KEGG ORTHOLOGY: K10424

ORTHOLOGY: K10424

Entry

K10424                      KO

Symbol

DCTN2

Name

dynactin 2

Pathway

map04814

Motor proteins

map04962

Vasopressin-regulated water reabsorption

map05014

Amyotrophic lateral sclerosis

map05016

Huntington disease

map05022

Pathways of neurodegeneration - multiple diseases

map05132

Salmonella infection

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    K10424  DCTN2; dynactin 2
09150 Organismal Systems
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K10424  DCTN2; dynactin 2
09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K10424  DCTN2; dynactin 2
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K10424  DCTN2; dynactin 2
   05016 Huntington disease
    K10424  DCTN2; dynactin 2
   05022 Pathways of neurodegeneration - multiple diseases
    K10424  DCTN2; dynactin 2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K10424  DCTN2; dynactin 2
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K10424  DCTN2; dynactin 2
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Centrosome formation proteins
   Microtubules and associated factors
    Dynactin complex
     K10424  DCTN2; dynactin 2
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Dynactins
     K10424  DCTN2; dynactin 2

Genes

HSA:	10540(DCTN2)

PTR:	100615725(DCTN2)

PPS:	100981249(DCTN2)

GGO:	101145272(DCTN2)

PON:	100171591(DCTN2)

NLE:	100580182(DCTN2)

HMH:	116480864(DCTN2)

MCC:	714948(DCTN2)

MCF:	101926870(DCTN2)

MTHB:

126930390

MNI:	105474098(DCTN2)

CSAB:

103238574(DCTN2)

CATY:

105587256(DCTN2)

PANU:

100999496(DCTN2)

TGE:	112634040(DCTN2)

MLEU:

105545578(DCTN2)

RRO:	104682359(DCTN2)

RBB:	108519684(DCTN2)

TFN:	117089883(DCTN2)

PTEH:

111541809(DCTN2)

CANG:

105500502(DCTN2)

CJC:	100402979(DCTN2)

SBQ:	101033772(DCTN2)

CIMI:

108309730(DCTN2)

CSYR:

103263162(DCTN2)

MMUR:

105877983(DCTN2)

LCAT:

123639604(DCTN2)

PCOQ:

105816385(DCTN2)

OGA:	100955547(DCTN2)

MMU:	69654(Dctn2)

MCAL:

110302822(Dctn2)

MPAH:

110326429(Dctn2)

RNO:	299850(Dctn2)

MCOC:

116076416(Dctn2)

ANU:	117696641(Dctn2)

MUN:	110561405(Dctn2)

CGE:	100757525(Dctn2)

MAUA:

101835010(Dctn2)

PROB:

127215670(Dctn2)

PLEU:

114704802(Dctn2)

MORG:

121455956(Dctn2)

MFOT:

126514794

AAMP:

119803284(Dctn2)

NGI:	103742910(Dctn2)

HGL:	101713049(Dctn2)

CPOC:

100721002(Dctn2)

CCAN:

109686351(Dctn2)

DORD:

105989503(Dctn2)

DSP:	122121071 122124057(Dctn2)

PLOP:

125362233(Dctn2)

NCAR:

124982924

MMMA:

107140131(Dctn2)

OCU:

100339187

OPI:	101525742(DCTN2)

TUP:	102498807(DCTN2)

GVR:	103594203(DCTN2)

CFA:	474415(DCTN2) 474547 611471

CLUD:

112652314 112668807 112669882 112677980(DCTN2)

VVP:	112922343(DCTN2)

VLG:	121491131(DCTN2)

NPO:	129511766 129511805(DCTN2)

AML:	100479564(DCTN2)

UMR:	103656621(DCTN2)

UAH:	113256379(DCTN2)

UAR:	123787213(DCTN2)

ELK:

111160098

LLV:	125095161 125106096

MPUF:

101688644(DCTN2)

MNP:	132019840(DCTN2)

MLK:	131838556(DCTN2)

NVS:	122892421(DCTN2) 122901764

ORO:	101381664(DCTN2)

EJU:	114214920(DCTN2)

ZCA:	113922613(DCTN2)

MLX:	118008671(DCTN2)

NSU:	110577778(DCTN2)

LWW:	102748471(DCTN2)

FCA:	101093950(DCTN2)

PYU:	121040873(DCTN2)

PCOO:

112863774(DCTN2)

PBG:	122473816(DCTN2)

PVIV:

125170894(DCTN2)

LRUF:

124501140

PTG:	102952303(DCTN2)

PPAD:

109270375(DCTN2)

PUC:

125919247

AJU:

106975863

HHV:	120248001(DCTN2)

BTA:	527201(DCTN2)

BOM:	102283130(DCTN2)

BIU:	109559325(DCTN2)

BBUB:

102406470(DCTN2)

BBIS:

104988124(DCTN2) 105002308

CHX:	102187922(DCTN2)

OAS:	101119807(DCTN2)

BTAX:

128048983(DCTN2)

ODA:	120857493(DCTN2)

CCAD:

122427415(DCTN2)

MBEZ:

129537220(DCTN2)

SSC:	100515661(DCTN2)

CFR:	102518272(DCTN2)

CBAI:

105062131(DCTN2)

CDK:	105100341(DCTN2)

VPC:	102527124(DCTN2)

BACU:

103020327(DCTN2)

BMUS:

118901768(DCTN2)

LVE:	103091163(DCTN2)

OOR:	101278579(DCTN2)

DLE:	111173835(DCTN2)

PCAD:

102981271(DCTN2)

PSIU:

116760112(DCTN2)

NASI:

112394141(DCTN2)

ECB:	100050464(DCTN2)

EPZ:	103559781(DCTN2)

EAI:	106833005(DCTN2)

MYB:	102256545(DCTN2)

MYD:	102762321(DCTN2)

MMYO:

118649618(DCTN2)

MLF:	102438117(DCTN2)

PKL:	118730270(DCTN2)

EFUS:

103292465(DCTN2)

MNA:	107546191(DCTN2)

DRO:	112319022(DCTN2)

SHON:

118975902(DCTN2)

AJM:	119035662(DCTN2)

PDIC:

114514100(DCTN2)

PHAS:

123812774(DCTN2)

MMF:	118623389(DCTN2)

PPAM:

129075816(DCTN2)

HAI:	109390743(DCTN2)

RFQ:	117028147(DCTN2)

PALE:

102891207(DCTN2)

PGIG:

120604960(DCTN2)

PVP:	105307381(DCTN2)

RAY:	107501501(DCTN2)

MJV:	108409976(DCTN2)

TOD:	119248091(DCTN2)

SARA:

101556587(DCTN2)

LAV:	100655036(DCTN2)

TMU:

101360333

ETF:	101651138(DCTN2)

DNM:	101422320(DCTN2)

GAS:	123250434(DCTN2)

SHR:	100934636(DCTN2)

AFZ:

127538073

PCW:	110210976(DCTN2)

OAA:	114814741(DCTN2)

GGA:	395587(DCTN2)

PCOC:

116238872(DCTN2)

MGP:

104915875

CJO:	107325781(DCTN2)

NMEL:

110391732(DCTN2)

APLA:

101796511 119715308

ACYG:

106029450 106047631 106047720

CATA:

118248901 118259330 118261345

AFUL:

116495800 116499408 116500011(DCTN2)

TGU:	100231323(DCTN2)

LSR:	110481829(DCTN2)

SCAN:

103823872(DCTN2)

PMOA:

120499547(DCTN2)

OTC:	121334274(DCTN2)

PRUF:

121356341(DCTN2)

OMA:	130265796(DCTN2)

PHI:	102105771(DCTN2)

PMAJ:

107199031(DCTN2)

CCAE:

111944812(DCTN2)

CBRC:

103611932(DCTN2)

SVG:	106862675(DCTN2)

MMEA:

130587210(DCTN2)

HRT:	120747876(DCTN2)

CLV:	102087959(DCTN2)

NNI:

104019185

TALA:

116959956 122153800 122153818

ACHC:

115338528 115351069

HLE:	104831184 104834316(DCTN2)

AGEN:

126046695 126046696 126046697 126046744 126046751

GCL:	127028508 127029060 127029063 127029066 127029069

CCRI:

104156813(DCTN2)

MUI:	104543054(DCTN2)

FGA:	104077214(DCTN2)

MNB:	103770298(DCTN2)

NNT:	104412504(DCTN2)

SHAB:

115618756(DCTN2)

ACAR:

104519691(DCTN2)

CPEA:

104394852(DCTN2)

CVF:	104288524(DCTN2)

RTD:	128901340(DCTN2)

CUCA:

104055545(DCTN2)

AAM:	106499410(DCTN2)

AROW:

112962408(DCTN2)

ASN:	102369088(DCTN2)

AMJ:	106737310(DCTN2)

CMY:	102935209(DCTN2)

CCAY:

125627750(DCTN2)

DCC:	119845719(DCTN2)

CPIC:

101946687(DCTN2)

TST:	117870583(DCTN2)

CABI:

116818860(DCTN2)

MRV:	120391087(DCTN2)

ACS:	100554435(dctn2)

ASAO:

132767720(DCTN2)

PVT:	110070784(DCTN2)

SUND:

121924327(DCTN2)

PBI:	103048665(DCTN2)

PMUR:

107293463(DCTN2)

CTIG:

120319361(DCTN2)

TSR:	106552743(DCTN2)

PGUT:

117666515(DCTN2)

APRI:

131190951(DCTN2)

PTEX:

113444881(DCTN2)

NSS:	113416177(DCTN2)

VKO:	123029892(DCTN2)

PMUA:

114592939(DCTN2)

PRAF:

128404808(DCTN2)

ZVI:	118078543(DCTN2)

HCG:	128345583(DCTN2)

GJA:	107118953(DCTN2)

STOW:

125428052(DCTN2)

EMC:	129346573(DCTN2)

XLA:	380299(dctn2.S) 447510(dctn2.L)

XTR:	548423(dctn2)

NPR:	108797989(DCTN2)

RTEM:

120929461(DCTN2)

BBUF:

120996065(DCTN2)

BGAR:

122932101(DCTN2)

MUO:	115465839(DCTN2)

GSH:	117357140(DCTN2)

DRE:	394141(dctn2)

SRX:	107734604(dctn2) 107758173

SANH:

107681283(dctn2) 107683619

SGH:	107558166 107566402(dctn2)

CCAR:

109072618 109072621 109091137

CAUA:

113050185 113102225 113102999

CGIB:

127960158 128016064

PTET:

122334342(dctn2)

LROH:

127166973(dctn2)

OMC:	131542765(dctn2)

PPRM:

120464585(dctn2)

RKG:	130072479(dctn2)

MAMB:

125273396(dctn2)

CIDE:

127514666

MASI:

127445789 127449583

TROS:

130557246(dctn2)

TDW:	130425121(dctn2)

MANU:

129451042(dctn2)

IPU:

108271974

IFU:	128614622(dctn2)

PHYP:

113530126(dctn2)

SMEO:

124376120(dctn2)

TFD:	113642774(dctn2)

TVC:	132844591(dctn2)

AMEX:

103023724(dctn2)

CMAO:

118808479(dctn2)

EEE:

113571561

CHAR:

105912290(dctn2)

TRU:	101061294(dctn2)

TFS:	130524413(dctn2)

TNG:	GSTEN00013576G001

LCO:	104919969(dctn2)

NCC:	104968148(dctn2)

TBEN:

117489605(dctn2)

CGOB:

115008531(dctn2)

PGEO:

117446946(dctn2)

GACU:

117534203(dctn2)

EMAC:

134883071(dctn2)

ELY:	117256518(dctn2)

EFO:	125888640(dctn2)

PLEP:

121957247(dctn2)

SLUC:

116051368(dctn2)

ECRA:

117943941(dctn2)

ESP:	116687897(dctn2)

PFLV:

114554063(dctn2)

GAT:	120835378(dctn2)

PPUG:

119230154(dctn2)

AFB:	129105565(dctn2)

CLUM:

117730785(dctn2)

PSWI:

130208455(dctn2)

MSAM:

119886314(dctn2)

SCHU:

122863369(dctn2)

CUD:	121507123(dctn2)

ALAT:

119020921(dctn2)

MZE:	101474281(dctn2)

ONL:	100711493(dctn2)

OAU:	116320725(dctn2)

OLA:	101162751(dctn2)

OML:	112144741(dctn2)

CSAI:

133448314(dctn2)

XMA:	102237333(dctn2)

XCO:	114135623(dctn2)

XHE:	116710753(dctn2)

PRET:

103464405(dctn2)

PFOR:

103135812(dctn2)

PLAI:

106956599(dctn2)

PMEI:

106928411(dctn2)

GAF:	122833412(dctn2)

PPRL:

129358389(dctn2)

CVG:	107103080(dctn2)

CTUL:

119790711(dctn2)

GMU:	124857145(dctn2)

NFU:	107385329(dctn2)

KMR:	108231714(dctn2)

ALIM:

106514740(dctn2)

NWH:	119412419(dctn2)

AOCE:

111576950(dctn2)

MCEP:

125006828(dctn2)

CSEM:

103386389(dctn2)

POV:	109635589(dctn2)

SSEN:

122776021(dctn2)

HHIP:

117762291(dctn2)

HSP:	118104883(dctn2)

SMAU:

118309620(dctn2)

LCF:

108884825

SDU:	111223954(dctn2)

SLAL:

111659806(dctn2)

XGL:	120783086(dctn2)

HCQ:	109510624(dctn2)

SSCV:

125977863

SBIA:

133506983(dctn2)

PEE:	133408329(dctn2)

PTAO:

133483831(dctn2)

BPEC:

110154552(dctn2)

MALB:

109973429(dctn2)

BSPL:

114855011(dctn2)

SJO:	128355971(dctn2)

SASA:

106566142(DCTN2) 106566145 106582665(DCTN2)

STRU:

115151077 115207333

OTW:	112236782(dctn2) 112254143

OMY:	110494784(dctn2) 110527690

OGO:	124003293(dctn2) 124031571

ONE:	115119824 115135313

OKI:	109883645(dctn2) 109890792

OKE:	118378333 118379211(dctn2)

SALP:

111970549 112072893

SNH:

120058220

CCLU:

121574793(dctn2) 121578696

ELS:	105028305(dctn2)

SFM:	108928329(dctn2)

PKI:	111835304(dctn2)

AANG:

118210922(dctn2)

LOC:	102693409(dctn2)

PSPA:

121308981(dctn2)

ARUT:

117401137 117967045

PSEX:

120524796(dctn2)

LCM:	102348445(DCTN2)

CMK:	103189069(dctn2)

HOC:	132812046(dctn2)

LERI:

129695193(dctn2)

PMRN:

116938584(DCTN2)

LRJ:	133346059(DCTN2)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG8269(DCTN2-p50)

DER:

6541895

DSE:

6608240

DSI:	Dsimw501_GD10607(Dsim_GD10607)

DYA:	Dyak_GE19232

DAN:

DSR:

DPO:

DPE:

DMN:	108160631 117188196

DWI:

6638474

DGR:

6568703

DMO:	Dmoj_GI18927

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119663735 119683563 119683586

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ005875

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100122883(Dctn2)

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	655964(Dctn2)

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_200821

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

API:	100164386 107885072

DNX:	107161502 107166154

AGS:	114126516 114127542

RMD:	113548405 113558785

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:	128987452 129004168

PHU:	Phum_PHUM169880

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_300326

DMK:

DPZ:

PVM:

PJA:

PCHN:

HAME:

PCLA:

CQD:

PTRU:

ESN:

HAZT:

EAF:	111700895 111707987

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:	129222004 129233318

SDM:

118198521

PMEO:

129587125

CEL:	CELE_C28H8.12(dnc-2)

CBR:	CBG_09048(Cbr-dnc-2)

CRQ:	GCK72_010663

BMY:	BM_BM2458(Bma-dnc-2)

LOA:	LOAG_12430

TSP:

Tsp_01415

HRO:	HELRODRAFT_192214 HELRODRAFT_193294

LGI:	LOTGIDRAFT_223566

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:	105317397 117683564

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_062630

SHX:	MS3_00007468(DCTN2_1)

OVI:	T265_07321

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_54892

AQU:

105316545

MBR:	MONBRDRAFT_32065

SRE:	PTSG_11640

DDI:	DDB_G0285503(dynB)

DPP:	DICPUDRAFT_35656

DFA:	DFA_10260(dynB)

ACAN:

ACA1_369250

TGO:	TGME49_246740

TET:	TTHERM_00086970

SMIN:

v1.2.002477.t1(symbB.v1.2.002477.t1)

FCY:	FRACYDRAFT_232564

PIF:	PITG_18189

PSOJ:

PHYSODRAFT_294311

SPAR:

SPRG_05132

NGR:	NAEGRDRAFT_68732(AM19)

» show all

Reference

PMID:8647893

Authors

Echeverri CJ, Paschal BM, Vaughan KT, Vallee RB

Title

Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis.

Journal

J Cell Biol 132:617-33 (1996)
DOI:10.1083/jcb.132.4.617

Sequence

[hsa:10540]

Reference

PMID:14983524

Authors

Uetake Y, Terada Y, Matuliene J, Kuriyama R

Title

Interaction of Cep135 with a p50 dynactin subunit in mammalian centrosomes.

Journal

Cell Motil Cytoskeleton 58:53-66 (2004)
DOI:10.1002/cm.10175

Sequence

[mmu:69654]

LinkDB

DBGET integrated database retrieval system