KEGG   ORTHOLOGY: K08523
Entry
K08523                      KO                                     
Symbol
HBEGF
Name
heparin-binding EGF-like growth factor
Pathway
map01522  Endocrine resistance
map04012  ErbB signaling pathway
map04912  GnRH signaling pathway
map04915  Estrogen signaling pathway
map04928  Parathyroid hormone synthesis, secretion and action
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05171  Coronavirus disease - COVID-19
map05205  Proteoglycans in cancer
map05219  Bladder cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K08523  HBEGF; heparin-binding EGF-like growth factor
 09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    K08523  HBEGF; heparin-binding EGF-like growth factor
   04915 Estrogen signaling pathway
    K08523  HBEGF; heparin-binding EGF-like growth factor
   04928 Parathyroid hormone synthesis, secretion and action
    K08523  HBEGF; heparin-binding EGF-like growth factor
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K08523  HBEGF; heparin-binding EGF-like growth factor
  09162 Cancer: specific types
   05219 Bladder cancer
    K08523  HBEGF; heparin-binding EGF-like growth factor
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K08523  HBEGF; heparin-binding EGF-like growth factor
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K08523  HBEGF; heparin-binding EGF-like growth factor
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K08523  HBEGF; heparin-binding EGF-like growth factor
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins
    K08523  HBEGF; heparin-binding EGF-like growth factor
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Growth factors/receptors
   K08523  HBEGF; heparin-binding EGF-like growth factor
Genes
HSA: 1839(HBEGF)
PTR: 735979(HBEGF)
PPS: 100977885(HBEGF)
GGO: 101138938(HBEGF)
PON: 100437870(HBEGF)
NLE: 100600047(HBEGF)
MCC: 695559(HBEGF)
MCF: 102120009(HBEGF)
CSAB: 103244654(HBEGF)
CATY: 105599879(HBEGF)
PANU: 101005723(HBEGF)
TGE: 112626891(HBEGF)
RRO: 104681756(HBEGF)
RBB: 108530840(HBEGF)
TFN: 117065760(HBEGF)
CJC: 100392997(HBEGF)
SBQ: 101029484(HBEGF)
CSYR: 103258463(HBEGF)
MMUR: 105862636(HBEGF)
LCAT: 123637855(HBEGF)
OGA: 100955169(HBEGF)
MMU: 15200(Hbegf)
MCAL: 110285141(Hbegf)
MPAH: 110333307(Hbegf)
RNO: 25433(Hbegf)
MCOC: 116087013(Hbegf)
MUN: 110557378(Hbegf)
CGE: 100689423(Hbegf)
MAUA: 101831451(Hbegf)
PLEU: 114705134(Hbegf)
AAMP: 119814969(Hbegf)
NGI: 103743072(Hbegf)
HGL: 101699647(Hbegf)
CPOC: 100731681(Hbegf)
CCAN: 109682066(Hbegf)
DORD: 105988669(Hbegf)
DSP: 122118157(Hbegf)
NCAR: 124987586
OCU: 100008809(HBEGF)
OPI: 101521874(HBEGF)
TUP: 102498262(HBEGF)
CFA: 607007(HBEGF)
VVP: 112907933(HBEGF)
VLG: 121498167(HBEGF)
AML: 100467713(HBEGF)
UMR: 103663938(HBEGF)
UAH: 113261821(HBEGF)
UAR: 123790277(HBEGF)
ELK: 111141144
LLV: 125100868
MPUF: 101688241(HBEGF)
ORO: 101380289(HBEGF)
EJU: 114209635(HBEGF)
ZCA: 113929679(HBEGF)
MLX: 118016713(HBEGF)
FCA: 101093578(HBEGF)
PYU: 121010805(HBEGF)
PBG: 122481122(HBEGF)
PTG: 102950862(HBEGF)
PPAD: 109252164(HBEGF)
AJU: 106968439(HBEGF)
HHV: 120245649(HBEGF)
BTA: 522921(HBEGF)
BOM: 102283032(HBEGF)
BIU: 109562095(HBEGF)
BBUB: 102411668(HBEGF)
CHX: 102185462(HBEGF)
OAS: 101118185(HBEGF)
ODA: 120863572(HBEGF)
CCAD: 122439834(HBEGF)
SSC: 397564(HBEGF)
CFR: 102510168(HBEGF)
CBAI: 105082198(HBEGF)
CDK: 105098108(HBEGF)
VPC: 102526952(HBEGF)
BACU: 102998316(HBEGF)
LVE: 103074900(HBEGF)
OOR: 101272130(HBEGF)
DLE: 111182530(HBEGF)
PCAD: 102994045(HBEGF)
PSIU: 116751582(HBEGF)
ECB: 100629956(HBEGF)
EPZ: 103548009(HBEGF)
EAI: 106823779(HBEGF)
MYB: 102244188(HBEGF)
MYD: 102751834(HBEGF)
MMYO: 118654551 118658125(HBEGF)
MLF: 102429167(HBEGF)
MNA: 107538002(HBEGF)
PKL: 118711649(HBEGF)
HAI: 109392466(HBEGF)
DRO: 112318203(HBEGF)
SHON: 118997917(HBEGF)
AJM: 119051085(HBEGF)
PDIC: 114509723(HBEGF)
PHAS: 123806596(HBEGF)
MMF: 118615761(HBEGF)
RFQ: 117016991(HBEGF)
PALE: 102882842(HBEGF)
PVP: 105306966(HBEGF)
RAY: 107521572(HBEGF)
MJV: 108392132(HBEGF)
TOD: 119243399(HBEGF)
SARA: 101548046(HBEGF)
LAV: 100675899(HBEGF)
TMU: 101344556
DNM: 101419059(HBEGF)
MDO: 100026152(HBEGF)
GAS: 123237560(HBEGF)
SHR: 100933188(HBEGF)
PCW: 110220941(HBEGF)
OAA: 100093606(HBEGF)
GGA: 395654(HBEGF)
PCOC: 116237734(HBEGF)
MGP: 100549227(HBEGF)
CJO: 107320476(HBEGF)
NMEL: 110405127(HBEGF)
APLA: 101799901(HBEGF)
ACYG: 106042744(HBEGF)
AFUL: 116494807(HBEGF)
TGU: 100232539(HBEGF)
LSR: 110471343(HBEGF)
SCAN: 103817449(HBEGF)
PMOA: 120500042(HBEGF)
OTC: 121332319(HBEGF)
PRUF: 121364627(HBEGF)
GFR: 102031792(HBEGF)
FAB: 101808558(HBEGF)
PHI: 102106304(HBEGF)
PMAJ: 107210893(HBEGF)
CCAE: 111945170(HBEGF)
CCW: 104693556(HBEGF)
ETL: 114059799(HBEGF)
ZAB: 102062370(HBEGF)
FPG: 101923240(HBEGF)
FCH: 102052533(HBEGF)
CLV: 102094772(HBEGF)
EGZ: 104135803(HBEGF)
NNI: 104009117(HBEGF)
PLET: 104621772(HBEGF)
TALA: 104361596(HBEGF)
PADL: 103915467(HBEGF)
ACHC: 115334277(HBEGF)
AAM: 106494293(HBEGF)
AROW: 112967120(HBEGF)
NPD: 112944353(HBEGF)
DNE: 112986312(HBEGF)
ASN: 102372604(HBEGF)
AMJ: 102565343(HBEGF)
CPOO: 109309909(HBEGF)
GGN: 109290185(HBEGF)
PSS: 102455005(HBEGF)
CMY: 102931453(HBEGF)
CPIC: 101934074(HBEGF)
TST: 117882042(HBEGF)
CABI: 116837401(HBEGF)
MRV: 120371178(HBEGF)
ACS: 100562149(hbegf)
PVT: 110082119(HBEGF)
SUND: 121929497(HBEGF)
PBI: 103051348(HBEGF)
PMUR: 107284145(HBEGF)
TSR: 106543418(HBEGF)
PGUT: 117662317(HBEGF)
VKO: 123029659(HBEGF)
PMUA: 114601160(HBEGF)
ZVI: 118079379(HBEGF)
GJA: 107119740(HBEGF)
XLA: 108710907(hbegf.L) 108713286(hbegf.S)
XTR: 100497436(hbegf)
BBUF: 121009495(HBEGF)
BGAR: 122926419(HBEGF)
DRE: 407664(hbegfb) 797938(hbegfa)
PPRM: 120460701(hbegfa) 120494574(hbegfb)
MAMB: 125252673(hbegfb) 125259283(hbegfa)
IPU: 108268609(hbegfa) 108278919(hbegfb)
SMEO: 124385631(hbegfa) 124398009(hbegfb)
TFD: 113644429(hbegfb) 113645969(hbegfa)
TRU: 101072713(hbegf)
LCO: 104924202
NCC: 104968122
CGOB: 115015187
ELY: 117260515(hbegfa)
PLEP: 121948069(hbegfa)
SLUC: 116064248(hbegfa)
ECRA: 117951488(hbegfa)
PFLV: 114562503
GAT: 120817552(hbegfa)
PPUG: 119211416(hbegfa)
MSAM: 119888537
CUD: 121516656(hbegfa)
ALAT: 119007116(hbegfa)
MZE: 101471223
ONL: 100691361
OAU: 116324567(hbegfa)
OLA: 101156096
OML: 112152992(hbegfa)
XMA: 102236217(hbegf)
XCO: 114139518
XHE: 116714743
PRET: 103471128
PLAI: 106961789
PMEI: 106906328
GAF: 122837147(hbegfa)
CVG: 107086019
CTUL: 119783215(hbegfa)
GMU: 124859891(hbegfa)
NFU: 107396576
KMR: 108242040(hbegfa)
ALIM: 106516002
NWH: 119409082(hbegfa)
AOCE: 111577694
CSEM: 103391240
POV: 109625710
SSEN: 122778144(hbegfa)
HHIP: 117769760(hbegfa)
HSP: 118111922(hbegfa)
LCF: 108882842
SDU: 111226747
SLAL: 111652063
XGL: 120784907(hbegfa)
HCQ: 109515923
BPEC: 110163727
MALB: 109954704
BSPL: 114864762
LOC: 102691139(hbegf)
LCM: 102353749(HBEGF)
CMK: 103186469
RTP: 109933026
 » show all
Reference
PMID:1840698
  Authors
Higashiyama S, Abraham JA, Miller J, Fiddes JC, Klagsbrun M
  Title
A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF.
  Journal
Science 251:936-9 (1991)
DOI:10.1126/science.1840698
  Sequence
[hsa:1839]
Reference
  Authors
Iwamoto R, Mekada E
  Title
Heparin-binding EGF-like growth factor: a juxtacrine growth factor.
  Journal
Cytokine Growth Factor Rev 11:335-44 (2000)
DOI:10.1016/S1359-6101(00)00013-7
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