KEGG ORTHOLOGY: K12362

ORTHOLOGY: K12362

Entry

K12362                      KO

Symbol

RASGRP3

Name

RAS guanyl-releasing protein 3

Pathway

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04662

B cell receptor signaling pathway

map05200

Pathways in cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K12362  RASGRP3; RAS guanyl-releasing protein 3
   04014 Ras signaling pathway
    K12362  RASGRP3; RAS guanyl-releasing protein 3
   04015 Rap1 signaling pathway
    K12362  RASGRP3; RAS guanyl-releasing protein 3
09150 Organismal Systems
  09151 Immune system
   04662 B cell receptor signaling pathway
    K12362  RASGRP3; RAS guanyl-releasing protein 3
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K12362  RASGRP3; RAS guanyl-releasing protein 3

Other DBs

GO:

0005085

Genes

HSA:	25780(RASGRP3)

PTR:	470348(RASGRP3)

PPS:	100973444(RASGRP3)

GGO:	101147649(RASGRP3)

PON:	100171706(RASGRP3)

PPYG:

129030190(RASGRP3)

NLE:	100603635(RASGRP3)

HMH:	116480555(RASGRP3)

SSYN:

129467231(RASGRP3)

MCC:	707225(RASGRP3)

MCF:	102136095(RASGRP3)

MTHB:

126934266

MNI:	105464819(RASGRP3)

CSAB:

103220524(RASGRP3)

CATY:

105578391(RASGRP3)

PANU:

101001477(RASGRP3)

TGE:	112604574(RASGRP3)

MLEU:

105542614(RASGRP3)

RRO:	104669440(RASGRP3)

RBB:	108528680(RASGRP3)

TFN:	117062489(RASGRP3)

PTEH:

111545404(RASGRP3)

CANG:

105507492(RASGRP3)

CJC:	100404102(RASGRP3)

SBQ:	101043633(RASGRP3)

CIMI:

108308850(RASGRP3)

ANAN:

105733093(RASGRP3)

CSYR:

103272652

MMUR:

105884482(RASGRP3)

LCAT:

123636786(RASGRP3)

PCOQ:

105816884(RASGRP3)

OGA:	100955151(RASGRP3)

MMU:	240168(Rasgrp3)

MCAL:

110312642(Rasgrp3)

MPAH:

110335530(Rasgrp3)

RNO:	313874(Rasgrp3)

MCOC:

116079748(Rasgrp3)

ANU:	117717216(Rasgrp3)

ASYL:

127687587(Rasgrp3)

MUN:	110562664(Rasgrp3)

CGE:	100764463(Rasgrp3)

MAUA:

101834186(Rasgrp3)

PROB:

127220138(Rasgrp3)

PLEU:

114695916(Rasgrp3)

PMAV:

102918596(Rasgrp3)

MORG:

121433070(Rasgrp3)

MFOT:

126514223

AAMP:

119806793(Rasgrp3)

NGI:	103746759(Rasgrp3)

HGL:	101717811(Rasgrp3)

CPOC:

100712845(Rasgrp3)

CCAN:

109694257(Rasgrp3)

DORD:

105983753(Rasgrp3)

DSP:	122102090(Rasgrp3)

DMER:

138829190(Rasgrp3)

PLOP:

125356569(Rasgrp3)

NCAR:

124963581

MMMA:

107137363(Rasgrp3)

ITI:	101976716(Rasgrp3)

OCU:

100342183

OPI:	101528696(RASGRP3)

OCZ:	121164799(RASGRP3)

TUP:	102498774(RASGRP3)

GVR:	103586838 103597236

CFA:	611329(RASGRP3)

CLUD:

112664548(RASGRP3)

VVP:	112933007(RASGRP3)

VLG:	121491177(RASGRP3)

NPO:	129511099(RASGRP3)

AML:	100484622(RASGRP3)

UMR:	103671590(RASGRP3)

UAH:	113241175(RASGRP3)

UAR:	123799845(RASGRP3)

ELK:

111158513

LLV:

125108393

MPUF:

101690986(RASGRP3)

MNP:	132021284(RASGRP3)

MLK:	131840530(RASGRP3)

NVS:	122915157(RASGRP3)

ORO:	101371588(RASGRP3)

EJU:	114219657(RASGRP3)

ZCA:	113937489(RASGRP3)

MLX:	118007758(RASGRP3)

NSU:	110587286(RASGRP3)

LWW:	102727777(RASGRP3)

FCA:	101085456(RASGRP3)

PYU:	121044329(RASGRP3)

PCOO:

112864119(RASGRP3)

PBG:	122466911(RASGRP3)

PVIV:

125162196(RASGRP3)

LRUF:

124503577

LGF:	123581256(RASGRP3)

AJU:

106967894

PTG:	102954264(RASGRP3)

PPAD:

109266029(RASGRP3)

PUC:

125937543

PLEZ:

122216436(RASGRP3)

HHV:	120244026(RASGRP3)

BTA:	523745(RASGRP3)

BOM:	102267127(RASGRP3)

BIU:	109565967(RASGRP3)

BBUB:

102410345(RASGRP3)

BBIS:

104980950(RASGRP3)

CHX:	102190608(RASGRP3)

OAS:	101101969(RASGRP3)

BTAX:

128055903(RASGRP3)

CSUM:

138083268(RASGRP3)

ODA:	120851660(RASGRP3)

CCAD:

122441553(RASGRP3)

MREE:

136164471(RASGRP3)

OVR:	110143774(RASGRP3)

MBEZ:

129539227(RASGRP3)

SSC:	100511446(RASGRP3)

CFR:	102506193(RASGRP3)

CBAI:

105078955(RASGRP3)

CDK:	105095517(RASGRP3)

VPC:	102539130(RASGRP3)

BACU:

103011501(RASGRP3)

BMUS:

118906428(RASGRP3)

LVE:	103070705(RASGRP3)

OOR:	101289392(RASGRP3)

LALB:

132531465(RASGRP3)

GMF:	115854135(RASGRP3)

DDP:	132434995(RASGRP3)

DLE:	111174894(RASGRP3)

PCAD:

102983100(RASGRP3)

PSIU:

116764722(RASGRP3)

PPHC:

136134241(RASGRP3)

NASI:

112391116(RASGRP3)

ECB:	100070505(RASGRP3)

EPZ:	103558532(RASGRP3)

EAI:	106839887(RASGRP3)

MYB:	102254297(RASGRP3)

MYD:	102754347(RASGRP3)

MMYO:

118669112(RASGRP3)

MLF:	102420246(RASGRP3)

MDT:	132213481(RASGRP3)

MYUM:

139019811(RASGRP3)

PKL:	118717122(RASGRP3)

EFUS:

103283126(RASGRP3)

MNA:	107541820(RASGRP3)

DRO:	112297824(RASGRP3)

SHON:

119001280(RASGRP3)

AJM:	119050336(RASGRP3)

PDIC:

114500279(RASGRP3)

PHAS:

123811574(RASGRP3)

MMF:	118630520(RASGRP3)

PPAM:

129066346(RASGRP3)

HAI:	109388799(RASGRP3)

RFQ:	117033403(RASGRP3)

PALE:

102888491(RASGRP3)

PGIG:

120621790(RASGRP3)

PVP:	105300076(RASGRP3)

RAY:	107505744(RASGRP3)

MJV:	108387321(RASGRP3)

TOD:	119259413(RASGRP3)

SARA:

101544723(RASGRP3)

SFUM:

130033458(RASGRP3)

SETR:

126023857(RASGRP3)

LAV:	100664201(RASGRP3)

TMU:

101360110

ETF:	101664472(RASGRP3)

DNM:	101430010(RASGRP3)

MDO:	100031591(RASGRP3)

GAS:	123237050(RASGRP3)

SHR:	100913998(RASGRP3)

AFZ:

127548645

PCW:	110198182(RASGRP3)

TVP:	118839898 118843973(RASGRP3)

PBRV:

138149189(RASGRP3)

MLAO:

141504590(RASGRP3)

OAA:	100080124(RASGRP3)

TACU:

119926215(RASGRP3)

GGA:	421460(RASGRP3)

PCOC:

116229146(RASGRP3)

MGP:	100539029(RASGRP3)

CJO:	107311289(RASGRP3)

TPAI:

128081129(RASGRP3)

LMUT:

125689864(RASGRP3)

NMEL:

110395671(RASGRP3)

APLA:

101790483(RASGRP3)

ACYG:

106029670(RASGRP3)

CATA:

118254707(RASGRP3)

AFUL:

116488345(RASGRP3)

TGU:	100229237(RASGRP3)

LSR:	110477906(RASGRP3)

SCAN:

103817484(RASGRP3)

PMOA:

120506902(RASGRP3)

OTC:	121335821(RASGRP3)

PRUF:

121358810(RASGRP3)

ATRC:

139591410(RASGRP3)

GFR:	102041260(RASGRP3)

FAB:	101810860(RASGRP3)

OMA:	130251073(RASGRP3)

PHI:	102113324(RASGRP3)

PMAJ:

107201851(RASGRP3)

CCAE:

111926964(RASGRP3)

CCW:	104684363(RASGRP3)

CBRC:

103624133(RASGRP3)

ACOE:

138108018(RASGRP3)

ETL:	114065392(RASGRP3)

ZAB:	102063415(RASGRP3)

ZLE:	135445746(RASGRP3)

ACHL:

103808255(RASGRP3)

SVG:	106853221(RASGRP3)

MMEA:

130575840(RASGRP3)

HRT:	120750743(RASGRP3)

SATI:

136359338(RASGRP3)

CCIC:

134041950(RASGRP3)

FPG:	101911870(RASGRP3)

FCH:	102049292(RASGRP3)

CCRI:

104164080(RASGRP3)

NNT:	104407224(RASGRP3)

SHAB:

115613685(RASGRP3)

ACUN:

113478681(RASGRP3)

TALA:

104360033(RASGRP3)

ACHC:

115350352(RASGRP3)

HALD:

104320661(RASGRP3)

HLE:	104840334(RASGRP3)

AGEN:

126051509

HHAR:

128150366(RASGRP3)

GCL:

127014499

CSTI:

104558909(RASGRP3)

LDI:	104348160(RASGRP3)

MNB:	103780984(RASGRP3)

DPUB:

104299959(RASGRP3)

PPUS:

135183584(RASGRP3)

AVIT:

104268376

BRHI:

104487972(RASGRP3)

EGZ:	104124127(RASGRP3)

NNI:	104018674(RASGRP3)

PCRI:

104033207(RASGRP3)

PADL:

103922848(RASGRP3)

AFOR:

103902687(RASGRP3)

FGA:	104073683(RASGRP3)

CBOR:

142080751(RASGRP3)

GSTE:

104263899(RASGRP3)

CBOY:

140649426(RASGRP3)

MAME:

142407071(RASGRP3)

CLV:	102091020(RASGRP3)

CNIC:

135986883(RASGRP3)

MUI:	104548321(RASGRP3)

PGUU:

104461654(RASGRP3)

PLET:

104627901(RASGRP3)

EHS:	104504507(RASGRP3)

CMAC:

104473755

CUCA:

104058191(RASGRP3)

TEO:	104374168(RASGRP3)

BREG:

104636973(RASGRP3)

OHA:	104329276(RASGRP3)

ACAR:

104527903(RASGRP3)

CPEA:

104397297(RASGRP3)

CVF:	104282315(RASGRP3)

RTD:	128907629(RASGRP3)

CRID:

134512913(RASGRP3)

LMIC:

141740713(RASGRP3)

AAM:	106485481(RASGRP3)

AROW:

112973411(RASGRP3)

NPD:	112957536(RASGRP3)

TGT:	104576866(RASGRP3)

DNE:	112997157(RASGRP3)

SCAM:

104151681(RASGRP3)

ASN:	102382991(RASGRP3)

AMJ:	102577025(RASGRP3)

CPOO:

109319877(RASGRP3)

GGN:	109304607(RASGRP3)

PSS:	102453442(RASGRP3)

CIZ:	142010988(RASGRP3)

CMY:	102940270(RASGRP3)

CCAY:

125633800(RASGRP3)

DCC:	119853954(RASGRP3)

CPIC:

101944566(RASGRP3)

TST:	117874607(RASGRP3)

CABI:

116819069(RASGRP3)

MRV:	120402105(RASGRP3)

ACS:	100560305(rasgrp3)

ASAO:

132761275(RASGRP3)

PVT:	110089042(RASGRP3)

SUND:

121919115(RASGRP3)

PBI:	103056770(RASGRP3)

PMUR:

107289694(RASGRP3)

CTIG:

120307730(RASGRP3)

TSR:	106543020(RASGRP3)

PGUT:

117671874(RASGRP3)

PCAE:

139321423(RASGRP3)

APRI:

131188633(RASGRP3)

PTEX:

113433142(RASGRP3)

NSS:	113420749(RASGRP3)

VKO:	123033808(RASGRP3)

PMUA:

114594505(RASGRP3)

PRAF:

128410951(RASGRP3)

ZVI:	118081795(RASGRP3)

HCG:	128348190(RASGRP3)

GJA:	107113460(RASGRP3)

STOW:

125426028(RASGRP3)

EMC:	129343032(RASGRP3)

XLA:	108716683(rasgrp3.L) 108717828(rasgrp3.S)

XTR:	100487452(rasgrp3)

NPR:	108784170(RASGRP3)

RTEM:

120937522(RASGRP3)

ACAT:

141140486(RASGRP3)

PADS:

140329136(RASGRP3)

BBUF:

120998745(RASGRP3)

BGAR:

122935658(RASGRP3)

DTC:	141063519(RASGRP3)

PWL:	138295998(RASGRP3)

MUO:	115465780(RASGRP3)

GSH:	117357677(RASGRP3)

DRE:	563441(rasgrp3)

SRX:	107744459 107755973

SANH:

107670874 107689794

SGH:	107553408(rasgrp3) 107583647

CCAR:

109070463 109077378

CAUA:

113113693 113117133

CGIB:

127976175 128031741

PTET:

122361807(rasgrp3)

LROH:

127179330(rasgrp3)

GRF:	141295990(rasgrp3)

OMC:	131522954(rasgrp3)

PPRM:

120477711(rasgrp3)

RKG:	130097429(rasgrp3)

MAMB:

125268731(rasgrp3)

CIDE:

127498373

CERY:

137006155(rasgrp3)

MASI:

127411156 127455550

TROS:

130560593(rasgrp3)

TDW:	130436652(rasgrp3)

MANU:

129417504(rasgrp3)

PDAB:

135727212(rasgrp3)

IPU:

108269749

IFU:	128612675(rasgrp3)

PHYP:

113547730(rasgrp3)

SMEO:

124390165(rasgrp3)

TFD:	113662041(rasgrp3)

TVC:	132852002(rasgrp3)

CGAR:

128535792(rasgrp3)

NGRA:

132894021(rasgrp3)

TRN:	134324888(rasgrp3)

AMEX:

103040612(rasgrp3)

CMAO:

118823184(rasgrp3)

EEE:	113591719(rasgrp3)

CHAR:

105911596(rasgrp3)

SPIL:

134063939(rasgrp3)

ASAD:

121685923(rasgrp3)

LCO:	104936034(rasgrp3)

TBEN:

117475884 117476075(rasgrp3)

CGOB:

115020482(rasgrp3)

PGEO:

117459822(rasgrp3)

GACU:

117550667(rasgrp3)

EMAC:

134858894(rasgrp3)

ELY:	117248788(rasgrp3)

EFO:	125903962(rasgrp3)

PLEP:

121954834(rasgrp3)

SLUC:

116064554(rasgrp3)

ECRA:

117960582(rasgrp3)

ESP:	116705728(rasgrp3)

PFLV:

114572113(rasgrp3)

GAT:	120820445(rasgrp3)

PPUG:

119214286(rasgrp3)

AFB:	129092292(rasgrp3)

CLUM:

117743982(rasgrp3)

PSWI:

130207012(rasgrp3)

CANA:

137779652(rasgrp3)

CVE:	137885951(rasgrp3)

MSAM:

119917380(rasgrp3)

SCHU:

122884779(rasgrp3)

CUD:	121511060(rasgrp3)

SPUL:

138588739(rasgrp3)

LMIX:

132975949(rasgrp3)

HTC:	141795481(rasgrp3)

MZE:	101478031(rasgrp3)

ONL:	109194145(rasgrp3)

OAU:	116333746(rasgrp3)

OLA:	101172059 105353619(rasgrp3)

OML:

112140997

CSAI:

133463662(rasgrp3)

XMA:	102217565(rasgrp3)

XCO:	114138554(rasgrp3)

XHE:	116712874(rasgrp3)

PRET:

103476548(rasgrp3)

PFOR:

103153120(rasgrp3)

PLAI:

106964690(rasgrp3)

PMEI:

106903385(rasgrp3)

GAF:	122842590(rasgrp3)

PPRL:

129356737 129360148

CVG:	107092582(rasgrp3)

CTUL:

119771882(rasgrp3)

GMU:	124859535(rasgrp3)

NFU:	107373003 107374414

KMR:	108242469(rasgrp3)

ALIM:

106513388(rasgrp3)

AOCE:

111586516(rasgrp3)

EJA:	138193685(rasgrp3)

BFRE:

138633389(rasgrp3)

MCEP:

125019224(rasgrp3)

CSEM:

103387702(rasgrp3)

POV:	109629944(rasgrp3)

SSEN:

122782229(rasgrp3)

SSOE:

131474526(rasgrp3)

HHIP:

117775293(rasgrp3)

HSP:	118118849(rasgrp3)

PPLT:

128453347(rasgrp3)

SMAU:

118283501(rasgrp3)

LCF:

108895765

SDU:	111236432(rasgrp3)

SLAL:

111647051(rasgrp3)

XGL:	120796640(rasgrp3)

HCQ:	109523135(rasgrp3)

SSCV:

125978488(rasgrp3)

SBIA:

133509394(rasgrp3)

PEE:	133409782(rasgrp3)

PTAO:

133485385(rasgrp3)

BPEC:

110158152(rasgrp3)

ENY:	140350828(rasgrp3)

MALB:

109960048(rasgrp3)

SJO:	128372869(rasgrp3)

SSCO:

133991450(rasgrp3)

TTY:	137196611(rasgrp3)

GMH:	115559983(rasgrp3)

SASA:

106576952 106606711

STRU:

115153175 115193819

OTW:	112252969(rasgrp3) 112254212

OMY:	110502432 110528321(rasgrp3)

OGO:	124038232 124041289(rasgrp3)

ONE:	115113248 115135152

OKI:	109889905 109899698

OKE:	118369668(rasgrp3) 118400476

OMM:	135510980(rasgrp3) 135512354

OCLA:

139381820 139411253

SALP:

111952076 111977356

SNH:	120017621 120045625

SFON:

129836299(rasgrp3) 129851263

CCLU:

121553501(rasgrp3) 121570227

ELS:	105023235(rasgrp3)

OEP:	134022201(rasgrp3)

SFM:	108918082(rasgrp3)

PKI:	111849035(rasgrp3)

AANG:

118218213(rasgrp3)

AROT:

135244507(rasgrp3)

CCOG:

133118665(rasgrp3)

LOC:	102698976(rasgrp3)

PSPA:

121315677 121316755

ARUT:

117403108 117411472

PSEX:

120516567(rasgrp3)

LCM:	102353784(RASGRP3)

CMK:	103181767(rasgrp3)

CPLA:

122552667(rasgrp3)

CPUN:

140482829(rasgrp3)

HOC:	132819678(rasgrp3)

SCAU:

119975238(rasgrp3)

LERI:

129699489(rasgrp3)

HAKA:

140730298(rasgrp3)

PMRN:

116943359 116947706

LRJ:	133341462 133342233

BFO:

BBEL:

SCLV:

SPU:

LPIC:

LVG:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

FOC:

TPAL:

ZNE:

CSEC:

PAME:

SGRE:

BROR:

FCD:

DPX:	DAPPUDRAFT_30396

DMK:

AFRA:

DSV:

DALB:

RSAN:

RMP:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

CEL:	CELE_F25B3.3(rgef-1)

CBR:	CBG_19309(Cbr-rgef-1)

CRQ:	GCK72_017128

BMY:	BM_BM3558(Bma-rgef-1)

LOA:	LOAG_03412

LGI:	LOTGIDRAFT_132094

PVUL:

PCAN:

LSAX:

BARL:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

YBA:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

LJP:

LAK:

LLON:

NVE:

EPA:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_19834

AQU:	100635858 100637689

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Reference

PMID:10934204

Authors

Rebhun JF, Castro AF, Quilliam LA

Title

Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction.

Journal

J Biol Chem 275:34901-8 (2000)
DOI:10.1074/jbc.M005327200

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