KEGG   ORTHOLOGY: K12675
Entry
K12675                      KO                                     
Symbol
cs
Name
clavaminate synthase [EC:1.14.11.21]
Pathway
map00331  Clavulanic acid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00674  Clavaminate biosynthesis, arginine + glyceraldehyde-3P => clavaminate
Reaction
R05466  deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
R05468  proclavaminate,2-oxoglutarate:oxygen oxidoreductase (cyclyzing)
R05469  dihydroclavaminate,2-oxoglutarate:oxygen oxidoreductase (desaturating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00331 Clavulanic acid biosynthesis
    K12675  cs; clavaminate synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.21  clavaminate synthase
     K12675  cs; clavaminate synthase
Other DBs
GO: 0033758
Genes
PCAV: D3880_00620
HPEG: EAO82_00795
SFA: Sfla_0558
STRP: F750_6321
SCLF: BB341_07820 BB341_13950
SFK: KY5_8015c
SVR: CP971_33670
SSPB: CP982_00555
SOV: QZH56_31600
SFIY: F0344_21135
KAB: B7C62_18900
KAU: B6264_26740
SVI: Svir_33410
DHI: LH044_18215
AG: AAA26722(cs1)
 » show all
Reference
PMID:7601835 (Cyanobacteria_CYB)
  Authors
Wu TK, Busby RW, Houston TA, McIlwaine DB, Egan LA, Townsend CA
  Title
Identification, cloning, sequencing, and overexpression of the gene encoding proclavaminate amidino hydrolase and characterization of protein function in clavulanic acid biosynthesis.
  Journal
J Bacteriol 177:3714-20 (1995)
DOI:10.1128/JB.177.13.3714-3720.1995
Reference
PMID:10655615
  Authors
Zhang Z, Ren J, Stammers DK, Baldwin JE, Harlos K, Schofield CJ
  Title
Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase.
  Journal
Nat Struct Biol 7:127-33 (2000)
DOI:10.1038/72398
  Sequence
[ag:AAA26722]
LinkDB

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