KEGG   ORTHOLOGY: K13382
Entry
K13382                      KO                                     
Symbol
NCS
Name
(S)-norcoclaurine synthase [EC:3.5.99.14]
Pathway
map00950  Isoquinoline alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00943  Reticuline biosynthesis, dopamine + 4HPAA => (S)-reticuline
Reaction
R04084  3,4-dihydroxyphenylacetaldehyde hydro-lyase (adding dopamine)
R04305  4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K13382  NCS; (S)-norcoclaurine synthase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.99  In other compounds
    3.5.99.14  (S)-norcoclaurine synthase
     K13382  NCS; (S)-norcoclaurine synthase
Other DBs
GO: 0050474
Genes
PSOM: 113277377 113326100 113340282
AG: AAR22502(NCS)
Reference
PMID:17696451
  Authors
Luk LY, Bunn S, Liscombe DK, Facchini PJ, Tanner ME
  Title
Mechanistic studies on norcoclaurine synthase of benzylisoquinoline alkaloid biosynthesis: an enzymatic Pictet-Spengler reaction.
  Journal
Biochemistry 46:10153-61 (2007)
DOI:10.1021/bi700752n
Reference
PMID:15447655
  Authors
Samanani N, Liscombe DK, Facchini PJ
  Title
Molecular cloning and characterization of norcoclaurine synthase, an enzyme catalyzing the first committed step in benzylisoquinoline alkaloid biosynthesis.
  Journal
Plant J 40:302-13 (2004)
DOI:10.1111/j.1365-313X.2004.02210.x
  Sequence
[ag:AAR22502]
LinkDB

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