KEGG ORTHOLOGY: K11160

ORTHOLOGY: K11160

Entry

K11160                      KO

Symbol

DGAT2

Name

diacylglycerol O-acyltransferase 2 [EC:2.3.1.20 2.3.1.75]

Pathway

map00561

Glycerolipid metabolism

map01100

Metabolic pathways

map04975

Fat digestion and absorption

Module

M00089

Triacylglycerol biosynthesis

Reaction

R02251

acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00561 Glycerolipid metabolism
    K11160  DGAT2; diacylglycerol O-acyltransferase 2
09150 Organismal Systems
  09154 Digestive system
   04975 Fat digestion and absorption
    K11160  DGAT2; diacylglycerol O-acyltransferase 2
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.20  diacylglycerol O-acyltransferase
     K11160  DGAT2; diacylglycerol O-acyltransferase 2
    2.3.1.75  long-chain-alcohol O-fatty-acyltransferase
     K11160  DGAT2; diacylglycerol O-acyltransferase 2

Other DBs

GO:

0004144

Genes

HSA:	84649(DGAT2)

PTR:	466714(DGAT2)

PPS:	100987880(DGAT2)

GGO:	101124779(DGAT2)

PON:	100442216(DGAT2)

PPYG:

129008079(DGAT2)

NLE:	100596453(DGAT2)

HMH:	116476704(DGAT2)

SSYN:

129484639(DGAT2)

MCC:	696549(DGAT2)

MCF:	102128601(DGAT2)

MTHB:

126935091

MNI:	105468770(DGAT2)

CSAB:

103248066(DGAT2)

CATY:

105578724(DGAT2)

PANU:

101004164(DGAT2)

TGE:	112606124(DGAT2)

MLEU:

105555210(DGAT2)

RRO:	104665097(DGAT2)

RBB:	108545121(DGAT2)

TFN:	117079794(DGAT2)

PTEH:

111540820(DGAT2)

CANG:

105511813(DGAT2)

CJC:	100414192(DGAT2)

SBQ:	101049433(DGAT2)

CIMI:

108307606(DGAT2)

ANAN:

105729008(DGAT2)

CSYR:

103260163(DGAT2)

MMUR:

105860306(DGAT2)

LCAT:

123641013(DGAT2)

PCOQ:

105811518(DGAT2)

OGA:	100955161(DGAT2)

MMU:	67800(Dgat2)

MCAL:

110298238(Dgat2)

MPAH:

110327696(Dgat2)

RNO:	252900(Dgat2)

MCOC:

116102617(Dgat2)

ANU:	117696383(Dgat2)

ASYL:

127665526(Dgat2)

MUN:	110566217(Dgat2)

CGE:	100774981(Dgat2)

MAUA:

101828109(Dgat2)

PROB:

127227942(Dgat2)

PLEU:

114698694(Dgat2)

MORG:

121447603 121451992 121458609 121464703

MFOT:

126489000 126508923

AAMP:

119802438(Dgat2)

NGI:	103743019(Dgat2)

HGL:	101698712(Dgat2)

CPOC:

100718670(Dgat2)

CCAN:

109680743(Dgat2)

DORD:

105984115(Dgat2)

DSP:	122116390(Dgat2)

PLOP:

125361512(Dgat2)

NCAR:

124959932

MMMA:

107135503(Dgat2)

ITI:	101959140(Dgat2)

OCU:

100354838

OPI:	101531109(DGAT2)

TUP:	102494423(DGAT2)

GVR:	103594072(DGAT2)

CFA:	485185(DGAT2)

CLUD:

112642159(DGAT2)

VVP:	112928729(DGAT2)

VLG:	121476006(DGAT2)

NPO:	129506629(DGAT2)

AML:	100468811(DGAT2)

UMR:	103678126(DGAT2)

UAH:	113269335(DGAT2)

UAR:	123804196(DGAT2)

ELK:

111159441

LLV:

125079109

MPUF:

101683621(DGAT2)

MNP:	132024524(DGAT2)

MLK:	131840540(DGAT2)

NVS:	122912570(DGAT2)

ORO:	101385232(DGAT2)

EJU:	114218654(DGAT2)

ZCA:	113914191(DGAT2)

MLX:	118004222(DGAT2)

NSU:	110593398(DGAT2)

LWW:	102734307(DGAT2)

FCA:	101100329(DGAT2)

PYU:	121039297(DGAT2)

PCOO:

112865756(DGAT2)

PBG:	122483320(DGAT2)

PVIV:

125146977(DGAT2)

LRUF:

124504588

LGF:	123601143(DGAT2)

AJU:

106976464

PTG:	102952153(DGAT2)

PPAD:

109267215(DGAT2)

PUC:

125914396

PLEZ:

122199213(DGAT2)

HHV:	120229587(DGAT2)

BTA:	404129(DGAT2)

BOM:	102285649(DGAT2)

BIU:	109569733(DGAT2)

BBUB:

102404874(DGAT2)

BBIS:

104994095(DGAT2)

CHX:	102174409(DGAT2)

OAS:	101110535(DGAT2)

BTAX:

128060168(DGAT2)

CSUM:

138092216(DGAT2)

ODA:	120876775(DGAT2)

CCAD:

122449555(DGAT2)

MREE:

136174238(DGAT2)

OVR:	110136487(DGAT2)

MBEZ:

129554690(DGAT2)

SSC:	100294675(DGAT2) 110259135

CFR:	102504113(DGAT2)

CBAI:

105083331(DGAT2)

CDK:	105097240(DGAT2)

VPC:	102543460(DGAT2)

BACU:

103018277(DGAT2)

BMUS:

118899636(DGAT2)

LVE:	103075069(DGAT2)

DLE:	111184877(DGAT2)

PSIU:

116758860(DGAT2)

NASI:

112411114(DGAT2)

ECB:	100064387(DGAT2)

EPZ:	103548227(DGAT2)

EAI:	106840399(DGAT2)

MYB:	102249216 102261774(DGAT2)

MYD:	102753473(DGAT2)

MMYO:

118664624(DGAT2)

MLF:	102432364(DGAT2)

MDT:	132227587 132229268 132240780(DGAT2)

MYUM:

139017352(DGAT2)

PKL:	118712749(DGAT2)

EFUS:

103293682(DGAT2)

MNA:	107524453(DGAT2)

DRO:	112316013(DGAT2)

SHON:

118981593(DGAT2)

AJM:	119038935(DGAT2)

PDIC:

114500700(DGAT2)

PHAS:

123805549(DGAT2)

MMF:	118628088(DGAT2)

PPAM:

129072761(DGAT2)

HAI:	109386362(DGAT2)

RFQ:	117030228(DGAT2)

PALE:

102898739(DGAT2)

PGIG:

120590367(DGAT2)

PVP:	105297629(DGAT2)

RAY:	107519183(DGAT2)

MJV:	108404469(DGAT2)

TOD:	119255640(DGAT2)

SARA:

101537208(DGAT2)

SFUM:

130025107(DGAT2)

SETR:

126018173(DGAT2)

LAV:	100657191(DGAT2)

TMU:

101355455

ETF:	101643400 101650984(DGAT2)

DNM:	101425617(DGAT2)

MDO:	100011089(DGAT2)

GAS:	123240512(DGAT2)

SHR:	100914285(DGAT2)

AFZ:

127555061

PCW:	110210559(DGAT2)

TVP:	118836122(DGAT2)

PBRV:

138148281(DGAT2)

OAA:	100088895(DGAT2)

TACU:

119941648(DGAT2)

GGA:	421309(DGAT2) 428693(AWAT1)

PCOC:

116229501 116237128(DGAT2)

MGP:	100540643 100545351(DGAT2)

CJO:	107308594(DGAT2) 107312638

TPAI:

128076077 128088612(DGAT2)

LMUT:

125695710(DGAT2) 125699771

NMEL:

110392121(DGAT2) 110403393

APLA:

101801215(DGAT2) 119717917

ACYG:

106042403(DGAT2) 106042952

CATA:

118245361 118254821(DGAT2)

AFUL:

116493702(DGAT2) 116494455

TGU:	100220095(DGAT2) 100232309

LSR:	110471640(DGAT2) 110474359

SCAN:

103816429 103823769(DGAT2)

PMOA:

120502902(DGAT2) 120508757

OTC:	121331883 121345447(DGAT2)

PRUF:

121353434(DGAT2) 121363220

ATRC:

139593044(DGAT2) 139597192

GFR:	102035873(DGAT2) 102037230

FAB:	101810713(DGAT2) 101820931

OMA:	130251414(DGAT2) 130253175

PHI:	102100921 102107779(DGAT2)

PMAJ:

107204039 107211569(DGAT2)

CCAE:

111928595 111941011(DGAT2)

CCW:	104686963(DGAT2) 104691343

CBRC:

103613828(DGAT2) 103623291

ACOE:

138100559(DGAT2) 138110346

ETL:	114059609(DGAT2) 114065167

ZAB:	102067962(DGAT2)

ZLE:	135447754 135454304(DGAT2)

ACHL:

103810882(DGAT2) 103811539

SVG:	106856601(DGAT2) 106860197 106864621

MMEA:

130579885(DGAT2) 130586372

HRT:	120748803(DGAT2)

SATI:

136373261 136373546 136375251(DGAT2)

CCIC:

134050029 134055402(DGAT2)

FPG:	101917877 101924658(DGAT2)

FCH:	102055207(DGAT2) 102057990

CCRI:

104155569(DGAT2)

NNT:	104413348(DGAT2)

SHAB:

115603651(DGAT2) 115612775

ACUN:

113481155(DGAT2)

TALA:

104359568(DGAT2) 116963760

ACHC:

115333797 115353408(DGAT2)

HALD:

104311450(DGAT2)

HLE:	104834787 104837474(DGAT2)

AGEN:

126048145 126050190

HHAR:

128153409(DGAT2) 128153958

GCL:	127019631 127027094

CSTI:

104561220(DGAT2)

LDI:

104353992

MNB:	103774229(DGAT2)

DPUB:

104297009 104302402(DGAT2)

PPUS:

135175860(DGAT2) 135183797

AVIT:

104268809(DGAT2)

BRHI:

104497704(DGAT2)

EGZ:	104124768(DGAT2) 104135988

NNI:	104012839 104022725(DGAT2)

PCRI:

104027365(DGAT2)

PCAO:

104049548(DGAT2)

PADL:

103915186(DGAT2) 103919207

AFOR:

103904653(DGAT2) 103906155

FGA:	104073309(AWAT2)

GSTE:

104251567(DGAT2)

CLV:	102085339 102087439(DGAT2)

MUI:	104546500(DGAT2) 104546921

PGUU:

104467335(DGAT2)

PLET:

104623782(DGAT2)

EHS:	104503936 104506915(DGAT2)

CMAC:

104481279(DGAT2)

CUCA:

104054299 104064126(DGAT2)

TEO:	104375044 104380910(DGAT2)

BREG:

104640377(DGAT2)

OHA:	104326275(DGAT2)

ACAR:

104522911(DGAT2) 104529705

CPEA:

104387831 104397247(DGAT2)

CVF:	104283492 104291467(DGAT2)

RTD:	128912285(DGAT2) 128915212

CRID:

134512128(DGAT2) 134520905

AAM:	106482698 106486174 106494604

AROW:

112966308 112970398(DGAT2)

NPD:	112942305 112948691(DGAT2)

TGT:	104566185 104571431(AWAT1)

DNE:	112980802 112981932(DGAT2)

SCAM:

104152363 104152792(DGAT2)

ASN:	102370139 102371123(DGAT2)

AMJ:	102557932(DGAT2) 102576534(AWAT2)

CPOO:

109306877(DGAT2) 109310891

GGN:	109300474 109303156(DGAT2)

PSS:	102449336 102453357(DGAT2)

CMY:	102929519 102930862(DGAT2)

CCAY:

125632198(DGAT2) 125642370

DCC:	119859717(DGAT2) 119861450

CPIC:

101930999(DGAT2) 101950557

TST:	117871307(DGAT2) 117882695

CABI:

116817074 116834584(DGAT2) 116834701

MRV:	120371561 120405842(DGAT2)

ACS:	100552736(dgat2) 100555636

ASAO:

132762813 132772295(DGAT2)

PVT:	110074308 110087798(DGAT2)

SUND:

121925502(DGAT2) 121936266

PBI:	103052621(DGAT2)

PMUR:

107299528

CTIG:

120318288

PGUT:

117679844(DGAT2)

APRI:

131199582(DGAT2)

PTEX:

113440386(DGAT2)

NSS:	113426993(DGAT2)

VKO:	123027242 123033546(DGAT2)

PMUA:

114589371 114595553(DGAT2)

PRAF:

128406436 128412475(DGAT2)

ZVI:	118084502 118085303(DGAT2)

HCG:	128335668 128349993(DGAT2)

GJA:	107110553 107112091(DGAT2)

STOW:

125425197 125430796(DGAT2)

EMC:	129325440(DGAT2) 129341379

XLA:	100126612(awat1.L) 100127341(awat1.S) 108698316(dgat2l6.L) 108710042(dgat2.S) 108710383(mogat3.L) 398800(dgat2.L)

XTR:	100127622(awat1) 100127752(dgat2l6) 100491581(mogat3) 395003(dgat2)

NPR:	108785624 108792522(DGAT2) 108795426(MOGAT3) 108796935

RTEM:

120928929(DGAT2) 120933489(MOGAT3) 120936575

BBUF:

120977260 120986523 120993143 120996506 120996508 120996509 120996510 120997731

BGAR:

122923132 122923133 122929349 122930942 122931919 122932546 122935739 122946501

PWL:	138249787(DGAT2) 138261170 138265609 138268068(MOGAT3)

MUO:	115457960 115458217 115468387(DGAT2) 115478347

GSH:	117350625(MOGAT3) 117363001(DGAT2) 117366878

DRE:	494083(mogat3b) 565316(dgat2)

SRX:	107746411 107746984 107752358

SANH:

107661213 107663414 107686128(dgat2) 107691652

SGH:	107578632 107588782(dgat2) 107596103 107599198(mogat3)

CCAR:

109052109 109068531 109090750 109098086

CAUA:

113049110 113049603 113054403 113077530 113109920

CGIB:

127958543 127966903 128003400 128021092

PTET:

122344800(mogat3b) 122353039(dgat2)

LROH:

127165559(mogat3b) 127172150(dgat2)

OMC:	131541659(mogat3b) 131547719(dgat2)

PPRM:

120469793(mogat3b) 120469794 120482752(dgat2)

RKG:	130072045(mogat3b) 130105523(dgat2)

MAMB:

125262200(dgat2) 125266968(mogat3b)

CIDE:

127512229 127520090

CERY:

137028691(dgat2) 137034036(mogat3b)

MASI:

127429735 127432910 127433001 127434001

TROS:

130546045(dgat2) 130570796(mogat3b)

TDW:	130412261(dgat2) 130419982(mogat3b)

MANU:

129440458(mogat3b) 129446838(dgat2)

PDAB:

135741045(dgat2) 135748912(mogat3b)

IPU:	100528806(dgat2) 108259936(mogat3b)

IFU:	128603439(mogat3b) 128620590(dgat2)

PHYP:

113524198(dgat2) 113531204

SMEO:

124379331(mogat3b) 124393940(dgat2)

TFD:	113641502(mogat3b) 113650339(dgat2)

TVC:	132841200(mogat3b) 132863066(dgat2)

CGAR:

128512372(mogat3b) 128512588 128545670(dgat2)

NGRA:

132873100(dgat2) 132875617(mogat3b)

TRN:	134302990(mogat3b) 134332394(dgat2)

AMEX:

103043884(dgat2) 111194470(mogat3b)

CMAO:

118803831(mogat3b) 118824300(dgat2)

EEE:	113589528(dgat2) 113590600

CHAR:

105900407(dgat2) 105903793 105906582 105906583 105906645 116221532 122129822

SPIL:

134066393 134080114 134080115(mogat3b) 134080264(dgat2)

TRU:	101071223 101079383(dgat2)

TFS:	130537054(mogat3b) 130537912(dgat2)

TNG:	GSTEN00016290G001 GSTEN00022150G001

LCO:	104931787(dgat2) 104937288

NCC:	104942132(dgat2)

TBEN:

117472193(dgat2) 117490458 117490459 117490460

CGOB:

115018989(dgat2) 115019169

PGEO:

117458100 117458101 117458154(dgat2) 117458676(mogat3b)

GACU:

117534113 117534121 117534130 117553070(dgat2)

EMAC:

134872221(mogat3b) 134872799(dgat2)

ELY:	117246453(dgat2) 117264098(mogat3b)

EFO:	125898139(mogat3b) 125899027(dgat2)

PLEP:

121952909(dgat2) 121953073(mogat3b)

SLUC:

116058252(dgat2) 116064928(mogat3b)

ECRA:

117955304(dgat2) 117955838(mogat3b)

ESP:	116677659 116700625 116700701(dgat2)

PFLV:

114566209 114566643(dgat2)

GAT:	120821650(mogat3b) 120822783(dgat2)

PPUG:

119215522(dgat2) 119215717(mogat3b)

AFB:	129113409(dgat2) 129113784(mogat3b)

CLUM:

117742639(dgat2) 117742871(mogat3b)

PSWI:

130191359(mogat3b) 130212050(dgat2)

CANA:

137802335(mogat3b) 137802789(dgat2)

CVE:	137876576(mogat3b) 137880185(dgat2)

MSAM:

119895050(mogat3b) 119895214(dgat2)

SCHU:

122888559(dgat2) 122888831(mogat3b)

CUD:	121518318(dgat2) 121518425(mogat3b)

SPUL:

138594828(mogat3b) 138602036(dgat2)

LMIX:

132988518(dgat2) 132988867(mogat3b)

ALAT:

119031173(mogat3b) 119031819(dgat2)

ASTR:

137606122(dgat2) 137606435(mogat3b)

MZE:	101484727 101485008(dgat2)

ONL:	100707401 100709028(dgat2)

OAU:	116320588(dgat2) 116330302(mogat3b)

OLA:	101166733 101175675(dgat2)

OML:	112142473(mogat3b) 112142623(dgat2)

CSAI:

133459672(mogat3b) 133459860(dgat2)

XMA:	102219836(dgat2) 102228247

XCO:	114152662 114153067(dgat2)

XHE:	116728361(dgat2) 116728435

PRET:

103475773 103476122(dgat2)

PFOR:

103142114(dgat2) 103145629

PLAI:

106951574(dgat2) 106953369

PMEI:

106922189 106926391(dgat2)

GAF:	122844303(mogat3b) 122845257(dgat2)

PPRL:

129368730(mogat3b) 129368797(dgat2)

CVG:	107097472(dgat2) 107099793

CTUL:

119771282(dgat2) 119789592(mogat3b)

GMU:	124876339(mogat3b) 124876553(dgat2)

NFU:	107386011(dgat2) 107386510

KMR:	108244705(dgat2) 108248268(mogat3b)

ALIM:

106517203(dgat2) 106535072

NWH:	119420166(mogat3b) 119420715(dgat2)

AOCE:

111577661(mogat3b) 111587031(dgat2)

EJA:	138195951(mogat3b) 138196725(dgat2)

BFRE:

138631457(mogat3b) 138635295(dgat2)

MCEP:

125020837(mogat3b) 125021413(dgat2)

CSEM:

103394818(dgat2) 103395417

POV:	109628346 109628731(dgat2)

SSEN:

122779148(dgat2) 122779643(mogat3b)

SSOE:

131458099(mogat3b) 131458769(dgat2)

HHIP:

117774123(dgat2) 117774187(mogat3b)

HSP:	118122023(mogat3b) 118122513 118122590(dgat2)

PPLT:

128457071(mogat3b) 128457189(dgat2)

SMAU:

118300617(mogat3b) 118300728(dgat2)

LCF:	108893507(mogat3b) 108893792

SDU:	111222364(dgat2) 111234506

SLAL:

111653950 111663527(dgat2)

XGL:	120802291(dgat2) 120802722(mogat3b)

HCQ:	109512376 109531183(dgat2)

SSCV:

125981751(mogat3b) 125982700(dgat2)

SBIA:

133491635(mogat3b) 133491707(dgat2)

PEE:	133415740(dgat2) 133416388(mogat3b)

PTAO:

133466967(dgat2) 133467247(mogat3b)

BPEC:

110158360 110165125(dgat2)

ENY:	140360907(mogat3b) 140361097(dgat2)

MALB:

109959536 109972857(dgat2)

BSPL:

114869513(mogat3b) 114869858(dgat2)

SJO:	128371165(dgat2) 128371219(mogat3b)

SSCO:

133993667 133993938(dgat2) 133994157

GMH:	115546693(dgat2) 115546890 115546891

SASA:

106567948 106581137 106603399 106603538

STRU:

115148293 115148893 115154352 115154431 115163481

OTW:	112220016 112228637(mogat3b) 112233379 112248141 112257827

OMY:	110503985 110507812 110508071 110523205 110533663 110533733(mogat3b) 110537459

OGO:	123989459 123992475 124000096 124009767 124010412

ONE:	115104779 115105564 115135832 115135895

OKI:	109873176 109875654 109892723

OKE:	118358328 118381492 118387285 118390100 118390170 118391173

OMM:	135518325 135545119 135547857 135548569 135550614 135550675 135553209

OCLA:

139385734 139418269 139418326 139423090

SALP:

111950522 111951175 111981045

SNH:	120018018 120025469 120041785 120045187(dgat2) 120057077 120057118(mogat3b)

CCLU:

121559152 121568006 121568310 121573579 121579776 121580310 121582010

ELS:	105005790 105010982(dgat2) 105023913

OEP:	134016181 134039439(dgat2) 134039874(mogat3b)

SFM:	108936020(dgat2)

PKI:	111858447(dgat2)

AANG:

118209231 118235037(mogat3b) 118235735(dgat2)

AROT:

135236363 135264029(dgat2) 135264184(mogat3b)

CCOG:

133108029 133132331(mogat3b) 133132608 133132769

LOC:	102684783(dgat2)

PSPA:

121305669 121306615 121320386(dgat2)

ARUT:

117405472 117406788 117968116

PSEX:

120523348(dgat2) 120525108

LCM:	102351093(DGAT2) 102359647(MOGAT3) 102360601

CMK:	103188598(dgat2) 103190916

RTP:	109918725(dgat2) 109923339

CPLA:

122547839 122550950(dgat2)

HOC:	132816562(dgat2) 132835147

LERI:

129698408(dgat2) 129715385

PMRN:

116937872

LRJ:	133357310(DGAT2)

AFIL:

HHAL:

TPAL:

EAF:

PMEO:

ATEN:

MCAZ:

MFOO:

Reference

PMID:19116371

Authors

Shi Y, Cheng D

Title

Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism.

Journal

Am J Physiol Endocrinol Metab 297:E10-8 (2009)
DOI:10.1152/ajpendo.90949.2008

Reference

PMID:11481335

Authors

Cases S, Stone SJ, Zhou P, Yen E, Tow B, Lardizabal KD, Voelker T, Farese RV Jr

Title

Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members.

Journal

J Biol Chem 276:38870-6 (2001)
DOI:10.1074/jbc.M106219200

Sequence

[hsa:84649]

LinkDB

DBGET integrated database retrieval system