KEGG ORTHOLOGY: K07861

ORTHOLOGY: K07861

Entry

K07861                      KO

Symbol

RAC3

Name

Ras-related C3 botulinum toxin substrate 3

Pathway

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04024

cAMP signaling pathway

map04062

Chemokine signaling pathway

map04071

Sphingolipid signaling pathway

map04310

Wnt signaling pathway

map04360

Axon guidance

map04370

VEGF signaling pathway

map04510

Focal adhesion

map04520

Adherens junction

map04650

Natural killer cell mediated cytotoxicity

map04662

B cell receptor signaling pathway

map04664

Fc epsilon RI signaling pathway

map04810

Regulation of actin cytoskeleton

map05135

Yersinia infection

map05163

Human cytomegalovirus infection

map05170

Human immunodeficiency virus 1 infection

map05200

Pathways in cancer

map05210

Colorectal cancer

map05212

Pancreatic cancer

map05231

Choline metabolism in cancer

map05416

Viral myocarditis

map05418

Fluid shear stress and atherosclerosis

Disease

H02535

Neurodevelopmental disorder with dysmorphic facies

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   04014 Ras signaling pathway
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   04015 Rap1 signaling pathway
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   04310 Wnt signaling pathway
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   04370 VEGF signaling pathway
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   04071 Sphingolipid signaling pathway
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   04024 cAMP signaling pathway
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   04520 Adherens junction
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   04662 B cell receptor signaling pathway
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   04664 Fc epsilon RI signaling pathway
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   04062 Chemokine signaling pathway
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
  09158 Development and regeneration
   04360 Axon guidance
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   05231 Choline metabolism in cancer
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
  09162 Cancer: specific types
   05210 Colorectal cancer
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   05212 Pancreatic cancer
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   05163 Human cytomegalovirus infection
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
   05416 Viral myocarditis
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3
GTP-binding proteins [BR:ko04031]
Small (monomeric) G-proteins
  Rho Family
   Rac/Cdc42 [OT]
    K07861  RAC3; Ras-related C3 botulinum toxin substrate 3

Genes

HSA:	5881(RAC3)

PTR:	747131(RAC3)

PPS:	100988790(RAC3)

GGO:	129533953(RAC3)

PON:	112129584(RAC3)

PPYG:

129017182(RAC3)

NLE:	100602123(RAC3)

HMH:	116483790(RAC3)

SSYN:

129461962(RAC3)

MCC:	719305(RAC3)

MCF:	102143597(RAC3)

MTHB:

126939124

MNI:	105469394(RAC3)

CSAB:

103243748(RAC3)

CATY:

105588572(RAC3)

PANU:

101011983(RAC3)

TGE:	112609500(RAC3)

MLEU:

105531520(RAC3)

RRO:	104654979(RAC3)

RBB:	108534092(RAC3)

TFN:	117066362(RAC3)

PTEH:

111527658(RAC3)

CANG:

105527815(RAC3)

CJC:	100400756(RAC3)

SBQ:	101046124(RAC3)

CIMI:

108301641(RAC3)

ANAN:

105717512(RAC3)

CSYR:

103251325(RAC3)

MMUR:

105878067(RAC3)

LCAT:

123650723(RAC3)

ERUF:

138391813(RAC3)

PCOQ:

105820016(RAC3)

OGA:	100948274(RAC3)

MMU:	170758(Rac3)

MCAL:

110305163(Rac3)

MPAH:

110331528(Rac3)

RNO:	688319(Rac3)

MCOC:

116077969(Rac3)

ANU:	117710799(Rac3)

ASYL:

127694194(Rac3)

MUN:	110548820(Rac3)

CGE:	100757479(Rac3)

MAUA:

101835840(Rac3)

PROB:

127220446(Rac3)

PLEU:

114680645(Rac3)

PMAV:

102912285(Rac3)

MORG:

121444055 121444624

MFOT:

126500329

AAMP:

119812100(Rac3)

HGL:	101723777(Rac3)

CPOC:

100736181(Rac3)

CCAN:

109702872(Rac3)

DORD:

105998414(Rac3)

DSP:	122099403(Rac3)

DMER:

138833207(Rac3)

PLOP:

125365137(Rac3)

NCAR:

124980331

MMMA:

107157825(Rac3)

ITI:	101960404(Rac3)

OPI:	101529472(RAC3)

OCZ:	121162607(RAC3)

TUP:	102494727(RAC3)

GVR:	103593345(RAC3)

CFA:	106559217(RAC3)

CLUD:

112672959(RAC3)

VVP:	112920582(RAC3)

VLG:	121473005(RAC3)

NPO:	129513923(RAC3)

AML:	100468971(RAC3)

UMR:	103666008(RAC3)

UAH:	113244670(RAC3)

UAR:	123777961(RAC3)

ELK:

111160304

LLV:

125086620

MPUF:

101688258(RAC3)

MNP:	132004336(RAC3)

MLK:	131816825(RAC3)

NVS:	122905874(RAC3)

ORO:	101374128(RAC3)

EJU:	114216204(RAC3)

ZCA:	113908122(RAC3)

MLX:	118024428(RAC3)

NSU:	110572418(RAC3)

LWW:	102746808(RAC3)

FCA:	101080496(RAC3)

PYU:	121018087(RAC3)

PBG:	122485969(RAC3)

PVIV:

125151943(RAC3)

LRUF:

124522479

LGF:	123604163(RAC3)

AJU:

106986311

PTG:	102955504(RAC3)

PPAD:

109277132(RAC3)

PUC:

125927618

PLEZ:

122206155(RAC3)

HHV:	120228188(RAC3)

BTA:	619066(RAC3)

BOM:	102286986(RAC3)

BIU:	109574290(RAC3)

BBIS:

105000595(RAC3)

CHX:	102178569(RAC3)

OAS:	101112406(RAC3)

BTAX:

128065663(RAC3)

CSUM:

138083185(RAC3)

ODA:	120866883(RAC3)

CCAD:

122438676(RAC3)

MREE:

136150285(RAC3)

OVR:	110145957(RAC3)

MBEZ:

129544591(RAC3)

SSC:	110255928(RAC3)

CFR:	102508710(RAC3)

CBAI:

105065540(RAC3)

CDK:	105102215(RAC3)

VPC:	102545613(RAC3)

BACU:

103019253(RAC3)

LVE:	103079514(RAC3)

OOR:	101278177(RAC3)

LALB:

132510676(RAC3)

DDP:	132414828(RAC3)

DLE:	111182681(RAC3)

PCAD:

102992553(RAC3)

PSIU:

116745822(RAC3)

PPHC:

136138781(RAC3)

NASI:

112410198(RAC3)

ECB:	100054738(RAC3)

EPZ:	103551104(RAC3)

EAI:	106846070(RAC3)

MYB:	102249503(RAC3)

MYD:	102760578(RAC3)

MMYO:

118671203(RAC3)

MDT:	132219231(RAC3)

MYUM:

138993894(RAC3)

PKL:	118704565(RAC3)

EFUS:

103298339(RAC3)

MNA:	107539040(RAC3)

DRO:	112298813(RAC3)

SHON:

119002854(RAC3)

AJM:	119058595(RAC3)

PDIC:

114503040(RAC3)

PHAS:

123817374(RAC3)

MMF:	118634237(RAC3)

PPAM:

129086649(RAC3)

HAI:	109393041(RAC3)

RFQ:	117012711(RAC3)

PALE:

102887421(RAC3)

PGIG:

120600327(RAC3)

PVP:	105301137(RAC3)

RAY:	107520254(RAC3)

TOD:	119230847(RAC3)

SARA:

101553997(RAC3)

SFUM:

130024916(RAC3)

SETR:

126013731(RAC3)

TMU:

101360313

ETF:	101660384(RAC3)

DNM:	101414043(RAC3)

MDO:	100029873(RAC3)

GAS:	123247605(RAC3)

SHR:	100924669(RAC3)

AFZ:

127560617

PCW:	110218260(RAC3)

TVP:	118846319(RAC3)

PBRV:

138142914(RAC3)

MLAO:

141514228(RAC3)

OAA:	114808823(RAC3)

TACU:

119923474(RAC3)

GGA:	395870(RAC3)

PCOC:

116232576(RAC3)

MGP:	100544672(RAC3)

CJO:	107322082(RAC3)

TPAI:

128083202(RAC3)

LMUT:

125702013(RAC3)

NMEL:

110407289(RAC3)

APLA:

101794915(RAC3)

AACU:

137841575(RAC3)

ACYG:

106046763(RAC3)

CATA:

118259247(RAC3)

AFUL:

116496439(RAC3)

TGU:	100220185(RAC3)

LSR:	110472410(RAC3)

SCAN:

103819726(RAC3)

PMOA:

120505627(RAC3)

OTC:	121338241(RAC3)

PRUF:

121352797(RAC3)

ATRC:

139602018(RAC3)

GFR:	102043334(RAC3)

FAB:	101821880(RAC3)

OMA:	130260475(RAC3)

PHI:	102103513(RAC3)

PMAJ:

107212321(RAC3)

CCAE:

111937502(RAC3)

CCW:	104698185(RAC3)

CBRC:

103613088(RAC3)

ACOE:

138120011(RAC3)

ETL:	114060329(RAC3)

ZAB:	102068911(RAC3)

ZLE:	135455357(RAC3)

ACHL:

103797226(RAC3)

SVG:	106859928(RAC3)

MMEA:

130581995(RAC3)

HRT:	120760855(RAC3)

SATI:

136369423(RAC3)

CFAI:

136299326(RAC3)

CCIC:

134051953(RAC3)

FPG:	101915014(RAC3)

FCH:	102054322(RAC3)

CCRI:

104156842

NNT:	104402957(RAC3)

SHAB:

115616605(RAC3)

ACUN:

113486843(RAC3)

SURA:

141952366(RAC3)

TALA:

104363047(RAC3)

ACHC:

115340958(RAC3)

HALD:

104312409(RAC3)

HLE:	104832123(RAC3)

AGEN:

126044128

HHAR:

128151066(RAC3)

BBUT:

142038580(RAC3)

CSTI:

104554064(RAC3)

LDI:	104353083(RAC3)

MNB:

103771344

DPUB:

104297886(RAC3)

PPUS:

135179264(RAC3)

AVIT:

104269613

BRHI:

104493342(RAC3)

EGZ:	104131087(RAC3)

NNI:	104014320(RAC3)

PCRI:

104026058(RAC3)

PCAO:

104044281(RAC3)

PADL:

103917419(RAC3)

AFOR:

103899000(RAC3)

FGA:	104084298(RAC3)

CBOR:

142090832(RAC3)

GSTE:

104252477(RAC3)

CBOY:

140660381(RAC3)

MAME:

142417847(RAC3)

CLV:	102094546(RAC3)

CNIC:

135996306(RAC3)

MUI:

104537329

PGUU:

104463010

PLET:

104615615(RAC3)

CMAC:

104475947(RAC3)

CUCA:

104057598(RAC3)

TEO:	104371078(RAC3)

BREG:

104631092(RAC3)

GAME:

129214479(RAC3)

OHA:	104327669(RAC3)

ACAR:

104519921

CPEA:

104398523(RAC3)

CVF:	104283115(RAC3)

RTD:	128917830(RAC3)

CRID:

134523366(RAC3)

LMIC:

141751378(RAC3)

AAM:	106487128 106487129

AROW:

112974771(RAC3)

NPD:	112945343(RAC3)

TGT:	104570223(RAC3)

DNE:	112990977(RAC3)

SCAM:

104140194(RAC3)

ASN:	102384004(RAC3)

AMJ:	102563759(RAC3)

CPOO:

109324502(RAC3)

GGN:	109286903(RAC3)

PSS:	102455375(RAC3)

CIZ:	142023383(RAC3)

CMY:	102938636(RAC3)

CCAY:

125621189(RAC3)

LKP:	140897721(RAC3)

NDS:	141998869(RAC3)

DCC:	119842977(RAC3)

CPIC:

101934732(RAC3)

CABI:

116815824(RAC3)

MRV:	120383388(RAC3)

ACS:	100568092(rac3)

ASAO:

132768694(RAC3)

PVT:	110091292(RAC3)

SUND:

121922534(RAC3)

PBI:	103065986(RAC3)

PMUR:

107288862(RAC3)

CTIG:

120308416(RAC3)

PGUT:

117663056(RAC3)

PCAE:

139310503(RAC3)

APRI:

131190088(RAC3)

PTEX:

113437082(RAC3)

NSS:	113412010(RAC3)

VKO:	123018124(RAC3)

PMUA:

114589702(RAC3)

PRAF:

128407402(RAC3)

ZVI:	118079760(RAC3)

HCG:	128344426(RAC3)

GJA:	107118111(RAC3)

STOW:

125430253(RAC3)

EMC:	129327373(RAC3)

XLA:

108700975

XTR:	100101726(rac3)

NPR:	108791334(RAC3)

RTEM:

120918911(RAC3)

ACAT:

141113534(RAC3)

PADS:

140325517(RAC3)

BBUF:

121003687(RAC3)

BGAR:

122940270(RAC3)

DTC:	141099984(RAC3)

DRE:	437027(rac3a) 795167(rac3b)

SRX:	107708991 107719987 107720282 107721474

SANH:

107654454 107688152 107689932 107693670(rac3)

SGH:	107571767 107590454 107601271

CCAR:

109045321 109050003 109099370(rac3b) 109099543

CAUA:

113042680 113056438 113098972 113102919 113112072

CGIB:

127951139 127952115 127968722 128025094

PTET:

122333431(rac3b) 122342115(rac3a)

LROH:

127163279(rac3a) 127174070(rac3b)

GRF:	141297629(rac3b) 141334314(rac3a) 141338690

OMC:	131537430(rac3a) 131551082(rac3b)

PPRM:

120469017(rac3b) 120489651(rac3a)

RKG:	130075850(rac3a) 130080630(rac3b)

MAMB:

125255025(rac3b) 125271584(rac3a)

CIDE:

127509821 127523939

CERY:

137007390(rac3b) 137017713(rac3a)

MASI:

127422812 127427419 127451761

TROS:

130562193(rac3a) 130569228(rac3b)

TDW:	130425813(rac3a) 130438947(rac3b)

MANU:

129420969(rac3b) 129434025(rac3a)

PDAB:

135739351(rac3b) 135758644(rac3a)

IPU:	108259609(rac3a)

IFU:	128602649(rac3a)

PHYP:

113528174

SMEO:

124396730(rac3a)

TFD:	113663539(rac3a)

TVC:	132861572(rac3a)

CGAR:

128544336(rac3a)

NGRA:

132868877(rac3a)

TRN:	134336006(rac3a)

AMEX:

103047109(rac3a) 111192386(rac3b)

CMAO:

118809795(rac3b) 118820980(rac3a)

EEE:	113574264 113580284(rac3)

CHAR:

105891207 105899959(rac3a)

SPIL:

134070318(rac3b) 134077242(rac3a)

ASAD:

121699630(rac3b) 121705193(rac3a)

TRU:

101064595

TFS:

130539274

LCO:	104927171 104929536

NCC:

104965188

TBEN:

117473618(rac3b)

CGOB:

115024221(rac3)

PGEO:

117465195(rac3b)

GACU:

117537676(rac3b)

EMAC:

134870859(rac3b)

ELY:	117247334(rac3b)

EFO:	125881024(rac3b)

PLEP:

121958523(rac3b)

SLUC:

116067499(rac3b)

ECRA:

117936772(rac3b)

ESP:	116671546 116704619

PFLV:

114547780(rac3)

GAT:	120818873(rac3b)

PPUG:

119213370(rac3b)

AFB:	129093091(rac3b)

CLUM:

117748311(rac3b)

PSWI:

130203394(rac3b)

CANA:

137789963

MSAM:

119915443(rac3b)

SCHU:

122867496(rac3b)

CUD:	121527981(rac3b)

SPUL:

138593950(rac3b)

LMIX:

132955689(rac3b)

HTC:	141784852(rac3b)

ALAT:

119009654(rac3b) 119013630(rac3a)

ASTR:

137587851(rac3b)

MZE:

101467064

ONL:	100712409(rac3)

OAU:	116320085(rac3b)

OLA:

105354522

OML:	112162359(rac3b)

CSAI:

133419696(rac3b)

XMA:

102224880

XCO:	114150885(rac3)

XHE:

116727748

PRET:

103482188

PFOR:

103142434(rac3)

PLAI:

106962762(rac3)

PMEI:

106904798

GAF:	122822891(rac3b)

PPRL:

129352230(rac3b)

CVG:

107087645

CTUL:

119796124(rac3b)

GMU:	124875062(rac3b)

NFU:

107395638

KMR:	108245165(rac3b)

ALIM:

106535622 106535925

NWH:	119423792(rac3b)

AOCE:

111565174(rac3b)

BFRE:

138626857(rac3b)

MCEP:

125022308(rac3b)

CSEM:

103381664

POV:	109626672 109640382

SSEN:

122758964(rac3b) 122785500

SSOE:

131448367(rac3b) 131474832

HHIP:

117753249 117765826(rac3a)

HSP:	118100767 118123199(rac3a)

PPLT:

128427331 128457989(rac3a)

SMAU:

118286998(rac3b) 118289018(rac3a)

LCF:	108882082 108897912(rac3a)

SDU:

111237036

SLAL:

111664334(rac3)

XGL:	120794754(rac3b)

HCQ:

109529292

SSCV:

125991053(rac3b)

SBIA:

133495104(rac3b)

PEE:	133395307(rac3b)

PTAO:

133469626

BPEC:

110154419

ENY:	140369120(rac3b)

MALB:

109966668

BSPL:

114845979

SJO:	128379611 128381029(rac3b)

SSCO:

134000175(rac3a) 134003761(rac3b)

TTY:	137167967(rac3a) 137172058(rac3b)

GMH:	115531392(rac3)

SASA:

106589606(rac3) 106595201 106606208 106610298

STRU:

115152909 115171935 115201417(rac3) 115208641

OTW:	112224482(rac3b) 112236328 112259175

OMY:	110485310 110485313 110499218 110503024

OGO:	124021557 124022143 124027077 124038580 124040216(rac3b)

ONE:	115115733 115144251(rac3)

OKI:	109869908(rac3) 109876169 109900052 116371029

OKE:	118370992 118402919(rac3b) 127930267

OMM:	135511952 135523636(rac3b) 135536077 135536079

OCLA:

139365253 139376770 139381232 139421652

SALP:

112070913 112080422(rac3)

SNH:	120030095(rac3b) 120042789 120044712 120045718

SFON:

129825597 129828895(rac3b) 129833698 129850352

CCLU:

121547550(rac3b) 121551449 121569982 121577608

ELS:	105005703(rac3) 105031329

OEP:	134031927(rac3b) 134036720(rac3a)

SFM:	108940081(rac3)

PKI:	111848451(rac3) 111856750

AANG:

118216047 118220757

AROT:

135243320 135248458

CCOG:

133111568 133114272

LOC:	102686683(rac3)

PSPA:

121295764(rac3a) 121296673

ARUT:

117423588(rac3a) 117424197

PSEX:

120517432

LCM:	102364586(RAC3)

CMK:	103175476(rac3a)

RTP:

109930936

CPLA:

122562137(rac3a)

CPUN:

140463980

HOC:	132828036(rac3a)

SCAU:

119953022

STOZ:

140395523

LERI:

129708424

HAKA:

140714661(rac3a)

AJJ:

PFLL:

TCF:

UDV:

BARL:

GAE:

MMER:

123562425 123564546 123564819

RPHI:

132715609

DPOL:

127848508 127860932 127869110

TAD:	TRIADDRAFT_19854

PIC:	PICST_82174(RAC1)

TVS:	TRAVEDRAFT_41792

DSQ:	DICSQDRAFT_142622

SHS:	STEHIDRAFT_136156

HIR:	HETIRDRAFT_437680

FME:	FOMMEDRAFT_161578

ABP:	AGABI1DRAFT96759(AGABI1DRAFT_96759)

ABV:	AGABI2DRAFT239537(AGABI2DRAFT_239537)

PCUB:

JR316_0000902

E1B28_001170(RAC3)

SGRA:

EX895_001010

PTRC:

PtA15_3A767

PSTR:

Pst134EA_006949

EDI:	EDI_002630

ACAN:

ACA1_007770 ACA1_064820 ACA1_070050

» show all

Reference

PMID:9252344

Authors

Haataja L, Groffen J, Heisterkamp N

Title

Characterization of RAC3, a novel member of the Rho family.

Journal

J Biol Chem 272:20384-8 (1997)
DOI:10.1074/jbc.272.33.20384

Sequence

[hsa:5881]

Reference

PMID:11756406

Authors

Haataja L, Kaartinen V, Groffen J, Heisterkamp N

Title

The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading.

Journal

J Biol Chem 277:8321-8 (2002)
DOI:10.1074/jbc.M105363200

Sequence

[hsa:5881]

LinkDB

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