KEGG ORTHOLOGY: K13309

ORTHOLOGY: K13309

Entry

K13309                      KO

Symbol

desII, eryCV

Name

dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase [EC:4.3.1.30]

Pathway

map00523

Polyketide sugar unit biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01250

Biosynthesis of nucleotide sugars

Module

M00797

dTDP-D-desosamine biosynthesis

Reaction

R08583

dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase (dTDP-3-oxo-4,6-dideoxy-D-glucose-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K13309  desII, eryCV; dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase
Enzymes [BR:ko01000]
4. Lyases
  4.3  Carbon-nitrogen lyases
   4.3.1  Ammonia-lyases
    4.3.1.30  dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase
     K13309  desII, eryCV; dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase

Genes

SCYE:

R2B67_24625(desII)

STRE:

GZL_03702

STRM:

M444_29865

SNR:	SNOUR_10125(eryCV)

SGF:	HEP81_07916(desII)

SGX:	H4W23_25495(desII)

SATA:

C5746_38525(desII)

SROI:

IAG44_15960(desII)

SHK:	J2N69_01050(desII)

SGK:	PET44_28285(desII)

SYUN:

MOV08_16380(desII)

AER:	AERYTH_15835

SEN:	SACE_0715(eryCV)

MCAB:

HXZ27_06185(rosR)

AEY:	CDG81_13215(desII)

AG:	AAC68683(desII)

» show all

Reference

PMID:19746907

Authors

Szu PH, Ruszczycky MW, Choi SH, Yan F, Liu HW

Title

Characterization and mechanistic studies of DesII: a radical S-adenosyl-L-methionine enzyme involved in the biosynthesis of TDP-D-desosamine.

Journal

J Am Chem Soc 131:14030-42 (2009)
DOI:10.1021/ja903354k

Reference

PMID:21513273

Authors

Ruszczycky MW, Choi SH, Mansoorabadi SO, Liu HW

Title

Mechanistic studies of the radical S-adenosyl-L-methionine enzyme DesII: EPR characterization of a radical intermediate generated during its catalyzed dehydrogenation of TDP-D-quinovose.

Journal

J Am Chem Soc 133:7292-5 (2011)
DOI:10.1021/ja201212f

Reference

PMID:9770448

Authors

Xue Y, Zhao L, Liu HW, Sherman DH

Title

A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.

Journal

Proc Natl Acad Sci U S A 95:12111-6 (1998)
DOI:10.1073/pnas.95.21.12111

Sequence

[ag:AAC68683]

LinkDB

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