KEGG ORTHOLOGY: K11542

ORTHOLOGY: K11542

Entry

K11542                      KO

Symbol

CASC5, KNL1

Name

protein CASC5

Pathway

map04110

Cell cycle

Disease

H00269

Primary microcephaly

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K11542  CASC5, KNL1; protein CASC5
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K11542  CASC5, KNL1; protein CASC5
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11542  CASC5, KNL1; protein CASC5
Protein phosphatases and associated proteins [BR:ko01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K11542  CASC5, KNL1; protein CASC5
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Centromeric chromatin formation proteins
   Kinetochore proteins
    KMN network proteins
     K11542  CASC5, KNL1; protein CASC5

Genes

HSA:	57082(KNL1)

PTR:	453338(KNL1)

PPS:	100986834(KNL1)

GGO:	101152498(KNL1)

PON:	100433210(KNL1)

NLE:	100607253(KNL1)

HMH:	116482020(KNL1)

MCC:	708271(KNL1)

MCF:	102115027(KNL1)

MTHB:

126959782

MNI:	105493188(KNL1)

CSAB:

103246102(KNL1)

CATY:

105574175(CASC5)

PANU:

101016674(KNL1)

TGE:	112627658(KNL1)

MLEU:

105546162(CASC5)

RRO:

104659656

RBB:	108523405(KNL1)

TFN:	117070860(KNL1)

PTEH:

111524270(KNL1)

CANG:

105505025(CASC5)

CJC:	100412512(KNL1)

SBQ:	101033614(CASC5)

CIMI:

108306104(KNL1)

CSYR:

103275325(KNL1)

MMUR:

105872448(KNL1)

LCAT:

123625897(KNL1)

PCOQ:

105814300(CASC5)

OGA:	100961960(KNL1)

MMU:	76464(Knl1)

MCAL:

110289886(Knl1)

MPAH:

110318212(Knl1)

RNO:	311327(Knl1)

MCOC:

116090708(Knl1)

ANU:	117703633(Knl1)

MUN:	110550606(Knl1)

CGE:	100755881(Knl1)

MAUA:

101839954(Knl1)

PROB:

127221635(Knl1)

PLEU:

114688796 114704599(Knl1)

MORG:

121465640(Knl1)

MFOT:

126495167

AAMP:

119814948(Knl1)

NGI:	103744976(Knl1)

HGL:	101715049(Knl1)

CPOC:

100730663(Knl1)

CCAN:

109677835(Knl1)

DORD:

105981134(Casc5)

DSP:	122114469(Knl1)

PLOP:

125340679(Knl1)

NCAR:

124977918

MMMA:

107137651(Knl1)

OCU:

100346129

OPI:	101528367(KNL1)

TUP:	102488319(KNL1)

GVR:	103588529(CASC5)

CFA:	478260(KNL1)

CLUD:

112676111(KNL1)

VVP:	112919807(KNL1)

VLG:	121479673(KNL1)

NPO:	129504219(KNL1)

AML:	100474010(KNL1)

UMR:	103673457(KNL1)

UAH:	113241920(KNL1)

UAR:	123775514(KNL1)

ELK:

111139232

LLV:

125104859

MPUF:

101679150(CASC5)

MNP:	131999636(KNL1)

MLK:	131836118(KNL1)

NVS:	122892918(KNL1)

ORO:	101370609(CASC5)

EJU:	114221459(KNL1)

ZCA:	113910310(KNL1)

MLX:	118003213(KNL1)

NSU:	110585269(KNL1)

LWW:	102739912(KNL1)

FCA:	101086398(KNL1)

PYU:	121041515(KNL1)

PCOO:

112855619(KNL1)

PBG:	122468769(KNL1)

PVIV:

125168588(KNL1)

LRUF:

124508705

PTG:	102950670(KNL1)

PPAD:

109263151(KNL1)

PUC:

125909864

AJU:

106968537

HHV:	120232275(KNL1)

BTA:	787969(KNL1)

BOM:	102279794(KNL1)

BIU:	109564941(KNL1)

BBUB:

102394964(KNL1)

BBIS:

104994408(CASC5)

CHX:	102171882(KNL1)

OAS:	101114616(KNL1)

BTAX:

128054420(KNL1)

ODA:	120853204(KNL1)

CCAD:

122443397(KNL1)

MBEZ:

129563177(KNL1)

SSC:	100626221(KNL1)

CFR:	102523367(KNL1)

CBAI:

105076901(CASC5)

CDK:	105096878(KNL1)

VPC:	102543448(KNL1)

BACU:

103014378(KNL1)

BMUS:

118891204(KNL1)

LVE:	103085999(CASC5)

OOR:	101288233(KNL1)

DLE:	111181741(KNL1)

PCAD:

102988354(KNL1)

PSIU:

116749724(KNL1)

NASI:

112391268(KNL1)

ECB:	100071354(KNL1)

EPZ:	103564231(KNL1)

EAI:	106830881(KNL1)

MYB:	102256740(KNL1)

MYD:	102758527(KNL1)

MMYO:

118649901(KNL1)

MLF:	102419103(KNL1)

PKL:	118723542(KNL1)

EFUS:

103287510(KNL1)

MNA:	107542996(CASC5)

DRO:	112311066(KNL1)

SHON:

118993581(KNL1)

AJM:	119061300(KNL1)

PDIC:

114492231(KNL1)

PHAS:

123808708(KNL1)

MMF:	118628947(KNL1)

PPAM:

129064063(KNL1)

HAI:	109383978(KNL1)

RFQ:	117023048(KNL1)

PALE:

102894269(KNL1)

PGIG:

120587176(KNL1)

PVP:	105288637(KNL1)

RAY:	107514473(CASC5)

MJV:	108394362(KNL1)

TOD:	119238489(KNL1)

SARA:

101552812(CASC5)

SETR:

126020270(KNL1)

LAV:	100670558(KNL1)

TMU:

101350470

ETF:	101651815(KNL1)

DNM:	101413602(KNL1)

MDO:	100032004(KNL1)

GAS:	123234080(KNL1)

SHR:	100931355(KNL1)

AFZ:

127546632

PCW:	110223688(KNL1)

OAA:	103169511(KNL1)

GGA:	423007(KNL1)

PCOC:

116237833(KNL1)

MGP:	104910959(KNL1)

CJO:	107314234(KNL1)

TPAI:

128086568(KNL1)

LMUT:

125694308(KNL1)

NMEL:

110400932(KNL1)

APLA:

101802583(KNL1)

ACYG:

106047058(KNL1)

CATA:

118244783(KNL1)

AFUL:

116490274(KNL1)

TGU:	105759275(KNL1)

LSR:	110467546(KNL1)

SCAN:

103822303(KNL1)

PMOA:

120500975(KNL1)

OTC:	121335710(KNL1)

PRUF:

121354787(KNL1)

GFR:	106631942(KNL1)

FAB:	101808023(KNL1)

OMA:	130254497(KNL1)

PHI:	106628496(CASC5)

PMAJ:

107206347(KNL1)

CCAE:

111930504(KNL1)

CCW:	104692988(KNL1)

CBRC:

108444698(KNL1)

ETL:	114067930(KNL1)

ZAB:	102069376(KNL1)

ACHL:

103800257(CASC5)

SVG:	106854790(CASC5)

MMEA:

130583359(KNL1)

HRT:	120753684(KNL1)

FPG:	101922798(KNL1)

FCH:	102048828(KNL1)

CLV:	102087534(KNL1)

NNI:	104020541(CASC5)

PCRI:

104032389(CASC5)

PLET:

104624173(CASC5)

PCAO:

104040683(CASC5)

ACUN:

113480950(KNL1)

TALA:

104356615(KNL1)

PADL:

103925234(CASC5)

AFOR:

103902629(KNL1)

ACHC:

115352058(KNL1)

HALD:

104312460(CASC5)

HLE:	104829840(CASC5)

AGEN:

126047369

GCL:

127016447

CCRI:

104156775(CASC5)

CSTI:

104552346(CASC5)

CMAC:

104487748(CASC5)

MUI:	104547252(CASC5)

BREG:

104642346(CASC5)

FGA:	104074173(CASC5)

GSTE:

104253836(CASC5)

MNB:	103772390(CASC5)

NNT:	104405146(CASC5)

SHAB:

115606927(KNL1)

PGUU:

104462619(CASC5)

ACAR:

104523929(KNL1)

AVIT:

104273095(CASC5)

RTD:	128909233(KNL1)

CUCA:

104055691(CASC5)

TEO:	104380370(CASC5)

BRHI:

104494542(CASC5)

AAM:	106486746(KNL1)

AROW:

112969677(KNL1)

NPD:	112948898(KNL1)

TGT:	104568714(CASC5)

DNE:	112992443(KNL1)

SCAM:

104141475(CASC5)

ASN:	102378056(KNL1)

AMJ:	102566260(KNL1)

CPOO:

109321366(KNL1)

GGN:	109298745(KNL1)

PSS:	102464005(KNL1)

CMY:	102932840(KNL1)

CCAY:

125638752(KNL1)

DCC:	119857576(KNL1)

CPIC:

101937128(KNL1)

TST:	117876836(KNL1)

CABI:

116826501(KNL1)

MRV:	120404715(KNL1)

ACS:	100553859(knl1)

PVT:	110080116(KNL1)

SUND:

121926848(KNL1)

PBI:	103052831(KNL1)

PMUR:

114922489(KNL1)

CTIG:

120299244(KNL1)

TSR:	106544877(CASC5)

PGUT:

117665685(KNL1)

VKO:	123026801(KNL1)

PMUA:

114593871(KNL1)

PRAF:

128410773(KNL1)

ZVI:	118083133(KNL1)

HCG:	128328066(KNL1)

GJA:	107113923(KNL1)

STOW:

125426492(KNL1)

XLA:

108700584

XTR:	100497601(knl1)

RTEM:

120920156(KNL1)

BBUF:

120981466(KNL1)

BGAR:

122939311(KNL1)

DRE:	327226(casc5)

SRX:	107723193 107758840

SANH:

107665952 107692623(casc5)

SGH:	107565070 107586816

CAUA:

113109282

CGIB:

127978340

PTET:

122350820(knl1)

LROH:

127171858(knl1)

OMC:	131543441(knl1)

RKG:	130097614(knl1)

MAMB:

125272786(knl1)

CIDE:

127518489

MASI:

127444273 127445226

TROS:

130552398(knl1)

TDW:	130412511(knl1)

MANU:

129444893(knl1)

IPU:

108258701

IFU:	128602388(knl1)

PHYP:

113535754(knl1)

SMEO:

124378238(knl1)

TFD:	113648800(knl1)

TVC:	132839624(knl1)

AMEX:

103025668(knl1)

CMAO:

118802018(knl1)

EEE:	113574949(knl1)

TRU:	101077728(knl1)

TFS:	130515766(knl1)

LCO:	104925680(knl1)

NCC:

104964207

TBEN:

117487016(knl1)

PGEO:

117440351(knl1)

GACU:

117534863

ELY:	117271019(knl1)

EFO:	125896640(knl1)

PLEP:

121955937

SLUC:

116066338(knl1)

ECRA:

117961839(knl1)

ESP:	116706749(knl1)

PFLV:

114572693(knl1)

GAT:	120808065(knl1)

PPUG:

119195199

AFB:	129107223(knl1)

CLUM:

117727104(knl1)

PSWI:

130202747 130209326

MSAM:

119908919(knl1)

SCHU:

122863237(knl1)

CUD:	121520902(knl1)

ALAT:

119012391(knl1)

MZE:	101467995(knl1)

ONL:	100704962(knl1)

OAU:	116311361(knl1)

OLA:	101156215(knl1)

OML:	112157830(knl1)

CSAI:

133418549(knl1)

XMA:	102220274(knl1)

XCO:	114158373(knl1)

XHE:	116734571(knl1)

PRET:

103457322(knl1)

PFOR:

103155892(casc5)

PLAI:

106959033(casc5)

PMEI:

106908900(casc5)

GAF:	122824955(knl1)

PPRL:

129375374(knl1)

CVG:	107094541(casc5)

CTUL:

119778374

GMU:	124882304(knl1)

NFU:	107377797(casc5)

KMR:	108233335(knl1)

ALIM:

106522410(casc5)

AOCE:

111589038(knl1)

CSEM:

103381188(casc5)

POV:	109635971(knl1)

SSEN:

122784412(knl1)

HHIP:

117758433(knl1)

HSP:	118099857(knl1)

LCF:

108887230

SDU:	111237084(knl1)

SLAL:

111661535(knl1)

XGL:	120789069(knl1)

HCQ:	109516291(knl1)

SSCV:

125990623

PEE:	133417148(knl1)

PTAO:

133468542(knl1)

BPEC:

110156707(knl1)

MALB:

109962339(knl1)

BSPL:

114849724(knl1)

SASA:

106571471(knl1)

STRU:

115174708(knl1)

OTW:	112250382(knl1)

OMY:	110529683(knl1)

OGO:	123990825(knl1)

ONE:	115107831(knl1)

OKI:	109900809(knl1)

OKE:	118398590(knl1)

SALP:

111954239(knl1)

SNH:	120024134(knl1)

CCLU:

121552315(knl1)

ELS:	105017606(knl1)

SFM:	108919439(knl1)

PKI:	111838806(knl1)

AANG:

118230321(knl1)

LOC:	102689059(casc5)

PSPA:

121323874 121330420

ARUT:

117416944 117421937 117963873

CMK:	103187516(knl1)

RTP:	109926837(knl1)

CPLA:

122553838(knl1)

BFO:

SPU:

HRJ:

OSN:

NVE:

EPA:

ADF:

AMIL:

PDAM:

SPIS:

Reference

PMID:15502821

Authors

Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M

Title

A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1.

Journal

Nat Cell Biol 6:1135-41 (2004)
DOI:10.1038/ncb1187

Sequence

[hsa:57082]

Reference

PMID:18045986

Authors

Cheeseman IM, Hori T, Fukagawa T, Desai A

Title

KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates.

Journal

Mol Biol Cell 19:587-94 (2008)
DOI:10.1091/mbc.E07-10-1051

Sequence

[hsa:57082]

LinkDB

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