K08523                      KO                                     

heparin-binding EGF-like growth factor
ko01522  Endocrine resistance
ko04012  ErbB signaling pathway
ko04912  GnRH signaling pathway
ko04915  Estrogen signaling pathway
ko04928  Parathyroid hormone synthesis, secretion and action
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05171  Coronavirus disease - COVID-19
ko05205  Proteoglycans in cancer
ko05219  Bladder cancer
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K08523  HBEGF; heparin-binding EGF-like growth factor
 09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    K08523  HBEGF; heparin-binding EGF-like growth factor
   04915 Estrogen signaling pathway
    K08523  HBEGF; heparin-binding EGF-like growth factor
   04928 Parathyroid hormone synthesis, secretion and action
    K08523  HBEGF; heparin-binding EGF-like growth factor
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K08523  HBEGF; heparin-binding EGF-like growth factor
  09162 Cancer: specific types
   05219 Bladder cancer
    K08523  HBEGF; heparin-binding EGF-like growth factor
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K08523  HBEGF; heparin-binding EGF-like growth factor
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K08523  HBEGF; heparin-binding EGF-like growth factor
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K08523  HBEGF; heparin-binding EGF-like growth factor
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins
    K08523  HBEGF; heparin-binding EGF-like growth factor
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Growth factors/receptors
   K08523  HBEGF; heparin-binding EGF-like growth factor
HSA: 1839(HBEGF)
PTR: 735979(HBEGF)
PPS: 100977885(HBEGF)
GGO: 101138938(HBEGF)
PON: 100437870(HBEGF)
NLE: 100600047(HBEGF)
MCC: 695559(HBEGF)
MCF: 102120009(HBEGF)
CSAB: 103244654(HBEGF)
CATY: 105599879(HBEGF)
RRO: 104681756(HBEGF)
RBB: 108530840(HBEGF)
TFN: 117065760(HBEGF)
CJC: 100392997(HBEGF)
SBQ: 101029484(HBEGF)
MMUR: 105862636(HBEGF)
MMU: 15200(Hbegf)
MCAL: 110285141(Hbegf)
MPAH: 110333307(Hbegf)
RNO: 25433(Hbegf)
MCOC: 116087013(Hbegf)
MUN: 110557378(Hbegf)
CGE: 100689423(Hbegf)
PLEU: 114705134(Hbegf)
NGI: 103743072(Hbegf)
HGL: 101699647(Hbegf)
CCAN: 109682066(Hbegf)
OCU: 100008809(HBEGF)
TUP: 102498262(HBEGF)
CFA: 607007(HBEGF)
VVP: 112907933(HBEGF)
AML: 100467713(HBEGF)
UMR: 103663938(HBEGF)
UAH: 113261821(HBEGF)
ORO: 101380289(HBEGF)
ELK: 111141144
MPUF: 101688241(HBEGF)
EJU: 114209635(HBEGF)
FCA: 101093578(HBEGF)
PTG: 102950862(HBEGF)
PPAD: 109252164(HBEGF)
AJU: 106968439(HBEGF)
BTA: 522921(HBEGF)
BOM: 102283032(HBEGF)
BIU: 109562095(HBEGF)
BBUB: 102411668(HBEGF)
CHX: 102185462(HBEGF)
OAS: 101118185(HBEGF)
SSC: 397564(HBEGF)
CFR: 102510168(HBEGF)
CDK: 105098108(HBEGF)
BACU: 102998316(HBEGF)
LVE: 103074900(HBEGF)
OOR: 101272130(HBEGF)
DLE: 111182530(HBEGF)
PCAD: 102994045(HBEGF)
ECB: 100629956(HBEGF)
EPZ: 103548009(HBEGF)
EAI: 106823779(HBEGF)
MYB: 102244188(HBEGF)
MYD: 102751834(HBEGF)
MMYO: 118654551 118658125(HBEGF)
MNA: 107538002(HBEGF)
HAI: 109392466(HBEGF)
DRO: 112318203(HBEGF)
SHON: 118997917(HBEGF)
AJM: 119051085(HBEGF)
MMF: 118615761(HBEGF)
PALE: 102882842(HBEGF)
RAY: 107521572(HBEGF)
MJV: 108392132(HBEGF)
LAV: 100675899(HBEGF)
TMU: 101344556
MDO: 100026152(HBEGF)
SHR: 100933188(HBEGF)
PCW: 110220941(HBEGF)
OAA: 100093606(HBEGF)
GGA: 395654(HBEGF)
MGP: 100549227(HBEGF)
CJO: 107320476(HBEGF)
NMEL: 110405127(HBEGF)
APLA: 101799901(HBEGF)
ACYG: 106042744(HBEGF)
TGU: 100232539(HBEGF)
LSR: 110471343(HBEGF)
SCAN: 103817449(HBEGF)
GFR: 102031792(HBEGF)
FAB: 101808558(HBEGF)
PHI: 102106304(HBEGF)
PMAJ: 107210893(HBEGF)
CCAE: 111945170(HBEGF)
CCW: 104693556(HBEGF)
ETL: 114059799(HBEGF)
FPG: 101923240(HBEGF)
FCH: 102052533(HBEGF)
CLV: 102094772(HBEGF)
EGZ: 104135803(HBEGF)
NNI: 104009117(HBEGF)
PADL: 103915467(HBEGF)
AAM: 106494293(HBEGF)
ASN: 102372604(HBEGF)
AMJ: 102565343(HBEGF)
PSS: 102455005(HBEGF)
CMY: 102931453(HBEGF)
CPIC: 101934074(HBEGF)
ACS: 100562149(hbegf)
PVT: 110082119(HBEGF)
PBI: 103051348(HBEGF)
PMUR: 107284145(HBEGF)
TSR: 106543418(HBEGF)
PMUA: 114601160(HBEGF)
GJA: 107119740(HBEGF)
XLA: 108710907(hbegf.L) 108713286(hbegf.S)
XTR: 100497436(hbegf)
DRE: 407664(hbegfb) 797938(hbegfa)
IPU: 108268609(HBEGF) 108278919(hbegf)
TRU: 101072713(hbegf)
LCO: 104924202
NCC: 104968122
MZE: 101471223
ONL: 100691361
OLA: 101156096
XMA: 102236217(hbegf)
XCO: 114139518
PRET: 103471128
CVG: 107086019
NFU: 107396576
KMR: 108242040(hbegfa)
ALIM: 106516002
AOCE: 111577694
CSEM: 103391240
POV: 109625710
LCF: 108882842
SDU: 111226747
SLAL: 111652063
HCQ: 109515923
BPEC: 110163727
MALB: 109954704
LCM: 102353749(HBEGF)
CMK: 103186469(hbegf)
RTP: 109933026
 » show all
Higashiyama S, Abraham JA, Miller J, Fiddes JC, Klagsbrun M
A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF.
Science 251:936-9 (1991)
Iwamoto R, Mekada E
Heparin-binding EGF-like growth factor: a juxtacrine growth factor.
Cytokine Growth Factor Rev 11:335-44 (2000)

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