KEGG ORTHOLOGY: K12665

ORTHOLOGY: K12665

Entry

K12665                      KO

Symbol

CYP26C

Name

cytochrome P450 family 26 subfamily C [EC:1.14.14.-]

Pathway

map00830

Retinol metabolism

map01100

Metabolic pathways

Reaction

R08390

R08392

Disease

H02083

Focal facial dermal dysplasia

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K12665  CYP26C; cytochrome P450 family 26 subfamily C
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K12665  CYP26C; cytochrome P450 family 26 subfamily C
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP26 family
   K12665  CYP26C; cytochrome P450 family 26 subfamily C

Genes

HSA:	340665(CYP26C1)

PTR:

100610581

PPS:	100989646(CYP26C1)

GGO:

PON:

PPYG:

NLE:

HMH:

SSYN:

MCC:

MCF:	102132475(CYP26C1)

MTHB:

MNI:

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100388017(CYP26C1)

SBQ:

101048691

CIMI:

108282302(CYP26C1)

ANAN:

105718896(CYP26C1)

MMUR:

105872179

LCAT:

123649642

ERUF:

138376605(CYP26C1)

PCOQ:

105822708

OGA:

100943822

MMU:	546726(Cyp26c1)

MCAL:

110285854

MPAH:

110313554

RNO:	308190(Cyp26c1)

MCOC:

116103796

ANU:	117695847(Cyp26c1)

ASYL:

MUN:

CGE:

MAUA:

PROB:

PLEU:

PMAV:

102911564(Cyp26c1)

MORG:

MFOT:

AAMP:

CNL:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

DMER:

138825669(Cyp26c1)

PLOP:

NCAR:

MMMA:

ITI:

OCU:

OPI:

OCZ:

TUP:

GVR:

CFA:	608216(CYP26C1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

MANO:

NSU:

LWW:

FCA:	101093894(CYP26C1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

LGF:

AJU:

PTG:

PPAD:

PUC:

PLEZ:

HHV:

CCRU:

144245002(CYP26C1)

BTA:	539048(CYP26C1)

BOM:	102270163(CYP26C1)

BIU:

BJV:

BBUB:

BKE:

BBIS:

CHX:

OAS:

OCAN:

138427700(CYP26C1)

BTAX:

128068068

CSUM:

138070535(CYP26C1)

ODA:

120873489

CCAD:

122446739

MREE:

136157277(CYP26C1)

OVR:	110145791(CYP26C1)

MBEZ:

SSC:

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

LALB:

GMF:	115857792(CYP26C1)

DDP:	132439355(CYP26C1)

DLE:

111172488

PCAD:

102991140

PSIU:

116741157

PPHC:

136136635(CYP26C1)

NASI:

112396048

ECB:

100071239

EPZ:	103551257(CYP26C1)

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

MYUM:

139021495(CYP26C1)

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:	108400362(CYP26C1)

TOD:

SARA:

SFUM:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:

PBRV:

138169619(CYP26C1)

MLAO:

141521141(CYP26C1)

OAA:

100074724

TACU:

119943462

GGA:	423806(CYP26C1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

AACU:

137859631(CYP26C1)

OJA:

118168994

ACYG:

106048341(CYP26C1)

CATA:

118244972

AFUL:

116491322

TGU:

100218943

LSR:	110475659(CYP26C1)

VMC:

128810696

VCHA:

128791416

AIB:	137478111(CYP26C1)

SCAN:

PMOA:

OTC:

PRUF:

ATRC:

139595332(CYP26C1)

MATE:

118688360

MAEN:

136559560(CYP26C1)

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ACOE:

138112839(CYP26C1)

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:

SATI:

136364518(CYP26C1)

CFAI:

136293665(CYP26C1)

CCIC:

FPG:

FCH:

FRS:

CCRI:

NNT:

SHAB:

POCC:

ACUN:

ANOC:

141961468(CYP26C1)

SURA:

141945644(CYP26C1)

TALA:

ACHC:

HLE:

AGEN:

HHAR:

BBUT:

142030665(CYP26C1)

GCL:

CSTI:

LDI:

MNB:

DPUB:

PPUS:

IIN:

BRHI:

EGZ:

NNI:

PARX:

142063722(CYP26C1)

PADL:

103926005

AFOR:

103897845

FGA:

104076988

CBOR:

142084538(CYP26C1)

CBOY:

140655610(CYP26C1)

MAME:

142410911(CYP26C1)

CLV:

CNIC:

MUI:

PGUU:

PLET:

CMAC:

CUCA:

PCUR:

138724035(CYP26C1)

TEO:

BREG:

GAME:

ACAR:

CPEA:

CVF:

RTD:

CRID:

LMIC:

141745375(CYP26C1)

NARQ:

AAM:

AROW:

NPD:

DNE:

ASN:

AMJ:

CPOO:

GGN:

PSS:

CIZ:	142015800(CYP26C1)

CMY:

102944483

CCAY:

125640311

LKP:	140915202(CYP26C1)

NDS:	141991664(CYP26C1)

DCC:

119859520

CPIC:

101934998

TST:

117881036

CABI:

116832425(CYP26C1)

MRV:

120409004

EMQ:	137156253(CYP26C1)

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

PCAE:

139318192(CYP26C1)

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	108696124(cyp26c1.L) 735026(cyp26c1.S)

XTR:	100489980(cyp26c1)

NPR:

108788831

RTEM:

120946940

ACAT:

141105877(CYP26C1)

PADS:

140339611(CYP26C1)

BBUF:

121005505

BGAR:

122942222

DTC:	141059723(CYP26C1)

PWL:	138300441(CYP26C1)

MUO:

115470108

GSH:

117360027

DRE:	554036(cyp26c1)

DAES:

130244967

SRX:	107717048 107750850

SANH:

107668609 107671105

SGH:	107553621 107583629

CCAR:

CAUA:

CGIB:

PTET:

LROH:

GRF:	141295744(cyp26c1)

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

137006593(cyp26c1)

MASI:

127411075 127455004

TROS:

130560814

TDW:

130436965

MANU:

129417293 141365237(cyp26c1)

PDAB:

135727134(cyp26c1)

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

SPIL:

ASAD:

TRU:

TFS:

TNG:	GSTEN00034587G001

LCO:

NCC:

TBEN:

CGOB:

EMAC:

ELY:	117247937(cyp26c1)

EFO:

125903686

PLEP:

121954537

SLUC:

116056405

SVIT:

144532709(cyp26c1)

ECRA:

ESP:

PFLV:

PFLT:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

137779955(cyp26c1)

CVE:	137888452(cyp26c1)

AMIR:

142931744(cyp26c1)

MSAM:

119913391

SCHU:

122884724

EARM:

139294105(cyp26c1)

CUD:

121511337

SPUL:

138588410(cyp26c1)

LMIX:

132975668

HTC:	141795242(cyp26c1)

ALAT:

119033069

ASTR:

137603747(cyp26c1)

PKLU:

139210914(cyp26c1)

MZE:	101468064(cyp26c1)

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

LTU:	140312533(cyp26c1)

AOCE:

111586172

EJA:	138215167(cyp26c1)

BFRE:

138627141(cyp26c1)

MCEP:

CSEM:

POV:

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

125978188(cyp26c1)

SBIA:

PEE:

PTAO:

BPEC:

ENY:	140351525(cyp26c1)

MALB:

109963802

SJO:

128373115

SSCO:

133991568

TTY:	137197490(cyp26c1)

GMH:

115560356

SASA:

106577135 106607892

STRU:

115153290 115193666

OTW:	112253113 112255305

OMY:	110502548 110529957

OGO:	124038298 124041186

ONE:	115113165 115136320

OKI:	109888814 109899122

OKE:	118369799 118399531

OMM:	135511101 135512270

OCLA:

139381519 139417604

SALP:

111952085 111978601

SNH:	120017805 120045910

SFON:

129836436 129858285

CCLU:

121553685 121571587

ELS:

105010533

OEP:	134022529 134031197

SFM:	108932780 108939510

PKI:	111853668 111858347

AANG:

AROT:

CCOG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CMK:

CPLA:

CPUN:

HOC:

SCAU:

LERI:

HAKA:

PMRN:

LRJ:

BFO:

BBEL:

SCLV:

CLEP:

PFLL:

BARL:

HRF:

HCRA:

OED:

Reference

PMID:14532297 (CYP26C1)

Authors

Taimi M, Helvig C, Wisniewski J, Ramshaw H, White J, Amad M, Korczak B, Petkovich M

Title

A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid.

Journal

J Biol Chem 279:77-85 (2004)
DOI:10.1074/jbc.M308337200

Sequence

[hsa:340665]

Reference

PMID:29476041

Authors

Zhong G, Ortiz D, Zelter A, Nath A, Isoherranen N

Title

CYP26C1 Is a Hydroxylase of Multiple Active Retinoids and Interacts with Cellular Retinoic Acid Binding Proteins.

Journal

Mol Pharmacol 93:489-503 (2018)
DOI:10.1124/mol.117.111039

LinkDB

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