KEGG   ORTHOLOGY: K10620
Entry
K10620                      KO                                     
Symbol
cmtB
Name
2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase [EC:1.3.1.58]
Pathway
map00622  Xylene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00539  Cumate degradation, p-cumate => 2-oxopent-4-enoate + 2-methylpropanoate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00622 Xylene degradation
    K10620  cmtB; 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.58  2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase
     K10620  cmtB; 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase
Dioxygenases [br01602.html]
 Dioxygenases in aromatic ring cleavage
  K10620
Other DBs
RN: R05240
GO: 0018511
Genes
RBD: ALSL_1090
PPF: Pput_2895
PPX: T1E_4251(cmtB)
PMON: X969_10860
PMOT: X970_10515
SPOI: IMCC21906_02718
ZAL: AZF00_03850
GBI: PG2T_14360
BXE: Bxe_A3553
BXB: DR64_1252
BARH: WN72_35385
SMAZ: LH19_27435
SWI: Swit_1755
SPHD: HY78_16810
MMAN: MMAN_42600
MSAK: MSAS_43610(benD)
MCOO: MCOO_07700
MHAS: MHAS_04024(fabG_14)
MANY: MANY_01920
ROP: ROP_46310(cmtB)
SALS: SLNWT_6904
 » show all
Reference
PMID:8631713
  Authors
Eaton RW.
  Title
p-Cumate catabolic pathway in Pseudomonas putida Fl: cloning and characterization of DNA carrying the cmt operon.
  Journal
J Bacteriol 178:1351-62 (1996)
DOI:10.1128/JB.178.5.1351-1362.1996
  Sequence
[ppf:Pput_2895]
LinkDB

KEGG   ENZYME: 1.3.1.58
Entry
EC 1.3.1.58                 Enzyme                                 
Name
2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
cis-2,3-dihydroxy-2,3-dihydro-p-cumate:NAD+ oxidoreductase
Reaction(IUBMB)
cis-5,6-dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylate + NAD+ = 2,3-dihydroxy-p-cumate + NADH + H+ [RN:R05240]
Reaction(KEGG)
R05240
Substrate
cis-5,6-dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylate [CPD:C06579];
NAD+ [CPD:C00003]
Product
2,3-dihydroxy-p-cumate [CPD:C06580];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Involved in the p-cymene degradation pathway in Pseudomonas putida.
History
EC 1.3.1.58 created 2000
Pathway
ec00622  Xylene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K10620  2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase
Genes
RBDALSL_1090
PPFPput_2895
PPXT1E_4251(cmtB)
PMONX969_10860
PMOTX970_10515
SPOIIMCC21906_02718
ZALAZF00_03850
GBIPG2T_14360
BXEBxe_A3553
BXBDR64_1252
PFIBPI93_021415
BRKCWS35_25075
BARHWN72_35385
MONG8E03_15205
NREBES08_18555
SMAZLH19_27435
SWISwit_1755
SPHDHY78_16810
RDICMV14_03925
BACIB1NLA3E_14005
VIGBKP57_09430
RUEDT065_15135
EFFskT53_02000
MMANMMAN_42600
MSAKMSAS_43610(benD)
MCOOMCOO_07700
MHASMHAS_04024(fabG_14)
MANYMANY_01920
ROPROP_46310(cmtB)
RRZCS378_10920
RKOJWS14_14225
SALSSLNWT_6904
SCZABE83_02000
FSYFsymDg_2035
AMQAMETH_1184
AACDLWP59_08670 LWP59_25390
PSEQAD006_28380
PECQAD017_28770
PBROHOP40_30830
PMADBAY61_11505
 » show all
Reference
1  [PMID:8631713]
  Authors
Eaton RW.
  Title
p-Cumate catabolic pathway in Pseudomonas putida Fl: cloning and characterization of DNA carrying the cmt operon.
  Journal
J Bacteriol 178:1351-62 (1996)
DOI:10.1128/JB.178.5.1351-1362.1996
  Sequence
[ppf:Pput_2895]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.58
IUBMB Enzyme Nomenclature: 1.3.1.58
ExPASy - ENZYME nomenclature database: 1.3.1.58
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.58
BRENDA, the Enzyme Database: 1.3.1.58
CAS: 176591-33-6
LinkDB

KEGG   REACTION: R05240
Entry
R05240                      Reaction                               
Name
cis-2,3-dihydroxy-2,3-dihydro-p-cumate:NAD+ oxidoreductase
Definition
cis-2,3-Dihydroxy-2,3-dihydro-p-cumate + NAD+ <=> 2,3-Dihydroxy-p-cumate + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00057  C06579_C06580
Enzyme
Pathway
rn00622  Xylene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00539  Cumate degradation, p-cumate => 2-oxopent-4-enoate + 2-methylpropanoate
Orthology
K10620  2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase [EC:1.3.1.58]
Other DBs
RHEA: 23775
LinkDB

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