KEGG   ORTHOLOGY: K13397
Entry
K13397                      KO                                     
Symbol
SMT
Name
(S)-scoulerine 9-O-methyltransferase [EC:2.1.1.117]
Pathway
map00950  Isoquinoline alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00946  Noscapine biosynthesis, (S)-reticuline => noscapine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K13397  SMT; (S)-scoulerine 9-O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.117  (S)-scoulerine 9-O-methyltransferase
     K13397  SMT; (S)-scoulerine 9-O-methyltransferase
Other DBs
RN: R03835
GO: 0030777
Genes
FVE: 101292538 101314449
RCN: 112164599 112175727 112178128
PPER: 18780355
PMUM: 103325170
PAVI: 110774000
PDUL: 117626380
MDM: 103435029
PXB: 103951323 103951351 103951352 103966079 103966114
JRE: 108979314 108981078 108981935 108986025 109004694 109018241 109018878 118348298
QSU: 111993653 111993655 112036190
QLO: 115961636
TWL: 120012623
VVI: 100265214
VRI: 117924373
AG: BAA06192(SMT)
 » show all
Reference
PMID:7719631
  Authors
Takeshita N, Fujiwara H, Mimura H, Fitchen JH, Yamada Y, Sato F
  Title
Molecular cloning and characterization of S-adenosyl-L-methionine:scoulerine-9-O-methyltransferase from cultured cells of Coptis japonica.
  Journal
Plant Cell Physiol 36:29-36 (1995)
DOI:10.1093/oxfordjournals.pcp.a078741
  Sequence
LinkDB

KEGG   ENZYME: 2.1.1.117
Entry
EC 2.1.1.117                Enzyme                                 
Name
(S)-scoulerine 9-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + (S)-scoulerine = S-adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine [RN:R03835]
Reaction(KEGG)
R03835
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(S)-scoulerine [CPD:C02106]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(S)-tetrahydrocolumbamine [CPD:C04118]
Comment
The product of this reaction is a precursor for protoberberine alkaloids in plants
History
EC 2.1.1.117 created 1999
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13397  (S)-scoulerine 9-O-methyltransferase
Genes
FVE101292538 101314449
RCN112164599 112175727 112178128
PPER18780355
PMUM103325170
PAVI110774000
PDUL117626380
MDM103435029
PXB103951323 103951351 103951352 103966079 103966114
JRE108979314 108981078 108981935 108986025 109004694 109018241 109018878 118348298
QSU111993653 111993655 112036190
QLO115961636
TWL120012623
VVI100265214
VRI117924373
NNU104586605 104600131
PSOM113293137 113322507 113362144
 » show all
Reference
1  [PMID:24253642]
  Authors
Muemmler S, Rueffer M, Nagakura N, Zenk MH
  Title
S-adenosyl-L-methionine: (S)-scoulerine 9-O-methyltransferase, a highly stereo- and regio-specific enzyme in tetrahydroprotoberberine biosynthesis.
  Journal
Plant Cell Rep 4:36-9 (1985)
DOI:10.1007/BF00285501
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.117
IUBMB Enzyme Nomenclature: 2.1.1.117
ExPASy - ENZYME nomenclature database: 2.1.1.117
BRENDA, the Enzyme Database: 2.1.1.117
CAS: 96380-65-3
LinkDB

KEGG   REACTION: R03835
Entry
R03835                      Reaction                               
Name
S-Adenosyl-L-methionine:(S)-scoclaurine 9-O-methyltransferase
Definition
S-Adenosyl-L-methionine + (S)-Scoulerine <=> S-Adenosyl-L-homocysteine + Isocorypalmine
Equation
Reaction class
RC00003  C00019_C00021
RC00392  C02106_C04118
Enzyme
Pathway
rn00950  Isoquinoline alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00946  Noscapine biosynthesis, (S)-reticuline => noscapine
Orthology
K13397  (S)-scoulerine 9-O-methyltransferase [EC:2.1.1.117]
Other DBs
RHEA: 23811
LinkDB

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