KEGG   ORTHOLOGY: K08328
Entry
K08328                      KO                                     
Symbol
GUCA1
Name
guanylate cyclase activator 1
Pathway
map04744  Phototransduction
Disease
H00481  Cone-rod dystrophy and cone dystrophy
H00527  Retinitis pigmentosa
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09157 Sensory system
   04744 Phototransduction
    K08328  GUCA1; guanylate cyclase activator 1
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified
    K08328  GUCA1; guanylate cyclase activator 1
Domain-containing proteins not elsewhere classified [BR:ko04990]
 EF-hand domain-containing proteins
  Other EF-hand domain-containing proteins
   K08328  GUCA1; guanylate cyclase activator 1
Other DBs
GO: 0030250
Genes
HSA: 118142757(GUCA1A) 2978(GUCA1A) 2979(GUCA1B) 9626(GUCA1C)
PTR: 460572(GUCA1C) 472007(GUCA1B) 748651(GUCA1A)
PPS: 100969746(GUCA1B) 100970089(GUCA1A) 100991552(GUCA1C)
GGO: 101135017(GUCA1C) 101135053(GUCA1A) 101135896(GUCA1B)
PON: 100443825(GUCA1C) 100458663(GUCA1A) 100459513(GUCA1B)
NLE: 100604636(GUCA1C) 100606451(GUCA1B) 100607696(GUCA1A)
MCC: 695552(GUCA1A) 695658(GUCA1B) 706071(GUCA1C)
MCF: 102133371(GUCA1C) 102146296(GUCA1B) 102146663(GUCA1A)
CSAB: 103221499(GUCA1B) 103221501(GUCA1A) 103228360(GUCA1C)
CATY: 105591774(GUCA1B) 105591786(GUCA1A) 105600920(GUCA1C)
PANU: 101001516(GUCA1A) 101013316(GUCA1B) 101021691(GUCA1C)
TGE: 112619123(GUCA1C) 112623015(GUCA1A) 112623191(GUCA1B)
RRO: 104667313(GUCA1A) 104667314(GUCA1B) 104680581(GUCA1C)
RBB: 108528860(GUCA1C) 108533496(GUCA1B) 108533497(GUCA1A)
TFN: 117076660(GUCA1C) 117087216(GUCA1A) 117087218(GUCA1B)
PTEH: 111541823 111543043(GUCA1B) 111543181(GUCA1A) 113225248(GUCA1C)
CJC: 100387684(GUCA1C) 100397971(GUCA1B) 100408987(GUCA1A)
SBQ: 101029842(GUCA1B) 101041597(GUCA1C) 101048697(GUCA1A)
CSYR: 103264872(GUCA1B) 103264888(GUCA1A) 103267806(GUCA1C)
MMUR: 105875851(GUCA1B) 105875875(GUCA1A) 105878052(GUCA1C)
LCAT: 123630563(GUCA1C) 123631873 123631874(GUCA1B)
OGA: 100947035(GUCA1A) 100947342(GUCA1B) 100950552(GUCA1C)
MMU: 107477(Guca1b) 14913(Guca1a)
MCAL: 110284221(Guca1a) 110284343(Guca1b)
MPAH: 110335787(Guca1b) 110335961(Guca1a)
RNO: 301233(Guca1a) 316218(Guca1b)
MCOC: 116074576(Guca1b) 116074853(Guca1a)
MUN: 110550227(Guca1b) 110550244(Guca1a)
CGE: 100766612(Guca1a) 100766902(Guca1b)
MAUA: 101828639(Guca1b) 101828906(Guca1a)
PLEU: 114705296(Guca1a) 114705350(Guca1b)
MORG: 121451046 121451048(Guca1b)
AAMP: 119822158(Guca1b) 119824063(Guca1a)
NGI: 103726014(Guca1a) 103726023(Guca1b)
HGL: 101705513(Guca1b) 101706235(Guca1a) 106009688(Guca1c)
CPOC: 100714867(Guca1b) 100715154(Guca1a)
CCAN: 109682088(Guca1b) 109682185(Guca1a)
DORD: 105987784(Guca1a) 105987786(Guca1b) 105994872(Guca1c)
DSP: 122101543 122101634(Guca1b) 122105459(Guca1c)
OCU: 100351008(GUCA1B) 100359051(GUCA1A) 108177903(GUCA1C)
OPI: 101536024 101536268(GUCA1B)
TUP: 102490015(GUCA1C) 102497234(GUCA1B) 102497651(GUCA1A)
CFA: 481801(GUCA1B) 487968(GUCA1C) 609180(GUCA1A)
CLUD: 112641587(GUCA1A) 112641588(GUCA1B) 112678840(GUCA1C)
VVP: 112913766(GUCA1C) 112913988(GUCA1A) 112913990(GUCA1B)
VLG: 121474478(GUCA1C) 121485219 121485241(GUCA1B)
AML: 100464300 100468451(GUCA1C)
UMR: 103664089(GUCA1B) 103664162(GUCA1A) 103677334(GUCA1C)
UAH: 113256399(GUCA1C) 113261027(GUCA1B) 113261041(GUCA1A)
UAR: 123779159(GUCA1B) 123779170 123784304(GUCA1C)
MPUF: 101686248(GUCA1C) 101687457(GUCA1B) 101688217(GUCA1A)
ORO: 101371140(GUCA1C) 101373845(GUCA1A) 101374139(GUCA1B)
EJU: 114204374(GUCA1B) 114204636(GUCA1A) 114214738(GUCA1C)
ZCA: 113918515(GUCA1C) 113927266(GUCA1A) 113927682(GUCA1B)
MLX: 118000569(GUCA1B) 118000849(GUCA1A) 118000994(GUCA1C)
FCA: 101080382(GUCA1A) 101080634(GUCA1B) 101084309(GUCA1C)
PYU: 121029451(GUCA1A) 121029452(GUCA1B) 121036204(GUCA1C)
PBG: 122489518 122489519(GUCA1B) 122491411(GUCA1C)
PTG: 102960621(GUCA1C) 102961020(GUCA1A) 102969272(GUCA1B)
PPAD: 109266362(GUCA1C) 109271619(GUCA1A) 109271620(GUCA1B)
AJU: 106972267(GUCA1C) 106973972(GUCA1A) 106973986(GUCA1B)
HHV: 120238694 120238722(GUCA1B)
BTA: 282243(GUCA1A) 286851(GUCA1B)
BOM: 102266761(GUCA1B) 102267311(GUCA1A)
BIU: 109576519(GUCA1A) 109576812(GUCA1B)
BBUB: 102415506 102416056(GUCA1B)
CHX: 102171919(GUCA1C) 102191474(GUCA1A) 102191747(GUCA1B)
OAS: 101108346(GUCA1A) 101108609(GUCA1B) 101112447(GUCA1C)
ODA: 120870122 120870123(GUCA1B) 120881968(GUCA1C)
CCAD: 122429677(GUCA1A) 122429678(GUCA1B)
SSC: 100739200(GUCA1A) 102167816(GUCA1B)
CFR: 102504037(GUCA1A) 102504285(GUCA1B) 102505485(GUCA1C)
CBAI: 105081650(GUCA1C) 105083778(GUCA1A) 105083779(GUCA1B)
CDK: 105086760(GUCA1A) 105086761(GUCA1B)
VPC: 102525668(GUCA1B) 102525915(GUCA1A) 116277682(GUCA1C)
BACU: 103005818(GUCA1B) 103006674(GUCA1A) 103011567(GUCA1C)
LVE: 103073868(GUCA1A) 103074145(GUCA1B) 103084658(GUCA1C)
OOR: 101273450(GUCA1B) 101273697(GUCA1A) 101286028(GUCA1C)
DLE: 111176430(GUCA1C) 111178620(GUCA1A) 111178621(GUCA1B)
PCAD: 102986581(GUCA1C) 102988744(GUCA1A) 102989033(GUCA1B)
PSIU: 116752659(GUCA1C) 116762742(GUCA1B) 116762823(GUCA1A)
ECB: 100054522(GUCA1B) 100066702(GUCA1A) 100071815(GUCA1C)
EPZ: 103558056(GUCA1C) 103559454(GUCA1B) 103559457(GUCA1A)
EAI: 106824502(GUCA1A) 106824536(GUCA1B) 106842169(GUCA1C)
MYB: 102250623(GUCA1B) 102250921(GUCA1A)
MYD: 102757876(GUCA1B) 102761465(GUCA1A)
MMYO: 118660597(GUCA1B) 118660701 118675713(GUCA1C)
MLF: 102428701 102435797(GUCA1A) 102436120(GUCA1B)
MNA: 107536682(GUCA1C) 107536831(GUCA1B) 107536863(GUCA1A)
PKL: 118705324(GUCA1B) 118706052 118722948(GUCA1C)
HAI: 109382859(GUCA1B) 109382861(GUCA1A) 109387334(GUCA1C)
DRO: 112302294(GUCA1B) 112302485(GUCA1A) 112320451(GUCA1C)
SHON: 118991471 118991476(GUCA1B) 118998999(GUCA1C)
AJM: 119051925(GUCA1C) 119056411 119056445(GUCA1B)
PDIC: 114495509(GUCA1A) 114495627(GUCA1B) 114514991(GUCA1C)
PHAS: 123821294(GUCA1A) 123821318(GUCA1B) 123826740(GUCA1C)
MMF: 118616980(GUCA1C) 118621280 118621736(GUCA1B)
RFQ: 117014119(GUCA1C) 117015929(GUCA1B) 117020775(GUCA1A)
PALE: 102881101(GUCA1B) 102881358(GUCA1A) 102884796(GUCA1C)
PGIG: 120596060(GUCA1B) 120596062 120598103(GUCA1C)
PVP: 105288439(GUCA1A) 105288440(GUCA1B) 105307041(GUCA1C)
RAY: 107501933(GUCA1A) 107502010(GUCA1B) 107519611(GUCA1C)
MJV: 108390303(GUCA1B) 108390305(GUCA1A)
TOD: 119251419(GUCA1A) 119252464(GUCA1B)
SARA: 101551024(GUCA1C) 101552706
LAV: 100663471(GUCA1B) 100663755(GUCA1A)
DNM: 101425535(GUCA1A) 101447699(GUCA1B)
MDO: 100010555(GUCA1C) 100030469(GUCA1A)
GAS: 123239511(GUCA1C) 123256317
SHR: 100922216(GUCA1A) 100928880(GUCA1C)
PCW: 110203295(GUCA1A) 110217467(GUCA1C)
OAA: 100077039(GUCA1A) 100077076(GUCA1B) 100078217(GUCA1C) 100087568
GGA: 374216(GUCA1A) 419864(GUCA1B) 427960(GUCA1C) 430443
PCOC: 116237040(GUCA1B) 116237063(GUCA1A) 116238655 116242382(GUCA1C)
MGP: 100538407 100542560(GUCA1B) 100542718(GUCA1A) 100549040(GUCA1C) 109364357
CJO: 107317046 107321138(GUCA1C) 107324843(GUCA1A) 107324850(GUCA1B)
NMEL: 110388208(GUCA1B) 110388355(GUCA1A) 110392524 110400774(GUCA1C)
APLA: 101790159(GUCA1B) 101790355(GUCA1A) 101802566(GUCA1C)
ACYG: 106039205(GUCA1C) 106041253(GUCA1B) 106041259(GUCA1A) 106048151
AFUL: 116498896(GUCA1B) 116498910(GUCA1A) 116501885 116502197(GUCA1C)
TGU: 100221886(GUCA1C) 100225533 115492489(GUCA1B) 115492493(GUCA1A)
LSR: 110475379(GUCA1A) 110475391(GUCA1B) 110477027(GUCA1C) 110479583
SCAN: 103820732(GUCA1C) 103823271(GUCA1B) 103823327(GUCA1A)
OTC: 121337173 121339287(GUCA1C) 121347980(GUCA1B) 121347981
PRUF: 121351609(GUCA1C) 121353663(GUCA1B) 121353669 121355109
GFR: 102035942(GUCA1B) 102036111(GUCA1A) 102039217 102042123(GUCA1C)
FAB: 101812265(GUCA1A) 101814628(GUCA1B) 101821699 101821964(GUCA1C)
PHI: 102100990(GUCA1A) 102106373(GUCA1C) 102107330 102113392(GUCA1B)
PMAJ: 107198753 107200044(GUCA1C) 107214848(GUCA1A) 107214849(GUCA1B)
CCAE: 111923203 111939806(GUCA1A) 111939807(GUCA1B) 111943909(GUCA1C)
CBRC: 103613855(GUCA1C) 103617099 103620351(GUCA1B) 103620352(GUCA1A)
ETL: 114057229(GUCA1C) 114063119(GUCA1B) 114063127(GUCA1A) 114069108
ZAB: 102065547 102069646(GUCA1C) 102070434(GUCA1B) 102070609(GUCA1A)
FPG: 101911639(GUCA1C) 101916831 101924247(GUCA1A) 101924422(GUCA1B)
FCH: 102052460(GUCA1B) 102052626(GUCA1A) 102052778(GUCA1C) 102059136
CLV: 102084773(GUCA1C) 102084960 102090494(GUCA1B) 102090680(GUCA1A)
EGZ: 104124389 104125037(GUCA1C) 104126795(GUCA1B) 104126796(GUCA1A)
NNI: 104010313(GUCA1B) 104010314(GUCA1A) 104014122(GUCA1C) 104019906
PLET: 104615155(GUCA1A) 104615889(GUCA1B) 104615988
PCRI: 104027205(GUCA1B) 104031401 104034937 104037601(GUCA1A)
ACUN: 113488875(GUCA1B) 113488892(GUCA1A) 113489529 113489995(GUCA1C)
TALA: 104356630 104359924 104365624(GUCA1B) 116964744(GUCA1C)
PADL: 103916827(GUCA1C) 103923562(GUCA1A) 103923563(GUCA1B) 103924102
ACHC: 115334962 115334963(GUCA1B) 115341542 115343877(GUCA1C)
HALD: 104312399 104314875 104323917(GUCA1B) 104323918(GUCA1A)
CCRI: 104159908(GUCA1A) 104160038 104160342(GUCA1B) 104168418(GUCA1C)
CSTI: 104556385 104558828 104560872(GUCA1B) 104560873(GUCA1A)
EHS: 104504532 104507340(GUCA1B) 104507342(GUCA1A) 104512709
FGA: 104076831(GUCA1A) 104076832(GUCA1B) 104080753 104081279
GSTE: 104251868(GUCA1A) 104254489 104256416 104258734(GUCA1B)
LDI: 104341578(GUCA1B) 104350346(GUCA1A) 104350448 104352611
MNB: 103773326(GUCA1A) 103776612 103780244(GUCA1B) 103782554
AAM: 106486081 106490624(GUCA1C) 106490979(GUCA1B) 106496142
AROW: 112962334(GUCA1C) 112963652 112971625(GUCA1B) 112971667(GUCA1A)
NPD: 112944622(GUCA1B) 112944623(GUCA1A) 112949460(GUCA1C) 112953972
DNE: 112989981 112990277(GUCA1A) 112990298(GUCA1B) 112990541(GUCA1C)
ASN: 102377349(GUCA1C) 102378112 102384385(GUCA1B) 102384639(GUCA1A)
AMJ: 102559358(GUCA1C) 102559646 102571576(GUCA1A) 102571805(GUCA1B)
CPOO: 109305608(GUCA1C) 109317889(GUCA1A) 109317890(GUCA1B)
GGN: 109295289(GUCA1B) 109295291(GUCA1A)
PSS: 102455136 102457858(GUCA1C) 102461056(GUCA1A)
CMY: 102934841(GUCA1B) 102935074(GUCA1A) 102936745 102944507(GUCA1C)
CPIC: 101930852(GUCA1B) 101941126(GUCA1A) 101943437 101953086(GUCA1C)
TST: 117871067(GUCA1C) 117873827 117876436(GUCA1B) 117876847(GUCA1A)
MRV: 120369074(GUCA1C) 120395729 120404337(GUCA1A) 120404526(GUCA1B)
ACS: 100555924(guca1b) 100556029 100558867(guca1a) 100560444(guca1c) 103279985
PVT: 110072362(GUCA1B) 110072382(GUCA1A) 110073516 110085847(GUCA1C)
PBI: 103057518 103064517(GUCA1B) 103065714(GUCA1A)
PMUR: 107292263(GUCA1A) 107292264(GUCA1B) 107293269(GUCA1C)
TSR: 106537599(GUCA1A) 106537699(GUCA1B)
PGUT: 117663831(GUCA1A) 117663837(GUCA1B) 117664376(GUCA1C)
VKO: 123023119 123026411 123029394(GUCA1C) 123034310(GUCA1B) 123034311(GUCA1A)
PMUA: 114595905(GUCA1C) 114596599 114598365(GUCA1B) 114599359(GUCA1A) 114605850
ZVI: 118085339(GUCA1C) 118088112 118088890(GUCA1A) 118089275(GUCA1B) 118091245
GJA: 107109932(GUCA1A) 107109933(GUCA1B) 107123971(GUCA1C)
STOW: 125431043(GUCA1C) 125432392(GUCA1B) 125433670(GUCA1A) 125434613
XLA: 108707686 108707701(guca1c.L) 108709108(guca1c.S) 108715065(guca1bl.S) 444645(guca1al.L) 447368(guca1al.S) 447765(guca1a.S) 447777(guca1a.L)
XTR: 100124863(guca1a) 100379842 100489509(guca1b) 100497028(guca1c) 779962(guca1al)
NPR: 108787353(GUCA1C) 108789676(GUCA1B) 108789678(GUCA1A) 108793467
RTEM: 120927076 120927077(GUCA1B) 120927290(GUCA1C) 120931577
DRE: 100330921(si:ch211-103a14.5) 140430(guca1a) 140431(guca1b) 373099(guca1c) 393629(guca1e) 494572(guca1g) 494573(guca1d)
PPRM: 120460237(guca1g) 120462934(guca1b) 120476924(guca1a) 120483362(guca1c) 120486262 120486285 120494723(guca1d)
MAMB: 125246155(guca1a) 125246987(guca1g) 125248439(guca1c) 125252280(guca1d) 125260133(guca1b) 125262783 125263082
IPU: 108264217 108276310(guca1b) 108277460(guca1c) 108278739(guca1d) 108279647(guca1a) 124627811 124627812
SMEO: 124394732(guca1c) 124395832 124398062(guca1d) 124399073(guca1b) 124400769(guca1a)
TFD: 113634960(guca1d) 113643426(guca1c) 113650798 113651862(guca1a) 113658089(guca1b) 125139261(guca1g)
EEE: 113567615 113569676(guca1a) 113570036(guca1b)
EFO: 125879948 125879960 125882682(guca1a) 125888459(si:ch211-103a14.5) 125888663(guca1c) 125891415(guca1b) 125897782(guca1d) 125905523 125905550(guca1g)
SLUC: 116041522 116048402(guca1c) 116060094(guca1a) 116062046(guca1b) 116062758(guca1d) 116067244 116067353
ECRA: 117938956(guca1a) 117941761 117941762(guca1g) 117941876(guca1c) 117942790 117948087(guca1b)
PPUG: 119194012 119194013(guca1g) 119194830 119210393(guca1a) 119214151(guca1c) 119222048(guca1b)
CUD: 121505605(guca1a) 121506023 121507297 121512281 121516983(guca1c) 121517833(guca1b) 121518887(guca1d) 121528345 121528515(guca1g)
OAU: 116310001(guca1d) 116310896(guca1b) 116329265(guca1c) 116329478 116329702(guca1g) 116334303(guca1a)
OML: 112138665(guca1d) 112144876 112144877 112149006(guca1c) 112156735(guca1a) 112159517(guca1b) 112160949
GAF: 122820278 122820620 122824286(guca1g) 122826538(guca1a) 122830311(guca1b) 122832672(guca1c) 122845446(guca1d)
CTUL: 119781162(guca1d) 119782035(guca1b) 119788856 119788859(guca1g) 119789517(guca1c) 119791150(guca1a) 119796328
GMU: 124866696 124867366(guca1g) 124867852(guca1b) 124875979(guca1d) 124882809(guca1a) 124884527(guca1c)
KMR: 108231951(guca1b) 108233321(guca1a) 108234764 108236008(guca1c) 108243988
NWH: 119410729(guca1c) 119416819(guca1b) 119419843(guca1d) 119428198(guca1a) 119430249
MCEP: 125000276(guca1a) 125005241 125005242 125005526 125005590 125007324(si:ch211-103a14.5) 125013226(guca1c) 125018045(guca1b) 125021544(guca1d)
SSEN: 122761596(si:ch211-103a14.5) 122762177 122766403(guca1a) 122772041(guca1g) 122772471 122772696 122773790(guca1c) 122776761(guca1b) 122780085(guca1d)
HSP: 118100518 118100661(guca1g) 118101330(guca1a) 118105367(si:ch211-103a14.5) 118106266(guca1c) 118110239 118111357(guca1b) 118112096 124854837(guca1d)
BSPL: 114850279(guca1b) 114852136(guca1g) 114852658 114862338(guca1a) 114868113(guca1c) 114869105(guca1d)
PKI: 111844732(guca1b) 111851212(guca1a) 111858063
LCM: 102350299(GUCA1A) 102357477(GUCA1B) 102362011 102366599
RTP: 109914002(guca1b) 109922765(guca1a)
LSM: 121130019
 » show all
Reference
PMID:7983048
  Authors
Subbaraya I, Ruiz CC, Helekar BS, Zhao X, Gorczyca WA, Pettenati MJ, Rao PN, Palczewski K, Baehr W
  Title
Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene.
  Journal
J Biol Chem 269:31080-9 (1994)
  Sequence
[hsa:2978]
Reference
  Authors
Dizhoor AM, Hurley JB
  Title
Regulation of photoreceptor membrane guanylyl cyclases by guanylyl cyclase activator proteins.
  Journal
Methods 19:521-31 (1999)
DOI:10.1006/meth.1999.0894
Reference
  Authors
Peshenko IV, Dizhoor AM
  Title
Activation and inhibition of photoreceptor guanylyl cyclase by guanylyl cyclase activating protein 1 (GCAP-1): the functional role of Mg2+/Ca2+ exchange in EF-hand domains.
  Journal
J Biol Chem 282:21645-52 (2007)
DOI:10.1074/jbc.M702368200
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