KEGG ORTHOLOGY: K08890

ORTHOLOGY: K08890

Entry

K08890                      KO

Symbol

BLK

Name

B lymphoid tyrosine kinase [EC:2.7.10.2]

Pathway

map04662

B cell receptor signaling pathway

Disease

H00410

Maturity onset diabetes of the young (MODY)

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04662 B cell receptor signaling pathway
    K08890  BLK; B lymphoid tyrosine kinase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08890  BLK; B lymphoid tyrosine kinase
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K08890  BLK; B lymphoid tyrosine kinase
Protein kinases [BR:ko01001]
Non-receptor tyrosine kinases
  SRC family
   K08890  BLK; B lymphoid tyrosine kinase

Other DBs

GO:

0004715

Genes

HSA:

640(BLK)

PTR:	463991(BLK)

PPS:	100989728(BLK)

GGO:	101149169(BLK)

PON:	100442545(BLK)

PPYG:

129042922(BLK)

NLE:	100601418(BLK)

HMH:	116473819(BLK)

SSYN:

129487486(BLK)

MCC:	696892(BLK)

MCF:	102134629(BLK)

MTHB:

126961061

MNI:	105491181(BLK)

CSAB:

103215326(BLK)

CATY:

105579384(BLK)

PANU:

101012728(BLK)

TGE:	112630034(BLK)

MLEU:

105532599(BLK)

RRO:	104679109(BLK)

RBB:	108536705(BLK)

TFN:	117063391(BLK)

PTEH:

111551355(BLK)

CANG:

105512402(BLK)

CJC:	100412187(BLK)

SBQ:	101046927(BLK)

CIMI:

108312515(BLK)

ANAN:

105720708(BLK)

CSYR:

103272696(BLK)

MMUR:

105864819(BLK)

LCAT:

123626542(BLK) 123638818 123640524 123645695 123648150 123648152 123648166 123648167 123648168 123648169 123649064

PCOQ:

105807222(BLK)

OGA:	100953369(BLK)

MMU:	12143(Blk)

MCAL:

110309102(Blk)

MPAH:

110325256(Blk)

RNO:	364403(Blk)

MCOC:

116084545(Blk)

ANU:	117705441(Blk)

ASYL:

127691419(Blk)

MUN:	110561868(Blk)

CGE:	100755534(Blk)

MAUA:

101842881(Blk)

PROB:

127230264(Blk)

PLEU:

114703376(Blk)

MORG:

121459646(Blk)

MFOT:

126507694

AAMP:

119800117(Blk)

NGI:	103730016(Blk)

HGL:	101707209(Blk)

CPOC:

100714723(Blk)

CCAN:

109678919(Blk)

DORD:

105991594(Blk)

DSP:	122125289(Blk)

PLOP:

125339293(Blk)

NCAR:

124982545

MMMA:

107153861(Blk)

ITI:	101957284(Blk)

OCU:

100345996

OPI:	101530673(BLK)

TUP:	102480506(BLK)

GVR:	103596274(BLK)

CFA:	486080(BLK)

CLUD:

112669650(BLK)

VVP:	112926712(BLK)

VLG:	121496652(BLK)

NPO:	129493706(BLK)

AML:	100479355(BLK)

UMR:	103675935(BLK)

UAH:	113269925(BLK)

UAR:	123793540(BLK)

ELK:	111154650 111154657

LLV:

125092931

MPUF:

101691826(BLK)

MNP:	131999448(BLK)

MLK:	131833704(BLK)

NVS:	122919192(BLK)

ORO:	101377076(BLK)

EJU:	114217382(BLK)

ZCA:	113925691(BLK)

MLX:	118022390(BLK)

NSU:	110588505(BLK)

LWW:	102730375(BLK)

FCA:	101084104(BLK)

PYU:	121026978(BLK)

PCOO:

112858898(BLK)

PBG:	122474342(BLK)

PVIV:

125164566(BLK)

LRUF:

124520848

LGF:	123589787(BLK)

AJU:

106975803

PTG:	102967571(BLK)

PPAD:

109262389(BLK)

PUC:	125917030 125917031

PLEZ:

122217684(BLK)

HHV:	120222045(BLK)

BTA:	532587(BLK)

BOM:	102283803(BLK)

BIU:	109562780(BLK)

BBUB:

102412376(BLK)

BBIS:

104988815(BLK)

CHX:	102174117(BLK)

OAS:	101111167(BLK)

BTAX:

128052176(BLK)

CSUM:

138080865(BLK)

ODA:	120857741(BLK)

CCAD:

122453187(BLK)

MREE:

136148435(BLK)

OVR:	110127112(BLK)

MBEZ:

129557243(BLK)

SSC:	100623761(BLK)

CFR:	102520055(BLK)

CBAI:

105083374(BLK)

CDK:	105101938(BLK)

VPC:	102529562(BLK)

BACU:

103000707(BLK)

BMUS:

118897022(BLK)

LVE:	103091634(BLK)

OOR:	101284189(BLK)

LALB:

132523048(BLK)

DLE:	111185368(BLK)

PCAD:

102982502(BLK)

PSIU:

116755991(BLK)

NASI:

112410700(BLK)

ECB:	100065099(BLK)

EPZ:	103565478(BLK)

EAI:	106822585(BLK)

MYB:	102243589(BLK)

MYD:	102769847(BLK)

MMYO:

118659301(BLK)

MLF:	102423825(BLK)

MDT:	132234238(BLK)

MYUM:

139010699(BLK)

PKL:	118711446(BLK)

EFUS:

103294358(BLK)

MNA:	107535018(BLK)

DRO:	112312450(BLK)

SHON:

118984320(BLK)

AJM:	119049443(BLK)

PDIC:

114502911(BLK)

PHAS:

123813778(BLK)

MMF:	118615701(BLK)

PPAM:

129072449(BLK)

HAI:	109379519(BLK)

RFQ:	117037947(BLK)

PALE:

102898235(BLK)

PGIG:

120613350(BLK)

PVP:	105291570(BLK)

RAY:	107518857(BLK)

MJV:	108402366(BLK)

TOD:	119257026(BLK)

SARA:

101558444(BLK)

SFUM:

130023614(BLK)

SETR:

126005815(BLK)

LAV:	100677743(BLK)

TMU:

101361885

ETF:	101642053(BLK)

DNM:	101433029(BLK)

MDO:	100032697(BLK)

GAS:	123234903(BLK)

SHR:	100923306(BLK)

AFZ:

127548518

PCW:	110207648(BLK)

TVP:	118843011(BLK)

PBRV:

138141883(BLK)

OAA:	100076440(BLK)

TACU:

119949440(BLK)

GGA:	422035(BLK)

PCOC:

116235589(BLK)

MGP:	100544594(BLK)

CJO:	107312432(BLK)

TPAI:

128085314(BLK)

LMUT:

125689785(BLK)

NMEL:

110396499(BLK)

APLA:

101794713(BLK)

ACYG:

106038127(BLK)

CATA:

118256520(BLK)

AFUL:

116487790(BLK)

TGU:	100223292(BLK)

LSR:	110475987(BLK)

SCAN:

103821296(BLK)

PMOA:

120496818(BLK)

OTC:	121347463(BLK)

PRUF:

121360791(BLK)

ATRC:

139599918(BLK)

GFR:	102031459(BLK)

FAB:	101816827(BLK)

OMA:	130250787(BLK)

PHI:	102102766(BLK)

PMAJ:

107202585(BLK)

CCAE:

111927368(BLK)

CCW:	104696874(BLK)

CBRC:

103613272(BLK)

ACOE:

138107442(BLK)

ETL:	114069194(BLK)

ZAB:	102069020(BLK)

ZLE:	135445106(BLK)

ACHL:

103798659(BLK)

SVG:	106863205(BLK)

MMEA:

130585629

HRT:	120750848(BLK)

SATI:

136358682(BLK)

CCIC:

134041554(BLK)

FPG:	101916421(BLK)

FCH:	102060264(BLK)

CCRI:

104165240

NNT:	104404686(BLK)

SHAB:

115609478(BLK)

ACUN:

113478164(BLK)

TALA:

104355483(BLK)

ACHC:

115351320(BLK)

HALD:

104321201

HLE:	104841451(BLK)

AGEN:

126046586

HHAR:

128152162(BLK)

GCL:

127014185

LDI:	104343996(BLK)

MNB:

103780836

DPUB:

104306742(BLK)

PPUS:

135177177(BLK)

AVIT:

104276923(BLK)

BRHI:

104492081

EGZ:	104127260(BLK)

NNI:	104014690(BLK)

PCRI:

104035595

PCAO:

104041288

PADL:

103913230(BLK)

AFOR:

103906888(BLK)

FGA:

104071003

GSTE:

104262589

CLV:	102092955(BLK)

MUI:

104538559

PGUU:

104465049(BLK)

PLET:

104623268

EHS:

104512854

CMAC:

104479960(BLK)

CUCA:

104060733(BLK)

TEO:

104378499

BREG:

104632799(BLK)

OHA:	104336470(BLK)

CPEA:

104392757(BLK)

CVF:	104289049(BLK)

RTD:	128907750(BLK)

CRID:

134512469(BLK)

AAM:

106482525

AROW:

112963763(BLK)

NPD:	112948644(BLK)

TGT:

104571872

DNE:	112991172(BLK)

SCAM:

104138993(BLK)

ASN:	102373406(BLK)

AMJ:	102570125(BLK)

CPOO:

109311515(BLK)

GGN:	109300248(BLK)

PSS:	102452970(BLK)

CMY:	102931113(BLK)

CCAY:

125634706(BLK)

DCC:	119853351(BLK)

CPIC:

101941279(BLK)

TST:	117875408(BLK)

CABI:

116815287(BLK)

MRV:	120401329(BLK)

ACS:	100559493(blk)

ASAO:

132761615(BLK)

PVT:

110091211

SUND:

121919940(BLK)

PBI:	103053213(BLK)

PMUR:

107289318(BLK)

CTIG:

120318778

TSR:

106541703

PGUT:

117667722(BLK)

APRI:

131189039(BLK)

PTEX:

113446321(BLK)

NSS:	113424349(BLK)

VKO:	123033601(BLK)

PMUA:

114593387(BLK)

PRAF:

128411410(BLK)

ZVI:	118082711(BLK)

HCG:	128324206(BLK)

GJA:	107123785(BLK)

STOW:

125437251(BLK)

EMC:	129325123(BLK)

XLA:	108717237(blk.L)

XTR:	100496460(blk)

NPR:

108800193

RTEM:

120936179

BBUF:

120997195(BLK)

BGAR:

122934092(BLK)

PWL:	138296746(BLK)

MUO:	115465160(BLK)

GSH:	117357343(BLK)

DRE:	567764(blk)

SRX:	107723466 107746144

SANH:

107684815 107701472

SGH:	107561930 107589086

CCAR:

109057663(blk) 109091682

CAUA:

113037757 113063220 113069958

CGIB:

127937982 127984446

PTET:

122325552(blk)

LROH:

127183409(blk)

OMC:	131527399(blk)

PPRM:

120494220(blk)

RKG:	130097578(blk)

MAMB:

125278945(blk)

CIDE:

127502228

CERY:

137019423(blk)

MASI:

127409796 127416291

TROS:

130566141(blk)

TDW:	130434572(blk)

MANU:

129429707(blk)

PDAB:

135738995(blk)

IPU:	108258139(blk)

IFU:	128601292(blk)

PHYP:

113545292(blk)

SMEO:

124377071(blk)

TFD:	113644829(blk)

TVC:	132843339(blk)

CGAR:

128515013(blk)

NGRA:

132883721(blk)

TRN:	134320043(blk)

AMEX:

103025639(blk)

CMAO:

118815509(blk)

EEE:

113569917

CHAR:

105897722(blk)

SPIL:

134097769(blk)

TRU:	101064341(blk)

TFS:	130516519(blk)

TNG:	GSTEN00030294G001

LCO:	104922438(blk)

NCC:	104962275(blk)

CGOB:

115003648(blk)

ELY:	117270745(blk)

EFO:	125896546(blk)

PLEP:

121955291(blk)

SLUC:

116066308(blk)

ECRA:

117961399(blk)

ESP:	116706739(blk)

PFLV:

114572758(blk)

GAT:	120808376(blk)

PPUG:

119195409(blk)

AFB:	129107630(blk)

CLUM:

117727474(blk)

PSWI:

130202133(blk)

CANA:

137785403(blk)

CVE:	137882318(blk)

MSAM:

119909242(blk)

SCHU:

122862835(blk)

CUD:	121521442(blk)

SPUL:

138610972(blk)

LMIX:

132985045(blk)

ALAT:

119013026(blk)

ASTR:

137613180(blk)

MZE:	101474727(blk)

ONL:	100692749(blk)

OAU:	116314080(blk)

CSAI:

133464427(blk)

AOCE:

111588222(blk)

EJA:	138193833(blk)

BFRE:

138637187(blk)

MCEP:

124999102(blk)

CSEM:

103398683

POV:

109632326

SSEN:

122784452(blk)

SSOE:

131444109(blk)

HHIP:

117758461(blk)

HSP:	118099891(blk)

PPLT:

128459902(blk)

SMAU:

118289790(blk)

LCF:

108895563

SDU:	111238823(blk)

SLAL:

111653479

XGL:	120788797(blk)

HCQ:	109524848(blk)

SSCV:

125989786(blk)

SBIA:

133496809(blk)

PEE:	133416761(blk)

MALB:

109970011(blk)

BSPL:

114849933(blk)

SSCO:

133997438(blk)

GMH:	115534626(blk)

SASA:

106608341

STRU:

115149525(blk)

OTW:	112247817(blk)

OMY:	110522661(blk)

OGO:	123995469(blk)

OKI:	109879154(blk)

OKE:	118381208(blk)

OMM:	135557995(blk)

OCLA:

139397811 139399188

SNH:	120019419(blk)

CCLU:

121548491(blk)

ELS:	109614593(blk)

SFM:	108922546 108929219

PKI:	111837295 111857980

AANG:

118222871(si:ch73-340m8.2) 118229054(blk)

AROT:

135238807(si:ch73-340m8.2) 135257781(blk)

CCOG:

133123098(si:ch73-340m8.2) 133128586(blk)

LOC:

102683224

PSPA:

121316437(lck) 121317321

ARUT:

117410400

PSEX:

120526327(blk)

LCM:

102350125

RTP:	109918180(si:ch73-340m8.2)

CPLA:

122543725(si:ch73-340m8.2)

HOC:

132806709

RPHI:

132732416

RIE:	OCT59_008953

» show all

Reference

PMID:7822795

Authors

Islam KB, Rabbani H, Larsson C, Sanders R, Smith CI

Title

Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk.

Journal

J Immunol 154:1265-72 (1995)

Sequence

[hsa:640]

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