KEGG ORTHOLOGY: K12664

ORTHOLOGY: K12664

Entry

K12664                      KO

Symbol

CYP26B

Name

cytochrome P450 family 26 subfamily B [EC:1.14.14.-]

Pathway

map00830

Retinol metabolism

map01100

Metabolic pathways

Reaction

R08390

R08392

Disease

H02766

Radiohumeral fusions with other skeletal and craniofacial anomalies

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K12664  CYP26B; cytochrome P450 family 26 subfamily B
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K12664  CYP26B; cytochrome P450 family 26 subfamily B
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP26 family
   K12664  CYP26B; cytochrome P450 family 26 subfamily B

Genes

HSA:	56603(CYP26B1)

PTR:

738157

PPS:	100990990(CYP26B1)

GGO:

PON:

PPYG:

NLE:

HMH:

SSYN:

MCC:

MCF:	102131789(CYP26B1)

MTHB:

126934032

MNI:

105465250

CSAB:

103220070(CYP26B1)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100393102(CYP26B1)

SBQ:

101035734

CIMI:

108299613(CYP26B1)

ANAN:

105733334(CYP26B1)

CSYR:

103262928

MMUR:

105863279

LCAT:

123637036

ERUF:

138399972(CYP26B1)

PCOQ:

105812070

OGA:

100954204

MMU:	232174(Cyp26b1)

MCAL:

110296452

MPAH:

110316287

RNO:	312495(Cyp26b1)

MCOC:

116099155

ANU:	117715307(Cyp26b1)

ASYL:

MUN:

CGE:

MAUA:

PROB:

PLEU:

PMAV:

102922819(Cyp26b1)

MORG:

MFOT:

AAMP:

CNL:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

DMER:

138804624(Cyp26b1)

PLOP:

NCAR:

MMMA:

ITI:

OCU:

OPI:

OCZ:

TUP:

GVR:

CFA:	483120(CYP26B1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

MANO:

NSU:

LWW:	102741428 115944826

FCA:	101100712(CYP26B1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

LGF:

AJU:

PTG:

PPAD:

PUC:

PLEZ:

HHV:

CCRU:

144233424(CYP26B1)

BTA:	540868(CYP26B1)

BOM:	102272258(CYP26B1)

BIU:

BJV:

BBUB:

BKE:

BBIS:

CHX:

OAS:

OCAN:

138435607(CYP26B1)

BTAX:

128055499

CSUM:

138085266(CYP26B1)

ODA:

120851283

CCAD:

122441519

MREE:

136164498(CYP26B1)

OVR:	110143003(CYP26B1)

MBEZ:

SSC:

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

LALB:

GMF:	115864094(CYP26B1)

DDP:	132435390(CYP26B1)

DLE:

111167902

PCAD:

102982571

PSIU:

116764687

PPHC:

136133913(CYP26B1)

NASI:

112407189

ECB:	100059609(CYP26B1)

EPZ:	103557120(CYP26B1)

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

MYUM:

139019994(CYP26B1)

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:	108402254(CYP26B1)

TOD:

SARA:

SFUM:

SETR:

LAV:

TMU:

ETF:

DNM:

GAS:

SHR:

PCW:

TVP:

PBRV:

138144950(CYP26B1)

MLAO:

141494491(CYP26B1)

OAA:

100075935

TACU:

119927029

GGA:	428809(CYP26B1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

AACU:

137855391(CYP26B1)

OJA:

118166911

ACYG:

106043174(CYP26B1)

CATA:

118248417

AFUL:

116489074

TGU:

100221095

LSR:	110468712(CYP26B1)

VMC:

128806351

VCHA:

128787063

AIB:	137473283(CYP26B1)

SCAN:

PMOA:

OTC:

PRUF:

ATRC:

139604655(CYP26B1)

MATE:

118686300

MAEN:

136556216(CYP26B1)

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ACOE:

138109210(CYP26B1)

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:	120748065 120748072

SATI:

136359933(CYP26B1)

CCIC:

FPG:

FCH:

FRS:

CCRI:

NNT:

SHAB:

POCC:

ACUN:

ANOC:

141959877(CYP26B1)

SURA:

141942354(CYP26B1)

TALA:

ACHC:

HALD:

HLE:

AGEN:

HHAR:

BBUT:

142037452(CYP26B1)

GCL:

LDI:

MNB:

DPUB:

PPUS:

IIN:

AVIT:

BRHI:

EGZ:

NNI:

PCRI:

PARX:

142056807(CYP26B1)

PADL:

103914285

AFOR:

103908354

FGA:

104078063

CBOR:

142082379(CYP26B1)

GSTE:

104253576

CBOY:

140651949(CYP26B1)

MAME:

142408566(CYP26B1)

CLV:

CNIC:

PGUU:

EHS:

CUCA:

PCUR:

138720434(CYP26B1)

TEO:

BREG:

GAME:

OHA:

ACAR:

CPEA:

CVF:

RTD:

CRID:

LMIC:

141743914(CYP26B1)

NARQ:

141464727(CYP26B1)

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102567612(CYP26B1)

CPOO:

109322259

GGN:

109304093

PSS:	102450173(CYP26B1)

CIZ:	142011916(CYP26B1)

CMY:

102946478

CCAY:

125635146

LKP:	140910900(CYP26B1)

NDS:	141986907(CYP26B1)

DCC:

CPIC:

TST:

EOB:

CABI:

116828685(CYP26B1)

MRV:

120407119

EMQ:	137143631(CYP26B1)

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

PGUT:

PCAE:

139320118(CYP26B1)

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	100170648(cyp26b1.L) 108706485(cyp26b1.S)

XTR:	780112(cyp26b1)

NPR:

108790844

RTEM:

120924565

ACAT:

141121036(CYP26B1)

PADS:

140327315(CYP26B1)

BBUF:

120990500

BGAR:

122938772

DTC:	141058869(CYP26B1)

HSQ:

130315155

PCOB:

134929685

PWL:	138250709(CYP26B1)

MUO:

115461257

GSH:

117364350

DRE:	324188(cyp26b1)

DAES:

130231884

SRX:	107749803 107750587

SANH:

107668329 107691896

SGH:	107562039 107588193

CCAR:

CAUA:

CGIB:

PTET:

LROH:

GRF:	141331269(cyp26b1)

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

137031023(cyp26b1)

MASI:

127414837 127454912

TROS:

130556321

TDW:

130425919

MANU:

129440950(cyp26b1)

PDAB:

135730824(cyp26b1)

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

SPIL:

ASAD:

TRU:

TFS:

TNG:	GSTEN00021185G001

LCO:

NCC:

TBEN:

CGOB:

PGEO:

117442852(cyp26b1)

GACU:

117534553

EMAC:

134876143

ELY:	117246222(cyp26b1)

EFO:

125884433

PLEP:

121961984

SLUC:

116053241

SVIT:

144534295(cyp26b1)

ECRA:

ESP:

PFLV:

PFLT:

GAT:

AFB:

CLUM:

PSWI:

CANA:

137792155(cyp26b1)

CVE:	137885943(cyp26b1)

AMIR:

142950617(cyp26b1)

MSAM:

119913165

SCHU:

122869690

EARM:

139305826(cyp26b1)

CUD:

121504567

SPUL:

138600946(cyp26b1)

LMIX:

132958229

HTC:	141784413(cyp26b1)

ALAT:

119027001

ASTR:

137590755(cyp26b1)

PKLU:

139222695(cyp26b1)

MZE:	101471303(cyp26b1)

ONL:

100690880

OAU:

116316199

OLA:	101159703(cyp26b1)

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

LTU:	140281795(cyp26b1)

AOCE:

111569154

EJA:	138211948(cyp26b1)

BFRE:

138630441(cyp26b1)

MCEP:

CSEM:

POV:

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

125985113(cyp26b1)

SBIA:

PEE:

PTAO:

BPEC:

ENY:	140371588(cyp26b1)

MALB:

BSPL:

SJO:

SSCO:

TTY:	137174118(cyp26b1)

GMH:

115529150

SASA:

106578148 106608464

OTW:	112241180 121839422

OMY:	110512281 110531356

OGO:	124008785 124014606

OKI:	109885013 109886637

OKE:	118383103 127927614

OMM:	135510222 135516476

OCLA:

139404212 139404213 139415805

SALP:

112075274

SNH:	120038587 120040106

SFON:

CCLU:

ELS:

SFM:

PKI:

AANG:

AROT:

CCOG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CMK:	103177379 103187260

RTP:	109918235 109923060

CPLA:

122549869 122556960

CPUN:

140481533(cyp26b1) 140491834

HOC:	132822954 132823522

SCAU:

119963822 119964165

LERI:

129701869 129715029

HAKA:

140726119(cyp26b1) 140739476

PMRN:

LRJ:

BFO:

BBEL:

SCLV:

120336410 120336652 120336653 120336654

AJJ:	139967677 139967772

PFLL:

139120378

LSAX:

138983184

HRF:	124139381 124139383

HRJ:

HCRA:

CANU:

PMAX:

LJP:

LLON:

Reference

PMID:10823918 (CYP26B1)

Authors

White JA, Ramshaw H, Taimi M, Stangle W, Zhang A, Everingham S, Creighton S, Tam SP, Jones G, Petkovich M

Title

Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism.

Journal

Proc Natl Acad Sci U S A 97:6403-8 (2000)
DOI:10.1073/pnas.120161397

Sequence

[hsa:56603]

LinkDB

DBGET integrated database retrieval system