KEGG ORTHOLOGY: K10811

ORTHOLOGY: K10811

Entry

K10811                      KO

Symbol

E2.5.1.2

Name

thiamine pyridinylase [EC:2.5.1.2]

Pathway

map00730

Thiamine metabolism

map01100

Metabolic pathways

Reaction

R02863

thiamin:beta 2-methyl-4-aminopyrimidine-5-methenyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00730 Thiamine metabolism
    K10811  E2.5.1.2; thiamine pyridinylase
Enzymes [BR:ko01000]
2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.2  thiamine pyridinylase
     K10811  E2.5.1.2; thiamine pyridinylase

Other DBs

GO:

0050332

Genes

SRR:	SerAS9_2400

SRS:	SerAS12_2400

SRA:	SerAS13_2401

PPAV:

LOZ86_19345

BPS:

BPSS1103

BPM:	BURPS1710b_A0059

BPL:	BURPS1106A_A1472

BPD:	BURPS668_A1560

BPR:	GBP346_B0803

BPSE:

BPSM:

BPSU:

BPSD:

BPZ:	BP1026B_II1163

BPQ:	BPC006_II1476

BPK:

BPSH:

BPSA:

BPSO:

BUT:

BTE:	BTH_II1306

BTQ:

BTJ:

BTZ:

BTD:

BTV:

BTHE:

BTHM:

BTHA:

BTHL:

BOK:

BOC:

BUU:	WS70_23065

BSAV:

WS86_24130

BHG:	I6G56_22415(bcmE)

BUD:	AQ610_25130

BGL:	bglu_2g17490

BGU:

KS03_4180

BUL:

BW21_5615

BGP:	BGL_2c23410

BPLA:

bpln_2g23690

RPOD:

E0E05_16885(bcmE)

OST:	ABWH87_16580(bcmE)

BJU:	BJ6T_82380

LABP:

FJ695_26280(bcmE)

DDE:

Dde_0637

MXA:

MXAN_4523

MSD:	MYSTI_05824

MFB:	MFUL124B02_18185

MYX:	QEG98_24300

MLAN:

JY572_38195

MYM:	A176_002382

CCX:	COCOR_04713

MFU:	LILAB_30640

MMAS:

MYMAC_004429

SUR:	STAUR_1070 STAUR_5800

AGE:	AA314_04006

AVM:	JQX13_02355 JQX13_08095

MBD:	MEBOL_006407

CFUS:

PBRU:

PRUE:

SCL:

SCU:	SCE1572_16110

CCRO:

CMC5_025790

HOH:

Hoch_1390

FEI:	K9M53_05980

SLMS:

MM221_15680(bcmE)

PTHI:

NDS46_27050(bcmE)

PKA:	PQ456_03600(bcmE)

PDY:	QJQ58_25220(bcmE)

PNK:	AASFL403_15660(bcmE)

CBO:

CBA:

CBH:

CBY:

CBL:

CBB:

CBI:

CBF:

CBM:

CBJ:	H04402_00829

CLD:	CLSPO_c07890

MFOR:

NQ534_11760

MED:

MELS_1668

RFA:	A3L23_04897

SRN:	A4G23_01805

SFB:	CP974_10120(bcmE)

AER:	AERYTH_06055 AERYTH_16485

CYC:	PCC7424_0400

MPRO:

RSIN:

CCUR:

SCYT:

LinkDB

ENZYME: 2.5.1.2

Entry

EC 2.5.1.2                  Enzyme

Name

thiamine pyridinylase;
pyrimidine transferase;
thiaminase I;
thiamin hydrolase;
thiamin pyridinolase;
thiaminase (ambiguous);
thiamine pyridinolase;
thiamin pyridinylase;
thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase

Reaction(IUBMB)

thiamine + pyridine = 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium + 4-methyl-5-(2-hydroxyethyl)thiazole [RN:R02863]

Reaction(KEGG)

R02863

Substrate

thiamine [CPD:C00378];
pyridine [CPD:C00747]

Product

1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium [CPD:C02691];
4-methyl-5-(2-hydroxyethyl)thiazole [CPD:C04294]

Comment

Various bases and thiol compounds can act instead of pyridine.

History

EC 2.5.1.2 created 1961, modified 1976, modified 2001

Pathway

ec00730

Thiamine metabolism

ec01100

Metabolic pathways

Orthology

K10811

thiamine pyridinylase

Genes

SRR:	SerAS9_2400

SRS:	SerAS12_2400

SRA:	SerAS13_2401

PPAV:

LOZ86_19345

BPS:

BPSS1103

BPM:	BURPS1710b_A0059

BPL:	BURPS1106A_A1472

BPD:	BURPS668_A1560

BPR:	GBP346_B0803

BPSE:

BDL_4389

BPSM:

BBQ_5068

BPSU:

BBN_4528

BPSD:

BBX_6232

BPZ:	BP1026B_II1163

BPQ:	BPC006_II1476

BPK:

BBK_6008

BPSH:

DR55_4224

BPSA:

BBU_4959

BPSO:

X996_4304

BUT:

X994_6054

BTE:	BTH_II1306

BTQ:

BTQ_4590

BTJ:

BTJ_5573

BTZ:

BTL_4040

BTD:

BTI_3614

BTV:

BTHA_3841

BTHE:

BTN_3627

BTHM:

BTRA_4326

BTHA:

DR62_3661

BTHL:

BG87_4047

BOK:

DM82_5265

BOC:

BG90_5344

BUU:	WS70_23065

BSAV:

WS86_24130

BHG:	I6G56_22415(bcmE)

BUD:	AQ610_25130

BGL:	bglu_2g17490

BGU:

KS03_4180

BUL:

BW21_5615

BGP:	BGL_2c23410

BPLA:

bpln_2g23690

RPOD:

E0E05_16885(bcmE)

OST:	ABWH87_16580(bcmE)

BJU:	BJ6T_82380

LABP:

FJ695_26280(bcmE)

DDE:

Dde_0637

MXA:

MXAN_4523

MSD:	MYSTI_05824

MFB:	MFUL124B02_18185

MYX:	QEG98_24300

MLAN:

JY572_38195

MYM:	A176_002382

CCX:	COCOR_04713

MFU:	LILAB_30640

MMAS:

MYMAC_004429

SUR:	STAUR_1070 STAUR_5800

AGE:	AA314_04006

AVM:	JQX13_02355 JQX13_08095

MBD:	MEBOL_006407

CFUS:

CYFUS_003904

PBRU:

LZC95_08685

PRUE:

LVJ94_09055

SCL:

sce5380

SCU:	SCE1572_16110

CCRO:

CMC5_025790

HOH:

Hoch_1390

FEI:	K9M53_05980

SLMS:

MM221_15680(bcmE)

PTHI:

NDS46_27050(bcmE)

PKA:	PQ456_03600(bcmE)

PDY:	QJQ58_25220(bcmE)

PNK:	AASFL403_15660(bcmE)

CBO:

CBO0770

CBA:

CLB_0812

CBH:

CLC_0826

CBY:

CLM_0920

CBL:

CLK_0178

CBB:

CLD_3794

CBI:

CLJ_B0819

CBF:

CLI_0856

CBM:

CBF_0826

CBJ:	H04402_00829

CLD:	CLSPO_c07890

MFOR:

NQ534_11760

MED:

MELS_1668

RFA:	A3L23_04897

SRN:	A4G23_01805

SFB:	CP974_10120(bcmE)

AER:	AERYTH_06055 AERYTH_16485

CYC:	PCC7424_0400

MPRO:

BJP34_31205

RSIN:

B6N60_00030

CCUR:

IAR63_14895

SCYT:

SAMD_39440

» show all

Reference

1 [PMID:13158184]

Authors

FUJITA A.

Title

Thiaminase.

Journal

Adv Enzymol Relat Subj Biochem 15:389-421 (1954)
DOI:10.1002/9780470122600.ch9

Reference

2 [PMID:13471505]

Authors

KENTEN RH.

Title

[Pteridium aquilinum (L.) Kuhn.]

Journal

Biochem J 67:25-33 (1957)
DOI:10.1042/bj0670025

Reference

3 [PMID:4966932]

Authors

Wittliff JL, Airth RL.

Title

The extracellular thiaminase I of Bacillus thiaminolyticus. I. Purification and physicochemical properties.

Journal

Biochemistry 7:736-44 (1968)
DOI:10.1021/bi00842a032

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.2

IUBMB Enzyme Nomenclature:

2.5.1.2

ExPASy - ENZYME nomenclature database:

2.5.1.2

BRENDA, the Enzyme Database:

2.5.1.2

CAS:

9030-35-7

LinkDB

REACTION: R02863

Entry

R02863                      Reaction

Name

thiamin:beta 2-methyl-4-aminopyrimidine-5-methenyltransferase

Definition

Thiamine + Pyridine <=> Heteropyrithiamine + 5-(2-Hydroxyethyl)-4-methylthiazole

Equation

C00378 + C00747 <=> C02691 + C04294

Reaction class

RC00224

C00378_C04294

RC00795

C00747_C02691

Enzyme

2.5.1.2

Pathway

rn00730

Thiamine metabolism

rn01100

Metabolic pathways

Brite

Enzymatic reactions [BR:br08201]
2. Transferase reactions
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.2
     R02863  Thiamine + Pyridine <=> Heteropyrithiamine + 5-(2-Hydroxyethyl)-4-methylthiazole

Orthology

K10811

thiamine pyridinylase [EC:2.5.1.2]

Other DBs

RHEA:

17700

LinkDB

DBGET integrated database retrieval system