KEGG ORTHOLOGY: K13397

ORTHOLOGY: K13397

Entry

K13397                      KO

Symbol

SMT

Name

(S)-scoulerine 9-O-methyltransferase [EC:2.1.1.117]

Pathway

map00950

Isoquinoline alkaloid biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00946

Noscapine biosynthesis, (S)-reticuline => noscapine

Reaction

R03835

S-adenosyl-L-methionine:(S)-scoclaurine 9-O-methyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K13397  SMT; (S)-scoulerine 9-O-methyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.117  (S)-scoulerine 9-O-methyltransferase
     K13397  SMT; (S)-scoulerine 9-O-methyltransferase

Other DBs

GO:

0030777

Genes

FVE:	101292538 101314449

AANS:

126785966 126786871 126787924 126788651

RCN:	112164599 112175727 112178128

PPER:

PMUM:

PAVI:

PDUL:

MDM:

PXB:	103951323 103951351 103951352 103966079 103966114

PCOX:

137728497 137728498

JRE:	108979314 108981078 108981935 108986025 109004694 109018241 109018878 118348298

CILL:

122278514 122278733 122278857 122278863

QLO:

CSAA:

TWL:

VVI:

VRI:

DLT:

NNU:	104586605 104600131

PSOM:

113293137 113322507 113362144

MSIN:

131239482 131242245 131242246 131242247 131242248 131252155 131252157

ACAK:

137937030 137937183 137937184 137937185 137937413 137937414 137937415 137937416 137937417 137937821

CJF:	131057780 131872838

AG:	BAA06192(SMT)

» show all

Reference

PMID:7719631

Authors

Takeshita N, Fujiwara H, Mimura H, Fitchen JH, Yamada Y, Sato F

Title

Molecular cloning and characterization of S-adenosyl-L-methionine:scoulerine-9-O-methyltransferase from cultured cells of Coptis japonica.

Journal

Plant Cell Physiol 36:29-36 (1995)
DOI:10.1093/oxfordjournals.pcp.a078741

Sequence

[ag:BAA06192]

LinkDB

ENZYME: 2.1.1.117

Entry

EC 2.1.1.117                Enzyme

Name

(S)-scoulerine 9-O-methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + (S)-scoulerine = S-adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine [RN:R03835]

Reaction(KEGG)

R03835

Substrate

S-adenosyl-L-methionine [CPD:C00019];
(S)-scoulerine [CPD:C02106]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
(S)-tetrahydrocolumbamine [CPD:C04118]

Comment

The product of this reaction is a precursor for protoberberine alkaloids in plants

History

EC 2.1.1.117 created 1999

Pathway

ec00950

Isoquinoline alkaloid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K13397

(S)-scoulerine 9-O-methyltransferase

Genes

FVE:	101292538 101314449

AANS:

126785966 126786871 126787924 126788651

RCN:	112164599 112175727 112178128

PPER:

18780355

PMUM:

103325170

PAVI:

110774000

PDUL:

117626380

MDM:

103435029

PXB:	103951323 103951351 103951352 103966079 103966114

PCOX:

137728497 137728498

JRE:	108979314 108981078 108981935 108986025 109004694 109018241 109018878 118348298

CILL:

122278514 122278733 122278857 122278863

QLO:

115961636

CSAA:

142615386

TWL:

120012623

VVI:

100265214

VRI:

117924373

DLT:

127793228

NNU:	104586605 104600131

PSOM:

113293137 113322507 113362144

MSIN:

131239482 131242245 131242246 131242247 131242248 131252155 131252157

ACAK:

137937030 137937183 137937184 137937185 137937413 137937414 137937415 137937416 137937417 137937821

CJF:	131057780 131872838

» show all

Reference

1 [PMID:24253642]

Authors

Muemmler S, Rueffer M, Nagakura N, Zenk MH

Title

S-adenosyl-L-methionine: (S)-scoulerine 9-O-methyltransferase, a highly stereo- and regio-specific enzyme in tetrahydroprotoberberine biosynthesis.

Journal

Plant Cell Rep 4:36-9 (1985)
DOI:10.1007/BF00285501

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.117

IUBMB Enzyme Nomenclature:

2.1.1.117

ExPASy - ENZYME nomenclature database:

2.1.1.117

BRENDA, the Enzyme Database:

2.1.1.117

CAS:	96380-65-3

LinkDB

REACTION: R03835

Entry

R03835                      Reaction

Name

S-adenosyl-L-methionine:(S)-scoclaurine 9-O-methyltransferase

Definition

S-Adenosyl-L-methionine + (S)-Scoulerine <=> S-Adenosyl-L-homocysteine + Isocorypalmine

Equation

C00019 + C02106 <=> C00021 + C04118

Reaction class

RC00003

C00019_C00021

RC00392

C02106_C04118

Enzyme

2.1.1.117

Pathway

rn00950

Isoquinoline alkaloid biosynthesis

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

Module

M00946

Noscapine biosynthesis, (S)-reticuline => noscapine

Brite

Enzymatic reactions [BR:br08201]
2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.117
     R03835  S-Adenosyl-L-methionine + (S)-Scoulerine <=> S-Adenosyl-L-homocysteine + Isocorypalmine

Orthology

K13397

(S)-scoulerine 9-O-methyltransferase [EC:2.1.1.117]

Other DBs

RHEA:

23811

LinkDB

DBGET integrated database retrieval system