KEGG ORTHOLOGY: K11146

ORTHOLOGY: K11146

Entry

K11146                      KO

Symbol

DHRS3

Name

short-chain dehydrogenase/reductase 3 [EC:1.1.1.300]

Pathway

map00830

Retinol metabolism

map01100

Metabolic pathways

map01240

Biosynthesis of cofactors

Reaction

R08379

retinol: NADP+ oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K11146  DHRS3; short-chain dehydrogenase/reductase 3
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.300  NADP-retinol dehydrogenase
     K11146  DHRS3; short-chain dehydrogenase/reductase 3

Other DBs

GO:

0052650

Genes

HSA:	9249(DHRS3)

PTR:	737006(DHRS3)

PPS:	100971367(DHRS3)

GGO:	101136764(DHRS3)

PON:	100446028(DHRS3)

PPYG:

129007548(DHRS3)

NLE:	100599507(DHRS3)

HMH:	116812943(DHRS3)

SSYN:

129472259(DHRS3)

MCC:	715548(DHRS3)

MCF:	102142015(DHRS3)

MTHB:

126953389

MNI:	105473180(DHRS3)

CSAB:

103225584(DHRS3)

CATY:

105580842(DHRS3)

PANU:

101025196(DHRS3)

TGE:	112634435(DHRS3)

MLEU:

105551362(DHRS3)

RRO:	104668927(DHRS3)

RBB:	108539385(DHRS3)

TFN:	117093295(DHRS3)

PTEH:

111526312(DHRS3)

CANG:

105526532(DHRS3)

CJC:	100386416(DHRS3)

SBQ:	101039627(DHRS3)

CIMI:

108286613(DHRS3)

ANAN:

105731784(DHRS3)

CSYR:

103276041(DHRS3)

MMUR:

105882703(DHRS3)

LCAT:

123634453(DHRS3)

PCOQ:

105824966(DHRS3)

OGA:	100963630(DHRS3)

MMU:	20148(Dhrs3)

MCAL:

110292172(Dhrs3)

MPAH:

110323041(Dhrs3)

RNO:	313689(Dhrs3)

MCOC:

116096993(Dhrs3)

ANU:	117709140(Dhrs3)

ASYL:

127681596(Dhrs3)

MUN:	110539426(Dhrs3)

CGE:	100756186(Dhrs3)

MAUA:

101840839(Dhrs3)

PROB:

127213384(Dhrs3)

PLEU:

114685519(Dhrs3)

PMAV:

102928159(Dhrs3)

MORG:

121441800 121448316

MFOT:

126508156

AAMP:

119817809(Dhrs3)

NGI:	103747479(Dhrs3)

HGL:	101707915(Dhrs3)

CPOC:

100722728(Dhrs3)

CCAN:

109683963(Dhrs3)

DORD:

105999947(Dhrs3)

DSP:	122121413(Dhrs3)

DMER:

138838194(Dhrs3)

PLOP:

125354593(Dhrs3)

NCAR:

124958517

MMMA:

107155480(Dhrs3)

ITI:	101960228(Dhrs3)

OCU:

100348969

OPI:	101527011(DHRS3)

OCZ:	121161511(DHRS3)

TUP:	102502620(DHRS3)

GVR:	103598934(DHRS3)

CFA:	487436(DHRS3)

CLUD:

112659809(DHRS3)

VVP:	112929696(DHRS3)

VLG:	121496751(DHRS3)

NPO:	129513642(DHRS3)

AML:	100481198(DHRS3)

UMR:	103666638(DHRS3)

UAH:	113270489(DHRS3)

UAR:	123779613(DHRS3)

ELK:

111154760

LLV:

125097812

MPUF:

101687558(DHRS3)

MNP:	132001364(DHRS3)

MLK:	131808935(DHRS3)

NVS:	122899471(DHRS3)

ORO:	101370738(DHRS3)

EJU:	114213406(DHRS3)

ZCA:	113933963(DHRS3)

MLX:	118019991(DHRS3)

NSU:	110574679(DHRS3)

LWW:	102731138(DHRS3)

FCA:	101080307(DHRS3)

PYU:	121021411(DHRS3)

PCOO:

112872083(DHRS3)

PBG:	122479945(DHRS3)

PVIV:

125172198(DHRS3)

LRUF:

124516401 124516405

LGF:	123597202(DHRS3)

AJU:

106988168

PTG:	102970609(DHRS3)

PPAD:

109274137(DHRS3)

PUC:

125913099

PLEZ:

122227033(DHRS3)

HHV:	120224913(DHRS3)

BTA:	281482(DHRS3)

BOM:	102265772(DHRS3)

BIU:	109570447(DHRS3)

BBUB:

102404826(DHRS3)

BBIS:

104995824(DHRS3)

CHX:	102179583(DHRS3)

OAS:	101109288(DHRS3)

BTAX:

128061372(DHRS3)

CSUM:

138090206(DHRS3)

ODA:	120880238(DHRS3)

CCAD:

122451887(DHRS3)

MREE:

136168362(DHRS3)

OVR:	110140000(DHRS3)

MBEZ:

129551554(DHRS3)

SSC:	100514967(DHRS3)

CFR:	102524578(DHRS3)

CBAI:

105070956(DHRS3)

CDK:	105107044(DHRS3)

VPC:	102535527(DHRS3)

BACU:

103018059(DHRS3)

BMUS:

118898828(DHRS3)

LVE:	103082238(DHRS3)

OOR:	101290385(DHRS3)

LALB:

132515218(DHRS3)

GMF:	115864381(DHRS3)

DDP:	132427333(DHRS3)

DLE:	111187101(DHRS3)

PCAD:

102982136(DHRS3)

PSIU:

116738948(DHRS3)

PPHC:

136121634(DHRS3)

NASI:

112402728(DHRS3)

ECB:	100055537(DHRS3)

EPZ:	103552172(DHRS3)

EAI:	106836659(DHRS3)

MYB:	102248154(DHRS3)

MYD:	102762827(DHRS3)

MMYO:

118676160(DHRS3)

MLF:	102417911(DHRS3)

MDT:	132231667(DHRS3)

MYUM:

139002886(DHRS3)

PKL:	118731971(DHRS3)

EFUS:

103295338(DHRS3)

MNA:	107531562(DHRS3)

DRO:	112299121(DHRS3)

SHON:

118986332(DHRS3)

AJM:	119064076(DHRS3)

PDIC:

114496658(DHRS3)

PHAS:

123831663(DHRS3)

MMF:	118627175(DHRS3)

PPAM:

129075644(DHRS3)

HAI:	109381266(DHRS3)

RFQ:	117026905(DHRS3)

PALE:

102880345(DHRS3)

PGIG:

120585801(DHRS3)

PVP:	105294422(DHRS3)

RAY:	107513138(DHRS3)

MJV:	108402930(DHRS3)

TOD:	119236996(DHRS3)

SARA:

101558421(DHRS3)

SFUM:

130020326(DHRS3)

SETR:

126011594(DHRS3)

LAV:	100656973(DHRS3)

TMU:

101360145

ETF:	101661630(DHRS3)

DNM:	101417782(DHRS3)

MDO:	100010099(DHRS3)

GAS:	123240318(DHRS3)

SHR:	100913855(DHRS3)

AFZ:

127555853

PCW:	110198918(DHRS3)

TVP:	118837636(DHRS3)

PBRV:

138154435(DHRS3)

MLAO:

141509128(DHRS3)

OAA:	100090663(DHRS3)

TACU:

119928236(DHRS3)

GGA:	419480(DHRS3)

PCOC:

116242686(DHRS3)

MGP:	100541886(DHRS3)

CJO:	107323359(DHRS3)

TPAI:

128084920(DHRS3)

LMUT:

125703520(DHRS3)

NMEL:

110408680(DHRS3)

APLA:

101792259(DHRS3)

AACU:

137843545(DHRS3)

ACYG:

106040190(DHRS3)

CATA:

118253419(DHRS3)

AFUL:

116497552(DHRS3)

TGU:	100221618(DHRS3)

LSR:	110476789(DHRS3)

SCAN:

103820840(DHRS3)

PMOA:

120496756(DHRS3)

OTC:	121343945(DHRS3)

PRUF:

121358418(DHRS3)

ATRC:

139600560(DHRS3)

GFR:	102032402(DHRS3)

FAB:	101814379(DHRS3)

OMA:	130261553(DHRS3)

PHI:	102110985(DHRS3)

PMAJ:

107213682(DHRS3)

CCAE:

111938724(DHRS3)

CCW:	104693251(DHRS3)

CBRC:

103616129(DHRS3)

ACOE:

138121550(DHRS3)

ETL:	114065123(DHRS3)

ZAB:	102072789(DHRS3)

ZLE:	135456560(DHRS3)

ACHL:

103808420(DHRS3)

SVG:	106856391(DHRS3)

MMEA:

130583467(DHRS3)

HRT:	120762269(DHRS3)

SATI:

136370752(DHRS3)

CFAI:

136300402(DHRS3)

CCIC:

134052905(DHRS3)

FPG:	101921484(DHRS3)

FCH:	102058887(DHRS3)

CCRI:

104162952(DHRS3)

NNT:	104403886(DHRS3)

SHAB:

115617558(DHRS3)

ACUN:

113487888(DHRS3)

SURA:

141953959(DHRS3)

TALA:

104357145(DHRS3)

ACHC:

115342535(DHRS3)

HALD:

104316790(DHRS3)

HLE:	104837875(DHRS3)

AGEN:

126043195

HHAR:

128143792(DHRS3)

GCL:

127024694

CSTI:

104563532(DHRS3)

LDI:	104341467(DHRS3)

MNB:	103774108(DHRS3)

DPUB:

104305829(DHRS3)

PPUS:

135190630(DHRS3)

AVIT:

104269010(DHRS3)

BRHI:

104496439(DHRS3)

EGZ:	104133092(DHRS3)

NNI:	104009010(DHRS3)

PCRI:

104030284(DHRS3)

PCAO:

104051518(DHRS3)

PADL:

103917993(DHRS3)

AFOR:

103907433(DHRS3)

FGA:	104071389(DHRS3)

CBOR:

142092460(DHRS3)

GSTE:

104252143(DHRS3)

CBOY:

140661523(DHRS3)

MAME:

142418451(DHRS3)

CLV:	102087489(DHRS3)

CNIC:

135997354(DHRS3)

MUI:	104544714(DHRS3)

PGUU:

104462147(DHRS3)

PLET:

104622674(DHRS3)

EHS:	104506231(DHRS3)

CMAC:

104483002(DHRS3)

CUCA:

104060564(DHRS3)

TEO:	104381116(DHRS3)

BREG:

104643166(DHRS3)

GAME:

129215841(DHRS3)

OHA:	104332601(DHRS3)

ACAR:

104529502(DHRS3)

CPEA:

104395427(DHRS3)

CVF:	104282942(DHRS3)

RTD:	128918294(DHRS3)

CRID:

134523986(DHRS3)

LMIC:

141751954(DHRS3)

AAM:	106482457(DHRS3)

AROW:

112970126(DHRS3)

NPD:	112959634(DHRS3)

TGT:	104570931(DHRS3)

DNE:	112980559(DHRS3)

SCAM:

104141848(DHRS3)

ASN:	102370531(DHRS3)

AMJ:	102574201(DHRS3)

CPOO:

109314392(DHRS3)

GGN:	109293769(DHRS3)

PSS:	102445977(DHRS3)

CIZ:	142025612(DHRS3)

CMY:	102944040(DHRS3)

CCAY:

125624544(DHRS3)

LKP:	140900078(DHRS3)

DCC:	119845196(DHRS3)

CPIC:

101941293(DHRS3)

TST:	117867783(DHRS3)

CABI:

116821896(DHRS3)

MRV:	120387748(DHRS3)

ACS:	100557137(dhrs3)

ASAO:

132764755(DHRS3)

PVT:	110082458(DHRS3)

SUND:

121936546(DHRS3)

PBI:	103054360(DHRS3)

PMUR:

107284674(DHRS3)

CTIG:

120319156(DHRS3)

TSR:

106555968

PGUT:

117656603(DHRS3)

PCAE:

139326181

APRI:

131187147(DHRS3)

PTEX:

113450786(DHRS3)

NSS:	113430539(DHRS3)

VKO:	123034700(DHRS3)

PMUA:

114602606(DHRS3)

PRAF:

128419634(DHRS3)

ZVI:	118086593(DHRS3)

HCG:	128338540(DHRS3)

GJA:	107124081(DHRS3)

STOW:

125445782(DHRS3)

EMC:	129344734(DHRS3)

XLA:	108697667(dhrs3.S) 444269(dhrs3.L)

XTR:	493258(dhrs3)

NPR:	108783931(DHRS3)

RTEM:

120915789(DHRS3)

ACAT:

141111434(DHRS3)

PADS:

140340827(DHRS3)

BBUF:

120998361(DHRS3)

BGAR:

122928885(DHRS3)

DTC:	141097999(DHRS3)

PWL:	138300892(DHRS3)

MUO:	115456552(DHRS3)

GSH:	117349434(DHRS3)

DRE:	445083(dhrs3a) 450050(dhrs3b)

SRX:	107712670 107727813 107737702 107749419

SANH:

107685629 107687474 107691330 107703071

SGH:	107555693 107568630(dhrs3) 107591109 107593436

CCAR:

109055081 109072076 109072700(dhrs3b) 109093510

CAUA:

113068382 113068878 113095954 113111094

CGIB:

127945187 127967727 128011309 128022245

PTET:

122328450(dhrs3a) 122354472(dhrs3b)

LROH:

127155242(dhrs3a) 127172836(dhrs3b)

GRF:	141291266(dhrs3a) 141293797(dhrs3b)

OMC:	131531510(dhrs3a) 131548900(dhrs3b)

PPRM:

120462751(dhrs3a) 120480236(dhrs3b)

RKG:	130085568(dhrs3b) 130102186(dhrs3a)

MAMB:

125256890(dhrs3b) 125260260(dhrs3a)

CIDE:

127504483 127522934

CERY:

137009232(dhrs3a) 137021052(dhrs3b)

MASI:

127419477 127420467 127426219 127427604

TROS:

130545182(dhrs3a) 130571716(dhrs3b)

TDW:	130409438(dhrs3a) 130410748(dhrs3b)

MANU:

129427553(dhrs3b) 129431000(dhrs3a)

PDAB:

135718847(dhrs3b) 135775576(dhrs3a)

IPU:	108255144(dhrs3b) 108275517(dhrs3a)

IFU:	128619005(dhrs3a) 128625045(dhrs3b)

PHYP:

113530392 113537937(dhrs3)

TFD:	113656474(dhrs3b) 113658105(dhrs3a)

TVC:	132837761(dhrs3b) 132862725(dhrs3a)

CGAR:

128510814(dhrs3a) 128511513(dhrs3b)

NGRA:

132874555(dhrs3b) 132896225(dhrs3a)

TRN:	134301914(dhrs3b) 134333178(dhrs3a)

AMEX:

103042050(dhrs3b) 103044922(dhrs3a)

CMAO:

118799509(dhrs3b) 118822999(dhrs3a)

EEE:	113570049 113586063

CHAR:

105894275(dhrs3a) 105912206(dhrs3b)

SPIL:

134088170(dhrs3a) 134092912(dhrs3b)

ASAD:

121707592(dhrs3b) 121713109(dhrs3a)

TRU:	101064046(dhrs3)

TFS:	130524543(dhrs3b)

TNG:	GSTEN00022954G001

LCO:	104917935(dhrs3)

NCC:	104955652(dhrs3)

TBEN:

117489360(dhrs3b)

CGOB:

115007670(dhrs3)

PGEO:

117447325(dhrs3b)

GACU:

117539471(dhrs3b)

EMAC:

134882207(dhrs3b)

ELY:	117256430(dhrs3b)

EFO:	125897523(dhrs3b)

PLEP:

121950706(dhrs3b)

SLUC:

116051562(dhrs3b)

ECRA:

117943810(dhrs3b)

ESP:	116687925(dhrs3)

PFLV:

114554569(dhrs3)

GAT:	120835162(dhrs3b)

PPUG:

119194272(dhrs3b)

AFB:	129106035(dhrs3b)

CLUM:

117731149(dhrs3b)

PSWI:

130208035(dhrs3b)

CANA:

137798880(dhrs3b)

CVE:	137874002(dhrs3b)

MSAM:

119886682(dhrs3b)

SCHU:

122862746(dhrs3b)

CUD:	121507446(dhrs3b)

SPUL:

138606195(dhrs3b)

LMIX:

132976914(dhrs3b)

HTC:	141789879(dhrs3b)

ALAT:

119021690(dhrs3b)

ASTR:

137595991(dhrs3b)

MZE:	101486960(dhrs3)

ONL:	100711752(dhrs3)

OAU:	116315043(dhrs3b)

OLA:	101159580(dhrs3)

OML:	112144521(dhrs3b)

CSAI:

133449313(dhrs3b)

XMA:	102237356(dhrs3)

XCO:	114135360(dhrs3)

XHE:	116710060(dhrs3)

PRET:

103464767(dhrs3)

PFOR:

103134657(dhrs3)

PLAI:

106951996(dhrs3)

PMEI:

106929712(dhrs3)

GAF:	122833705(dhrs3b)

PPRL:

129372883(dhrs3b)

CVG:	107085136(dhrs3)

CTUL:

119780742(dhrs3b)

GMU:	124856614(dhrs3b)

NFU:	107384894(dhrs3)

KMR:	108231475(dhrs3b)

ALIM:

106518344(dhrs3)

NWH:	119412626(dhrs3b)

AOCE:

111581142(dhrs3b)

EJA:	138198329(dhrs3b)

BFRE:

138628307(dhrs3b)

MCEP:

125007388(dhrs3b)

CSEM:

103386641(dhrs3)

POV:	109635620(dhrs3)

SSEN:

122767833(dhrs3b)

SSOE:

131460515(dhrs3b)

HHIP:

117761746(dhrs3b)

HSP:	118105483(dhrs3b)

PPLT:

128457545(dhrs3b)

SMAU:

118309907(dhrs3b)

LCF:	108885195(dhrs3b)

SDU:	111233594(dhrs3)

SLAL:

111660657(dhrs3)

XGL:	120807538(dhrs3b)

HCQ:	109521619(dhrs3)

SSCV:

125977522(dhrs3b)

SBIA:

133508024(dhrs3b)

PEE:	133409052(dhrs3b)

PTAO:

133483908(dhrs3b)

BPEC:

110174741(dhrs3)

ENY:	140365644(dhrs3b)

MALB:

109972345(dhrs3)

BSPL:

114855329(dhrs3b)

SJO:	128355698(dhrs3b)

SSCO:

133977322(dhrs3b)

TTY:	137181116(dhrs3b)

SASA:

100380445(dhrs3) 106566814 106572239 106582983

STRU:

115150719 115166280 115168272 115207720

OTW:	112215877 112218506(dhrs3b) 112222076 112254479

OMY:	110492292 110494444(dhrs3b) 110528002 110532123

OGO:	124004031 124031383 124031804 124045771

ONE:	115102208 115132008 115138849 115143269

OKI:	109869210 109890204 109896619(dhrs3) 109907865

OKE:	118359728 118361282 118388479(dhrs3b) 118400210

OMM:	135504542 135528097 135540080(dhrs3b) 135542038

OCLA:

139367697 139369855 139414303 139416373

SALP:

111966310 111967734(dhrs3) 111969990 111977048

SNH:	120024688 120058965 120060732 120064901

SFON:

129815164 129830276 129850105 129860949

CCLU:

121538189 121545517 121575964 121577724

ELS:	105013897(dhrs3)

OEP:	134019092(dhrs3a) 134021137(dhrs3b)

SFM:	108918261 108933492

PKI:	111852055 111859170

AANG:

118208501 118211933(dhrs3b)

AROT:

135233954 135237532(dhrs3b)

CCOG:

133109955(dhrs3b) 133139173

LOC:	102697001(dhrs3)

PSPA:

121329268 121329334

ARUT:

117432364 117963616

PSEX:

120530803(dhrs3b)

LCM:	102361459(DHRS3)

CMK:

CPLA:

CPUN:

HOC:

SCAU:

STOZ:

140392777(dhrs3b)

LERI:

129711452

HAKA:

140718267

PMRN:

116950500(DHRS3)

LRJ:	133352398(DHRS3)

BFO:	118417570 118417791

BBEL:

SKO:

PFLL:

AALB:

LSAX:

BGT:

GAE:

HASI:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

YBA:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:	115222602 118767231

LAK:	106156832 106164481

NCE:	NCER_100360

» show all

Reference

PMID:9705317

Authors

Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K

Title

Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal.

Journal

J Biol Chem 273:21790-9 (1998)
DOI:10.1074/jbc.273.34.21790

Sequence

[hsa:9249] [mmu:20148] [bta:281482]

LinkDB

DBGET integrated database retrieval system