KEGG   ORTHOLOGY: K10676
Entry
K10676                      KO                                     
Symbol
tfdB
Name
2,4-dichlorophenol 6-monooxygenase [EC:1.14.13.20]
Pathway
map00361  Chlorocyclohexane and chlorobenzene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Reaction
R03997  2,4-dichlorophenol,NADPH:oxygen oxidoreductase(6-hydroxylating)
R05441  4-chlorophenol,NADPH:oxygen oxidoreductase (6-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00361 Chlorocyclohexane and chlorobenzene degradation
    K10676  tfdB; 2,4-dichlorophenol 6-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.20  2,4-dichlorophenol 6-monooxygenase
     K10676  tfdB; 2,4-dichlorophenol 6-monooxygenase
Other DBs
GO: 0018666
Genes
PAKH: B0X70_03075
PLUI: CE143_03060
PCQ: PcP3B5_21640(tfdB)
PNT: G5B91_07365(hbpA)
PPUH: B479_25850
PDR: H681_09635
PSV: PVLB_26087
PBEJ: PSH84_15845
MSHE: MAALD49_03580
MANP: EHN06_06635 EHN06_06685
ACB: A1S_1079
ACAL: BUM88_05190
ASEI: I8T81_13610
ACD: AOLE_13995
AEI: AOY20_13805
ACUM: C9E88_009150
ALW: FOB21_04930
ACHI: CDG60_06750
ASHA: G8E00_06060
ABOU: ACBO_09460
ACIU: A3K93_08085
APOT: MZO21_08345
ACIE: KIP84_13070
ACIG: BS636_09830
ATV: ABEF79_04780
ACWC: CDG61_06380
ACZQ: SC192_13060
ACAZ: ABJ384_04665
ACAQ: IHE35_09890
ACHU: ABLB96_08015
AASZ: K6I41_13410
MCAH: U0021_02310
OSG: BST96_10705
MGEO: CFI10_06255
CKS: H9L41_22945
CNC: CNE_BB2p00380(tfdB)
REU: Reut_B4679 Reut_D6462 Reut_D6470
COX: E0W60_36470 E0W60_36560 E0W60_36900
BCEN: DM39_5592(tfdB)
BMJ: BMULJ_00773
BMU: Bmul_2460
BCT: GEM_2096
BPSL: WS57_14635
BANN: JFN94_06885
BYI: BYI23_F000530(mhqA) BYI23_F000610(mhqA)
BURF: Bsp3421_003705
BUZ: AYM40_28715
PHS: C2L64_52635
PCAF: DSC91_003624
PACP: FAZ97_19160
PPAI: E1956_31265 E1956_41035 E1956_42495 E1956_45915
PADD: ACOCG7_00700
PPUL: RO07_24965
TVL: FAZ95_22945
BPT: Bpet1331
AXY: AXYL_03121
AIS: BUW96_12410
APES: FOC84_29900
AALN: Q3V95_01245
PIG: EGT29_10725
ADN: Alide_3930
ADK: Alide2_4275
HYY: JNX00_20670
DRG: H9K76_13735
PAQA: K9V56_003680
DAR: Daro_0899
THK: CCZ27_15525
MLN: A9174_15455
MCI: Mesci_5342
MCIC: A4R28_00400
MAMO: A6B35_10195
MESW: A9K65_029190
MJR: EB229_15655
MESU: LHFGNBLO_002367
MEIR: GA829_06005
NIY: FQ775_05325
MESO: BSQ44_19310
RPOD: E0E05_06010
AMAX: ABWH92_10425
PLA: Plav_0131
PECT: BN1012_Phect175
RBS: RHODOSMS8_01308(tfdB) RHODOSMS8_03465(tfdB)
SIX: BSY16_5886(tfdB)
EAK: EKH55_4641
STEG: QA637_22765
AGC: BSY240_3583(tfdB)
RLE: pRL120094(tfdB)
RLG: Rleg_5534
RHL: LPU83_3293(tfdB)
RGR: FZ934_22095
RLN: J0663_26265
RRG: J3P73_27975
RROS: D4A92_03065
RAW: NE851_01970
RBW: RLCC275e_25950
RIF: U5G49_006798
RHIW: KQ933_22510
RHIS: N2A41_27115
RHIC: MF410_27515
AVV: RvVAT039_pl00630
AVF: RvVAR031_pl02700
AVI: Avi_7439
SHZ: shn_17085
SOJ: K6301_14535
SSUM: Q9314_11240
ABAW: D5400_18555
HOAX: ABWH89_20795
BRA: BRADO2271(tfdB)
BRO: BRAD285_6478(tfdB)
BRK: CWS35_17625
BVZ: BRAD3257_2215(tfdB)
BSEP: HAP48_0030295
BQB: J4P68_0031560
BBAN: J4G43_002830
BCAN: BcanWSM471_04095 BcanWSM471_18225
BGEA: ACP2YP_15325
BGEP: ACP2YO_41970
RBK: E0H22_14530
LNE: FZC33_07665
MSL: Msil_1463
PHL: KKY_3150
PNF: V6617_15880
DEA: FPZ08_02915
PLEO: OHA_1_04031(tfdB)
MAAD: AZF01_21740
MMED: Mame_00353(tfdB_1)
MLUT: JET14_22390
BRN: D1F64_20720
RPON: G3256_03730
PPIC: PhaeoP14_02543
PHAE: N1037_16900
OAT: OAN307_c31200
LEJ: ETW24_15985
LEIM: K3557_01990
CEH: CEW89_05510
SULZ: C1J03_12300
TATE: ACMHLQ_06170
TATY: ACERHN_15075
ACLD: ACIRQ6_18685
PZH: CX676_20335
PPAN: ESD82_09880
PSTL: JHW45_15635
PFEO: E3U26_16715
TAW: EI545_03210 EI545_15125
CACT: HZ995_11470
NSM: JO391_15080
AMYL: QBD29_07650
RBG: BG454_13025
NRE: BES08_18240
NOVB: ACFFDA_06440
SPHF: DM480_04910 DM480_13535
ACOA: RB602_01155
SINA: KNJ79_21045
SPHU: SPPYR_1422
SWI: Swit_2298 Swit_3045
SPHD: HY78_10325 HY78_14035
RDI: CMV14_05145
SJP: SJA_C1-21170(tfdB)
SINB: SIDU_04775
SPPH: KFK14_07125 KFK14_10980 KFK14_23090
SPTA: Sj15T_14040
SCL: sce6695(cadA)
ABAS: ACPOL_6348 ACPOL_6587
MARP: QYS47_31295
MSAA: QYS49_15220
EUZ: DVS28_a4350
MMI: MMAR_3384
MMAE: MMARE11_32850
MDX: BTO20_24030
MSAK: MSAS_18810 MSAS_43450
MKU: I2456_26965
MLJ: MLAC_15310
MSPG: F6B93_10655
MYJ: BCA37_17855
MVA: Mvan_4406
MYN: MyAD_07550
MTHN: 4412656_01070(tfdB) 4412656_02644(tcmG)
MCHT: MCHIJ_49160
MIJ: MINS_17270
MMUC: C1S78_006365
CEF: CE2219
CHN: A605_00660 A605_12305
CMD: B841_02870
CHM: B842_00260 B842_11315
CDX: CDES_03630(tfdB)
CCOE: CETAM_00270(tfdB)
COK: COCCU_00115(tfdB1) COCCU_00185(tfdB2)
CGF: CGUA_01850(tfdB)
CSUE: QP029_02345 QP029_06365
CBRE: QP027_01750 QP027_10725
NSL: BOX37_13460
NTP: CRH09_29765
NWL: NWFMUON74_39440 NWFMUON74_45630
NTC: KHQ06_23985
RHA: RHA1_ro00520(ohpB) RHA1_ro00538 RHA1_ro10313
REB: XU06_29335
RQI: C1M55_30810
ROP: ROP_46190
ROA: Pd630_LPD12046
RPY: Y013_12685
RAV: AAT18_09060 AAT18_09315
RAET: JQ505_21700
RRZ: CS378_24130
RHOD: AOT96_34420
RKO: JWS14_14265 JWS14_20530 JWS14_46965 JWS14_47000 JWS14_47920
ROZ: CBI38_01165 CBI38_32790
RPSK: JWS13_03800 JWS13_05395 JWS13_45120
RHOU: KZJ41_02715 KZJ41_10185 KZJ41_10460
RHOW: A4U64_15285 A4U64_15535
RHOJ: JVH1_35200 JVH1_35285 JVH1_41775
RHOS: QWW67_20085 QWW67_27165
RHOQ: QWW98_20095 QWW98_27185
RHOY: QNA09_06810 QNA09_26540
RHOX: RBB84_12190
RHJS: OYT95_35380 OYT95_36275 OYT95_42125 OYT95_42195
RHPD: U9J23_25405
RHON: EHW12_34165
RHWB: FND50_12115
RHWY: GFS60_00227
RHDM: HFP48_02785 HFP48_09705 HFP48_09965
RHWQ: HUN07_25410
RHMM: ISO16_20025 ISO16_26790
RHZP: HYG77_14755 HYG77_15510 HYG77_32475 HYG77_35050
RHRD: RDE2_45640
RHDK: PST05_02560
RHDE: PSR88_02470
GOC: CXX93_14715
GOJ: GR168_23140
GAM: GII34_02375
GOI: LK459_00990
GSI: P5P27_07205 P5P27_08345
TSD: MTP03_45030
SGRF: SGFS_022110 SGFS_022650 SGFS_026090 SGFS_100090
SCB: SCAB_12351 SCAB_14111 SCAB_23631
SVL: Strvi_3710 Strvi_4586
SHY: SHJG_8539
SHO: SHJGH_8299
SANT: QR300_06020
SDV: BN159_1741
SCW: TU94_32215
SXI: SXIM_06260 SXIM_35670
STRC: AA958_24210
SCX: AS200_01245 AS200_38910
SLE: sle_04010(sle_04010)
SGS: AVL59_28985
STSI: A4E84_33880
SGM: GCM10017557_34850
SCAD: DN051_01855 DN051_35330 DN051_39765 DN051_43520
SLS: SLINC_1036
SNW: BBN63_05670
SGE: DWG14_00198(tfdB_1) DWG14_01104(tfdB_2)
SDX: C4B68_17110
SCYA: EJ357_04120 EJ357_37240
SFY: GFH48_10085
SAQU: EJC51_07500 EJC51_44160
SBY: H7H31_31070
SPHV: F9278_41170
SPAC: B1H29_00665 B1H29_36395
SCHA: CP983_03980
SCOE: CP976_36295
STUI: GCM10017668_59540
SCHF: IPT68_02060
SHAR: HUT13_00410
SFEU: IM697_19750
SMOB: J7W19_03210 J7W19_27645
SROI: IAG44_02080 IAG44_37690
SMAO: CAG99_11020 CAG99_26330
SINE: KI385_36970
SLF: JEQ17_02155 JEQ17_08035
SDEC: L3078_39450
SAKB: K1J60_04890
SCAE: IHE65_05265
SARG: HKX69_01025
SJN: RI060_06610
SCYN: N8I84_06530 N8I84_40540
SKG: KJK29_04965
SCOA: QU709_40790
STRZ: OYE22_30335
KBU: Q4V64_45110 Q4V64_48910
SMIB: SMIR_01605 SMIR_05670
SCAJ: O1G22_43855
STRL: HEP84_02415 HEP84_39870 HEP84_42970
STSD: HEP87_03905
SRPZ: HEP85_31345
SCHE: QRN89_34630
STRV: EZV63_28170
SPAZ: ABXI76_06590
SMOD: POD33_35305
STBR: ABDE16_20770
STRJ: H7827_10105 H7827_25555
SFLU: ACKTSN_02140
SSTO: ACE1OC_14825
STRQ: CGL27_41725
SSEC: ABZO29_02305 ABZO29_03240
SHUG: ABVG11_01675
STRK: R2B38_37740 R2B38_44215
STHP: MQE23_08040
STPG: C1703_33490(tfdB2)
KIS: HUT16_21995
KNB: ACF9IK_04730
PPOD: AB0761_38175
STRH: GXP74_28295
ABRY: NYE86_28185
AGLA: OIE69_08690
AREV: RVR_1635
MCAW: F6J84_00360
MAZA: NFX31_14545
MELY: L2X98_27600 L2X98_30500
MVD: AWU67_12435 AWU67_12440
FRP: AX769_00705
AARC: G127AT_14245
MDB: OVN18_09695
SALD: FVA74_01625
LRP: MUN76_11660
SUBT: KPL76_07445
ART: Arth_1929
ARTP: E5206_04650 E5206_13920
AJG: KKR91_07500
ASUN: KG104_03755
ASUF: MNQ99_07130
AGEG: MUG94_07235
ACH: Achl_4564
PSEY: GU243_16740
KPL: KPaMU14_06545
CCYC: SCMU_34840
NAE: BHE16_06590
CIG: E7744_15345
PAEY: KUF55_08570
ACRY: AC20117_12520
PROU: AB1046_15760
PROZ: ACO229_22500
OFA: NF556_06305
BCAU: I6G59_06830 I6G59_09640 I6G59_09900
BREB: PGC08_07035
AFUV: AADG42_00965 AADG42_00975
NANO: G5V58_19740
NARO: CFH99_24180
NAQU: ENKNEFLB_03878(tfdB)
NRO: K8W59_17650 K8W59_18520
NMAR: HPC71_03210 HPC71_13685
NOCQ: QI633_11210
NLB: P5P86_19935
PSIM: KR76_25500
AEF: GEV26_15515
AWN: NQV15_13620
KSL: OG809_09400
NGV: CDO52_16685
AWS: ACN3XK_69270
FRE: Franean1_2986
NML: Namu_0227
NAKA: H7F38_04265
MOM: KUM42_01170
AMD: AMED_5991
AMN: RAM_30725
AMM: AMES_5907
AMZ: B737_5907
AMQ: AMETH_1296
AMYC: CU254_22230 CU254_25580
AACD: LWP59_06385
APRT: MUY14_05945
ARHD: VSH64_17320 VSH64_18835
AMOG: QRX60_46765
ACAB: QRX50_27770
ANW: QP939_32830
AMYD: K1T34_09230 K1T34_50680
ABAR: AMYBAR_003741
ARHI: AB5I40_00205
PSEA: WY02_07855
PSEH: XF36_06625
PHH: AFB00_24145
PAUT: Pdca_45420
PBRO: HOP40_17930
PPEL: H6H00_04965 H6H00_25965
KUT: JJ691_01250 JJ691_13930
KBR: Q4V65_39945 Q4V65_50590
KPHY: AOZ06_37215
LENT: JNUCC0626_02480
AHM: TL08_18505
UME: RM788_03215
STP: Strop_2185
MCRA: ID554_06970
ACTL: L3i22_033060
ASIC: Q0Z83_037310
AFS: AFR_25335
DVC: Dvina_24335 Dvina_29130
DMAT: Dmats_19960 Dmats_24370
EKE: EK0264_03995 EK0264_08060 EK0264_11535
RMAR: GBA65_09710
PARQ: DSM112329_03646(tfdB)
SBAE: DSM104329_02808(tfdB)
 » show all
Reference
PMID:2185214
  Authors
Perkins EJ, Gordon MP, Caceres O, Lurquin PF
  Title
Organization and sequence analysis of the 2,4-dichlorophenol hydroxylase and dichlorocatechol oxidative operons of plasmid pJP4.
  Journal
J Bacteriol 172:2351-9 (1990)
DOI:10.1128/jb.172.5.2351-2359.1990
  Sequence
[reu:Reut_D6462]
LinkDB

KEGG   ENZYME: 1.14.13.20
Entry
EC 1.14.13.20               Enzyme                                 
Name
2,4-dichlorophenol 6-monooxygenase;
2,4-dichlorophenol hydroxylase;
2,4-dichlorophenol monooxygenase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
2,4-dichlorophenol,NADPH:oxygen oxidoreductase (6-hydroxylating)
Reaction(IUBMB)
2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O [RN:R03997]
Reaction(KEGG)
R03997;
(other) R05441
Substrate
2,4-dichlorophenol [CPD:C02625];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
3,5-dichlorocatechol [CPD:C02933];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A flavoprotein (FAD). Also acts, more slowly, on 4-chlorophenol and 4-chloro-2-methylphenol; NADH can act instead of NADPH, but more slowly.
History
EC 1.14.13.20 created 1983
Pathway
ec00361  Chlorocyclohexane and chlorobenzene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K10676  2,4-dichlorophenol 6-monooxygenase
Genes
PAKH: B0X70_03075
PLUI: CE143_03060
PCQ: PcP3B5_21640(tfdB)
PNT: G5B91_07365(hbpA)
PPUH: B479_25850
PDR: H681_09635
PSV: PVLB_26087
PBEJ: PSH84_15845
MSHE: MAALD49_03580
MANP: EHN06_06635 EHN06_06685
ACB: A1S_1079
ACAL: BUM88_05190
ASEI: I8T81_13610
ACD: AOLE_13995
AEI: AOY20_13805
ACUM: C9E88_009150
ALW: FOB21_04930
ACHI: CDG60_06750
ASHA: G8E00_06060
ABOU: ACBO_09460
ACIU: A3K93_08085
APOT: MZO21_08345
ACIE: KIP84_13070
ACIG: BS636_09830
ATV: ABEF79_04780
ACWC: CDG61_06380
ACZQ: SC192_13060
ACAZ: ABJ384_04665
ACAQ: IHE35_09890
ACHU: ABLB96_08015
AASZ: K6I41_13410
MCAH: U0021_02310
OSG: BST96_10705
MGEO: CFI10_06255
CKS: H9L41_22945
CNC: CNE_BB2p00380(tfdB)
REU: Reut_B4679 Reut_D6462 Reut_D6470
COX: E0W60_36470 E0W60_36560 E0W60_36900
BCEN: DM39_5592(tfdB)
BMJ: BMULJ_00773
BMU: Bmul_2460
BCT: GEM_2096
BPSL: WS57_14635
BANN: JFN94_06885
BYI: BYI23_F000530(mhqA) BYI23_F000610(mhqA)
BURF: Bsp3421_003705
BUZ: AYM40_28715
PHS: C2L64_52635
PCAF: DSC91_003624
PACP: FAZ97_19160
PPAI: E1956_31265 E1956_41035 E1956_42495 E1956_45915
PADD: ACOCG7_00700
PPUL: RO07_24965
TVL: FAZ95_22945
BPT: Bpet1331
AXY: AXYL_03121
AIS: BUW96_12410
APES: FOC84_29900
AALN: Q3V95_01245
PIG: EGT29_10725
ADN: Alide_3930
ADK: Alide2_4275
HYY: JNX00_20670
DRG: H9K76_13735
PAQA: K9V56_003680
DAR: Daro_0899
THK: CCZ27_15525
MLN: A9174_15455
MCI: Mesci_5342
MCIC: A4R28_00400
MAMO: A6B35_10195
MESW: A9K65_029190
MJR: EB229_15655
MESU: LHFGNBLO_002367
MEIR: GA829_06005
NIY: FQ775_05325
MESO: BSQ44_19310
RPOD: E0E05_06010
AMAX: ABWH92_10425
PLA: Plav_0131
PECT: BN1012_Phect175
RBS: RHODOSMS8_01308(tfdB) RHODOSMS8_03465(tfdB)
SIX: BSY16_5886(tfdB)
EAK: EKH55_4641
STEG: QA637_22765
AGC: BSY240_3583(tfdB)
RLE: pRL120094(tfdB)
RLG: Rleg_5534
RHL: LPU83_3293(tfdB)
RGR: FZ934_22095
RLN: J0663_26265
RRG: J3P73_27975
RROS: D4A92_03065
RAW: NE851_01970
RBW: RLCC275e_25950
RIF: U5G49_006798
RHIW: KQ933_22510
RHIS: N2A41_27115
RHIC: MF410_27515
AVV: RvVAT039_pl00630
AVF: RvVAR031_pl02700
AVI: Avi_7439
SHZ: shn_17085
SOJ: K6301_14535
SSUM: Q9314_11240
ABAW: D5400_18555
HOAX: ABWH89_20795
BRA: BRADO2271(tfdB)
BRO: BRAD285_6478(tfdB)
BRK: CWS35_17625
BVZ: BRAD3257_2215(tfdB)
BSEP: HAP48_0030295
BQB: J4P68_0031560
BBAN: J4G43_002830
BCAN: BcanWSM471_04095 BcanWSM471_18225
BGEA: ACP2YP_15325
BGEP: ACP2YO_41970
RBK: E0H22_14530
LNE: FZC33_07665
MSL: Msil_1463
PHL: KKY_3150
PNF: V6617_15880
DEA: FPZ08_02915
PLEO: OHA_1_04031(tfdB)
MAAD: AZF01_21740
MMED: Mame_00353(tfdB_1)
MLUT: JET14_22390
BRN: D1F64_20720
RPON: G3256_03730
PPIC: PhaeoP14_02543
PHAE: N1037_16900
OAT: OAN307_c31200
LEJ: ETW24_15985
LEIM: K3557_01990
CEH: CEW89_05510
SULZ: C1J03_12300
TATE: ACMHLQ_06170
TATY: ACERHN_15075
ACLD: ACIRQ6_18685
PZH: CX676_20335
PPAN: ESD82_09880
PSTL: JHW45_15635
PFEO: E3U26_16715
TAW: EI545_03210 EI545_15125
CACT: HZ995_11470
NSM: JO391_15080
AMYL: QBD29_07650
RBG: BG454_13025
NRE: BES08_18240
NOVB: ACFFDA_06440
SPHF: DM480_04910 DM480_13535
ACOA: RB602_01155
SINA: KNJ79_21045
SPHU: SPPYR_1422
SWI: Swit_2298 Swit_3045
SPHD: HY78_10325 HY78_14035
RDI: CMV14_05145
SJP: SJA_C1-21170(tfdB)
SINB: SIDU_04775
SPPH: KFK14_07125 KFK14_10980 KFK14_23090
SPTA: Sj15T_14040
SCL: sce6695(cadA)
ABAS: ACPOL_6348 ACPOL_6587
MARP: QYS47_31295
MSAA: QYS49_15220
EUZ: DVS28_a4350
MMI: MMAR_3384
MMAE: MMARE11_32850
MDX: BTO20_24030
MSAK: MSAS_18810 MSAS_43450
MKU: I2456_26965
MLJ: MLAC_15310
MSPG: F6B93_10655
MYJ: BCA37_17855
MVA: Mvan_4406
MYN: MyAD_07550
MTHN: 4412656_01070(tfdB) 4412656_02644(tcmG)
MCHT: MCHIJ_49160
MIJ: MINS_17270
MMUC: C1S78_006365
CEF: CE2219
CHN: A605_00660 A605_12305
CMD: B841_02870
CHM: B842_00260 B842_11315
CDX: CDES_03630(tfdB)
CCOE: CETAM_00270(tfdB)
COK: COCCU_00115(tfdB1) COCCU_00185(tfdB2)
CGF: CGUA_01850(tfdB)
CSUE: QP029_02345 QP029_06365
CBRE: QP027_01750 QP027_10725
NSL: BOX37_13460
NTP: CRH09_29765
NWL: NWFMUON74_39440 NWFMUON74_45630
NTC: KHQ06_23985
RHA: RHA1_ro00520(ohpB) RHA1_ro00538 RHA1_ro10313
REB: XU06_29335
RQI: C1M55_30810
ROP: ROP_46190
ROA: Pd630_LPD12046
RPY: Y013_12685
RAV: AAT18_09060 AAT18_09315
RAET: JQ505_21700
RRZ: CS378_24130
RHOD: AOT96_34420
RKO: JWS14_14265 JWS14_20530 JWS14_46965 JWS14_47000 JWS14_47920
ROZ: CBI38_01165 CBI38_32790
RPSK: JWS13_03800 JWS13_05395 JWS13_45120
RHOU: KZJ41_02715 KZJ41_10185 KZJ41_10460
RHOW: A4U64_15285 A4U64_15535
RHOJ: JVH1_35200 JVH1_35285 JVH1_41775
RHOS: QWW67_20085 QWW67_27165
RHOQ: QWW98_20095 QWW98_27185
RHOY: QNA09_06810 QNA09_26540
RHOX: RBB84_12190
RHJS: OYT95_35380 OYT95_36275 OYT95_42125 OYT95_42195
RHPD: U9J23_25405
RHON: EHW12_34165
RHWB: FND50_12115
RHWY: GFS60_00227
RHDM: HFP48_02785 HFP48_09705 HFP48_09965
RHWQ: HUN07_25410
RHMM: ISO16_20025 ISO16_26790
RHZP: HYG77_14755 HYG77_15510 HYG77_32475 HYG77_35050
RHRD: RDE2_45640
RHDK: PST05_02560
RHDE: PSR88_02470
GOC: CXX93_14715
GOJ: GR168_23140
GAM: GII34_02375
GOI: LK459_00990
GSI: P5P27_07205 P5P27_08345
TSD: MTP03_45030
SGRF: SGFS_022110 SGFS_022650 SGFS_026090 SGFS_100090
SCB: SCAB_12351 SCAB_14111 SCAB_23631
SVL: Strvi_3710 Strvi_4586
SHY: SHJG_8539
SHO: SHJGH_8299
SANT: QR300_06020
SDV: BN159_1741
SCW: TU94_32215
SXI: SXIM_06260 SXIM_35670
STRC: AA958_24210
SCX: AS200_01245 AS200_38910
SLE: sle_04010(sle_04010)
SGS: AVL59_28985
STSI: A4E84_33880
SGM: GCM10017557_34850
SCAD: DN051_01855 DN051_35330 DN051_39765 DN051_43520
SLS: SLINC_1036
SNW: BBN63_05670
SGE: DWG14_00198(tfdB_1) DWG14_01104(tfdB_2)
SDX: C4B68_17110
SCYA: EJ357_04120 EJ357_37240
SFY: GFH48_10085
SAQU: EJC51_07500 EJC51_44160
SBY: H7H31_31070
SPHV: F9278_41170
SPAC: B1H29_00665 B1H29_36395
SCHA: CP983_03980
SCOE: CP976_36295
STUI: GCM10017668_59540
SCHF: IPT68_02060
SHAR: HUT13_00410
SFEU: IM697_19750
SMOB: J7W19_03210 J7W19_27645
SROI: IAG44_02080 IAG44_37690
SMAO: CAG99_11020 CAG99_26330
SINE: KI385_36970
SLF: JEQ17_02155 JEQ17_08035
SDEC: L3078_39450
SAKB: K1J60_04890
SCAE: IHE65_05265
SARG: HKX69_01025
SJN: RI060_06610
SCYN: N8I84_06530 N8I84_40540
SKG: KJK29_04965
SCOA: QU709_40790
STRZ: OYE22_30335
KBU: Q4V64_45110 Q4V64_48910
SMIB: SMIR_01605 SMIR_05670
SCAJ: O1G22_43855
STRL: HEP84_02415 HEP84_39870 HEP84_42970
STSD: HEP87_03905
SRPZ: HEP85_31345
SCHE: QRN89_34630
STRV: EZV63_28170
SPAZ: ABXI76_06590
SMOD: POD33_35305
STBR: ABDE16_20770
STRJ: H7827_10105 H7827_25555
SFLU: ACKTSN_02140
SSTO: ACE1OC_14825
STRQ: CGL27_41725
SSEC: ABZO29_02305 ABZO29_03240
SHUG: ABVG11_01675
STRK: R2B38_37740 R2B38_44215
STHP: MQE23_08040
STPG: C1703_33490(tfdB2)
KIS: HUT16_21995
KNB: ACF9IK_04730
PPOD: AB0761_38175
STRH: GXP74_28295
ABRY: NYE86_28185
AGLA: OIE69_08690
AREV: RVR_1635
MCAW: F6J84_00360
MAZA: NFX31_14545
MELY: L2X98_27600 L2X98_30500
MVD: AWU67_12435 AWU67_12440
FRP: AX769_00705
AARC: G127AT_14245
MDB: OVN18_09695
SALD: FVA74_01625
LRP: MUN76_11660
SUBT: KPL76_07445
ART: Arth_1929
ARTP: E5206_04650 E5206_13920
AJG: KKR91_07500
ASUN: KG104_03755
ASUF: MNQ99_07130
AGEG: MUG94_07235
ACH: Achl_4564
PSEY: GU243_16740
KPL: KPaMU14_06545
CCYC: SCMU_34840
NAE: BHE16_06590
CIG: E7744_15345
PAEY: KUF55_08570
ACRY: AC20117_12520
PROU: AB1046_15760
PROZ: ACO229_22500
OFA: NF556_06305
BCAU: I6G59_06830 I6G59_09640 I6G59_09900
BREB: PGC08_07035
AFUV: AADG42_00965 AADG42_00975
NANO: G5V58_19740
NARO: CFH99_24180
NAQU: ENKNEFLB_03878(tfdB)
NRO: K8W59_17650 K8W59_18520
NMAR: HPC71_03210 HPC71_13685
NOCQ: QI633_11210
NLB: P5P86_19935
PSIM: KR76_25500
AEF: GEV26_15515
AWN: NQV15_13620
KSL: OG809_09400
NGV: CDO52_16685
AWS: ACN3XK_69270
FRE: Franean1_2986
NML: Namu_0227
NAKA: H7F38_04265
MOM: KUM42_01170
AMD: AMED_5991
AMN: RAM_30725
AMM: AMES_5907
AMZ: B737_5907
AMQ: AMETH_1296
AMYC: CU254_22230 CU254_25580
AACD: LWP59_06385
APRT: MUY14_05945
ARHD: VSH64_17320 VSH64_18835
AMOG: QRX60_46765
ACAB: QRX50_27770
ANW: QP939_32830
AMYD: K1T34_09230 K1T34_50680
ABAR: AMYBAR_003741
ARHI: AB5I40_00205
PSEA: WY02_07855
PSEH: XF36_06625
PHH: AFB00_24145
PAUT: Pdca_45420
PBRO: HOP40_17930
PPEL: H6H00_04965 H6H00_25965
KUT: JJ691_01250 JJ691_13930
KBR: Q4V65_39945 Q4V65_50590
KPHY: AOZ06_37215
LENT: JNUCC0626_02480
AHM: TL08_18505
UME: RM788_03215
STP: Strop_2185
MCRA: ID554_06970
ACTL: L3i22_033060
ASIC: Q0Z83_037310
AFS: AFR_25335
DVC: Dvina_24335 Dvina_29130
DMAT: Dmats_19960 Dmats_24370
EKE: EK0264_03995 EK0264_08060 EK0264_11535
RMAR: GBA65_09710
PARQ: DSM112329_03646(tfdB)
SBAE: DSM104329_02808(tfdB)
 » show all
Reference
1  [PMID:7075592]
  Authors
Beadle CA, Smith AR.
  Title
The purification and properties of 2,4-dichlorophenol hydroxylase from a strain of Acinetobacter species.
  Journal
Eur J Biochem 123:323-32 (1982)
DOI:10.1111/j.1432-1033.1982.tb19771.x
Reference
2  [PMID:2185214]
  Authors
Perkins EJ, Gordon MP, Caceres O, Lurquin PF
  Title
Organization and sequence analysis of the 2,4-dichlorophenol hydroxylase and dichlorocatechol oxidative operons of plasmid pJP4.
  Journal
J Bacteriol 172:2351-9 (1990)
DOI:10.1128/jb.172.5.2351-2359.1990
Reference
3  [PMID:1898014]
  Authors
Radjendirane V, Bhat MA, Vaidyanathan CS.
  Title
Affinity purification and characterization of 2,4-dichlorophenol hydroxylase from Pseudomonas cepacia.
  Journal
Arch Biochem Biophys 288:169-76 (1991)
DOI:10.1016/0003-9861(91)90180-q
Reference
4  [PMID:16597983]
  Authors
Ledger T, Pieper DH, Gonzalez B.
  Title
Chlorophenol hydroxylases encoded by plasmid pJP4 differentially contribute to chlorophenoxyacetic acid degradation.
  Journal
Appl Environ Microbiol 72:2783-92 (2006)
DOI:10.1128/AEM.72.4.2783-2792.2006
Reference
5  [PMID:21293902]
  Authors
Lu Y, Yu Y, Zhou R, Sun W, Dai C, Wan P, Zhang L, Hao D, Ren H.
  Title
Cloning and characterisation of a novel 2,4-dichlorophenol hydroxylase from a metagenomic library derived from polychlorinated biphenyl-contaminated soil.
  Journal
Biotechnol Lett 33:1159-67 (2011)
DOI:10.1007/s10529-011-0549-0
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.20
IUBMB Enzyme Nomenclature: 1.14.13.20
ExPASy - ENZYME nomenclature database: 1.14.13.20
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.20
BRENDA, the Enzyme Database: 1.14.13.20
CAS: 82047-82-3
LinkDB

KEGG   REACTION: R03997
Entry
R03997                      Reaction                               
Name
2,4-dichlorophenol,NADPH:oxygen oxidoreductase(6-hydroxylating)
Definition
2,4-Dichlorophenol + Oxygen + NADPH + H+ <=> 3,5-Dichlorocatechol + NADP+ + H2O
Equation
C02625 + C00007 + C00005 + C00080 <=> C02933 + C00006 + C00001
Reaction class
RC00001  C00005_C00006
RC00046  C02625_C02933
Enzyme
1.14.13.20
Pathway
rn00361  Chlorocyclohexane and chlorobenzene degradation
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.20
     R03997  2,4-Dichlorophenol + Oxygen + NADPH + H+ <=> 3,5-Dichlorocatechol + NADP+ + H2O
Orthology
K10676  2,4-dichlorophenol 6-monooxygenase [EC:1.14.13.20]
Other DBs
RHEA: 20923
LinkDB

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