(ptk2b) 113573003

CHAR:

105895697(ptk2ba) 105897727(ptk2bb)

TRU:	101066596(ptk2b) 101067972

TFS:	130515673(ptk2bb) 130523181

TNG:	GSTEN00027121G001 GSTEN00030312G001

LCO:	104922431(ptk2b) 104929121

NCC:	104964448(ptk2b)

TBEN:

117492574(ptk2bb) 117499048

CGOB:

115003734(ptk2b) 115017135

PGEO:

117439984(ptk2bb) 117460188

GACU:

117533772(ptk2bb) 117546892

EMAC:

134860757 134876646(ptk2bb)

ELY:	117255568 117270872(ptk2bb)

EFO:	125884879 125896531(ptk2bb)

PLEP:

121955332 121962660

SLUC:

116044716 116066076(ptk2bb)

ECRA:

117939207 117961384(ptk2bb)

ESP:	116673744 116706211(ptk2b)

PFLV:

114550829 114572960(ptk2b)

GAT:	120808070(ptk2bb) 120824977

PPUG:

119194952(ptk2bb) 119221937

AFB:	129107377(ptk2bb) 129111585

CLUM:

117727328(ptk2bb) 117743579

PSWI:

130202125(ptk2bb) 130204622

MSAM:

119887582 119902997 119908914(ptk2bb)

SCHU:

122863255(ptk2bb) 122871805

CUD:	121506250 121521567(ptk2bb)

ALAT:

119012956(ptk2bb) 119015368

MZE:	101466145 101469888(ptk2b)

ONL:	100691138(ptk2b) 100702843

OAU:	116314090(ptk2bb) 116327901

OLA:	101166779 101168007(ptk2b)

OML:	112138372 112157942(ptk2bb)

CSAI:

133418528(ptk2bb) 133425339

XMA:	102220254(ptk2b) 102237728

XCO:	114137677 114158618(ptk2b)

XHE:	116715778 116734185

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122825179(ptk2bb) 122826862

PPRL:

129351157(ptk2bb) 129355414

CVG:	107083800(ptk2b) 107092212

CTUL:

119785101(ptk2bb) 119793630

GMU:	124861361 124881821(ptk2bb)

NFU:	107380902 107397038(ptk2b)

KMR:	108242464(ptk2bb) 108244129

ALIM:

106525285(ptk2b) 106529652

NWH:	119418531(ptk2bb) 119428711

AOCE:

111585687 111587153(ptk2b)

MCEP:

124998729(ptk2bb) 125000744

CSEM:

103389360 103398680

POV:	109636011 109640090

SSEN:

122784027(ptk2bb)

HHIP:

117758326(ptk2bb) 117772460

HSP:	118099834(ptk2bb) 118103620

PPLT:

128430878 128460416(ptk2bb)

SMAU:

118289928(ptk2bb) 118301915

LCF:	108892923 108895601(ptk2bb)

SDU:	111237992 111239921

SLAL:

111652662 111665302

XGL:	120788723(ptk2bb) 120798377

HCQ:	109520887 109524920(ptk2b)

SSCV:

125988876 125990611

SBIA:

133492446 133496510(ptk2bb)

PEE:	133411001 133417259(ptk2bb)

PTAO:

133467880(ptk2bb) 133490120

BPEC:

110166006 110175523(ptk2b)

MALB:

109960575 109970009

BSPL:

114849564(ptk2bb) 114851144

SJO:	128354547(ptk2ba)

SASA:

106571025(ptk2b) 106603693 106608317

STRU:

115147339 115172956 115175167

OTW:	112235635 112236672 112262237

OMY:	110498235(ptk2ba) 110522644 110529162

OGO:	123990476 124001761(ptk2ba) 124019145

ONE:	115110872 115120329 115123001(ptk2b)

OKI:	109879499 109883186 109887799

OKE:	118377175 118377755

SNH:	120019200 120024469 120060127

CCLU:

121539063(ptk2ba) 121552414 121556174(ptk2bb)

ELS:	105007684 105028736

SFM:	108924101 108934847

PKI:	111841315 111857950

AANG:

118229639(ptk2bb)

LOC:	102695443(ptk2b)

PSPA:

121316233 121317355(ptk2ba)

ARUT:

117402900 117411343

PSEX:

120526386(ptk2ba)

LCM:	102364762(PTK2B)

RTP:	109915589(ptk2ba)

HOC:	132819612(ptk2ba)

LERI:

129699358(ptk2ba)

OVI:	T265_13813

EPA:

110254117

» show all

Reference

PMID:7544443

Authors

Lev S, Moreno H, Martinez R, Canoll P, Peles E, Musacchio JM, Plowman GD, Rudy B, Schlessinger J

Title

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions.

Journal

Nature 376:737-45 (1995)
DOI:10.1038/376737a0

Sequence

[hsa:2185]

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