| Entry |
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| Name |
propanoyl-CoA:(2S)-methylmalonyl-CoA malonyltransferase (cyclizing);
propanoyl-CoA:(2S)-methylmalonyl-CoA 2-C-acyltransferase (decarboxylating, oxoacyl-reducing and cyclizing)
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| Definition |
Propanoyl-CoA + 6 (S)-Methylmalonyl-CoA + 6 NADPH + 6 H+ <=> 6-Deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
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| Equation |
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| Comment |
EryA MegA
multi-step reaction
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| Reaction class |
| RC00004 | C00010_C00100 C00010_C00683 |
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| Enzyme |
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| Pathway |
| rn00522 | Biosynthesis of 12-, 14- and 16-membered macrolides |
| rn01110 | Biosynthesis of secondary metabolites |
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| Module |
| M00774 | Erythromycin biosynthesis, propanoyl-CoA + methylmalonyl-CoA => deoxyerythronolide B => erythromycin A/B |
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| Brite |
Enzymatic reactions [BR:br08201]
2. Transferase reactions
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.94
R00918 Propanoyl-CoA + 6 (S)-Methylmalonyl-CoA + 6 NADPH + 6 H+ <=> 6-Deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+
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| Orthology |
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| Reference |
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| Authors |
Tsai SC, Miercke LJ, Krucinski J, Gokhale R, Chen JC, Foster PG, Cane DE, Khosla C, Stroud RM |
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| Title |
Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel. |
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| Journal |
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| Other DBs |
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| LinkDB |
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