KEGG   ORTHOLOGY: K10817
Entry
K10817                      KO                                     
Symbol
eryAI
Name
6-deoxyerythronolide-B synthase EryAI [EC:2.3.1.94]
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00774  Erythromycin biosynthesis, propanoyl-CoA + methylmalonyl-CoA => deoxyerythronolide B => erythromycin A/B
Reaction
R00918  propanoyl-CoA:(2S)-methylmalonyl-CoA malonyltransferase (cyclizing)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K10817  eryAI; 6-deoxyerythronolide-B synthase EryAI
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K10817  eryAI; 6-deoxyerythronolide-B synthase EryAI
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K10817  eryAI; 6-deoxyerythronolide-B synthase EryAI
   01008 Polyketide biosynthesis proteins
    K10817  eryAI; 6-deoxyerythronolide-B synthase EryAI
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.94  6-deoxyerythronolide-B synthase
     K10817  eryAI; 6-deoxyerythronolide-B synthase EryAI
Lipid biosynthesis proteins [BR:ko01004]
 Polyketide synthase
  Modular PKS
   K10817  eryAI; 6-deoxyerythronolide-B synthase EryAI
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Erythronolide PKS
     K10817  eryAI; 6-deoxyerythronolide-B synthase EryAI
Other DBs
GO: 0047879
Genes
SNR: SNOUR_10075
SGF: HEP81_07912
AER: AERYTH_15920
SEN: SACE_0721(eryAI)
AEY: CDG81_13185
AG: AAG13917(megAI)
Reference
PMID:1618327
  Authors
Caffrey P, Bevitt DJ, Staunton J, Leadlay PF
  Title
Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea.
  Journal
FEBS Lett 304:225-8 (1992)
DOI:10.1016/0014-5793(92)80624-P
Reference
PMID:11851474
  Authors
Staunton J, Wilkinson B
  Title
Biosynthesis of Erythromycin and Rapamycin.
  Journal
Chem Rev 97:2611-2630 (1997)
DOI:10.1021/cr9600316
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