KEGG ORTHOLOGY: K14257

ORTHOLOGY: K14257

Entry

K14257                      KO

Symbol

ctcP, cts4, prnC

Name

tetracycline 7-halogenase / FADH2 O2-dependent halogenase [EC:1.14.19.49 1.14.19.-]

Pathway

map00253

Tetracycline biosynthesis

map00404

Staurosporine biosynthesis

map01057

Biosynthesis of type II polyketide products

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00790

Pyrrolnitrin biosynthesis, tryptophan => pyrrolnitrin

M00823

Chlortetracycline biosynthesis, pretetramide => chlortetracycline

Reaction

R11106

R11478

tetracycline:FADH2 oxidoreductase (7-halogenating)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K14257  ctcP, cts4, prnC; tetracycline 7-halogenase / FADH2 O2-dependent halogenase
   00253 Tetracycline biosynthesis
    K14257  ctcP, cts4, prnC; tetracycline 7-halogenase / FADH2 O2-dependent halogenase
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K14257  ctcP, cts4, prnC; tetracycline 7-halogenase / FADH2 O2-dependent halogenase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14257  ctcP, cts4, prnC; tetracycline 7-halogenase / FADH2 O2-dependent halogenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.49  tetracycline 7-halogenase
     K14257  ctcP, cts4, prnC; tetracycline 7-halogenase / FADH2 O2-dependent halogenase
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide tailoring proteins
  Halogenase
   K14257  ctcP, cts4, prnC; tetracycline 7-halogenase / FADH2 O2-dependent halogenase

Other DBs

COG:

COG0644

Genes

ECLN:

ECNIH4_08285

ENO:	ECENHK_14345

ECHG:

FY206_15895

END:	A4308_19035

ENZ:	G0034_14940

SRR:	SerAS9_4266

SRL:	SOD_c39980(prnC)

SRY:	M621_21735

SPLY:

Q5A_021590(soxA)

SRS:	SerAS12_4267

SRA:	SerAS13_4267

SMAF:

D781_2599

SRZ:	AXX16_2518

SERM:

CLM71_13480

SRHZ:

FO014_20185

SGRI:

SGBXF1_00335(soxA)

SERT:

TAN611_2783(prnC)

DYE:	EO087_02530

PAG:	PLES_25781 PLES_25851(pltD)

PAF:	PAM18_2383(pltM) PAM18_2389(pltD)

PAEL:

T223_13175 T223_13210

PFL:	PFL_2784(pltM) PFL_2790(pltD) PFL_3606(prnC)

PPRC:

PFLCHA0_c28420(pltM) PFLCHA0_c28480(pltD) PFLCHA0_c36470(prnC)

PPRO:

PPC_2829(pltM) PPC_2835(pltD) PPC_3745(prnC)

PCH:	EY04_18025

PCZ:	PCL1606_28090

PCP:	JM49_15080

PSEM:

TO66_16625

PPII:

QL104_13925 QL104_13955 QL104_19155 QL104_23510

PDAN:

PFZ56_19920

PCAA:

V6L78_22535

CJA:	CJA_2999(halA)

MMT:	Metme_1103

HCH:

HCH_02500

HAHE:

ENC22_11335

HAHH:

O5O45_06390

ZPL:	ZBT109_0564

BMA:	BMAA1201(prnC)

BMV:	BMASAVP1_0165(prnC)

BML:	BMA10229_0442(prnC)

BMN:	BMA10247_A1135(prnC)

BMAZ:

BMAL:

BMAE:

BMAQ:

BMAI:

BMAF:

BMAB:

BPS:

BPM:	BURPS1710b_A0003(prnC) BURPS1710b_A1117(prnC)

BPL:	BURPS1106A_A1397(halB) BURPS1106A_A2735

BPD:	BURPS668_A1482 BURPS668_A2887

BPR:	GBP346_B0728 GBP346_B2174

BPSE:

BPSM:

BPSU:

BPSD:

BPZ:	BP1026B_II1107

BPQ:	BPC006_II1407 BPC006_II2698

BPK:	BBK_4753 BBK_6130

BPSH:

DR55_4322 DR55_5720

BPSA:

BBU_3997 BBU_5014

BPSO:

X996_4250 X996_5524

BUT:	X994_5082 X994_6109

BTZ:

BTL_5468

BTHA:

DR62_5268

BOK:	DM82_2185 DM82_6304

BOC:

BG90_2527

BUU:	WS70_23845

BSAV:

WS86_22610

BUR:	Bcep18194_C6708

BCM:	Bcenmc03_6985

BAM:

Bamb_4728

BAC:	BamMC406_5266

BCEP:

BPYR:

BCON:

BUB:

BSEM:

BMEC:

BARI:

BSER:

BSOA:

BGD:	bgla_2g02310

BURK:

DM992_38825

BURM:

GJG85_34560

BURF:

Bsp3421_002342

BUV:	FPJ27_11850

MBD:	MEBOL_008076

PBRU:

PALJ:

SAMY:

NANN:

RBA:	RB1653(prnC)

RHOI:

PSR62_20040

PIR:	VN12_12750

RUL:

UC8_31640

ROL:	CA51_40950

RUV:

EC9_43150

AHEL:

Q31a_04260

RLC:	K227x_49800

SMAM:

Mal15_37510

SNEP:

Enr13x_29450

SMAE:

TBK1r_19870

PLS:	VT03_06115

FMR:	Fuma_06477

GMR:	GmarT_34080

GIM:	F1728_29395

GPN:	Pan110_32210

GFM:	Enr17x_33880

GAZ:	Pan241w_32920

GAW:	V144x_26700

GAX:	Pan161_35060

MRI:	Mal4_16350

ACAF:

PVAR:

CCOP:

CSPN:

SCHL:

SSPE:

GES:	VT84_18145

GMS:	SOIL9_20870

LRS:	PX52LOC_00381

FTJ:

FTUN_8502

ULI:	ETAA1_02960

UHL:	UABHE_004247 UABHE_004920

ABAS:

ACPOL_5987

EPL:	P4G45_06590

ADIN:

ABAC:

GBA:

THEO:

MGIN:

RMR:

RMG:	Rhom172_0794

RLO:	GQ464_016890

RBAR:

AWN76_015905

CPRV:

CYPRO_2187

PIH:	UB51_18965

PCHI:

PC41400_07730

MAB:

MAB_2284

MMV:	MYCMA_09365

MABB:

MASS_2208

MABL:

MMASJCM_2233

MIZ:	BAB75_12200

MSTE:

MSTE_02497

NFR:	ERS450000_00759

NCY:	NOCYR_5153

NBR:	O3I_018870

NNO:	NONO_c51090(prnC)

NTP:	CRH09_09475 CRH09_09510

NOZ:	DMB37_02795

NOD:	FOH10_15045 FOH10_23420

NWL:	NWFMUON74_24270(prnC)

NVU:	V7968_26565

RRZ:	CS378_19305

RHOY:

QNA09_01210

SCO:	SCO1275(2SCG18.22)

SFI:

SFUL_3996

SSX:	SACTE_6340

SRC:	M271_09845

SVE:

SVEN_0488

SDV:	BN159_0503 BN159_0504 BN159_2478 BN159_2479 BN159_2480 BN159_2482 BN159_2483(halB) BN159_2484

SLV:	SLIV_31415

SGU:	SGLAU_28900 SGLAU_28930

SAMB:

SAM23877_1355(prnC)

SCZ:	ABE83_16275

SPAV:

Spa2297_04645

SGS:	AVL59_19215

SCAD:

DN051_32680

SPHW:

NFX46_19280

STRD:

NI25_18925 NI25_32825

SNZ:	DC008_13265

SVQ:	N6Q81_05840

SGD:	ELQ87_03590

SVR:	CP971_23950

SFY:	GFH48_20345

SCAV:

CVT27_18180

SPAC:

B1H29_04740 B1H29_31235

SCHA:

SCHF:

SFEU:

SMOB:

SCIR:

STRCI_006110 STRCI_006112 STRCI_006113 STRCI_006114 STRCI_007874 STRCI_007875

STUD:

STRTU_005058

KBU:	Q4V64_07440

SARM:

DVA86_03325 DVA86_18260 DVA86_18265 DVA86_18280

SPRF:

K4G22_30710 K4G22_30780

SMIB:

STRL:

STSD:

SRPZ:

STRV:

SMOD:

STBR:

SSOC:

STYI:

SFLU:

ACKTSN_12250 ACKTSN_40245

SSTO:

STCZ:

STJL:

SCT:

SCY:	SCATT_55980

KAU:	B6264_18525

KCH:	O1G21_22165

STRI:

C7M71_024630

ABRY:

NYE86_15915 NYE86_16955

ACTW:

F7P10_30225

SPIQ:

OHA34_06380

ACTQ:

OG417_42950

FRA:	Francci3_0437

FAL:

FRAAL0926

FRE:	Franean1_6189

SEN:

AORI:

SSYI:

ASE:

ACTS:

AIH:	Aiant_03700

ACTR:

Asp14428_76420

ACTL:

L3i22_052610

AOU:	ACTOB_004306 ACTOB_005290

PSUU:

Psuf_005050(prnC) Psuf_005170

CATI:

CS0771_15270(prnC) CS0771_15280 CS0771_15290

DVC:	Dvina_26625

DMAT:

Dmats_22070

DAUR:

Daura_27000 Daura_37810

CAI:	Caci_3552 Caci_6353

AMR:

AM1_6083

CTHE:

Chro_3657

CAP:	CLDAP_18670

CCZ:	CCALI_00884

HLT:	I7X12_12635

HALE:

G3A49_13210

HGI:	ABY42_10695

HLR:	HALLA_01030

AG:	AAB97506(prnC) AEI98659(ctcP) BAA07389(cts4)

» show all

Reference

PMID:7612997 (cts4)

Authors

Dairi T, Nakano T, Aisaka K, Katsumata R, Hasegawa M.

Title

Cloning and nucleotide sequence of the gene responsible for chlorination of tetracycline.

Journal

Biosci Biotechnol Biochem 59:1099-106 (1995)
DOI:10.1271/bbb.59.1099

Sequence

[ag:BAA07389]

Reference

PMID:9172332 (prnC)

Authors

Hammer PE, Hill DS, Lam ST, Van Pee KH, Ligon JM

Title

Four genes from Pseudomonas fluorescens that encode the biosynthesis of pyrrolnitrin.

Journal

Appl Environ Microbiol 63:2147-54 (1997)
DOI:10.1128/AEM.63.6.2147-2154.1997

Sequence

[ag:AAB97506]

Reference

PMID:23800859 (ctcP)

Authors

Zhu T, Cheng X, Liu Y, Deng Z, You D

Title

Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens.

Journal

Metab Eng 19:69-78 (2013)
DOI:10.1016/j.ymben.2013.06.003

Sequence

[ag:AEI98659]

Reference

PMID:16895332

Authors

Vaillancourt FH, Yeh E, Vosburg DA, Garneau-Tsodikova S, Walsh CT

Title

Nature's inventory of halogenation catalysts: oxidative strategies predominate.

Journal

Chem Rev 106:3364-78 (2006)
DOI:10.1021/cr050313i

LinkDB

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