KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04121 Ubiquitin system
K10443 KLHL2_3; kelch-like protein 2/3
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
Multi subunit type E3
Cul3 complex
Adoptor and target recognizing subunit (BTB)
K10443 KLHL2_3; kelch-like protein 2/3
Ohta A, Schumacher FR, Mehellou Y, Johnson C, Knebel A, Macartney TJ, Wood NT, Alessi DR, Kurz T
Title
The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.