dimethylallyl-diphosphate:12alpha,13alpha-dihydroxyfumitremorgin C dimethylallyl-N-1-transferase
Brite
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09110 Biosynthesis of other secondary metabolites
00404 Staurosporine biosynthesis
K14134 FTMPT2; 12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase
09180 Brite Hierarchies
09181 Protein families: metabolism
01006 Prenyltransferases
K14134 FTMPT2; 12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase
Enzymes [BR:ko01000]
2. Transferases
2.5 Transferring alkyl or aryl groups, other than methyl groups
2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
2.5.1.110 12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase
K14134 FTMPT2; 12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase
Prenyltransferases [BR:ko01006]
Compound prenylation
Indole prenyltransferase
K14134 FTMPT2; 12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase
12alpha,13alpha-dihydroxyfumitremorgin C prenyltransferase;
ftmH (gene name);
FtmPT2;
dimethylallyl-diphosphate:12alpha,13alpha-dihydroxyfumitremorgin C dimethylallyl-N-1-transferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
prenyl-diphosphate:12alpha,13alpha-dihydroxyfumitremorgin C prenyl-N-1-transferase
Reaction(IUBMB)
prenyl diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin C = diphosphate + fumitremorgin B [RN:R10457]
prenyl diphosphate [CPD:C00235];
12alpha,13alpha-dihydroxyfumitremorgin C [CPD:C20605]
Product
diphosphate [CPD:C00013];
fumitremorgin B [CPD:C20630]
Comment
The enzyme from the fungus Aspergillus fumigatus also shows some activity with fumitremorgin C. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen.
Enzymatic reactions [BR:br08201]
2. Transferase reactions
2.5 Transferring alkyl or aryl groups, other than methyl groups
2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
2.5.1.110
R10457 Dimethylallyl diphosphate + 12alpha,13alpha-Dihydroxyfumitremorgin C <=> Diphosphate + Fumitremorgin B
