KEGG ORTHOLOGY: K10977

ORTHOLOGY: K10977

Entry

K10977                      KO

Symbol

aksA

Name

methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-]

Pathway

map00300

Lysine biosynthesis

map00620

Pyruvate metabolism

map00680

Methane metabolism

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01120

Microbial metabolism in diverse environments

map01210

2-Oxocarboxylic acid metabolism

map01230

Biosynthesis of amino acids

map01240

Biosynthesis of cofactors

Module

M00608

2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate

Reaction

R00271

acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)

R08213

R08331

acetyl-CoA:2-oxoadipate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)

R08332

acetyl-CoA:2-oxopimelate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K10977  aksA; methanogen homocitrate synthase
  09102 Energy metabolism
   00680 Methane metabolism
    K10977  aksA; methanogen homocitrate synthase
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K10977  aksA; methanogen homocitrate synthase
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.14  homocitrate synthase
     K10977  aksA; methanogen homocitrate synthase
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
2-Oxoacid chain elongation
  K10977

Other DBs

COG:

COG0119

GO:

0004410

Genes

CCE:

Ccel_1624

TCP:	Q5761_09240

MJA:

MJ_0503

MFE:	Mefer_0710

MVU:	Metvu_1576

MFS:	MFS40622_1791

MIF:	Metin_1354

MJH:	JH146_1425

MESG:

MLAUSG7_0108(aksA)

MESA:

MLASG1_1291(aksA)

MIG:	Metig_0696

MMP:	MMP0153(aksA)

MMQ:	MmarC5_1522

MMX:	MmarC6_0797

MMZ:	MmarC7_1153

MMD:	GYY_00785(aksA)

MMAK:

MMKA1_01580(cimA)

MMAO:

MMOS7_01840(cimA)

MMAD:

MMJJ_09310(leuA_1)

MAE:

Maeo_0994

MVN:	Mevan_1158

MVO:

Mvol_1568

MOK:	Metok_0640

METF:

CFE53_04770(aksA)

MTH:

MTH_1630

MMG:	MTBMA_c02150(leuA2)

MWO:	MWSIV6_0176(aksA)

MTEE:

MTTB_13800(aksA)

METC:

MTCT_1489

METE:

tca_01580(leuA_3)

METZ:

METK:

MTHM:

METJ:

MST:	Msp_1099(leuA2)

METB:

AW729_10320(aksA)

MRU:	mru_0385(aksA)

MSI:

Msm_0722

MEB:	Abm4_0181(aksA)

MMIL:

sm9_2160(aksA)

MEYE:

TL18_01070(aksA)

MOL:

YLM1_0056

MARO:

MarbSA_09070(aksA_1) MarbSA_13810(aksA_2)

METV:

K4897_04155

MEL:	Metbo_2071

MEW:	MSWAN_0569

METH:

MBMB1_0290(aksA)

MFC:	BRM9_1985(aksA)

MFI:	DSM1535_0177(aksA)

MCUB:

MCBB_0566(aksA)

MSUB:

BK009_11615(aksA)

METN:

BK008_07190(aksA)

METT:

CIT01_06835(aksA)

METO:

CIT02_05435(aksA)

MEME:

HYG87_07555

MFEG:

GCM10025860_11500(aksA)

MFV:

Mfer_0964

MKA:	MK1209(leuA)

MBA:	Mbar_A2192

MBY:	MSBRM_2239

MBW:	MSBRW_2549

MBAR:

MSBR2_0170

MBAK:

MSBR3_1047

MAC:	MA_3342(leuA)

MMA:

MM_2785

MMAZ:

MmTuc01_2834

MMJ:	MSMAS_1942

MMAC:

MSMAC_1183

MVC:	MSVAZ_2030

MEK:	MSKOL_2008

MLS:	MSLAZ_1553

METM:

MSMTP_1363

MEF:	MSWH1_1527

MEQ:	MSWHS_1780

MSJ:	MSSAC_2553

MSZ:	MSSIH_2157

MSW:	MSSIT_2270

MTHR:

MSTHT_0432

MTHE:

MSTHC_0289

MHOR:

MSHOH_1618

MFZ:	AOB57_000055(aksA)

MBU:	Mbur_0854(cimA)

MMET:

MCMEM_0986

MELO:

J7W08_02750(aksA)

MMH:

Mmah_1162

MHAZ:

BHR79_07725(aksA)

MEV:	Metev_0432

MZH:	Mzhil_1141

MPY:

Mpsy_2899

MZI:	HWN40_08205(aksA)

MHZ:	Metho_0886

MEHF:

MmiHf6_03460(leuA_1)

MEES:

MmiEs2_06200(leuA_1)

MTP:

Mthe_1533

MCJ:	MCON_2596(leuA)

MHI:

MHU:

MRTJ:

MLA:

MEM:	Memar_0633

MBG:	BN140_1718(aksA)

MEMA:

MMAB1_2210(aksA)

MCHK:

MchiMG62_07630(aksA)

MSUM:

OH143_09885

MRC:	R6Y96_02550

MPI:

Mpet_2488

MEND:

L6E24_09230

MAQE:

RJ40_05985(aksA)

MOU:	OU421_03650

MANQ:

L1994_01090

MBN:

Mboo_0598

MFO:	Metfor_2593

MPL:

Mpal_2142

MPD:	MCP_1960(aksA)

MEZ:	Mtc_1560(aksA)

RCI:	RCIX2647(leuA-4)

HASV:

SVXHr_0597(leuA)

HABN:

HBNXHr_0575(leuA)

MEUZ:

KRP56_01640

» show all

Reference

PMID:9665716

Authors

Howell DM, Harich K, Xu H, White RH

Title

Alpha-keto acid chain elongation reactions involved in the biosynthesis of coenzyme B (7-mercaptoheptanoyl threonine phosphate) in methanogenic Archaea.

Journal

Biochemistry 37:10108-17 (1998)
DOI:10.1021/bi980662p

Sequence

[mja:MJ_0503]

LinkDB

REACTION: R08331

Entry

R08331                      Reaction

Name

acetyl-CoA:2-oxoadipate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)

Definition

2-Oxoadipate + Acetyl-CoA + H2O <=> (R)-(Homo)2-citrate + CoA

Equation

C00322 + C00024 + C00001 <=> C16583 + C00010

Reaction class

RC00004

C00010_C00024

RC00067

C00322_C16583

Enzyme

2.3.3.-

Pathway

rn00680

Methane metabolism

rn01100

Metabolic pathways

rn01120

Microbial metabolism in diverse environments

rn01210

2-Oxocarboxylic acid metabolism

rn01240

Biosynthesis of cofactors

Module

M00608

2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate

Brite

Enzymatic reactions [BR:br08201]
2. Transferase reactions
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.-
     R08331  2-Oxoadipate + Acetyl-CoA + H2O <=> (R)-(Homo)2-citrate + CoA

Orthology

K10977

methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-]

Reference

1 [PMID:10940051]

Authors

Howell DM, Graupner M, Xu H, White RH

Title

Identification of enzymes homologous to isocitrate dehydrogenase that are involved in coenzyme B and leucine biosynthesis in methanoarchaea.

Journal

J Bacteriol 182:5013-6 (2000)
DOI:10.1128/JB.182.17.5013-5016.2000

Other DBs

RHEA:

44927

LinkDB

DBGET integrated database retrieval system