KEGG ORTHOLOGY: K14020

ORTHOLOGY: K14020

Entry

K14020                      KO

Symbol

WFS1

Name

wolfamin

Pathway

map04141

Protein processing in endoplasmic reticulum

Disease

H00409

Type 2 diabetes mellitus

H00604

Deafness, autosomal dominant

H00854

Wolfram syndrome

H01202

Cataract

H01705

Bilateral sudden sensorineural hearing loss

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K14020  WFS1; wolfamin

Genes

HSA:	7466(WFS1)

PTR:	461100(WFS1)

PPS:	100983540(WFS1)

GGO:	101140111(WFS1)

PON:	100174672(WFS1)

PPYG:

129034917(WFS1)

NLE:	100582796(WFS1)

HMH:	116456979(WFS1)

SSYN:

129464604(WFS1)

MCC:	710948(WFS1)

MCF:	101926576(WFS1)

MTHB:

126955485

MNI:	105483912(WFS1)

CSAB:

103246405(WFS1)

CATY:

105585422(WFS1)

PANU:

101021357(WFS1)

TGE:	112624852(WFS1)

MLEU:

105555282

RRO:	104667560(WFS1)

RBB:	108538799(WFS1)

TFN:	117085112(WFS1)

PTEH:

111539129(WFS1)

CANG:

105507055(WFS1)

CJC:	100386022(WFS1)

SBQ:	101032223(WFS1)

CIMI:

108311625(WFS1)

ANAN:

105727217(WFS1)

MMUR:

105861836(WFS1)

LCAT:

123622191(WFS1)

PCOQ:

105827096(WFS1)

OGA:	100956334(WFS1)

MMU:	22393(Wfs1)

MCAL:

110294183(Wfs1)

MPAH:

110330419(Wfs1)

RNO:	83725(Wfs1)

MCOC:

116070479(Wfs1)

ANU:	117712880(Wfs1)

ASYL:

127696304(Wfs1)

MUN:	110544856(Wfs1)

CGE:	100770775(Wfs1)

MAUA:

101837234(Wfs1)

PROB:

127233631(Wfs1)

PLEU:

114702073(Wfs1)

MORG:

121436547(Wfs1)

MFOT:

126500920

AAMP:

119802260(Wfs1)

NGI:	103750637(Wfs1)

HGL:	101711151(Wfs1)

CPOC:

100731167(Wfs1)

CCAN:

109687310(Wfs1)

DORD:

105991346(Wfs1)

DSP:	122099774(Wfs1)

PLOP:

125364767(Wfs1)

NCAR:

124994836

MMMA:

107139116(Wfs1)

ITI:	101959388(Wfs1)

OCU:

103346422

OPI:	101518362(WFS1)

TUP:	102501003(WFS1)

GVR:	103596788(WFS1)

CFA:	482113(WFS1)

CLUD:

112662160(WFS1)

VVP:	112909875(WFS1)

VLG:	121483903(WFS1)

NPO:	129520461(WFS1)

AML:	100469519(WFS1)

UMR:	103658294(WFS1)

UAH:	113266656(WFS1)

UAR:	123775817(WFS1)

ELK:

111149055

LLV:

125093523

MPUF:

101686915(WFS1)

MNP:	132004268(WFS1)

MLK:	131826419(WFS1)

NVS:	122890556(WFS1)

ORO:	101378249(WFS1)

EJU:	114197890(WFS1)

ZCA:	113925297(WFS1)

MLX:	118010732(WFS1)

NSU:	110569737(WFS1)

LWW:	102739767(WFS1)

FCA:	101092024(WFS1)

PYU:	121038665(WFS1)

PCOO:

112858265(WFS1)

PBG:	122479067(WFS1)

PVIV:

125163986(WFS1)

LRUF:

124520606

LGF:	123596202(WFS1)

AJU:

106982717

PTG:	102969992(WFS1)

PPAD:

109269700(WFS1)

PUC:

125922607

PLEZ:

122218639(WFS1)

HHV:	120231838(WFS1)

BTA:	100298456(WFS1)

BOM:	102270797(WFS1)

BBUB:

102391511(WFS1)

BBIS:

104994281(WFS1)

CHX:	102188574(WFS1)

OAS:	101112732(WFS1)

BTAX:

128049576(WFS1)

CSUM:

138081945(WFS1)

ODA:	120861557(WFS1)

CCAD:

122428212(WFS1)

MREE:

136152922(WFS1)

OVR:	110149210(WFS1)

SSC:	100621070(WFS1)

CFR:	102507025(WFS1)

CBAI:

105083214(WFS1)

CDK:	105085108(WFS1)

VPC:	102541348(WFS1)

BACU:

103001171(WFS1)

BMUS:

118895411(WFS1)

LVE:	103070663(WFS1)

OOR:	101281370(WFS1)

LALB:

132519676(WFS1)

DLE:	111179115(WFS1)

PCAD:

102985279(WFS1)

PSIU:

116754531(WFS1)

NASI:

112393789(WFS1)

ECB:	100070117(WFS1)

EPZ:	103561812(WFS1)

EAI:	106843315(WFS1)

MYB:	102243829(WFS1)

MYD:	102774692(WFS1)

MMYO:

118666319(WFS1)

MDT:	132221660(WFS1)

MYUM:

138997766(WFS1)

PKL:	118709050(WFS1)

EFUS:

103294547(WFS1)

MNA:	107524058(WFS1)

DRO:	112316856(WFS1)

SHON:

118987054(WFS1)

AJM:	119035544(WFS1)

PDIC:

114492694(WFS1)

PHAS:

123815892(WFS1)

MMF:	118619579(WFS1)

PPAM:

129077517(WFS1)

HAI:	109374121(WFS1)

RFQ:	117022324(WFS1)

PALE:

102889841(WFS1)

PGIG:

120582866(WFS1)

PVP:	105304478(WFS1)

RAY:	107519034(WFS1)

MJV:	108409758(WFS1)

TOD:	119260880(WFS1)

SARA:

101537141(WFS1)

SFUM:

130040757(WFS1)

SETR:

126020935(WFS1)

LAV:	100669166(WFS1)

TMU:

101356143

ETF:	101662197(WFS1)

DNM:	101446754(WFS1)

MDO:	100018961(WFS1)

GAS:	123251503(WFS1)

SHR:	100922667(WFS1)

AFZ:

127539840

PCW:	110212263(WFS1)

TVP:	118854172(WFS1)

PBRV:

138147553(WFS1)

OAA:	100079398(WFS1)

TACU:

119927213(WFS1)

GGA:	422857(WFS1)

PCOC:

116225786(WFS1)

MGP:	104910845(WFS1)

CJO:	107314009(WFS1)

TPAI:

128080220(WFS1)

LMUT:

125692524(WFS1)

NMEL:

110397902(WFS1)

APLA:

101800827(WFS1)

ACYG:

106035101(WFS1)

CATA:

118248345(WFS1)

AFUL:

116488583(WFS1)

TGU:	100231376(WFS1)

LSR:	110481862(WFS1)

SCAN:

103824125(WFS1)

PMOA:

120511580(WFS1)

OTC:	121334989(WFS1)

PRUF:

121357360(WFS1)

ATRC:

139599702(WFS1)

GFR:	102032466(WFS1)

FAB:	101818977(WFS1)

OMA:	130252560(WFS1)

PHI:	102105537(WFS1)

PMAJ:

107203219(WFS1)

CCAE:

111928206(WFS1)

CCW:	104690742(WFS1)

CBRC:

103625608(WFS1)

ACOE:

138109980(WFS1)

ETL:	114065677(WFS1)

ZAB:	102066655(WFS1)

ZLE:	135447043(WFS1)

ACHL:

103809509(WFS1)

SVG:	106865324(WFS1)

MMEA:

130573076(WFS1)

HRT:	120753027(WFS1)

SATI:

136360186(WFS1)

CCIC:

134044244(WFS1)

FPG:	101922103(WFS1)

FCH:	102050774(WFS1)

CCRI:

104163157(WFS1)

NNT:	104413712(WFS1)

SHAB:

115610700(WFS1)

ACUN:

113479339(WFS1)

TALA:

104360760(WFS1)

ACHC:

115343563(WFS1)

HALD:

104323405(WFS1)

HLE:	104841664(WFS1)

AGEN:

126037543

HHAR:

128138871(WFS1)

GCL:

127015742

CSTI:

104549300(WFS1)

LDI:	104348960(WFS1)

MNB:	103774411(WFS1)

DPUB:

104303560(WFS1)

PPUS:

135179549(WFS1)

AVIT:

104280722(WFS1)

BRHI:

104500025(WFS1)

EGZ:	104123275(WFS1)

NNI:	104018038(WFS1)

PCRI:

104026879(WFS1)

PCAO:

104051963(WFS1)

PADL:

103920952(WFS1)

AFOR:

103894389(WFS1)

FGA:	104083106(WFS1)

GSTE:

104264035(WFS1)

CLV:	102090163(WFS1)

MUI:	104540041(WFS1)

PGUU:

104460883(WFS1)

PLET:

104618766(WFS1)

EHS:	104505618(WFS1)

CMAC:

104480426(WFS1)

CUCA:

104062601(WFS1)

TEO:	104379514(WFS1)

BREG:

104639965(WFS1)

OHA:	104331075(WFS1)

ACAR:

104532751(WFS1)

CPEA:

104393603(WFS1)

CVF:	104291317(WFS1)

RTD:	128910339(WFS1)

CRID:

134516494(WFS1)

AAM:	106498757(WFS1)

AROW:

112960493(WFS1)

NPD:	112943040(WFS1)

TGT:	104567029(WFS1)

DNE:	112996499(WFS1)

SCAM:

104151391(WFS1)

ASN:	102378020(WFS1)

AMJ:	102558683(WFS1)

CPOO:

109322229(WFS1)

GGN:	109303961(WFS1)

PSS:	102460839(WFS1)

CMY:	102947530(WFS1)

CCAY:

125636188(WFS1)

DCC:	119854779(WFS1)

CPIC:

101950225(WFS1)

TST:	117877962(WFS1)

CABI:

116831743(WFS1)

MRV:	120406912(WFS1)

ACS:	100566233(wfs1)

ASAO:

132776410(WFS1)

PVT:	110088717(WFS1)

SUND:

121932315(WFS1)

PBI:	103055967(WFS1)

PMUR:

107299172(WFS1)

CTIG:

120316201(WFS1)

TSR:	106544483(WFS1)

PGUT:

117669958 132712637

APRI:

131202950(WFS1)

PTEX:

113435763(WFS1)

NSS:	113427747(WFS1)

VKO:	123016943(WFS1)

PMUA:

114604764(WFS1)

PRAF:

128420823(WFS1)

ZVI:	118083905(WFS1)

HCG:	128327233(WFS1)

GJA:	107121379(WFS1)

STOW:

125440338(WFS1)

EMC:	129343733(WFS1)

XLA:	108706536(wfs1.S) 734911(wfs1.L)

XTR:	100127642(wfs1)

NPR:	108791049(WFS1)

RTEM:

120924432(WFS1)

BBUF:

120990360(WFS1)

BGAR:

122939987(WFS1)

PWL:	138249095(WFS1)

MUO:	115461402(WFS1)

GSH:	117362756(WFS1)

DRE:	556580(wfs1b) 566876(wfs1a)

SRX:	107730573 107742510 107749704

SANH:

107661056 107666128 107692704

SGH:	107562941 107565338 107591887

CCAR:

109047951(wfs1a) 109049829(wfs1b) 109106842

CAUA:

113044295 113113460(wfs1)

CGIB:

127948682 127971019

PTET:

122343239(wfs1a) 122357942(wfs1b)

LROH:

127163861(wfs1a) 127176431(wfs1b)

OMC:	131542752(wfs1a) 131553534(wfs1b)

PPRM:

120462149(wfs1b) 120481201(wfs1a)

RKG:	130071402(wfs1a) 130085467(wfs1b)

MAMB:

125261360(wfs1b) 125272500(wfs1a)

CIDE:

127494674 127511856

CERY:

137023595(wfs1b) 137032242(wfs1a)

MASI:

127413361 127418200 127444290 127445278

TROS:

130553586(wfs1a) 130564193(wfs1b)

TDW:	130435393(wfs1a) 130438276(wfs1b)

MANU:

129422480(wfs1b) 129444830(wfs1a)

PDAB:

135731277 135736141(wfs1a) 135749412

IPU:	108260676(wfs1a) 108269302(wfs1b)

IFU:	128604372(wfs1a) 128611658(wfs1b)

PHYP:

113525730 113542876(wfs1)

SMEO:

124381695(wfs1a) 124386432(wfs1b)

TFD:	113647776(wfs1b) 113661789(wfs1a)

TVC:	132842042(wfs1a) 132855499(wfs1b)

CGAR:

128508203(wfs1a) 128531541(wfs1b)

NGRA:

132882795(wfs1a) 132890498(wfs1b)

TRN:	134319603(wfs1b) 134326495(wfs1a)

AMEX:

103030254(wfs1a) 103038069(wfs1b)

CMAO:

118807080(wfs1b) 118817042(wfs1a)

EEE:	113572494 113587342

CHAR:

105897437(wfs1b) 105903568(wfs1a)

SPIL:

134064512(wfs1a) 134095708(wfs1b)

TRU:	101062334(wfs1) 101064513

TFS:	130527638(wfs1a) 130531200(wfs1b)

TNG:	GSTEN00024585G001 GSTEN00033039G001

LCO:	104922614(wfs1) 104924361

NCC:	104957012 104961175(wfs1)

TBEN:

117474807(wfs1a) 117477234

CGOB:

115009529 115014907(wfs1)

PGEO:

117445456(wfs1a) 117454048(wfs1b)

GACU:

117543429(wfs1a) 117555720(wfs1b)

EMAC:

134859611(wfs1b) 134865170(wfs1a)

ELY:	117255541(wfs1a) 117261332(wfs1b)

EFO:	125886093(wfs1a) 125894623(wfs1b)

PLEP:

121941555(wfs1a) 121948394(wfs1b)

SLUC:

116040487(wfs1a) 116052597(wfs1b)

ECRA:

117935703(wfs1a) 117951447(wfs1b)

ESP:	116670418 116696817(wfs1)

PFLV:

114545750 114562623(wfs1)

GAT:	120818119(wfs1b) 120825626(wfs1a)

PPUG:

119211257(wfs1b) 119218662(wfs1a)

AFB:	129089659(wfs1b) 129095746(wfs1a)

CLUM:

117737779(wfs1b) 117739108(wfs1a)

PSWI:

130190327(wfs1a) 130210241(wfs1b)

CANA:

137794796(wfs1a) 137796135(wfs1b)

CVE:	137875506(wfs1b) 137884906(wfs1a)

MSAM:

119888693(wfs1b) 119899110(wfs1a)

SCHU:

122873636(wfs1a) 122880561(wfs1b)

CUD:	121507922(wfs1a) 121516849(wfs1b)

SPUL:

138595206(wfs1a) 138598203(wfs1b)

LMIX:

132981920(wfs1b) 132994818(wfs1a)

ALAT:

119007908(wfs1b) 119024811(wfs1a)

ASTR:

137599893(wfs1a) 137602566(wfs1b)

MZE:	101464362 101479301(wfs1)

ONL:	100690548(wfs1) 100709626

OAU:	116326021(wfs1a) 116334596(wfs1b)

OLA:	101167425 101168126(wfs1)

OML:	112153192(wfs1b) 112156968(wfs1a)

CSAI:

133447014(wfs1b) 133451262(wfs1a)

XMA:	102220803 102236466(wfs1)

XCO:	114139445(wfs1) 114145132

XHE:	116714286 116720334

PRET:

103469373 103471345(wfs1)

PFOR:

103137797 103147457(wfs1)

PLAI:

106942071(wfs1) 106954672

PMEI:

106928344(wfs1) 106928658

GAF:	122829078(wfs1a) 122836643(wfs1b)

PPRL:

129362811(wfs1b)

CVG:	107085724 107096697 107101009

CTUL:

119773836(wfs1a) 119796526(wfs1b)

GMU:	124860832(wfs1b) 124868462(wfs1a)

NFU:	107376626(wfs1) 107382173

KMR:	108241546(wfs1a) 108243015(wfs1b)

ALIM:

106511061(wfs1) 106531114

NWH:	119408148(wfs1a) 119408981(wfs1b)

AOCE:

111567096(wfs1a) 111583655(wfs1b)

EJA:	138209688(wfs1a) 138211480(wfs1b)

BFRE:

138620309(wfs1a) 138633532(wfs1b)

MCEP:

125001014(wfs1a) 125007930(wfs1b)

CSEM:

103383729 103390930(wfs1)

POV:	109628768(wfs1) 109637739

SSEN:

122770782(wfs1a) 122778929

SSOE:

131466829(wfs1a) 131472845(wfs1b)

HHIP:

117761222(wfs1a) 117769530

HSP:	118112117(wfs1b) 118116452(wfs1a)

PPLT:

128430875(wfs1a) 128446305(wfs1b)

SMAU:

118312878(wfs1a) 118319623(wfs1b)

LCF:	108885533(wfs1b) 108896423

SDU:	111231387 111232763(wfs1)

SLAL:

111662769(wfs1) 111664506

XGL:	120785588(wfs1b) 120800643(wfs1a)

HCQ:	109511429 109524358(wfs1)

SSCV:

125969499(wfs1a) 125988931(wfs1b)

SBIA:

133506141(wfs1a) 133508892(wfs1b)

PEE:	133403764(wfs1a) 133408008(wfs1b)

PTAO:

133477049(wfs1a) 133485277(wfs1b)

BPEC:

110162317 110165303

ENY:	140354610(wfs1b) 140376993(wfs1a)

MALB:

109957891(wfs1) 109958469

BSPL:

114845297(wfs1a) 114864233(wfs1b)

SJO:	128362906 128365905(wfs1a)

SSCO:

133985488 133985983(wfs1a)

GMH:	115540956 115552321(wfs1)

SASA:

106597865 106604863 106611899

STRU:

115173920 115184186 115184189 115205366

OTW:	112220791 112241557

OMY:	110488645(wfs1b) 110504851 110514270 110516987

OGO:	123993277 124010375 124024500 124026265

ONE:	115122863(wfs1) 115130554

OKI:	109864666 109905089 116360129 116371279

OKE:	118363394 118384018 127908069 127920342 127923124

OMM:	135507199 135526253 135528960 135528961 135545762

OCLA:

139366181 139391131 139394149 139394223 139395369

SALP:

111965417 112069052

SNH:	120038337 120048181

CCLU:

121544273 121561478 121578965

ELS:	105020812 105025217(wfs1)

OEP:	134032852(wfs1b) 134033217(wfs1a)

SFM:	108924155(wfs1) 108925906

PKI:	111836210(wfs1) 111836784

AANG:

118227147 118231966

AROT:

135255992(wfs1a) 135259335

CCOG:

133131259 133134985

LOC:	102693007(wfs1)

PSPA:

121324742 121330163

ARUT:

117408502 117421108

PSEX:

120527715

LCM:	102355317(WFS1)

CMK:

103181324

CPLA:

122539412(wfs1b)

HOC:

132833348

LERI:

129701663

PMRN:

116941206 116954067(WFS1)

LRJ:	133345639 133355755 133355756

CIN:

100186442

SCLV:

120339284

SKO:	100329063(WFS1)

PFLL:

139120054

DME:	Dmel_CG4917(wfs1)

DER:

6554917

DSE:

6607474

DSI:	Dsimw501_GD18439(Dsim_GD18439)

DYA:	Dyak_GE24017

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI12633

DAZ:

108613700

DNV:

108651586

DHE:

111597753

DVI:	6632383(wfs1)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135963461(wfs1)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ013087

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139103167(Wfs1)

TLN:	139809081(Wfs1)

HST:

DQU:

CFO:

FEX:

PMEC:

138934507(Wfs1)

LHU:	105672435(wfs1)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:	124216024(wfs1)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138127398(wfs1)

DPA:

109535223

ESIM:

136418624(wfs1)

EFOR:

136343091(wfs1)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_210285

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137925933(wfs1)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

CSTB:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:	111064064 120351933

HVI:

124374860

MQU:

128982767

PHU:	Phum_PHUM420890

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

HAMR:

139688160(wfs1)

FCD:

110845444

DPX:	DAPPUDRAFT_300109

DMK:

116918355

DPZ:

124343156

PVM:	113804408(wfs1)

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123754471(wfs1)

CQD:	128687237(wfs1)

PTRU:

123501428

ESN:

127006176

MNZ:

135208652

MRJ:	136845943(wfs1)

PORN:

139751361(wfs1)

HAZT:

108673805

EAF:

111699878

PPOI:

119092824 119092826 119092853

CSCU:

111621063

CVS:	136974435(wfs1)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

HRO:	HELRODRAFT_168124

LGI:	LOTGIDRAFT_171654

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:	110464346 110464351

PMAX:

AIRR:

MMER:

RPHI:

DPOL:

MAEA:

128238816 128238824 128238833

OBI:

OSN:

LJP:

LAK:

NVE:

EPA:

ATEN:

PDAM:

SPIS:

TAD:	TRIADDRAFT_58543

AQU:

105316107

» show all

Reference

PMID:16989814

Authors

Takei D, Ishihara H, Yamaguchi S, Yamada T, Tamura A, Katagiri H, Maruyama Y, Oka Y

Title

WFS1 protein modulates the free Ca(2+) concentration in the endoplasmic reticulum.

Journal

FEBS Lett 580:5635-40 (2006)
DOI:10.1016/j.febslet.2006.09.007

Sequence

[hsa:7466]

Reference

PMID:20160352

Authors

Fonseca SG, Ishigaki S, Oslowski CM, Lu S, Lipson KL, Ghosh R, Hayashi E, Ishihara H, Oka Y, Permutt MA, Urano F

Title

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells.

Journal

J Clin Invest 120:744-55 (2010)
DOI:10.1172/JCI39678

Sequence

[hsa:7466] [mmu:22393] [rno:83725]

LinkDB

DBGET integrated database retrieval system