KEGG ORTHOLOGY: K07419

ORTHOLOGY: K07419

Entry

K07419                      KO

Symbol

CYP2R1

Name

vitamin D 25-hydroxylase [EC:1.14.14.24]

Pathway

map00100

Steroid biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00103

Cholecalciferol biosynthesis

Reaction

R03611

calciol,NADPH-hemoprotein reductase:oxygen oxidoreductase (25-hydroxylating)

Disease

H01143

Vitamin D-dependent rickets

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K07419  CYP2R1; vitamin D 25-hydroxylase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07419  CYP2R1; vitamin D 25-hydroxylase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.24  vitamin D 25-hydroxylase
     K07419  CYP2R1; vitamin D 25-hydroxylase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP2 family
   K07419  CYP2R1; vitamin D 25-hydroxylase

Other DBs

GO:

0030343

Genes

HSA:	120227(CYP2R1)

PTR:	451042(CYP2R1)

PPS:	100973299(CYP2R1)

GGO:

PON:

PPYG:

NLE:

HMH:

SSYN:

MCC:	698834(CYP2R1)

MCF:	102138775(CYP2R1)

MTHB:

126936604

MNI:

105486927

CSAB:

103239784(CYP2R1)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100394527(CYP2R1)

SBQ:

101037293

CIMI:

108302167(CYP2R1)

ANAN:

105720230(CYP2R1)

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:

MMU:	244209(Cyp2r1)

MCAL:

110298348

MPAH:

110332047

RNO:	361631(Cyp2r1)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

OCU:

OPI:

TUP:

GVR:

CFA:	612993(CYP2R1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:	113246269 130541824 130541833

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101093889(CYP2R1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	541302(CYP2R1)

BOM:

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

ODA:

CCAD:

MBEZ:

SSC:	100124375(CYP2R1)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100146381(CYP2R1)

EPZ:

EAI:

MYB:

MYD:

MMYO:

MLF:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:

OAA:

GGA:	423065(CYP2R1)

PCOC:

116242990

MGP:	100547524 104910999

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCW:

CBRC:

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

FPG:

FCH:

CLV:

EGZ:

NNI:

PCRI:

PLET:

EHS:

PCAO:

ACUN:

TALA:

PADL:

AFOR:

ACHC:

HALD:

HLE:

AGEN:

GCL:

CCRI:

CSTI:

CMAC:

MUI:

BREG:

FGA:

GSTE:

LDI:

MNB:

OHA:

NNT:

SHAB:

DPUB:

PGUU:

ACAR:

CPEA:

AVIT:

CVF:

RTD:

CUCA:

TEO:

BRHI:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102564928(CYP2R1)

CPOO:

GGN:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	108713716(cyp2r1.L) 108715308(cyp2r1.S)

XTR:	100127674(cyp2r1)

NPR:

RTEM:

BBUF:

BGAR:

MUO:

GSH:

DRE:	563369(cyp2r1)

SRX:

107750548

SANH:

107688167 107700616

SGH:	107585944 107594282

CCAR:

CAUA:

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

MASI:

TROS:

TDW:

MANU:

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

TRU:

TFS:

TNG:	GSTEN00017808G001

LCO:

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

MCEP:

CSEM:

POV:

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

MALB:

BSPL:

SJO:

SASA:

STRU:

OTW:	112235131 112263818

OMY:	110506679 110526546

OGO:	124033625 124035615

ONE:	115116668 115121138

OKI:	109874864 109895334

OKE:	118371435 118372852

SALP:

111969491 111975524

SNH:	120025336 120056899

CCLU:

121556199 121582909

ELS:

105022275

SFM:	108934550 108940274

PKI:

AANG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

SCLV:

LPIC:

BCOO:

DSV:

RSAN:

UDV:

SDM:

CRQ:	GCK72_015232

HRF:

124143094

MMER:

123525246 123537876 123537877

RPHI:

132725786 132754871

MAEA:

128206018 128232545 128239806

LLON:

135483451

» show all

Reference

PMID:15465040

Authors

Shinkyo R, Sakaki T, Kamakura M, Ohta M, Inouye K

Title

Metabolism of vitamin D by human microsomal CYP2R1.

Journal

Biochem Biophys Res Commun 324:451-7 (2004)
DOI:10.1016/j.bbrc.2004.09.073

Reference

PMID:12867411

Authors

Cheng JB, Motola DL, Mangelsdorf DJ, Russell DW

Title

De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase.

Journal

J Biol Chem 278:38084-93 (2003)
DOI:10.1074/jbc.M307028200

Sequence

[hsa:120227] [mmu:244209]

LinkDB

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