KEGG   ORTHOLOGY: K08847
Entry
K08847                      KO                                     
Symbol
RIPK3
Name
receptor-interacting serine/threonine-protein kinase 3 [EC:2.7.11.1]
Pathway
map04217  Necroptosis
map04621  NOD-like receptor signaling pathway
map04623  Cytosolic DNA-sensing pathway
map04668  TNF signaling pathway
map05132  Salmonella infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K08847  RIPK3; receptor-interacting serine/threonine-protein kinase 3
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K08847  RIPK3; receptor-interacting serine/threonine-protein kinase 3
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K08847  RIPK3; receptor-interacting serine/threonine-protein kinase 3
   04623 Cytosolic DNA-sensing pathway
    K08847  RIPK3; receptor-interacting serine/threonine-protein kinase 3
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K08847  RIPK3; receptor-interacting serine/threonine-protein kinase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08847  RIPK3; receptor-interacting serine/threonine-protein kinase 3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08847  RIPK3; receptor-interacting serine/threonine-protein kinase 3
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  RIPK family [OT]
   K08847  RIPK3; receptor-interacting serine/threonine-protein kinase 3
Genes
HSA: 11035(RIPK3)
PTR: 452820(RIPK3)
PPS: 100982151(RIPK3)
GGO: 101126247(RIPK3)
PON: 100461174(RIPK3)
NLE: 100589021(RIPK3)
MCC: 716138(RIPK3)
MCF: 102124880(RIPK3)
MTHB: 126958796
CSAB: 103228724(RIPK3)
CATY: 105600226(RIPK3)
PANU: 101027042(RIPK3)
TGE: 112628650(RIPK3)
RRO: 104662673(RIPK3)
RBB: 108540959(RIPK3)
TFN: 117069903(RIPK3)
PTEH: 111552879(RIPK3)
CJC: 100398268(RIPK3)
SBQ: 101046389(RIPK3)
CSYR: 103272227(RIPK3)
MMUR: 105866618(RIPK3)
LCAT: 123650691(RIPK3)
OGA: 100958984(RIPK3)
MMU: 56532(Ripk3)
MCAL: 110309461(Ripk3)
MPAH: 110325658(Ripk3)
RNO: 246240(Ripk3)
MCOC: 116084409(Ripk3)
MUN: 110556511(Ripk3)
CGE: 100768712(Ripk3)
MAUA: 101841763(Ripk3)
PLEU: 114708758(Ripk3)
MORG: 121435046(Ripk3)
MFOT: 126490854
AAMP: 119800090(Ripk3)
NGI: 103739494(Ripk3)
HGL: 101719112(Ripk3)
CPOC: 100734737(Ripk3)
CCAN: 109685840(Ripk3)
DORD: 105992443(Ripk3)
DSP: 122113463(Ripk3)
NCAR: 124976756
OPI: 101517316(RIPK3)
TUP: 102503180(RIPK3)
CFA: 608486(RIPK3)
CLUD: 112657037(RIPK3)
VVP: 112926559(RIPK3)
VLG: 121493260(RIPK3)
AML: 100465668(RIPK3)
UMR: 103679293(RIPK3)
UAH: 113246058(RIPK3)
UAR: 123795736(RIPK3)
ELK: 111160345
LLV: 125104721
MPUF: 101675101(RIPK3)
ORO: 101383873(RIPK3)
EJU: 114217948(RIPK3)
ZCA: 113908985(RIPK3)
MLX: 118003694(RIPK3)
NSU: 110585228(RIPK3)
FCA: 101097985(RIPK3)
PYU: 121031371(RIPK3)
PBG: 122468954(RIPK3)
LRUF: 124508869
PTG: 102965180(RIPK3)
PPAD: 109254967(RIPK3)
AJU: 106987875(RIPK3)
HHV: 120246980(RIPK3)
BTA: 507427(RIPK3)
BOM: 102285892(RIPK3)
BIU: 109564762(RIPK3)
BBUB: 102409412(RIPK3)
CHX: 102185184(RIPK3)
OAS: 101118877(RIPK3)
ODA: 120853483(RIPK3)
CCAD: 122443150(RIPK3)
SSC: 100153263(RIPK3)
CFR: 102524455(RIPK3)
CBAI: 105068852(RIPK3)
CDK: 105102433(RIPK3)
VPC: 102544472(RIPK3)
BACU: 102998617(RIPK3)
LVE: 103079725(RIPK3)
OOR: 101288355(RIPK3)
PCAD: 102976899(RIPK3)
ECB: 100054255(RIPK3)
EPZ: 103561048(RIPK3)
EAI: 106848614(RIPK3)
MYB: 102247700(RIPK3)
MYD: 107182662
MMYO: 118663992 118678603
MLF: 102417652(RIPK3)
MNA: 107531682(RIPK3)
PKL: 118726027(RIPK3)
HAI: 109393623(RIPK3)
DRO: 112300852(RIPK3)
SHON: 118980904(RIPK3)
AJM: 119037319(RIPK3)
PDIC: 114492079(RIPK3)
PHAS: 123820471(RIPK3)
MMF: 118639126(RIPK3)
RFQ: 117022802(RIPK3)
PALE: 102889734(RIPK3)
PGIG: 120608527(RIPK3)
PVP: 105309402(RIPK3)
RAY: 107498016(RIPK3)
MJV: 108410203(RIPK3)
TOD: 119238077
SARA: 101554573(RIPK3)
LAV: 100675807(RIPK3)
TMU: 101355323
DNM: 101417987(RIPK3)
ASN: 102384398(RIPK3)
AMJ: 106737053(RIPK3)
PSS: 102451749
CMY: 102947847
CPIC: 101936248
CABI: 116839024(RIPK3)
MRV: 120381149(RIPK3)
ACS: 100562959(ripk3) 103282606
PVT: 110091694(RIPK3)
SUND: 121932626(RIPK3)
PBI: 103056331
PMUR: 107286631(RIPK3)
CTIG: 120314856
TSR: 106549301
PGUT: 117662239(RIPK3)
PMUA: 114582501(RIPK3) 114582853
ZVI: 118078721(RIPK3)
STOW: 125445015(RIPK3)
XLA: 108699327(ripk3l.1.L) 108715017(ripk3.L) 733239(ripk3L.2.L)
XTR: 100490493(ripk3.2) 100491169(ripk3.1) 100497374
RTEM: 120920813 120921148 120940425(RIPK3)
BBUF: 120982054 120988971(RIPK3)
BGAR: 122922036 122923944(RIPK3)
DRE: 100004555(ripk3)
SRX: 107720485 107740770
SANH: 107693415 107698141
SGH: 107572655 107572835
CCAR: 109092949
CAUA: 113096283 113105406
PPRM: 120477354(ripk3)
MAMB: 125264282(ripk3)
IPU: 108260981(ripk3)
PHYP: 113544370
SMEO: 124381440(ripk3)
TFD: 113635479(ripk3)
AMEX: 103032582
EEE: 113581408
LCO: 104936986
CGOB: 115003517 115009922 115023646
ELY: 117261881 117272892(ripk3)
EFO: 125883490(ripk3) 125887355
PLEP: 121950386 121962244(ripk3)
SLUC: 116034155 116040211 116045695 116049156 116049187 116049189 116049191 116049192 116052977 116052983 116053250(ripk3) 116054943 116061666 116061815
ECRA: 117935041(ripk3) 117949536
ESP: 116676848 116678473 116684150 116694699 116702278 116707151
PFLV: 114545523 114546040 114553058 114560514 114563685 114572890
GAT: 120808783 120812610 120822400(ripk3)
PPUG: 119196678 119222943(ripk3)
MSAM: 119894247 119912361(ripk3)
CUD: 121505059(ripk3) 121515441
ALAT: 119024762 119024763 119027238(ripk3)
MZE: 101480907 106674752
ONL: 100694194 109194160
OAU: 116310296(ripk3) 116318317
OLA: 101159560 101168038 101168078 101168093 101168285 110013360
OML: 112139809 112151834 112151835 112152644 112155945(ripk3) 112163261
XMA: 102226269 111612340
XCO: 114151261 114157131
XHE: 116729831 116733297
PRET: 103466013 103480422
PFOR: 103133762 103144632
PLAI: 106945511 106958005
PMEI: 106906322 106925217
GAF: 122819911(ripk3) 122835324
CVG: 107091989
CTUL: 119793049 119794499(ripk3)
GMU: 124856640 124880094(ripk3)
NFU: 107373738
KMR: 108230000 108248610(ripk3)
ALIM: 106527055
NWH: 119415592(ripk3) 119416035
AOCE: 111585529
MCEP: 125014303(ripk3) 125014937
CSEM: 103380583 103384523
POV: 109624265 109646466(ripk3)
SSEN: 122766557(ripk3) 122775637
HHIP: 117752129(ripk3) 117762684
HSP: 118102817(ripk3) 118109029
LCF: 108875165 108890753(ripk3)
SDU: 111228668 111238592
SLAL: 111653316 111661685
XGL: 120792776 120797023(ripk3)
BPEC: 110158285
MALB: 109952017 109967425
BSPL: 114847805(ripk3) 114857396
SASA: 100195444(ripk4) 106573411
STRU: 115152032 115194583
OTW: 112252436 112259780(ripk3)
OMY: 110521454 110531501(ripk3)
OGO: 124001421 124007787(ripk3) 124019368
ONE: 115109452 115137906
SALP: 111952754
SNH: 120030698(ripk3) 120037248 120038206 120053250
CCLU: 121554607(ripk3)
ELS: 105030095
SFM: 108930640 114911906
PKI: 111856483
AANG: 118231452(ripk3)
PSPA: 121307397(ripk3)
ARUT: 117398869(ripk3)
 » show all
Reference
PMID:19524513
  Authors
Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M, Chan FK
  Title
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.
  Journal
Cell 137:1112-23 (2009)
DOI:10.1016/j.cell.2009.05.037
Reference
PMID:10339433
  Authors
Yu PW, Huang BC, Shen M, Quast J, Chan E, Xu X, Nolan GP, Payan DG, Luo Y
  Title
Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB.
  Journal
Curr Biol 9:539-42 (1999)
DOI:10.1016/S0960-9822(99)80239-5
  Sequence
[hsa:11035]
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