KEGG ORTHOLOGY: K12367

ORTHOLOGY: K12367

Entry

K12367                      KO

Symbol

DOCK2

Name

dedicator of cytokinesis protein 2

Pathway

map04062

Chemokine signaling pathway

Disease

H00093

Combined immunodeficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    K12367  DOCK2; dedicator of cytokinesis protein 2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K12367  DOCK2; dedicator of cytokinesis protein 2
Membrane trafficking [BR:ko04131]
Others
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    K12367  DOCK2; dedicator of cytokinesis protein 2

Other DBs

GO:	0005085 0005096

Genes

HSA:	1794(DOCK2)

PTR:	471731(DOCK2)

PPS:	100973015(DOCK2)

GGO:	101139420(DOCK2)

PON:	100456474(DOCK2)

PPYG:

129036364(DOCK2)

NLE:	100596090(DOCK2)

HMH:	116471833(DOCK2)

SSYN:

129486029(DOCK2)

MCC:	704061(DOCK2)

MCF:	107130111(DOCK2)

MTHB:

126957128

MNI:	105480844(DOCK2)

CSAB:

103244950(DOCK2)

CATY:

105581631(DOCK2)

PANU:

101019414(DOCK2)

TGE:	112626544(DOCK2)

MLEU:

105530931(DOCK2)

RRO:	104663613(DOCK2)

RBB:	108513615(DOCK2)

TFN:	117065431(DOCK2)

PTEH:

111547206(DOCK2)

CANG:

105515825(DOCK2)

CJC:	100397465(DOCK2)

SBQ:	101050901(DOCK2)

CIMI:

108317349(DOCK2)

ANAN:

105723137(DOCK2)

CSYR:

103263014

MMUR:

105880137(DOCK2)

LCAT:

123637974(DOCK2)

PCOQ:

105814635(DOCK2)

OGA:	100947188(DOCK2)

MMU:	94176(Dock2)

MCAL:

110304405(Dock2)

MPAH:

110331331(Dock2)

MCOC:

116076732(Dock2)

ANU:	117711181(Dock2)

ASYL:

127693749(Dock2)

MUN:	110545462(Dock2)

CGE:	100766266(Dock2)

MAUA:

101843588(Dock2)

PROB:

127219430(Dock2)

PLEU:

114710658(Dock2)

MORG:

121463761(Dock2)

MFOT:

126499473

AAMP:

119811683(Dock2)

HGL:	101707633(Dock2)

CPOC:

100714041(Dock2)

CCAN:

109686849(Dock2)

DORD:

DSP:

PLOP:

NCAR:

MMMA:

107147964(Dock2)

ITI:	101957457(Dock2)

OCU:

100357300

OPI:	101528474(DOCK2)

TUP:	102472239(DOCK2)

CFA:	489128(DOCK2)

CLUD:

112651202(DOCK2)

VVP:

112926358

VLG:	121488108(DOCK2)

NPO:	129509971(DOCK2)

AML:

100465542

UMR:	103664785(DOCK2)

UAH:	113264075(DOCK2)

UAR:	123788581(DOCK2)

ELK:

111140871

LLV:

125099858

MPUF:

101678489(DOCK2)

MNP:	132027527(DOCK2)

MLK:	131831893(DOCK2)

NVS:	122892984(DOCK2)

ORO:	101383042(DOCK2)

EJU:	114208685(DOCK2)

ZCA:	113929141(DOCK2)

MLX:	118016576(DOCK2)

NSU:	110587923(DOCK2)

FCA:	101097544(DOCK2)

PYU:	121010716(DOCK2)

PCOO:

112860515(DOCK2)

PBG:	122492679(DOCK2)

PVIV:

125162379(DOCK2)

LRUF:

124520400

LGF:	123610855(DOCK2)

AJU:

106969263

PTG:	102972543(DOCK2)

PPAD:

109267473(DOCK2)

PUC:

125934429

PLEZ:

122224778(DOCK2)

HHV:	120234070(DOCK2)

BTA:	510083(DOCK2)

BOM:	102283435(DOCK2)

BIU:	109574918(DOCK2)

BBUB:

102389854(DOCK2)

BBIS:

104999107(DOCK2)

CHX:	102177564(DOCK2)

OAS:	101104011(DOCK2)

BTAX:

128066259(DOCK2)

CSUM:

138094721(DOCK2)

ODA:	120879696(DOCK2)

CCAD:

122454347(DOCK2)

MREE:

136146522(DOCK2)

OVR:	110125774(DOCK2)

MBEZ:

129553133(DOCK2)

SSC:	100512021(DOCK2)

CFR:	102511337(DOCK2)

CBAI:

105082635(DOCK2)

CDK:	105089389(DOCK2)

VPC:	102537686(DOCK2)

BACU:

103011592(DOCK2)

BMUS:

118893440(DOCK2)

LVE:	103078799(DOCK2)

OOR:	101284407(DOCK2)

LALB:

132518579(DOCK2)

DLE:	111185489(DOCK2)

PCAD:

102994703(DOCK2)

PSIU:

116750967(DOCK2)

NASI:

112405061(DOCK2)

ECB:	100070446(DOCK2)

EPZ:	103540168(DOCK2)

EAI:	106837369(DOCK2)

MYB:	102241503(DOCK2)

MYD:	102756868(DOCK2)

MMYO:

118657842(DOCK2)

MLF:	102441351(DOCK2)

MDT:	132235947(DOCK2)

MYUM:

139010236(DOCK2)

PKL:	118710918(DOCK2)

EFUS:

103291565(DOCK2)

MNA:	107537891(DOCK2)

DRO:	112319431(DOCK2)

SHON:

118994933(DOCK2)

AJM:	119036197(DOCK2)

PDIC:

114510283(DOCK2)

PHAS:

123806744(DOCK2)

MMF:	118615340(DOCK2)

PPAM:

129066490(DOCK2)

HAI:	109379373(DOCK2)

RFQ:	117016732(DOCK2)

PALE:

102890291(DOCK2)

PGIG:

120613599(DOCK2)

PVP:	105289940(DOCK2)

RAY:	107518467(DOCK2)

MJV:	108396111(DOCK2)

TOD:	119236765(DOCK2)

SARA:

101550515(DOCK2)

SFUM:

130041063(DOCK2)

SETR:

126011896(DOCK2)

LAV:	100655974(DOCK2)

TMU:

101357939

ETF:	101656937(DOCK2)

DNM:	101431675(DOCK2)

MDO:	100030952(DOCK2)

GAS:	123233792(DOCK2)

SHR:	100921385(DOCK2)

AFZ:

127550187

PCW:	110212317(DOCK2)

TVP:	118841783(DOCK2)

PBRV:

138172667(DOCK2)

OAA:	100077856(DOCK2)

TACU:

119949834

GGA:	427612(DOCK2) 429518(DOCK2L)

PCOC:

116225614 116231983(DOCK2)

MGP:	100539674(DOCK2) 100541844

CJO:	107306830 107320251(DOCK2)

TPAI:

128071999 128081532(DOCK2)

LMUT:

125692664 125700023(DOCK2)

NMEL:

110390922 110405556(DOCK2)

APLA:

101802192(DOCK2) 101803899

ACYG:

106034371(DOCK2) 106043193

CATA:

118256223(DOCK2) 118260608

AFUL:

116488954 116494733(DOCK2)

TGU:	100227341 100231624(DOCK2)

LSR:	110468737 110471339(DOCK2)

SCAN:

103817226(DOCK2) 103823113

PMOA:

120498672(DOCK2) 120509036

OTC:	121332270(DOCK2) 121335159

PRUF:

121364597(DOCK2) 121364684

ATRC:

139597611(DOCK2) 139604659

GFR:	102042659 102044813(DOCK2)

FAB:	101806235 101816594(DOCK2)

OMA:	130252082 130258648(DOCK2)

PHI:	102100339 102108751(DOCK2)

PMAJ:

107203409 107210604(DOCK2)

CCAE:

111929154 111935731(DOCK2)

CCW:	104690947 104693530(DOCK2)

CBRC:

103621141 103624882(DOCK2)

ACOE:

138109200 138118359(DOCK2)

ETL:	114059793 114068871

ZAB:	102073768(DOCK2)

ZLE:	135447182 135453538(DOCK2)

ACHL:

103801464(DOCK2)

SVG:	106853112 106860028(DOCK2)

MMEA:

130575445 130580899(DOCK2)

HRT:	120752684 120759366(DOCK2)

SATI:

136360318 136367387(DOCK2)

CCIC:

134044167 134049747(DOCK2)

FPG:	101911287 101915777(DOCK2)

FCH:	102050732 102055998(DOCK2)

NNT:	104410941(DOCK2)

SHAB:

115603587 115615504(DOCK2)

ACUN:

113485253(DOCK2) 113490508

TALA:

104369059(DOCK2) 116962489

ACHC:

115334233(DOCK2) 115338038

HLE:	104832339 104839035(DOCK2)

AGEN:

126050890 126052025

HHAR:

128134403(DOCK2) 128139055

GCL:	127015486 127022153

DPUB:

104299046(DOCK2)

PPUS:

135185146(DOCK2)

EGZ:	104135691(DOCK2)

NNI:	104014139 104016586(DOCK2)

PADL:

103918757(DOCK2) 103922174

AFOR:

103902155 103904280(DOCK2)

CBOY:

140652459 140656860(DOCK2)

CLV:	102085717 102087155(DOCK2)

MUI:

104548300

EHS:	104510121(DOCK2)

CUCA:

104056873 104062457(DOCK2)

TEO:	104376664(DOCK2)

OHA:	104332172(DOCK2)

ACAR:

104527894(DOCK2)

CPEA:

104392532(DOCK2) 104398129

CVF:	104282637(DOCK2) 104294208

RTD:	128910374 128916047(DOCK2)

CRID:

134516074 134521849(DOCK2)

AAM:	106493556(DOCK2)

AROW:

112963878(DOCK2) 112978208

NPD:	112944281(DOCK2) 112954038

TGT:	104566300(DOCK2) 104575977

DNE:	112982216(DOCK2) 112994540

SCAM:

104154074(DOCK2)

ASN:	102377683 102384798(DOCK2)

AMJ:	102573430(DOCK2) 102574301

CPOO:

109309845(DOCK2) 109324490

GGN:	109290133(DOCK2)

PSS:	102457670(DOCK2)

CMY:	102930173(DOCK2) 102937744

CCAY:

125635193 125641478(DOCK2)

DCC:	119854624 119860258(DOCK2)

CPIC:

101936905(DOCK2) 101941224

TST:	117878454 117881690(DOCK2)

CABI:

116838461(DOCK2)

MRV:	120369956(DOCK2) 120406127

ACS:	100558131(dock2)

ASAO:

132768782(DOCK2)

PVT:	110072295(DOCK2)

SUND:

121923281(DOCK2)

PBI:

103064376

PMUR:

107285851(DOCK2)

CTIG:

120312456(DOCK2)

PGUT:

117657912(DOCK2)

APRI:

131190539(DOCK2)

PTEX:

113433540(DOCK2)

NSS:	113426203(DOCK2)

VKO:	123035490(DOCK2)

PMUA:

114590896(DOCK2)

PRAF:

128407750(DOCK2)

ZVI:	118076508(DOCK2)

HCG:	128344563(DOCK2)

GJA:	107125973(DOCK2)

STOW:

125428311(DOCK2)

EMC:	129328150(DOCK2)

XLA:	108710913(dock2.L)

XTR:	100497849(dock2)

NPR:	108788549(DOCK2)

RTEM:

120932352(DOCK2)

BBUF:

121009584(DOCK2)

BGAR:

122928241(DOCK2)

PWL:	138245610(DOCK2) 138255404

MUO:

115461208

GSH:	117351652(DOCK2) 117365127

SRX:

107750047

SANH:

107654652 107677012

SGH:	107552325(dock2)

CCAR:

CAUA:

CGIB:

PTET:

LROH:

OMC:

PPRM:

MAMB:

CIDE:

CERY:

137024038(dock2-like)

MASI:

TROS:

TDW:

MANU:

PDAB:

IPU:

IFU:

PHYP:

113529552(dock2)

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:	113577131(dock2)

CHAR:

105903231

SPIL:

134069448

TRU:	101068169(dock2)

TFS:

130531158

LCO:	104933610(dock2)

TBEN:

117485498

CGOB:

115014336(dock2)

PGEO:

117453573(dock2-like)

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116696814(dock2)

PFLV:

114562504(dock2)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

137792083(dock2-like)

CVE:	137875498(dock2-like)

MSAM:

119888509

SCHU:

122880560

CUD:

121515909

SPUL:

138598733(dock2-like)

LMIX:

132981928

ALAT:

119007156

ASTR:

137602293(dock2-like)

MZE:	101476504(dock2)

ONL:	100712098(dock2)

OAU:

116335174

OLA:	101168874(dock2)

OML:

112153224

CSAI:

133447008

XMA:	102236684(dock2)

XCO:	114139346(dock2)

XHE:	116714512(dock2)

PRET:

103471338(dock2)

PFOR:

103147450(dock2)

PLAI:

106941964(dock2)

PMEI:

106926402(dock2)

GAF:

122836636

PPRL:

129362977

CVG:	107096704(dock2)

CTUL:

119796527

GMU:

124860244

NFU:	107376550(dock2)

KMR:

108243080

ALIM:

106516737(dock2)

NWH:

119408457

AOCE:

111575946

EJA:	138211074(dock2-like)

BFRE:

138633520(dock2-like)

MCEP:

125008053

CSEM:

103390941(dock2)

POV:	109628663(dock2)

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:	111232389(dock2)

SLAL:

111662793(dock2)

XGL:

120785038

HCQ:	109524347(dock2)

SSCV:

125988891(dock2-like)

SBIA:

133508833

PEE:

133407349

PTAO:

133484570

BPEC:

110162300(dock2)

ENY:	140354603(dock2-like)

MALB:

109957552(dock2)

BSPL:

114863910

SJO:

128362656

SSCO:

133986217

GMH:	115552664(dock2)

SASA:

106604826 106611864

STRU:

115173846 115205359

OTW:	112220473 112238187

OMY:	110488657 110504415

OGO:	123993286 124011625

ONE:

115130563

OKI:	109864674(dock2) 109881350

OKE:	118374637 118384019

OMM:	135526261 135545768

OCLA:

139366186 139391188

SALP:

111964784

SNH:	120048179(dock2) 120062377

CCLU:

121532851 121544127

ELS:	105025225(dock2)

OEP:	134032859 134032860(dock2)

SFM:	108925426(dock2)

PKI:	111859859(dock2)

AANG:

AROT:

CCOG:

LOC:

PSPA:

121297270 121324489 121327399

ARUT:

117403985 117413226 117973525 117973667(dock2)

PSEX:

120542177

LCM:	102347512(DOCK2)

CMK:	103177303 103188103

RTP:

109937103

CPLA:

122553785 122556798

HOC:	132823334 132824791

LERI:

SCLV:

CPII:

IEL:

PTRU:

DFR:

Reference

PMID:11518968

Authors

Fukui Y, Hashimoto O, Sanui T, Oono T, Koga H, Abe M, Inayoshi A, Noda M, Oike M, Shirai T, Sasazuki T

Title

Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration.

Journal

Nature 412:826-31 (2001)
DOI:10.1038/35090591

Sequence

[mmu:94176]

Reference

PMID:12829596

Authors

Sanui T, Inayoshi A, Noda M, Iwata E, Stein JV, Sasazuki T, Fukui Y

Title

DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1.

Journal

Blood 102:2948-50 (2003)
DOI:10.1182/blood-2003-01-0173

LinkDB

DBGET integrated database retrieval system