KEGG ORTHOLOGY: K08847

ORTHOLOGY: K08847

Entry

K08847                      KO

Symbol

RIPK3

Name

receptor-interacting serine/threonine-protein kinase 3 [EC:2.7.11.1]

Pathway

map04217

Necroptosis

map04621

NOD-like receptor signaling pathway

map04623

Cytosolic DNA-sensing pathway

map04668

TNF signaling pathway

map05132

Salmonella infection

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K08847  RIPK3; receptor-interacting serine/threonine-protein kinase 3
09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K08847  RIPK3; receptor-interacting serine/threonine-protein kinase 3
09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K08847  RIPK3; receptor-interacting serine/threonine-protein kinase 3
   04623 Cytosolic DNA-sensing pathway
    K08847  RIPK3; receptor-interacting serine/threonine-protein kinase 3
09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K08847  RIPK3; receptor-interacting serine/threonine-protein kinase 3
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08847  RIPK3; receptor-interacting serine/threonine-protein kinase 3
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08847  RIPK3; receptor-interacting serine/threonine-protein kinase 3
Protein kinases [BR:ko01001]
Serine/threonine kinases: TKL group
  RIPK family [OT]
   K08847  RIPK3; receptor-interacting serine/threonine-protein kinase 3

Genes

HSA:	11035(RIPK3)

PTR:	452820(RIPK3)

PPS:	100982151(RIPK3)

GGO:	101126247(RIPK3)

PON:	100461174(RIPK3)

PPYG:

129012613(RIPK3)

NLE:	100589021(RIPK3)

HMH:	116484981(RIPK3)

SSYN:

129489294(RIPK3)

MCC:	716138(RIPK3)

MCF:	102124880(RIPK3)

MTHB:

126958796

MNI:	105477873(RIPK3)

CSAB:

103228724(RIPK3)

CATY:

105600226(RIPK3)

PANU:

101027042(RIPK3)

TGE:	112628650(RIPK3)

MLEU:

105532739(RIPK3)

RRO:	104662673(RIPK3)

RBB:	108540959(RIPK3)

TFN:	117069903(RIPK3)

PTEH:

111552879(RIPK3)

CANG:

105503714(RIPK3)

CJC:	100398268(RIPK3)

SBQ:	101046389(RIPK3)

CIMI:

108297938(RIPK3)

ANAN:

105727877(RIPK3)

CSYR:

103272227(RIPK3)

MMUR:

105866618(RIPK3)

LCAT:

123650691(RIPK3)

PCOQ:

105812766(RIPK3)

OGA:	100958984(RIPK3)

MMU:	56532(Ripk3)

MCAL:

110309461(Ripk3)

MPAH:

110325658(Ripk3)

RNO:	246240(Ripk3)

MCOC:

116084409(Ripk3)

ANU:	117705541(Ripk3)

ASYL:

127691510(Ripk3)

MUN:	110556511(Ripk3)

CGE:	100768712(Ripk3)

MAUA:

101841763(Ripk3)

PROB:

127230358(Ripk3)

PLEU:

114708758(Ripk3)

MORG:

121435046(Ripk3)

MFOT:

126490854

AAMP:

119800090(Ripk3)

NGI:	103739494(Ripk3)

HGL:	101719112(Ripk3)

CPOC:

100734737(Ripk3)

CCAN:

109685840(Ripk3)

DORD:

105992443(Ripk3)

DSP:	122113463(Ripk3)

DMER:

138841812(Ripk3)

NCAR:

124976756

MMMA:

107147456(Ripk3)

ITI:	101960523(Ripk3)

OPI:	101517316(RIPK3)

TUP:	102503180(RIPK3)

GVR:	103590143(RIPK3)

CFA:	608486(RIPK3)

CLUD:

112657037(RIPK3)

VVP:	112926559(RIPK3)

VLG:	121493260(RIPK3)

NPO:	129499572(RIPK3)

AML:	100465668(RIPK3)

UMR:	103679293(RIPK3)

UAH:	113246058(RIPK3)

UAR:	123795736(RIPK3)

ELK:

111160345

LLV:

125104721

MPUF:

101675101(RIPK3)

MNP:	131998756(RIPK3)

MLK:	131836407(RIPK3)

NVS:	122893085(RIPK3)

ORO:	101383873(RIPK3)

EJU:	114217948(RIPK3)

ZCA:	113908985(RIPK3)

MLX:	118003694(RIPK3)

NSU:	110585228(RIPK3)

LWW:	102729957(RIPK3)

FCA:	101097985(RIPK3)

PYU:	121031371(RIPK3)

PCOO:

112856348(RIPK3)

PBG:	122468954(RIPK3)

PVIV:

125167445(RIPK3)

LRUF:

124508869

LGF:	123583468(RIPK3)

AJU:

106987875

PTG:	102965180(RIPK3)

PPAD:

109254967(RIPK3)

PUC:

125909636

PLEZ:

122221280(RIPK3)

HHV:	120246980(RIPK3)

BTA:	507427(RIPK3)

BOM:	102285892(RIPK3)

BIU:	109564762(RIPK3)

BBIS:

104982049(RIPK3)

CHX:	102185184(RIPK3)

OAS:	101118877(RIPK3)

BTAX:

128054462(RIPK3)

CSUM:

138073232(RIPK3)

ODA:	120853483(RIPK3)

CCAD:

122443150(RIPK3)

MREE:

136171433(RIPK3)

OVR:	110129542(RIPK3)

MBEZ:

129562625(RIPK3)

SSC:	100153263(RIPK3)

CFR:	102524455(RIPK3)

CBAI:

105068852(RIPK3)

CDK:	105102433(RIPK3)

VPC:	102544472(RIPK3)

BACU:

102998617(RIPK3)

BMUS:

118889888(RIPK3)

LVE:	103079725(RIPK3)

DDP:	132418075(RIPK3)

PCAD:

102976899(RIPK3)

PPHC:

136118416(RIPK3)

NASI:

112405028(RIPK3)

ECB:	100054255(RIPK3)

EPZ:	103561048(RIPK3)

EAI:	106848614(RIPK3)

MYB:	102247700(RIPK3)

MYD:

107182662

MMYO:

118663992 118678603

MLF:	102417652(RIPK3)

MDT:	132241054(RIPK3) 132241088

MYUM:

139004108(RIPK3)

PKL:	118726027(RIPK3)

EFUS:

103301469(RIPK3)

MNA:	107531682(RIPK3)

DRO:	112300852(RIPK3)

SHON:

118980904(RIPK3)

AJM:	119037319(RIPK3)

PDIC:

114492079(RIPK3)

PHAS:

123820471(RIPK3)

MMF:	118639126(RIPK3)

PPAM:

129074065(RIPK3)

HAI:	109393623(RIPK3)

RFQ:	117022802(RIPK3)

PALE:

102889734(RIPK3)

PGIG:

120608527(RIPK3)

PVP:	105309402(RIPK3)

RAY:	107498016(RIPK3)

MJV:	108410203(RIPK3)

TOD:	119238077(RIPK3)

SARA:

101554573(RIPK3)

SFUM:

130041648(RIPK3)

SETR:

126001711(RIPK3)

LAV:	100675807(RIPK3)

TMU:

101355323

ETF:	101639698(RIPK3)

DNM:	101417987(RIPK3)

ASN:	102384398(RIPK3)

AMJ:	106737053(RIPK3)

PSS:

102451749

CMY:

102947847

CCAY:

125622323(RIPK3)

DCC:	119841926(RIPK3)

CPIC:

101936248

CABI:

116839024(RIPK3)

MRV:	120381149(RIPK3)

ACS:	100562959(ripk3) 103282606

ASAO:

132765356 132777698(RIPK3)

PVT:	110091694(RIPK3)

SUND:

121932626(RIPK3)

PBI:

103056331

PMUR:

107286631(RIPK3)

CTIG:

120314856

TSR:

106549301

PGUT:

117662239(RIPK3)

APRI:

131197141

PTEX:

113450843(RIPK3)

NSS:

113425501

PMUA:

114582501(RIPK3) 114582853

PRAF:

128399749(RIPK3)

ZVI:	118078721(RIPK3)

HCG:

128330505

STOW:

125445015(RIPK3)

EMC:	129338253(RIPK3)

XLA:	108699327(ripk3l.1.L) 108715017(ripk3.L) 733239(ripk3L.2.L)

XTR:	100490493(ripk3.2) 100491169(ripk3.1) 100497374

RTEM:

120920813 120921148 120940425(RIPK3)

ACAT:

141117132 141117133 141117134 141117516 141117640 141145276(RIPK3)

BBUF:

120982054 120988971(RIPK3)

BGAR:

122922036 122923944(RIPK3)

DTC:	141083071 141083075 141089177(RIPK3)

PWL:	138299753(RIPK3)

MUO:	115458113(RIPK3)

GSH:	117350770(RIPK3)

DRE:	100004555(ripk3)

SRX:	107720485 107740770

SANH:

107693415 107698141

SGH:	107572655 107572835

CCAR:

109075771(ripk3) 109092949

CAUA:

113096283 113105406

CGIB:

127962248 128017792

PTET:

122349727(ripk3)

LROH:

127167929(ripk3)

GRF:	141332314(ripk3)

OMC:	131544080(ripk3)

PPRM:

120477354(ripk3)

RKG:	130071099(ripk3)

MAMB:

125264282(ripk3)

CIDE:

127516504 127516575

CERY:

137030184(ripk3)

MASI:

127410624 127441691 127447798

TROS:

130555383(ripk3)

TDW:	130435912(ripk3)

MANU:

129453798(ripk3)

PDAB:

135743982(ripk3)

IPU:	108260981(ripk3)

IFU:	128604355(ripk3)

PHYP:

113544370

SMEO:

124381440(ripk3)

TFD:	113635479(ripk3)

TVC:	132841767(ripk3)

CGAR:

128508342(ripk3)

NGRA:

132883404(ripk3)

TRN:	134326539(ripk3)

AMEX:

103032582(ripk3)

CMAO:

118816549(ripk3)

EEE:

113581408

CHAR:

105912877(ripk3)

SPIL:

134059515(ripk3)

LCO:

104936986

NCC:

104965116

TBEN:

117491219 117491221 117494654(ripk3)

CGOB:

115003517 115009922 115023646

PGEO:

117448727 117463677(ripk3)

GACU:

117536371 117545770

EMAC:

134876137(ripk3) 134882996

ELY:	117261881 117272892(ripk3)

EFO:	125883490(ripk3) 125887355

PLEP:

121950386 121962244(ripk3)

SLUC:

116034155 116040211 116045695 116049156 116049187 116049189 116049191 116049192 116052977 116052983 116053250(ripk3) 116054943 116061666 116061815

ECRA:

117935041(ripk3) 117949536

ESP:	116676848 116678473 116684150 116694699 116702278 116707151

PFLV:

114545523 114546040 114553058 114560514 114563685 114572890

GAT:	120808783 120812610 120822400(ripk3)

PPUG:

119196678 119222943(ripk3)

AFB:	129093213(ripk3) 129108125

CLUM:

117732832 117747537(ripk3)

PSWI:

130195493 130211564(ripk3)

CANA:

137792363(ripk3) 137804333

CVE:	137881432 137885956(ripk3)

MSAM:

119894247 119912361(ripk3)

SCHU:

122869766(ripk3) 122875537

CUD:	121505059(ripk3) 121515441

SPUL:

138600821 138613135

LMIX:

132958367(ripk3) 132972389

ALAT:

119024762 119024763 119027238(ripk3)

ASTR:

137590213(ripk3) 137593831

MZE:	101480907 106674752

ONL:	100694194 109194160

OAU:	116310296(ripk3) 116318317

OLA:	101159560 101168038 101168078 101168093 101168285 110013360

OML:	112139809 112151834 112151835 112152644 112155945(ripk3) 112163261

CSAI:

133420168(ripk3) 133444309 133444311 133444770

XMA:	102226269 111612340

XCO:	114151261 114157131

XHE:	116729831 116733297

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122819911(ripk3) 122835324

PPRL:

129352389(ripk3) 129367423

CVG:

107091989

CTUL:

119793049 119794499(ripk3)

GMU:	124856640 124880094(ripk3)

NFU:

107373738

KMR:	108230000 108248610(ripk3)

ALIM:

106527055

NWH:	119415592(ripk3) 119416035

AOCE:

111585529(ripk3)

EJA:	138203929(ripk3) 138206285

BFRE:

138626415(ripk3) 138628231

MCEP:

125014303(ripk3) 125014937

CSEM:

103380583 103384523

POV:	109624265 109646466(ripk3)

SSEN:

122766557(ripk3) 122775637

SSOE:

131456291(ripk3) 131470183

HHIP:

117752129(ripk3) 117762684

HSP:	118102817(ripk3) 118109029

PPLT:

128429822 128430563 128444353

SMAU:

118290377(ripk3) 118315714

LCF:	108875165 108890753(ripk3)

SDU:	111228668 111238592

SLAL:

111653316 111661685

XGL:	120792776 120797023(ripk3)

BPEC:

110158285

ENY:	140348513 140371642(ripk3)

MALB:

109952017 109967425

BSPL:

114847805(ripk3) 114857396

SJO:	128383532(ripk3)

SSCO:

133982287 134005885(ripk3)

GMH:	115529123 115551353

SASA:

100195444(ripk4) 106573411

STRU:

115152032 115194583

OTW:	112252436 112259780(ripk3)

OMY:	110521454 110531501(ripk3)

OGO:	124001421 124007787(ripk3)

ONE:	115109452 115137906

OKI:	109889396 109906346

OKE:	118368960(ripk3) 127910608

OMM:	135510381(ripk3) 135524351 135536677

OCLA:

139370219 139405434 139405762 139415924

SALP:

111952754

SNH:	120030698(ripk3) 120037248 120038206 120053250

CCLU:

121554607(ripk3)

ELS:

105030095

OEP:	134010077(ripk3)

SFM:	108930640 114911906

PKI:

111856483

AANG:

118231452(ripk3)

AROT:

135258704(ripk3)

CCOG:

133134427 133134558 133135047 133135055 133135540 133141618 133141627

PSPA:

121307397(ripk3)

ARUT:

117398869(ripk3)

HAKA:

140716330

PMRN:

116945942

LRJ:

133340453

AFIL:

140150860 140151243 140151263 140164211 140164319 140169254 140170986

RIE:	OCT59_007709 OCT59_011404 OCT59_011554 OCT59_012488 OCT59_014130 OCT59_022315 OCT59_023891 OCT59_024031 OCT59_024042 OCT59_027479

» show all

Reference

PMID:19524513

Authors

Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M, Chan FK

Title

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.

Journal

Cell 137:1112-23 (2009)
DOI:10.1016/j.cell.2009.05.037

Reference

PMID:10339433

Authors

Yu PW, Huang BC, Shen M, Quast J, Chan E, Xu X, Nolan GP, Payan DG, Luo Y

Title

Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB.

Journal

Curr Biol 9:539-42 (1999)
DOI:10.1016/S0960-9822(99)80239-5

Sequence

[hsa:11035]

LinkDB

DBGET integrated database retrieval system