KEGG ORTHOLOGY: K09071

ORTHOLOGY: K09071

Entry

K09071                      KO

Symbol

HAND1

Name

heart-and neural crest derivatives-expressed protein 1

Pathway

map04550

Signaling pathways regulating pluripotency of stem cells

Disease

H01272

Hypoplastic left heart syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K09071  HAND1; heart-and neural crest derivatives-expressed protein 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09071  HAND1; heart-and neural crest derivatives-expressed protein 1
Transcription factors [BR:ko03000]
Eukaryotic type
  Basic helix-loop-helix (bHLH)
   Tal/Twist/Atonal/Hen, Mesodermal Twist-like factors
    K09071  HAND1; heart-and neural crest derivatives-expressed protein 1

Genes

HSA:	9421(HAND1)

PTR:	462209(HAND1)

PPS:	100981382(HAND1)

GGO:	101149977(HAND1)

PON:	100451943(HAND1)

PPYG:

129036800(HAND1)

NLE:	100580213(HAND1)

HMH:	116470481(HAND1)

SSYN:

129486121(HAND1)

MCC:	714450(HAND1)

MCF:	102132552(HAND1)

MTHB:

126956750

MNI:	105482399(HAND1)

CSAB:

103244836(HAND1)

CATY:

105589924(HAND1)

PANU:

101002590(HAND1)

TGE:	112626437(HAND1)

MLEU:

105540564(HAND1)

RRO:	104660241(HAND1)

RBB:	108532085(HAND1)

TFN:	117065639(HAND1)

PTEH:

111552692(HAND1)

CANG:

105504268(HAND1)

CJC:	100399939(HAND1)

SBQ:	101049611(HAND1)

CIMI:

108312571(HAND1)

ANAN:

105715944(HAND1)

MMUR:

105866247(HAND1)

LCAT:

123638036(HAND1)

ERUF:

138393188(HAND1)

PCOQ:

105817489(HAND1)

OGA:	100943383(HAND1)

MMU:	15110(Hand1)

MCAL:

110306081(Hand1)

MPAH:

110332556(Hand1)

RNO:	59112(Hand1)

MCOC:

116077613(Hand1)

ANU:	117711746(Hand1)

ASYL:

127695548(Hand1)

MUN:	110551750(Hand1)

CGE:	100767952(Hand1)

MAUA:

101835482(Hand1)

PROB:

127219251(Hand1)

PLEU:

114700389(Hand1)

PMAV:

102910790(Hand1)

MORG:

121456816(Hand1)

MFOT:

126510911

AAMP:

119813539(Hand1)

CNL:	130878567(Hand1)

NGI:	103741515(Hand1)

HGL:	101721169(Hand1)

CPOC:

100722914(Hand1)

CCAN:

109690280(Hand1)

DORD:

105999787(Hand1)

DSP:	122118572(Hand1)

DMER:

138808679 138824937

PLOP:

125342152(Hand1)

NCAR:

124987631

MMMA:

107148170(Hand1)

ITI:	101956556(Hand1)

OCU:

100009575

OPI:	101529292(HAND1)

OCZ:	121164637(HAND1)

TUP:	102481534(HAND1)

GVR:	103590842(HAND1)

CFA:	489164(HAND1)

CLUD:

112651817(HAND1)

VVP:	112928677(HAND1)

VLG:	121486179(HAND1)

NPO:	129509869(HAND1)

AML:	100470676(HAND1)

UMR:	103664805 121102778

UAH:	113263871(HAND1)

UAR:	123788624(HAND1)

ELK:

111141262

LLV:

125100072

MPUF:

101688211(HAND1)

MNP:	132027805(HAND1)

MLK:	131831344(HAND1)

NVS:	122902051(HAND1)

ORO:	101374148(HAND1)

EJU:	114211836(HAND1)

ZCA:	113929408(HAND1)

MLX:	118015569(HAND1)

NSU:	110587092(HAND1)

LWW:	102731295(HAND1)

FCA:	101096445(HAND1)

PYU:	121009690(HAND1)

PCOO:

112861356(HAND1)

PBG:	122493285(HAND1)

PVIV:

125175144(HAND1)

LRUF:

124507147

LGF:	123575784(HAND1)

AJU:

106967668

PTG:	102952610(HAND1)

PPAD:

109276001(HAND1)

PUC:

125935164

PLEZ:

122201652(HAND1)

HHV:	120248982(HAND1)

BTA:	517952(HAND1)

BOM:	102270674(HAND1)

BIU:	109561295(HAND1)

BBUB:

102397378(HAND1)

BKE:	129642257(HAND1)

BBIS:

104980617(HAND1)

CHX:	102172808(HAND1)

OAS:	443353(HAND1)

BTAX:

128051581(HAND1)

CSUM:

138086501(HAND1)

ODA:	120864407(HAND1)

CCAD:

122439188(HAND1)

MREE:

136168543(HAND1)

OVR:	110145436(HAND1)

MBEZ:

129559462(HAND1)

SSC:	541594(HAND1)

CFR:	102515835(HAND1)

CBAI:

105080940(HAND1)

CDK:	105095171(HAND1)

VPC:	102533629(HAND1)

BACU:

103017016(HAND1)

BMUS:

118892878(HAND1)

LVE:	103072384(HAND1)

OOR:	101287078(HAND1)

LALB:

132518539(HAND1)

GMF:	115840806(HAND1)

DDP:	132421997(HAND1)

DLE:	111183134(HAND1)

PCAD:

102983366(HAND1)

PSIU:

116751787(HAND1)

PPHC:

136120896(HAND1)

NASI:

112409806(HAND1)

ECB:	100071390(HAND1)

EPZ:	103552422(HAND1)

EAI:	106834917(HAND1)

MYB:	102244340(HAND1)

MYD:	102768926(HAND1)

MMYO:

118658621(HAND1)

MLF:	102420010(HAND1)

MDT:	132235890(HAND1)

MYUM:

139011603(HAND1)

PKL:	118711480(HAND1)

EFUS:

103295780(HAND1)

MNA:	107537989(HAND1)

DRO:	112319435(HAND1)

SHON:

118986211(HAND1)

AJM:	119057948(HAND1)

PDIC:

114510081(HAND1)

PHAS:

123811197(HAND1)

MMF:	118616268(HAND1)

PPAM:

129066371(HAND1)

HAI:	109390797(HAND1)

RFQ:	117016798(HAND1)

PALE:

102898644(HAND1)

PGIG:

120581612(HAND1)

PVP:	105289930(HAND1)

RAY:	107521938(HAND1)

MJV:	108408584(HAND1)

TOD:	119237053(HAND1)

SARA:

101553351(HAND1)

SFUM:

130021535(HAND1)

SETR:

126012250(HAND1)

LAV:	100653807(HAND1)

TMU:

101350271

ETF:	101659466(HAND1)

DNM:	101435512(HAND1)

MDO:	100025000(HAND1)

GAS:	123235585(HAND1)

SHR:	100923907(HAND1)

AFZ:

127546660

PCW:	110199725(HAND1)

TVP:	118841571(HAND1)

PBRV:

138172560(HAND1)

MLAO:

141518323(HAND1)

OAA:	100076784(HAND1)

TACU:

119919729(HAND1)

GGA:	395812(HAND1)

PCOC:

116231912(HAND1)

MGP:	104917023(HAND1)

CJO:	107320101(HAND1)

TPAI:

128081448(HAND1)

LMUT:

125700203(HAND1)

NMEL:

110405588(HAND1)

APLA:

101804900(HAND1)

AACU:

137864387(HAND1)

ACYG:

125181983(HAND1)

CATA:

118254530(HAND1)

AFUL:

116495059(HAND1)

TGU:	115497165(HAND1)

LSR:	110482745(HAND1)

SCAN:

103817494(HAND1)

PMOA:

120498615(HAND1)

OTC:	121332351(HAND1)

PRUF:

121361459(HAND1)

ATRC:

139597921(HAND1)

FAB:	101818068(HAND1)

OMA:	130258806(HAND1)

PHI:	102102016(HAND1)

CCW:	120410770(HAND1)

ACOE:

138118255(HAND1)

ETL:	114058354(HAND1)

ZLE:	135453783(HAND1)

SVG:	106852943(HAND1)

MMEA:

130582309(HAND1)

HRT:	120759242(HAND1)

SATI:

136367304(HAND1)

CFAI:

136297340(HAND1)

CCIC:

134049726(HAND1)

FPG:	101914089(HAND1)

FCH:	102048775(HAND1)

SHAB:

115615925(HAND1)

SURA:

141949672(HAND1)

TALA:

116964940(HAND1)

ACHC:

115334444(HAND1)

HLE:	104838928(HAND1)

AGEN:

126050955

HHAR:

128134458(HAND1)

BBUT:

142044123(HAND1)

GCL:

127022076

PPUS:

135185018(HAND1)

EGZ:	104122576(HAND1)

NNI:	104014258(HAND1)

AFOR:

103904549(HAND1)

CBOR:

142088678(HAND1)

CBOY:

140656963(HAND1)

MAME:

142413650(HAND1)

CLV:	102088367(HAND1)

CNIC:

135994076(HAND1)

CUCA:

104063092(HAND1)

GAME:

129213012(HAND1)

CPEA:

104392696(HAND1)

RTD:	128916185(HAND1)

CRID:

134521967(HAND1)

LMIC:

141749775(HAND1)

NARQ:

141470340(HAND1)

AROW:

112966473(HAND1)

NPD:	112954498(HAND1)

DNE:	112994328(HAND1)

ASN:	102375937(HAND1)

AMJ:	102568228(HAND1)

GGN:	109289760(HAND1)

CIZ:	142021211(HAND1)

CMY:	102948197(HAND1)

CCAY:

125641874(HAND1)

LKP:	140916474(HAND1)

NDS:	141992726(HAND1)

DCC:	119860455(HAND1)

CPIC:

101933806(HAND1)

TST:	117881737(HAND1)

CABI:

116836120(HAND1)

MRV:	120370698(HAND1)

ACS:	100552140(hand1)

PVT:	110080773(HAND1)

SUND:

121920371(HAND1)

PBI:	103062443(HAND1)

PMUR:

107290972(HAND1)

CTIG:

120304772(HAND1)

TSR:	106540408(HAND1)

PGUT:

117660634(HAND1)

PCAE:

139312422(HAND1)

APRI:

131191816(HAND1)

PTEX:

113433559(HAND1)

NSS:	113423567(HAND1)

VKO:	123033965(HAND1)

PMUA:

114591385(HAND1)

PRAF:

128407998(HAND1)

ZVI:	118080030(HAND1)

HCG:	128345914(HAND1)

GJA:	107109515(HAND1)

STOW:

125427809(HAND1)

EMC:	129327607(HAND1)

XLA:	108712623 373663(hand1.L)

XTR:	549497(hand1)

NPR:	108801107(HAND1)

RTEM:

120930862(HAND1)

ACAT:

141134611(HAND1)

PADS:

140325012(HAND1)

BBUF:

120986971(HAND1)

BGAR:

122926503(HAND1)

DTC:	141083161(HAND1)

PWL:	138245743(HAND1)

MUO:	115476230(HAND1)

GSH:	117351888(HAND1)

IPU:

IFU:

AMEX:

CMAO:

EEE:

CHAR:

SPIL:

ASAD:

TRU:	101065452(hand1)

TFS:	130537708(hand2)

TNG:	GSTEN00014615G001

LCO:	104921818(hand1)

NCC:	104964997(hand1)

TBEN:

117490205

CGOB:

115019144(hand1)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116700843(hand1)

PFLV:

114567248(hand1)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

137802963(hand2)

CVE:

MSAM:

SCHU:

EARM:

CUD:

SPUL:

LMIX:

HTC:

ALAT:

ASTR:

PKLU:

MZE:	101471856(hand1)

ONL:	100689786(hand1)

OAU:

116328535

OLA:	101159460(hand1)

OML:

112142649

CSAI:

133460069

XMA:	102218866(hand1)

XCO:	114152575(hand1)

XHE:	116727962(hand1)

PRET:

103461043

PFOR:

103152885(hand1)

PLAI:

106960172(hand1)

PMEI:

106926496(hand1)

GAF:

122844300

PPRL:

129370598(hand2)

CVG:	107081166(hand1)

CTUL:

119776926

GMU:

124876570

NFU:	107387105(hand1)

KMR:

108245649

ALIM:

106535718(hand1)

NWH:

AOCE:

EJA:

BFRE:

MCEP:

125021220(hand2)

CSEM:

103395610(hand1)

POV:	109635657(hand1)

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:	111221320(hand1)

SLAL:

111656028(hand1)

XGL:

120803116

HCQ:	109508233(hand1)

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110156417(hand1)

ENY:

140360313

MALB:

109975056(hand1)

BSPL:

SJO:

SSCO:

TTY:

GMH:	115547889(hand1)

SASA:

106603969

STRU:

115148421 115153883

OTW:	112228236 112258352

OMY:	110533287 110537849

OGO:	123999419 124015059

ONE:	115105377 115136243

OKI:	109873322 109893041

OKE:	118389747 118390995

OMM:	135547990 135549251

OCLA:

139417933 139422097

SALP:

111963492 111981308

SNH:	120044428 120056408

SFON:

129867770 129868952

CCLU:

121574106 121579126

ELS:	105011190(hand1)

OEP:

134013847

SFM:	108920050(hand1)

PKI:	111860904(hand1)

AANG:

118235754

AROT:

135262645

CCOG:

133134126

LOC:	102691681(hand1)

PSPA:

121296778 121324704

ARUT:

117412864 117973636

PSEX:

120542785

LCM:	102348022(HAND1)

RTP:

CPLA:

CPUN:

HOC:

SCAU:

HAKA:

PMRN:

LRJ:

PPOT:

PVM:

PJA:

PCHN:

HAME:

PCLA:

VDE:

VJA:

XEN:

RES:

Reference

PMID:11802795

Authors

Knofler M, Meinhardt G, Bauer S, Loregger T, Vasicek R, Bloor DJ, Kimber SJ, Husslein P

Title

Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains.

Journal

Biochem J 361:641-51 (2002)
DOI:10.1042/bj3610641

Sequence

[hsa:9421]

LinkDB

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