KEGG ORTHOLOGY: K13310

ORTHOLOGY: K13310

Entry

K13310                      KO

Symbol

desV, eryCI

Name

dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase [EC:2.6.1.106]

Pathway

map00523

Polyketide sugar unit biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01250

Biosynthesis of nucleotide sugars

Module

M00797

dTDP-D-desosamine biosynthesis

Reaction

R06426

dTDP-3-amino-3,4,6-trideoxy-D-glucose:2-oxoglutarate aminotransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K13310  desV, eryCI; dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase
Enzymes [BR:ko01000]
2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.106  dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase
     K13310  desV, eryCI; dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase

Genes

MALC:

QQG91_02920

TFV:	IDJ81_02380

OLV:	ACMYLB_18780

LUB:	TBR22_A49060

TOB:	V4D31_02595

SRN:	A4G23_00481(fdtB_1)

SPAV:

Spa2297_32850

SHAW:

CEB94_04710

SCOA:

QU709_45620

SEN:	SACE_0734(eryCI)

ACTI:

UA75_17820

ACAD:

UA74_17285

AHG:	AHOG_15460(fdtB2)

PLAB:

C6361_24070

PLAT:

C6W10_35925

AEY:	CDG81_13130

ADAE:

ACE2AJ_08060

AG:	AAC68680(desV)

» show all

Reference

PMID:17456741

Authors

Burgie ES, Thoden JB, Holden HM

Title

Molecular architecture of DesV from Streptomyces venezuelae: a PLP-dependent transaminase involved in the biosynthesis of the unusual sugar desosamine.

Journal

Protein Sci 16:887-96 (2007)
DOI:10.1110/ps.062711007

Reference

PMID:16187386

Authors

Szu PH, He X, Zhao L, Liu HW

Title

Biosynthesis of TDP-D-desosamine: identification of a strategy for C4 deoxygenation.

Journal

Angew Chem Int Ed Engl 44:6742-6 (2005)
DOI:10.1002/anie.200501998

Reference

PMID:9770448

Authors

Xue Y, Zhao L, Liu HW, Sherman DH

Title

A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.

Journal

Proc Natl Acad Sci U S A 95:12111-6 (1998)
DOI:10.1073/pnas.95.21.12111

Sequence

[ag:AAC68680]

LinkDB

ORTHOLOGY: K16436

Entry

K16436                      KO

Symbol

evaB, megDII, angB, staI

Name

dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase [EC:2.6.1.- 2.6.1.106]

Pathway

map00523

Polyketide sugar unit biosynthesis

map01055

Biosynthesis of vancomycin group antibiotics

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01250

Biosynthesis of nucleotide sugars

Module

M00797

dTDP-D-desosamine biosynthesis

M00800

dTDP-L-megosamine biosynthesis

M00803

dTDP-D-angolosamine biosynthesis

Reaction

R06426

dTDP-3-amino-3,4,6-trideoxy-D-glucose:2-oxoglutarate aminotransferase

R06631

dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose:2-oxoglutarate aminotransferase

R08928

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K16436  evaB, megDII, angB, staI; dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase
   01055 Biosynthesis of vancomycin group antibiotics
    K16436  evaB, megDII, angB, staI; dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase
Enzymes [BR:ko01000]
2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.106  dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase
     K16436  evaB, megDII, angB, staI; dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase

Genes

DTX:	ATSB10_36020

OME:	OLMES_5572

BOK:

DM82_922

BOC:

BG90_13

BUU:	WS70_10345

PTRP:

DCO17_01695

CSER:

CCO03_02175

BGZ:	XH91_11590

BSEI:

BROS:

BRAB:

RPE:

GEM:

GUR:

GEO:

GBM:

GBN:	GEOBRER4_09100

GER:	KP004_03990

GSUB:

KP001_11415

GPL:	M1B72_16735

DMA:

DMR_07600

DCB:	C3Y92_16655

SOLI:

ACP59X_05480

OLV:	ACMYLB_10365

PLS:	VT03_24275(fdtB)

CCOS:

Pan44_47430(fdtB)

LKB:	LPTSP3_g21180

NBR:	O3I_007490

NIE:	KV110_35795

NVU:	V7968_14880

DPC:	A6048_11425

SGR:

SGR_631

SGRF:

SGFS_016280

SCYE:

R2B67_24630

SXI:	SXIM_35740

SAMB:

SAM23877_7111

SLE:	sle_09260(sle_09260)

SRN:	A4G23_02284(fdtB_3)

SCLF:

BB341_29650

SGM:	GCM10017557_01770

SCAD:

DN051_13785

SALF:

SMD44_08276

SLK:	SLUN_13800

STIR:

DDW44_27825

SKA:	CP970_39865

SFIC:

EIZ62_03940 EIZ62_09600

SGAL:

SSPO:

SPAD:

SRIM:

SPHV:

SCIN:

STSU:

SCHA:

SCOE:

SFEU:

SLIA:

SFB:	CP974_12570

SMOB:

J7W19_00830

SPEU:

CGZ69_24380

SGJ:	IAG43_33085

SMAO:

SAOV:

SRUG:

SAKB:

STAA:

SNIG:

STUD:

SJN:	RI060_18320

SHAU:

K9S39_40580

SKG:	KJK29_16120

SFP:	QUY26_02165

SCHG:

NRO40_12725

STTN:

BSL84_24970

SPRF:

K4G22_02655 K4G22_25835

SCHE:

STRV:

SPAZ:

SSOC:

STRJ:

SOKE:

KAB:	B7C62_31175

CRY:	B7495_14410

ARUB:

J5A65_00470

NCA:

Noca_4220

TALX:

FOF52_07485 FOF52_14840

NDA:

Ndas_4709

NAL:

B005_1433

NGV:	CDO52_02790

NAKE:

KGD83_01610

NCG:	KGD84_13445

NOCB:

UIS43_17160

STRR:

EKD16_15580(fdtB)

SNAH:

SAIU:

TCU:

ACTQ:

NOW:	GBF35_40090

NCX:	Nocox_25585(fdtB)

SVI:	Svir_29860

SACC:

EYD13_16495(fdtB)

AOI:

AORI_1500

AJA:	AJAP_32020(dnrJ)

AMYC:

CU254_17445

AMYB:

BKN51_41540

AMYY:

YIM_11615(fdtB1) YIM_22860(fdtB2)

AORI:

AROO:

ACYN:

ACOR:

AMYE:

AMYS:

CVV72_21495 CVV72_32490

PSEQ:

AD006_30040

PECQ:

AD017_31210

PALQ:

PaSha_27330

SESP:

BN6_58910(sam30)

SSYI:

EKG83_32250

KAL:	KALB_6580(acuN1)

KUT:	JJ691_101530 JJ691_70310

KPHY:

AOZ06_22490 AOZ06_23370

LED:	BBK82_43745

LXR:	ACRSBM_11740

AHM:	TL08_05640

ACTI:

UA75_05680

ACAD:

UA74_05675

AHG:	AHOG_05440(fdtB1)

ACTA:

C1701_01555

ALO:

CRK56086

PMAD:

BAY61_07750

ACTU:

Actkin_00392(fdtB_1)

AAUR:

V5P93_001202(knm30)

SAQ:

Sare_2337

MAU:	Micau_3988

MIL:

ML5_4433

MICB:

MicB006_4930

MCAB:

HXZ27_04125(evdS12)

MCRA:

ID554_11925 ID554_28075

VER:	HUT12_18910

MENO:

MCHL:

MCAY:

MICN:

AMS:	AMIS_50590 AMIS_56730

AOU:	ACTOB_006482

PFLA:

Pflav_057110

PSUU:

Psuf_016700(gnnB) Psuf_058220

DAUR:

Daura_37950

NHY:	JQS43_06860

PVN:	A7sIIA15_06590

AG:	AAG13910(megDII) ABV49595(angB) BAC55216(staI)

» show all

Reference

PMID:24884615

Authors

Xu L, Huang H, Wei W, Zhong Y, Tang B, Yuan H, Zhu L, Huang W, Ge M, Yang S, Zheng H, Jiang W, Chen D, Zhao GP, Zhao W

Title

Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis.

Journal

BMC Genomics 15:363 (2014)
DOI:10.1186/1471-2164-15-363

Sequence

[aoi:AORI_1500]

Reference

PMID:20418422

Authors

Useglio M, Peiru S, Rodriguez E, Labadie GR, Carney JR, Gramajo H

Title

TDP-L-megosamine biosynthesis pathway elucidation and megalomicin a production in Escherichia coli.

Journal

Appl Environ Microbiol 76:3869-77 (2010)
DOI:10.1128/AEM.03083-09

Sequence

[ag:AAG13910]

Reference

PMID:16514147

Authors

Rodriguez E, Peiru S, Carney JR, Gramajo H

Title

In vivo characterization of the dTDP-D-desosamine pathway of the megalomicin gene cluster from Micromonospora megalomicea.

Journal

Microbiology 152:667-73 (2006)
DOI:10.1099/mic.0.28680-0

Sequence

[ag:AAG13910]

Reference

PMID:18802638

Authors

Schell U, Haydock SF, Kaja AL, Carletti I, Lill RE, Read E, Sheehan LS, Low L, Fernandez MJ, Grolle F, McArthur HA, Sheridan RM, Leadlay PF, Wilkinson B, Gaisser S

Title

Engineered biosynthesis of hybrid macrolide polyketides containing D-angolosamine and D-mycaminose moieties.

Journal

Org Biomol Chem 6:3315-27 (2008)
DOI:10.1039/b807914e

Sequence

[ag:ABV49595]

Reference

PMID:12617516

Authors

Onaka H, Taniguchi S, Igarashi Y, Furumai T

Title

Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.

Journal

J Antibiot (Tokyo) 55:1063-71 (2002)
DOI:10.7164/antibiotics.55.1063

Sequence

[ag:BAC55216]

LinkDB

ENZYME: 2.6.1.106

Entry

EC 2.6.1.106                Enzyme

Name

dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase;
desV (gene name);
megDII (gene name);
eryCI (gene name)

Class

Transferases;
Transferring nitrogenous groups;
Transaminases

Sysname

dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose:2-oxoglutarate aminotransferase

Reaction(IUBMB)

dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2-oxoglutarate = dTDP-3-dehydro-4,6-deoxy-alpha-D-glucose + L-glutamate [RN:R06426]

Reaction(KEGG)

R06426

Substrate

dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose [CPD:C11910];
2-oxoglutarate [CPD:C00026]

Product

dTDP-3-dehydro-4,6-deoxy-alpha-D-glucose [CPD:C11909];
L-glutamate [CPD:C00025]

Comment

A pyridoxal-phosphate protein. The enzyme is involved in the biosynthesis of dTDP-alpha-D-desosamine, a sugar found in several bacterial macrolide antibiotics including erythromycin, megalomicin A, mycinamicin II, and oleandomycin. The reaction occurs in the reverse direction.

History

EC 2.6.1.106 created 2014

Pathway

ec00523

Polyketide sugar unit biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K13310

dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase

K16436

dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase

Genes

DTX:	ATSB10_36020

OME:	OLMES_5572

BOK:

DM82_922

BOC:

BG90_13

BUU:	WS70_10345

PTRP:

DCO17_01695

CSER:

CCO03_02175

BGZ:	XH91_11590

BSEI:

KMZ68_19085

BROS:

QUH67_25980

BRAB:

RX331_10945

RPE:

RPE_1521

MALC:

QQG91_02920

TFV:	IDJ81_02380

GEM:

GM21_0941

GUR:

Gura_4276

GEO:

Geob_0430

GBM:

Gbem_3307

GBN:	GEOBRER4_09100

GER:	KP004_03990

GSUB:

KP001_11415

GPL:	M1B72_16735

DMA:

DMR_07600

DCB:	C3Y92_16655

SOLI:

ACP59X_05480

OLV:	ACMYLB_10365 ACMYLB_18780

PLS:	VT03_24275(fdtB)

CCOS:

Pan44_47430(fdtB)

LKB:	LPTSP3_g21180

LUB:	TBR22_A49060

TOB:	V4D31_02595

NBR:	O3I_007490

NIE:	KV110_35795

NVU:	V7968_14880

DPC:	A6048_11425

SGR:

SGR_631

SGRF:

SGFS_016280

SCYE:

R2B67_24630

SXI:	SXIM_35740

SAMB:

SAM23877_7111

SLE:	sle_09260(sle_09260)

SRN:	A4G23_00481(fdtB_1) A4G23_02284(fdtB_3)

SPAV:

Spa2297_32850

SCLF:

BB341_29650

SGM:	GCM10017557_01770

SCAD:

DN051_13785

SALF:

SMD44_08276

SLK:	SLUN_13800

STIR:

DDW44_27825

SKA:	CP970_39865

SHAW:

CEB94_04710

SFIC:

EIZ62_03940 EIZ62_09600

SGAL:

CP966_29030

SSPO:

DDQ41_30670

SPAD:

DVK44_01725

SRIM:

CP984_10775

SPHV:

F9278_28225

SCIN:

CP977_28095

STSU:

B7R87_21940

SCHA:

CP983_27955

SCOE:

CP976_32980

SFEU:

IM697_37655

SLIA:

HA039_05665

SFB:	CP974_12570

SMOB:

J7W19_00830

SPEU:

CGZ69_24380

SGJ:	IAG43_33085

SMAO:

CAG99_12110

SAOV:

G3H79_01880

SRUG:

F0345_27610

SAKB:

K1J60_45155

STAA:

LDH80_09665

SNIG:

HEK616_47520

STUD:

STRTU_005103

SJN:	RI060_18320

SHAU:

K9S39_40580

SKG:	KJK29_16120

SCOA:

QU709_45620

SFP:	QUY26_02165

SCHG:

NRO40_12725

STTN:

BSL84_24970

SPRF:

K4G22_02655 K4G22_25835

SCHE:

QRN89_14785

STRV:

EZV63_00140

SPAZ:

ABXI76_00240

SSOC:

ABZO31_28450

STRJ:

H7827_10070

SOKE:

ACE1N8_24215

KAB:	B7C62_31175

CRY:	B7495_14410

ARUB:

J5A65_00470

NCA:

Noca_4220

TALX:

FOF52_07485 FOF52_14840

NDA:

Ndas_4709

NAL:

B005_1433

NGV:	CDO52_02790

NAKE:

KGD83_01610

NCG:	KGD84_13445

NOCB:

UIS43_17160

STRR:

EKD16_15580(fdtB)

SNAH:

OUQ99_30540

SAIU:

J4H86_24150

TCU:

Tcur_2777

ACTQ:

OG417_42725

NOW:	GBF35_40090

NCX:	Nocox_25585(fdtB)

SEN:	SACE_0734(eryCI)

SVI:	Svir_29860

SACC:

EYD13_16495(fdtB)

AOI:

AORI_1500

AJA:	AJAP_32020(dnrJ)

AMYC:

CU254_17445

AMYB:

BKN51_41540

AMYY:

YIM_11615(fdtB1) YIM_22860(fdtB2)

AORI:

SD37_33620

AROO:

NQK81_15390

ACYN:

ORV05_18110

ACOR:

LCL61_00280

AMYE:

MJQ72_33880

AMYS:

CVV72_21495 CVV72_32490

PSEQ:

AD006_30040

PECQ:

AD017_31210

PALQ:

PaSha_27330

SESP:

BN6_58910(sam30)

SSYI:

EKG83_32250

KAL:	KALB_6580(acuN1)

KUT:	JJ691_101530 JJ691_70310

KPHY:

AOZ06_22490 AOZ06_23370

LED:	BBK82_43745

LXR:	ACRSBM_11740

AHM:	TL08_05640

ACTI:

UA75_05680 UA75_17820

ACAD:

UA74_05675 UA74_17285

AHG:	AHOG_05440(fdtB1) AHOG_15460(fdtB2)

ACTA:

C1701_01555

ALO:

CRK56086

PMAD:

BAY61_07750

ACTU:

Actkin_00392(fdtB_1)

AAUR:

V5P93_001202(knm30)

SAQ:

Sare_2337

MAU:	Micau_3988

MIL:

ML5_4433

MICB:

MicB006_4930

MCAB:

HXZ27_04125(evdS12)

MCRA:

ID554_11925 ID554_28075

VER:	HUT12_18910

MENO:

Jiend_53130

MCHL:

PVK74_00295

MCAY:

PVK37_23840

MICN:

WHN02_15900

AMS:	AMIS_50590 AMIS_56730

AOU:	ACTOB_006482

PLAB:

C6361_24070

PLAT:

C6W10_35925

PFLA:

Pflav_057110

PSUU:

Psuf_016700(gnnB) Psuf_058220

DAUR:

Daura_37950

NHY:	JQS43_06860

AEY:	CDG81_13130

PVN:	A7sIIA15_06590

ADAE:

ACE2AJ_08060

» show all

Reference

1 [PMID:17456741]

Authors

Burgie ES, Thoden JB, Holden HM

Title

Molecular architecture of DesV from Streptomyces venezuelae: a PLP-dependent transaminase involved in the biosynthesis of the unusual sugar desosamine.

Journal

Protein Sci 16:887-96 (2007)
DOI:10.1110/ps.062711007

Sequence

[ag:AAC68680]

Other DBs

ExplorEnz - The Enzyme Database:

2.6.1.106

IUBMB Enzyme Nomenclature:

2.6.1.106

ExPASy - ENZYME nomenclature database:

2.6.1.106

BRENDA, the Enzyme Database:

2.6.1.106

LinkDB

REACTION: R06426

Entry

R06426                      Reaction

Name

dTDP-3-amino-3,4,6-trideoxy-D-glucose:2-oxoglutarate aminotransferase

Definition

dTDP-3-oxo-4,6-dideoxy-D-glucose + L-Glutamate <=> dTDP-3-amino-3,4,6-trideoxy-D-glucose + 2-Oxoglutarate

Equation

C11909 + C00025 <=> C11910 + C00026

Reaction class

RC00006

C00025_C00026

RC01514

C11909_C11910

Enzyme

2.6.1.106

Pathway

rn00523

Polyketide sugar unit biosynthesis

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

rn01250

Biosynthesis of nucleotide sugars

Module

M00797

dTDP-D-desosamine biosynthesis

Brite

Enzymatic reactions [BR:br08201]
2. Transferase reactions
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.106
     R06426  dTDP-3-oxo-4,6-dideoxy-D-glucose + L-Glutamate <=> dTDP-3-amino-3,4,6-trideoxy-D-glucose + 2-Oxoglutarate

Orthology

K13310

dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase [EC:2.6.1.106]

K16436

dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase [EC:2.6.1.- 2.6.1.106]

Other DBs

RHEA:

39910

LinkDB

DBGET integrated database retrieval system