KEGG   ORTHOLOGY: K13308
Entry
K13308                      KO                                     
Symbol
desI, eryCIV
Name
dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
Pathway
map00523  Polyketide sugar unit biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01250  Biosynthesis of nucleotide sugars
Module
M00797  dTDP-D-desosamine biosynthesis
Reaction
R02773  dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K13308  desI, eryCIV; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.33  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
     K13308  desI, eryCIV; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
Other DBs
COG: COG0399
GO: 0019179
Genes
SCYE: R2B67_24620
STRE: GZL_03714
SXI: SXIM_35940
STRM: M444_29855
SCAD: DN051_13755
SNR: SNOUR_10120(eryCIV)
SGF: HEP81_07915
SGX: H4W23_25490
SATA: C5746_38530
SROI: IAG44_16020
SHK: J2N69_01045
SGK: PET44_28275
SYUN: MOV08_16445
AER: AERYTH_15840
SEN: SACE_0716(eryCIV)
AMOG: QRX60_49190
KAL: KALB_4714 KALB_6578(acuN2)
STP: Strop_2221
MCAB: HXZ27_06180(rosQ)
AEY: CDG81_13210
AG: AAC68684(desI)
 » show all
Reference
PMID:17630700
  Authors
Burgie ES, Holden HM
  Title
Molecular architecture of DesI: a key enzyme in the biosynthesis of desosamine.
  Journal
Biochemistry 46:8999-9006 (2007)
DOI:10.1021/bi700751d
Reference
PMID:9770448
  Authors
Xue Y, Zhao L, Liu HW, Sherman DH
  Title
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.
  Journal
Proc Natl Acad Sci U S A 95:12111-6 (1998)
DOI:10.1073/pnas.95.21.12111
  Sequence
[ag:AAC68684]
LinkDB

KEGG   ORTHOLOGY: K21328
Entry
K21328                      KO                                     
Symbol
calS13, atmS13
Name
dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase [EC:2.6.1.33 2.6.1.-]
Pathway
map00523  Polyketide sugar unit biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R02773  dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase
R11475  dTDP-4-amino-2,4-dideoxy-beta-L-xylose:2-oxoglutarate aminotransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K21328  calS13, atmS13; dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.33  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
     K21328  calS13, atmS13; dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase
Other DBs
COG: COG0399
Genes
CTEZ: CT3_36500 CT3_36510
CSUA: IM538_21580 IM538_21585
NFS: OIE67_22410
KUT: JJ691_31610
SAQ: Sare_2034 Sare_2945
BFH: F1611_19170 F1611_19175
MJJ: PQO05_04315
HMT: MTP16_12000
HSK: H4317_15125
MHAA: Q3Y49_04760 Q3Y49_04765
CHRC: QGN23_07260 QGN23_07265
AG: AAM94797(calS13) ABC02793(atmS13)
 » show all
Reference
PMID:26289554
  Authors
Peltier-Pain P, Singh S, Thorson JS
  Title
Characterization of Early Enzymes Involved in TDP-Aminodideoxypentose Biosynthesis en Route to Indolocarbazole AT2433.
  Journal
Chembiochem 16:2141-6 (2015)
DOI:10.1002/cbic.201500365
Reference
PMID:26061967
  Authors
Singh S, Kim Y, Wang F, Bigelow L, Endres M, Kharel MK, Babnigg G, Bingman CA, Joachimiak A, Thorson JS, Phillips GN Jr
  Title
Structural characterization of AtmS13, a putative sugar aminotransferase involved in indolocarbazole AT2433 aminopentose biosynthesis.
  Journal
Proteins 83:1547-54 (2015)
DOI:10.1002/prot.24844
Reference
PMID:12183629 (calS13)
  Authors
Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS
  Title
The calicheamicin gene cluster and its iterative type I enediyne PKS.
  Journal
Science 297:1173-6 (2002)
DOI:10.1126/science.1072105
  Sequence
[ag:AAM94797]
Reference
PMID:16873021 (atmS13)
  Authors
Gao Q, Zhang C, Blanchard S, Thorson JS
  Title
Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus.
  Journal
Chem Biol 13:733-43 (2006)
DOI:10.1016/j.chembiol.2006.05.009
  Sequence
[ag:ABC02793]
LinkDB

KEGG   ORTHOLOGY: K20428
Entry
K20428                      KO                                     
Symbol
acbV
Name
dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
Pathway
map00525  Acarbose and validamycin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R02773  dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00525 Acarbose and validamycin biosynthesis
    K20428  acbV; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.33  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
     K20428  acbV; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
Other DBs
COG: COG0160 COG4992
GO: 0019179
Genes
THAT: H3N35_23260
TVD: SG34_025420
PAEW: KIH87_05075
CJA: CJA_3257
SUR: STAUR_1378(gacV)
SGU: SGLAU_00985(gacV)
STRH: GXP74_26620
ASE: ACPL_3667(acbV)
MOX: DAMO_2610
Reference
PMID:22944206
  Authors
Wendler S, Hurtgen D, Kalinowski J, Klein A, Niehaus K, Schulte F, Schwientek P, Wehlmann H, Wehmeier UF, Puhler A
  Title
The cytosolic and extracellular proteomes of Actinoplanes sp. SE50/110 led to the identification of gene products involved in acarbose metabolism.
  Journal
J Biotechnol 167:178-89 (2013)
DOI:10.1016/j.jbiotec.2012.08.011
  Sequence
[ase:ACPL_3667]
LinkDB

KEGG   ORTHOLOGY: K20429
Entry
K20429                      KO                                     
Symbol
vioA
Name
dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
Pathway
map00541  O-Antigen nucleotide sugar biosynthesis
map01100  Metabolic pathways
map01250  Biosynthesis of nucleotide sugars
Reaction
R02773  dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00541 O-Antigen nucleotide sugar biosynthesis
    K20429  vioA; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.33  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
     K20429  vioA; dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
Other DBs
COG: COG0399
GO: 0019179
Genes
ECT: ECIAI39_0979(vioA)
EOC: CE10_2353(vioA)
EBR: ECB_01942(vioA)
ECOB: C3029_14350
EBL: ECD_01942(vioA)
EBE: B21_01931(ybl97)
EBD: ECBD_1619
SHQ: A0259_14015
ESH: C1N69_14925
PDZ: HHA33_11055
EBB: F652_1773
PAY: PAU_04327(vioA)
HAV: AT03_13955
SHE: Shewmr4_1321
SHW: Sputw3181_1468
SCHK: GII14_07745
AHI: VU14_07300
ASAA: KXJ75_15915(vioA)
SCOM: PYG29_10110
AG: AAD44154(vioA) AAR97958(vioA)
 » show all
Reference
PMID:17905981
  Authors
Wang Y, Xu Y, Perepelov AV, Qi Y, Knirel YA, Wang L, Feng L
  Title
Biochemical characterization of dTDP-D-Qui4N and dTDP-D-Qui4NAc biosynthetic pathways in Shigella dysenteriae type 7 and Escherichia coli O7.
  Journal
J Bacteriol 189:8626-35 (2007)
DOI:10.1128/JB.00777-07
  Sequence
[ag:AAD44154 AAR97958]
LinkDB

KEGG   ENZYME: 2.6.1.33
Entry
EC 2.6.1.33                 Enzyme                                 
Name
dTDP-4-amino-4,6-dideoxy-D-glucose transaminase;
thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase;
thymidine diphospho-4-amino-6-deoxyglucose aminotransferase;
thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase;
thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase;
TDP-4-keto-6-deoxy-D-glucose transaminase;
VioA;
dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
dTDP-4-amino-4,6-dideoxy-alpha-D-glucose:2-oxoglutarate aminotransferase
Reaction(IUBMB)
dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate [RN:R02773]
Reaction(KEGG)
R02773;
(other) R02772
Substrate
dTDP-4-amino-4,6-dideoxy-alpha-D-glucose [CPD:C04268];
2-oxoglutarate [CPD:C00026]
Product
dTDP-4-dehydro-6-deoxy-alpha-D-glucose [CPD:C11907];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein.
History
EC 2.6.1.33 created 1972
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec00525  Acarbose and validamycin biosynthesis
ec00541  O-Antigen nucleotide sugar biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13308  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
K20428  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
K20429  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
K21328  dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase
Genes
ECT: ECIAI39_0979(vioA)
EOC: CE10_2353(vioA)
EBR: ECB_01942(vioA)
ECOB: C3029_14350
EBL: ECD_01942(vioA)
EBE: B21_01931(ybl97)
EBD: ECBD_1619
SHQ: A0259_14015
ESH: C1N69_14925
PDZ: HHA33_11055
EBB: F652_1773
PAY: PAU_04327(vioA)
HAV: AT03_13955
SHE: Shewmr4_1321
SHW: Sputw3181_1468
SCHK: GII14_07745
THAT: H3N35_23260
TVD: SG34_025420
PAEW: KIH87_05075
CJA: CJA_3257
AHI: VU14_07300
ASAA: KXJ75_15915(vioA)
SCOM: PYG29_10110
CTEZ: CT3_36500 CT3_36510
SUR: STAUR_1378(gacV)
CSUA: IM538_21580 IM538_21585
SCYE: R2B67_24620
SGU: SGLAU_00985(gacV)
STRE: GZL_03714
SXI: SXIM_35940
STRM: M444_29855
SCAD: DN051_13755
SNR: SNOUR_10120(eryCIV)
SGF: HEP81_07915
SGX: H4W23_25490
SATA: C5746_38530
SROI: IAG44_16020
SHK: J2N69_01045
SGK: PET44_28275
SYUN: MOV08_16445
STRH: GXP74_26620
AER: AERYTH_15840
NFS: OIE67_22410
SEN: SACE_0716(eryCIV)
AMOG: QRX60_49190
KAL: KALB_4714 KALB_6578(acuN2)
KUT: JJ691_31610
STP: Strop_2221
SAQ: Sare_2034 Sare_2945
MCAB: HXZ27_06180(rosQ)
ASE: ACPL_3667(acbV)
AEY: CDG81_13210
BFH: F1611_19170 F1611_19175
MJJ: PQO05_04315
HMT: MTP16_12000
HSK: H4317_15125
MHAA: Q3Y49_04760 Q3Y49_04765
CHRC: QGN23_07260 QGN23_07265
MOX: DAMO_2610
 » show all
Reference
1  [PMID:5332731]
  Authors
Matsuhashi M, Strominger JL.
  Title
Thymidine diphosphate 4-acetamido-2,6-dideoxyhexoses. 3. Purification and properties of thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase from Escherichia coli strain B.
  Journal
J Biol Chem 241:4738-44 (1966)
Reference
2  [PMID:17905981]
  Authors
Wang Y, Xu Y, Perepelov AV, Qi Y, Knirel YA, Wang L, Feng L
  Title
Biochemical characterization of dTDP-D-Qui4N and dTDP-D-Qui4NAc biosynthetic pathways in Shigella dysenteriae type 7 and Escherichia coli O7.
  Journal
J Bacteriol 189:8626-35 (2007)
DOI:10.1128/JB.00777-07
  Sequence
[ag:AAD44154 AAR97958]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.33
IUBMB Enzyme Nomenclature: 2.6.1.33
ExPASy - ENZYME nomenclature database: 2.6.1.33
BRENDA, the Enzyme Database: 2.6.1.33
CAS: 9023-19-2
LinkDB

KEGG   REACTION: R02773
Entry
R02773                      Reaction                               
Name
dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase
Definition
dTDP-4-amino-4,6-dideoxy-D-glucose + 2-Oxoglutarate <=> dTDP-4-oxo-6-deoxy-D-glucose + L-Glutamate
Equation
C04268 + C00026 <=> C11907 + C00025
Reaction class
RC00006  C00025_C00026
RC00781  C04268_C11907
Enzyme
2.6.1.33
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn00525  Acarbose and validamycin biosynthesis
rn00541  O-Antigen nucleotide sugar biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01250  Biosynthesis of nucleotide sugars
Module
M00797  dTDP-D-desosamine biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.33
     R02773  dTDP-4-amino-4,6-dideoxy-D-glucose + 2-Oxoglutarate <=> dTDP-4-oxo-6-deoxy-D-glucose + L-Glutamate
Orthology
K13308  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
K20428  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
K20429  dTDP-4-amino-4,6-dideoxy-D-glucose transaminase [EC:2.6.1.33]
K21328  dTDP-4-amino-4,6-dideoxy-D-glucose/dTDP-4-amino-2,4-dideoxy-beta-L-xylose transaminase [EC:2.6.1.33 2.6.1.-]
Other DBs
RHEA: 19088
LinkDB

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