KEGG REACTION: R08392

REACTION: R08392

Entry

R08392                      Reaction

Definition

Retinoate + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> all-trans-4-Hydroxyretinoic acid + [Oxidized NADPH---hemoprotein reductase] + H2O

Equation

C00777 + C03024 + C00007 <=> C16677 + C03161 + C00001

Comment

CYP1A1/2, CYP2A6, CYP2B6, CYP2C8/9/18, CYP3A4/5/7, CYP26, CYP2S1

Reaction class

RC00723

C00777_C16677

Enzyme

1.14.14.1 1.14.14.-

Pathway

rn00830

Retinol metabolism

rn01100

Metabolic pathways

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1
     R08392  Retinoate + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> all-trans-4-Hydroxyretinoic acid + [Oxidized NADPH---hemoprotein reductase] + H2O
    1.14.14.-
     R08392  Retinoate + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> all-trans-4-Hydroxyretinoic acid + [Oxidized NADPH---hemoprotein reductase] + H2O

Orthology

K07408

cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]

K07409

cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]

K07411

cytochrome P450 family 2 subfamily A [EC:1.14.14.1]

K07412

cytochrome P450 family 2 subfamily B [EC:1.14.14.1]

K07413

cytochrome P450 family 2 subfamily C [EC:1.14.14.1]

K07420